JPH03167191A - イソチアゾロキノリン誘導体およびそれを含有する腫瘍性疾患治療剤 - Google Patents

イソチアゾロキノリン誘導体およびそれを含有する腫瘍性疾患治療剤

Info

Publication number
JPH03167191A
JPH03167191A JP2286931A JP28693190A JPH03167191A JP H03167191 A JPH03167191 A JP H03167191A JP 2286931 A JP2286931 A JP 2286931A JP 28693190 A JP28693190 A JP 28693190A JP H03167191 A JPH03167191 A JP H03167191A
Authority
JP
Japan
Prior art keywords
group
tetrahydroisothiazolo
quinoline
dione
difluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2286931A
Other languages
English (en)
Japanese (ja)
Inventor
Daniel T Chu
ダニエル・ティ・チュウ
Larry L Klein
ラリー・エル・クレイン
Jacob J Pattner
ヤコブ・ジェイ・プラットナー
Linus L Shen
ライナス・エル・シェン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of JPH03167191A publication Critical patent/JPH03167191A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/06—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
JP2286931A 1989-10-23 1990-10-23 イソチアゾロキノリン誘導体およびそれを含有する腫瘍性疾患治療剤 Pending JPH03167191A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/425,536 US5071848A (en) 1989-10-23 1989-10-23 Tricyclic quinoline antineoplastic agents
US425536 1989-10-23

Publications (1)

Publication Number Publication Date
JPH03167191A true JPH03167191A (ja) 1991-07-19

Family

ID=23686982

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2286931A Pending JPH03167191A (ja) 1989-10-23 1990-10-23 イソチアゾロキノリン誘導体およびそれを含有する腫瘍性疾患治療剤

Country Status (11)

Country Link
US (1) US5071848A (da)
EP (1) EP0424802B1 (da)
JP (1) JPH03167191A (da)
AT (1) ATE131809T1 (da)
CA (1) CA2028246A1 (da)
DE (1) DE69024322T2 (da)
DK (1) DK0424802T3 (da)
ES (1) ES2083990T3 (da)
GR (1) GR3018961T3 (da)
IE (1) IE71688B1 (da)
PT (1) PT95646A (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216444B2 (en) 2008-01-25 2015-12-22 Mitsubishi Materials Corporation Reactor cleaning apparatus

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
ATE445623T1 (de) * 2004-11-11 2009-10-15 Achillion Pharmaceuticals Inc 8a, 9-dihydro-4a-h-isothiazoloä5,4-bü chinolin-3, 4-dione und verwandte verbindungen als infektionsschutzmittel
WO2006074317A1 (en) * 2005-01-05 2006-07-13 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]naphthalene-3,4-diones and related compounds as anti-infective agents
WO2006084053A1 (en) * 2005-02-02 2006-08-10 Achillion Pharmaceuticals, Inc. 8-n-substituted-2h-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
EP1848723B1 (en) * 2005-02-16 2010-12-15 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
CN101263146B (zh) 2005-07-27 2012-12-05 艾其林医药公司 抗感染试剂8-甲氧基-9h-异噻唑并[5,4-b]喹啉-3,4-二酮及相关化合物
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
WO2010115184A2 (en) * 2009-04-03 2010-10-07 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN115650913B (zh) * 2022-10-12 2024-03-01 北京中医药大学 醌式喹啉类化合物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
US4880814A (en) * 1987-11-13 1989-11-14 Abbott Laboratories 7-cycloalkyl naphthyridines
JP2681190B2 (ja) * 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216444B2 (en) 2008-01-25 2015-12-22 Mitsubishi Materials Corporation Reactor cleaning apparatus

Also Published As

Publication number Publication date
DE69024322T2 (de) 1996-10-31
DE69024322D1 (de) 1996-02-01
EP0424802B1 (en) 1995-12-20
PT95646A (pt) 1991-09-13
IE903633A1 (en) 1991-04-24
ATE131809T1 (de) 1996-01-15
IE71688B1 (en) 1997-02-26
US5071848A (en) 1991-12-10
DK0424802T3 (da) 1996-04-22
EP0424802A3 (en) 1992-05-06
EP0424802A2 (en) 1991-05-02
CA2028246A1 (en) 1991-04-24
GR3018961T3 (en) 1996-05-31
ES2083990T3 (es) 1996-05-01

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