DK0418797T3 - Pyrimidin-4,6-dicarboxylsyrediamider, fremgangsmåde til deres fremstilling, deres anvendelse samt lægemiddel på basis af disse forbindelser - Google Patents

Pyrimidin-4,6-dicarboxylsyrediamider, fremgangsmåde til deres fremstilling, deres anvendelse samt lægemiddel på basis af disse forbindelser

Info

Publication number: DK0418797T3
Authority: DK; Denmark
Prior art keywords: pyrimidine; compounds; preparation; dicarboxylic acid; drug based
Prior art date: 1989-09-21

Application number

DK90117894.7T

Other languages

English (en)

Inventor

Ekkehard Dr Baader

Martin Dr Bickel

Volkmar Dr Guenzler-Pukall

Stephan Dr Henke

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-21

Filing date

1990-09-18

Publication date

1995-01-02

1990-09-18 Application filed by Hoechst Ag filed Critical Hoechst Ag

1995-01-02 Application granted granted Critical

1995-01-02 Publication of DK0418797T3 publication Critical patent/DK0418797T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
QZMMMOWLQLKASC-UHFFFAOYSA-N pyrimidine-4,6-dicarboxamide Chemical class NC(=O)C1=CC(C(N)=O)=NC=N1 QZMMMOWLQLKASC-UHFFFAOYSA-N 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
102000008490 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Human genes 0.000 abstract 1
108010020504 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Proteins 0.000 abstract 1
102000004079 Prolyl Hydroxylases Human genes 0.000 abstract 1
108010043005 Prolyl Hydroxylases Proteins 0.000 abstract 1
229960003444 immunosuppressant agent Drugs 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Obesity (AREA)
Diabetes (AREA)
Hematology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Plural Heterocyclic Compounds (AREA)
Adhesives Or Adhesive Processes (AREA)
Compositions Of Macromolecular Compounds (AREA)
Dental Preparations (AREA)

DK90117894.7T 1989-09-21 1990-09-18 Pyrimidin-4,6-dicarboxylsyrediamider, fremgangsmåde til deres fremstilling, deres anvendelse samt lægemiddel på basis af disse forbindelser DK0418797T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3931432A DE3931432A1 (de)	1989-09-21	1989-09-21	Pyrimidin-4,6-dicarbonsaeurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen

Publications (1)

Publication Number	Publication Date
DK0418797T3 true DK0418797T3 (da)	1995-01-02

Family

ID=6389833

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90117894.7T DK0418797T3 (da)	1989-09-21	1990-09-18	Pyrimidin-4,6-dicarboxylsyrediamider, fremgangsmåde til deres fremstilling, deres anvendelse samt lægemiddel på basis af disse forbindelser

Country Status (22)

Country	Link
US (1)	US5130317A (da)
EP (1)	EP0418797B1 (da)
JP (1)	JPH03240776A (da)
KR (1)	KR910006241A (da)
AT (1)	ATE110369T1 (da)
AU (2)	AU633142B2 (da)
CA (1)	CA2025799A1 (da)
CZ (1)	CZ458390A3 (da)
DD (1)	DD295835A5 (da)
DE (2)	DE3931432A1 (da)
DK (1)	DK0418797T3 (da)
ES (1)	ES2062239T3 (da)
FI (1)	FI904604A7 (da)
HU (2)	HU207853B (da)
IE (1)	IE903403A1 (da)
IL (1)	IL95740A (da)
LV (1)	LV10441A (da)
NO (1)	NO904114L (da)
PL (1)	PL164989B1 (da)
PT (1)	PT95375A (da)
RU (1)	RU1836359C (da)
ZA (1)	ZA907535B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3930696A1 (de) *	1989-09-14	1991-03-28	Hoechst Ag	Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
ES2131556T3 (es) *	1992-01-13	1999-08-01	Hercules Inc	Fibra aglutinable termicamente para telas no tejidas de alta resistencia.
SG50447A1 (en)	1993-06-24	1998-07-20	Hercules Inc	Skin-core high thermal bond strength fiber on melt spin system
DK0719879T3 (da) *	1994-12-19	2000-09-18	Fibervisions L P	Fremgangsmåde til fremstilling af fibre til ikke-vævede materialer af høj styrke og de resulterende fibre og ikke-vævede ma
US5968965A (en) *	1996-01-30	1999-10-19	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
DOP2002000333A (es)	2001-02-14	2002-09-30	Warner Lambert Co	Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
DOP2002000332A (es)	2001-02-14	2002-08-30	Warner Lambert Co	Inhibidores de piridina de metaloproteinasas de la matriz
JP2004518723A (ja)	2001-02-14	2004-06-24	ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー	ピリミジンマトリックスメタロプロテイナーゼ阻害剤
US6924276B2 (en)	2001-09-10	2005-08-02	Warner-Lambert Company	Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
WO2003032999A1 (en)	2001-10-12	2003-04-24	Warner-Lambert Company Llc	Alkyne matrix metalloproteinase inhibitors
US6933298B2 (en)	2001-12-08	2005-08-23	Aventis Pharma Deutschland Gmbh	Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases
DE10160357A1 (de) *	2001-12-08	2003-06-18	Aventis Pharma Gmbh	Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen
WO2004014384A2 (en) *	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors
PA8578101A1 (es) *	2002-08-13	2004-05-07	Warner Lambert Co	Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
EP1394159A1 (fr) *	2002-08-13	2004-03-03	Warner-Lambert Company LLC	Nouveaux dérivés de thiophène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
WO2004014892A1 (en) *	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Monocyclic derivatives as matrix metalloproteinase inhibitors
JP2006500351A (ja) *	2002-08-13	2006-01-05	ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー	マトリックスメタロプロテアーゼ−１３阻害剤としてのピリミジン−２，４−ジオン誘導体
DE10251019A1 (de) *	2002-11-02	2004-05-19	Aventis Pharma Deutschland Gmbh	Neue Pyrimidin-4,6-dicarbonsäurediamide zur selektiven Inhibierung von Kollagenasen
MXPA05004365A (es) *	2002-11-02	2005-07-05	Aventis Pharma Gmbh	Nuevas diamidas del acido pirimidin -4, 6 - dicarboxilico para la inhibicion selectiva de colagenasas.
US7166609B2 (en) *	2002-11-02	2007-01-23	Sanofi-Aventis Deutschland Gmbh	Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases
US20050004111A1 (en) *	2003-01-03	2005-01-06	Aventis Pharma Deutschland Gmbh	Selective MMP-13 inhibitors
DE10300017A1 (de) *	2003-01-03	2004-07-15	Aventis Pharma Deutschland Gmbh	Selektive MMP 13 Inhibitoren
WO2005016926A1 (en) *	2003-08-19	2005-02-24	Warner-Lambert Company Llc	Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors
WO2007079199A2 (en) *	2005-12-30	2007-07-12	Alantos Pharmaceuticals, Holding, Inc.	Substituted bis-amide metalloprotease inhibitors
DK2379525T3 (da) *	2008-12-19	2015-10-19	Boehringer Ingelheim Int	Cyklisk pyrimidin-4-carboxamider, som CCR2-receptor-antagonister til behandling af inflammation, astma og COPD

