JPH03167191A - イソチアゾロキノリン誘導体およびそれを含有する腫瘍性疾患治療剤 - Google Patents

イソチアゾロキノリン誘導体およびそれを含有する腫瘍性疾患治療剤

Info

Publication number
JPH03167191A
JPH03167191A JP2286931A JP28693190A JPH03167191A JP H03167191 A JPH03167191 A JP H03167191A JP 2286931 A JP2286931 A JP 2286931A JP 28693190 A JP28693190 A JP 28693190A JP H03167191 A JPH03167191 A JP H03167191A
Authority
JP
Japan
Prior art keywords
group
tetrahydroisothiazolo
quinoline
dione
difluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2286931A
Other languages
English (en)
Japanese (ja)
Inventor
Daniel T Chu
ダニエル・ティ・チュウ
Larry L Klein
ラリー・エル・クレイン
Jacob J Pattner
ヤコブ・ジェイ・プラットナー
Linus L Shen
ライナス・エル・シェン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of JPH03167191A publication Critical patent/JPH03167191A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/06—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
JP2286931A 1989-10-23 1990-10-23 イソチアゾロキノリン誘導体およびそれを含有する腫瘍性疾患治療剤 Pending JPH03167191A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/425,536 US5071848A (en) 1989-10-23 1989-10-23 Tricyclic quinoline antineoplastic agents
US425536 1989-10-23

Publications (1)

Publication Number Publication Date
JPH03167191A true JPH03167191A (ja) 1991-07-19

Family

ID=23686982

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2286931A Pending JPH03167191A (ja) 1989-10-23 1990-10-23 イソチアゾロキノリン誘導体およびそれを含有する腫瘍性疾患治療剤

Country Status (11)

Country Link
US (1) US5071848A (da)
EP (1) EP0424802B1 (da)
JP (1) JPH03167191A (da)
AT (1) ATE131809T1 (da)
CA (1) CA2028246A1 (da)
DE (1) DE69024322T2 (da)
DK (1) DK0424802T3 (da)
ES (1) ES2083990T3 (da)
GR (1) GR3018961T3 (da)
IE (1) IE71688B1 (da)
PT (1) PT95646A (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216444B2 (en) 2008-01-25 2015-12-22 Mitsubishi Materials Corporation Reactor cleaning apparatus

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2006118605A2 (en) * 2004-11-11 2006-11-09 Achillion Pharmaceuticals, Inc. 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents
US7659399B2 (en) * 2005-01-05 2010-02-09 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]napththalene-3,4-diones and related compounds as anti-infective agents
US7199128B2 (en) * 2005-02-02 2007-04-03 Achillion Pharmaceuticals, Inc. 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
BRPI0607723A2 (pt) * 2005-02-16 2009-10-06 Achillion Pharmaceuticals Inc isotiazoloquinolonas e compostos relacionados como agentes antiinfecciosos
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
AU2006272571B2 (en) 2005-07-27 2012-03-08 Achillion Pharmaceuticals, Inc. 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
WO2010115184A2 (en) * 2009-04-03 2010-10-07 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN115650913B (zh) * 2022-10-12 2024-03-01 北京中医药大学 醌式喹啉类化合物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
US4880814A (en) * 1987-11-13 1989-11-14 Abbott Laboratories 7-cycloalkyl naphthyridines
JP2681190B2 (ja) * 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216444B2 (en) 2008-01-25 2015-12-22 Mitsubishi Materials Corporation Reactor cleaning apparatus

Also Published As

Publication number Publication date
ES2083990T3 (es) 1996-05-01
EP0424802A2 (en) 1991-05-02
US5071848A (en) 1991-12-10
GR3018961T3 (en) 1996-05-31
DE69024322D1 (de) 1996-02-01
DK0424802T3 (da) 1996-04-22
IE71688B1 (en) 1997-02-26
PT95646A (pt) 1991-09-13
EP0424802A3 (en) 1992-05-06
IE903633A1 (en) 1991-04-24
DE69024322T2 (de) 1996-10-31
CA2028246A1 (en) 1991-04-24
ATE131809T1 (de) 1996-01-15
EP0424802B1 (en) 1995-12-20

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