DK0424802T3 - Tricykliske quinolinforbindelser med antineoplastisk aktivitet - Google Patents

Tricykliske quinolinforbindelser med antineoplastisk aktivitet

Info

Publication number
DK0424802T3
DK0424802T3 DK90119985.1T DK90119985T DK0424802T3 DK 0424802 T3 DK0424802 T3 DK 0424802T3 DK 90119985 T DK90119985 T DK 90119985T DK 0424802 T3 DK0424802 T3 DK 0424802T3
Authority
DK
Denmark
Prior art keywords
lower alkyl
group
phenyl group
heterocyclic group
quinoline compounds
Prior art date
Application number
DK90119985.1T
Other languages
English (en)
Inventor
Daniel T Chu
Jacob J Plattner
Larry L Klein
Linus L Shen
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK0424802T3 publication Critical patent/DK0424802T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/06—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
DK90119985.1T 1989-10-23 1990-10-18 Tricykliske quinolinforbindelser med antineoplastisk aktivitet DK0424802T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/425,536 US5071848A (en) 1989-10-23 1989-10-23 Tricyclic quinoline antineoplastic agents

Publications (1)

Publication Number Publication Date
DK0424802T3 true DK0424802T3 (da) 1996-04-22

Family

ID=23686982

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90119985.1T DK0424802T3 (da) 1989-10-23 1990-10-18 Tricykliske quinolinforbindelser med antineoplastisk aktivitet

Country Status (11)

Country Link
US (1) US5071848A (da)
EP (1) EP0424802B1 (da)
JP (1) JPH03167191A (da)
AT (1) ATE131809T1 (da)
CA (1) CA2028246A1 (da)
DE (1) DE69024322T2 (da)
DK (1) DK0424802T3 (da)
ES (1) ES2083990T3 (da)
GR (1) GR3018961T3 (da)
IE (1) IE71688B1 (da)
PT (1) PT95646A (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2006118605A2 (en) * 2004-11-11 2006-11-09 Achillion Pharmaceuticals, Inc. 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents
US7659399B2 (en) * 2005-01-05 2010-02-09 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]napththalene-3,4-diones and related compounds as anti-infective agents
US7199128B2 (en) * 2005-02-02 2007-04-03 Achillion Pharmaceuticals, Inc. 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
BRPI0607723A2 (pt) * 2005-02-16 2009-10-06 Achillion Pharmaceuticals Inc isotiazoloquinolonas e compostos relacionados como agentes antiinfecciosos
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
AU2006272571B2 (en) 2005-07-27 2012-03-08 Achillion Pharmaceuticals, Inc. 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
EP2082814B1 (en) 2008-01-25 2011-04-27 Mitsubishi Materials Corporation Reactor cleaning apparatus
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
WO2010115184A2 (en) * 2009-04-03 2010-10-07 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN115650913B (zh) * 2022-10-12 2024-03-01 北京中医药大学 醌式喹啉类化合物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
US4880814A (en) * 1987-11-13 1989-11-14 Abbott Laboratories 7-cycloalkyl naphthyridines
JP2681190B2 (ja) * 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤

Also Published As

Publication number Publication date
ES2083990T3 (es) 1996-05-01
EP0424802A2 (en) 1991-05-02
US5071848A (en) 1991-12-10
GR3018961T3 (en) 1996-05-31
DE69024322D1 (de) 1996-02-01
IE71688B1 (en) 1997-02-26
PT95646A (pt) 1991-09-13
JPH03167191A (ja) 1991-07-19
EP0424802A3 (en) 1992-05-06
IE903633A1 (en) 1991-04-24
DE69024322T2 (de) 1996-10-31
CA2028246A1 (en) 1991-04-24
ATE131809T1 (de) 1996-01-15
EP0424802B1 (en) 1995-12-20

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