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0112617B1 (en) *	1982-11-04	1986-12-30	Imperial Chemical Industries Plc	Process for the extraction of metal values and novel metal extractants
US4962109A (en) *	1985-12-23	1990-10-09	Imperial Chemical Industries Plc	Insecticidally and acaricidally active pyrimidine esters and intermediates therefor
WO1988000237A1 (en) *	1986-06-27	1988-01-14	Damon Biotech, Inc.	Covalent membranes
DE3703959A1 (de) *	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
WO1990007575A1 (en) *	1988-12-30	1990-07-12	Anderson David M	Stabilized microporous materials and hydrogel materials

1989
- 1989-09-21 DE DE3931432A patent/DE3931432A1/de not_active Withdrawn
1990
- 1990-09-18 DK DK90117894.7T patent/DK0418797T3/da active
- 1990-09-18 EP EP90117894A patent/EP0418797B1/de not_active Expired - Lifetime
- 1990-09-18 ES ES90117894T patent/ES2062239T3/es not_active Expired - Lifetime
- 1990-09-18 AT AT90117894T patent/ATE110369T1/de not_active IP Right Cessation
- 1990-09-18 DE DE59006893T patent/DE59006893D1/de not_active Expired - Fee Related
- 1990-09-19 RU SU904831137A patent/RU1836359C/ru active
- 1990-09-19 IL IL9574090A patent/IL95740A/en not_active IP Right Cessation
- 1990-09-19 FI FI904604A patent/FI904604A7/fi not_active Application Discontinuation
- 1990-09-19 US US07/584,655 patent/US5130317A/en not_active Expired - Fee Related
- 1990-09-19 DD DD90344102A patent/DD295835A5/de not_active IP Right Cessation
- 1990-09-20 AU AU62698/90A patent/AU633142B2/en not_active Ceased
- 1990-09-20 NO NO90904114A patent/NO904114L/no unknown
- 1990-09-20 KR KR1019900014872A patent/KR910006241A/ko not_active Withdrawn
- 1990-09-20 PT PT95375A patent/PT95375A/pt not_active Application Discontinuation
- 1990-09-20 AU AU62699/90A patent/AU635326B2/en not_active Expired - Fee Related
- 1990-09-20 IE IE340390A patent/IE903403A1/en unknown
- 1990-09-20 PL PL90286972A patent/PL164989B1/pl unknown
- 1990-09-20 JP JP2249018A patent/JPH03240776A/ja active Pending
- 1990-09-20 ZA ZA907535A patent/ZA907535B/xx unknown
- 1990-09-20 CA CA002025799A patent/CA2025799A1/en not_active Abandoned
- 1990-09-20 CZ CS904583A patent/CZ458390A3/cs unknown
- 1990-09-21 HU HU906007A patent/HU207853B/hu not_active IP Right Cessation
1993
- 1993-05-06 LV LV930293A patent/LV10441A/xx unknown
1995
- 1995-03-01 HU HU95P/P00086P patent/HU210822A9/hu unknown

Also Published As

Publication number	Publication date
AU633142B2 (en)	1993-01-21
DE59006893D1 (de)	1994-09-29
ES2062239T3 (es)	1994-12-16
EP0418797A2 (de)	1991-03-27
NO904114L (no)	1991-03-22
HU210822A9 (en)	1995-08-28
DE3931432A1 (de)	1991-04-04
HU906007D0 (en)	1991-03-28
JPH03240776A (ja)	1991-10-28
EP0418797A3 (en)	1991-05-08
KR910006241A (ko)	1991-04-27
CZ458390A3 (en)	1995-01-18
HU207853B (en)	1993-06-28
LV10441A (lv)	1995-02-20
IL95740A0 (en)	1991-06-30
US5130317A (en)	1992-07-14
ZA907535B (en)	1991-06-26
PL164989B1 (en)	1994-10-31
FI904604A7 (fi)	1991-03-22
RU1836359C (ru)	1993-08-23
IE903403A1 (en)	1991-04-10
AU6269990A (en)	1991-04-11
HUT55002A (en)	1991-04-29
AU635326B2 (en)	1993-03-18
NO904114D0 (no)	1990-09-20
EP0418797B1 (de)	1994-08-24
IL95740A (en)	1994-07-31
ATE110369T1 (de)	1994-09-15
AU6269890A (en)	1991-04-11
CA2025799A1 (en)	1991-03-22
PT95375A (pt)	1991-05-22
PL286972A1 (en)	1991-10-21
DD295835A5 (de)	1991-11-14
FI904604A0 (fi)	1990-09-19

Publication	Publication Date	Title
NO904114L (no)	1991-03-22	Pyrimidin-4,6-dikarboksylsyrediamider samt fremgangsmaate for fremstilling derav.
NZ229832A (en)	1992-08-26	Condensed heterocyclic compounds, preparation and pharmaceutical compositions thereof
DE122006000010I2 (de)	2007-10-04	Benzocyclobutyl- oder Indanyl-Alkyl-Amino-Alkyl substituierte 3-Benzazepin-2-ones, verwendbar in derBehandlung von kardiovaskularen Krankheiten
DK0624595T3 (da)	1999-05-17	Nor-galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidler
ES2074846T3 (es)	1995-09-16	Nuevas naftil-etil-ureas y naftil-etil-tioureas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.
DK0598770T3 (da)	1997-12-15	Pyrazinderivater samt fremstilling og anvendelse deraf
DK0422485T3 (da)	1996-08-19	Quinoloncarboxylsyrederivater, fremgangsmåder til deres fremstilling samt deres anvendelse som antivirale midler
DK0474712T3 (da)	1993-11-29	Anvendelse af lysolecitinderivater til fremstilling af et farmaceutisk præparat
DK148183A (da)	1983-10-03	Fremgangsmaade til fremstilling af imidazolylphenyl-tetrahydropyridaziner
DK0386451T3 (da)	1993-05-24	Oxiderede diphenylheteroalkaner, fremgangsmåde til fremstilling heraf og anvendelsen af disse
IE880628L (en)	1988-09-07	Substituted pyridine-2,4-dicarboxylic acid derivatives,¹processes for their preparation, the use thereof and¹medicaments based on these compounds
NO930205L (no)	1993-07-23	Benzimidazoler, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling
DK0617027T3 (da)	2000-10-09	N-benzylpiperazinforbindelser, fremgangsmåde til fremstilling heraf og sammensætninger indeholdende forbindelserne
BR8203379A (pt)	1983-05-31	Composicoes herbicidas baseadas em derivados de cloro-aceto-ciclo-alquil-amidas
ATE92070T1 (de)	1993-08-15	Azachromanderivate.
DK519783D0 (da)	1983-11-14	Fremgangsmade til fremstilling af 1-aroyl-5-oxo-2-pyrrolidinpropansyrer samt beslaegtede estre samt kompositioner indeholdende disse
DK47988D0 (da)	1988-01-29	Substituerede 3-phenyl-7h-thiazolooe3,2-baaoe1,2,4aatriazin-7-oner, deres fremstilling og anvendelse som laegemiddel, samt ved fremstillingen anvendelige mellemprodukter
NO960271D0 (no)	1996-01-23	Tiokarbamoylforbindelser anvendt som mikrobiocider
SE8603517D0 (sv)	1986-08-20	Heterocyclic compounds and their preparation and pharmaceutical formulation
DK484988D0 (da)	1988-08-31	Thionophosphonsyreestere, deres fremstilling og anvendelse til bekaempelse af skadelige organismer
ZA902167B (en)	1990-12-28	Thienylpiperazines,process for the preparation thereof,the use thereof,and pharmaceuticals containing these and the preparation thereof