DK0427799T3 - Fremgangsmåde og forbindelser til indgivelse af AICA-ribosid og til nedsættelse af blodglucose - Google Patents

Fremgangsmåde og forbindelser til indgivelse af AICA-ribosid og til nedsættelse af blodglucose

Info

Publication number: DK0427799T3
Authority: DK; Denmark
Prior art keywords: aica riboside; blood glucose; lowering blood; compounds; prodrugs
Prior art date: 1989-01-24

Application number

DK90903063.7T

Other languages

Danish (da)

English (en)

Inventor

Harry E Gruber

Ronald E Tuttle

Clinton E Browne

Bheemarao G Ugarkar

Jack W Reich

Ernest Kurt Metzner

Paul J Marangos

Original Assignee

Gensia Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-24

Filing date

1990-01-24

Publication date

1995-05-08

1989-01-24 Priority claimed from US07/301,453 external-priority patent/US5200525A/en

1989-01-24 Priority claimed from US07/301,222 external-priority patent/US5082829A/en

1990-01-24 Application filed by Gensia Inc filed Critical Gensia Inc

1995-05-08 Application granted granted Critical

1995-05-08 Publication of DK0427799T3 publication Critical patent/DK0427799T3/da

Links

RTRQQBHATOEIAF-UHFFFAOYSA-N AICA riboside Natural products NC1=C(C(=O)N)N=CN1C1C(O)C(O)C(CO)O1 RTRQQBHATOEIAF-UHFFFAOYSA-N 0.000 title abstract 5
RTRQQBHATOEIAF-UUOKFMHZSA-N acadesine Chemical compound NC1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 RTRQQBHATOEIAF-UUOKFMHZSA-N 0.000 title abstract 5
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 3
239000008280 blood Substances 0.000 title abstract 3
210000004369 blood Anatomy 0.000 title abstract 3
239000008103 glucose Substances 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
229940002612 prodrug Drugs 0.000 abstract 2
239000000651 prodrug Substances 0.000 abstract 2
OOXNYFKPOPJIOT-UHFFFAOYSA-N 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine;dihydrochloride Chemical compound Cl.Cl.C=12C(N)=NC=NC2=NC(C=2C=NC(=CC=2)N2CCOCC2)=CC=1C1=CC=CC(Br)=C1 OOXNYFKPOPJIOT-UHFFFAOYSA-N 0.000 abstract 1
108010076278 Adenosine kinase Proteins 0.000 abstract 1
102100032534 Adenosine kinase Human genes 0.000 abstract 1
208000013016 Hypoglycemia Diseases 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
206010022489 Insulin Resistance Diseases 0.000 abstract 1
230000007812 deficiency Effects 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
230000002218 hypoglycaemic effect Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
External Artificial Organs (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Prostheses (AREA)

DK90903063.7T 1989-01-24 1990-01-24 Fremgangsmåde og forbindelser til indgivelse af AICA-ribosid og til nedsættelse af blodglucose DK0427799T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/301,453 US5200525A (en)	1989-01-24	1989-01-24	Anti-seizure compounds
US07/301,222 US5082829A (en)	1989-01-24	1989-01-24	AICA riboside prodrugs
US40810789A	1989-09-15	1989-09-15

Publications (1)

Publication Number	Publication Date
DK0427799T3 true DK0427799T3 (da)	1995-05-08

Family

ID=27404800

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90903063.7T DK0427799T3 (da)	1989-01-24	1990-01-24	Fremgangsmåde og forbindelser til indgivelse af AICA-ribosid og til nedsættelse af blodglucose

Country Status (13)

Country	Link
EP (1)	EP0427799B1 (de)
JP (1)	JPH03504728A (de)
KR (1)	KR910700057A (de)
AT (1)	ATE114474T1 (de)
AU (2)	AU5086190A (de)
CA (1)	CA2008325A1 (de)
DE (1)	DE69014562T2 (de)
DK (1)	DK0427799T3 (de)
FI (1)	FI904694A0 (de)
IE (1)	IE75372B1 (de)
IL (1)	IL93164A0 (de)
NO (1)	NO904149L (de)
WO (1)	WO1990009163A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5214048A (en) *	1987-05-19	1993-05-25	Nippon Kayaku Kabushiki Kaisha	Oxetanocins
US7776838B1 (en)	1987-10-28	2010-08-17	Wellstat Therapeutics Corporation	Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5736531A (en) *	1987-10-28	1998-04-07	Pro-Neuron, Inc.	Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US5968914A (en)	1987-10-28	1999-10-19	Pro-Neuron, Inc.	Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5202459A (en) *	1989-11-07	1993-04-13	Nippon Kayaku Kabushiki Kaisha	Process for producing cyclobutane derivative
JPH0615556B2 (ja) *	1989-11-10	1994-03-02	旭化成工業株式会社	４―カルバモイル―１―β―Ｄ―リボフラノシル―イミダゾリウム―５―オレイト無水結晶
US5324730A (en) *	1990-05-24	1994-06-28	Nippon Kayaku Kabushiki Kaisha	Phenoxyphosphoryloxymethyl cyclobutyl purines
IL99124A (en) *	1990-08-10	1998-02-22	Gensia Pharma	Substituted imidazole analogs of aica riboside
US5236908A (en) *	1991-06-07	1993-08-17	Gensia Pharmaceuticals, Inc.	Methods of treating injury to the central nervous system
IL103294A0 (en) *	1991-09-30	1993-05-13	Gensia Pharma	Pharmaceutical compositions for preventing tissue damage associated with decreased blood flow
IL108523A0 (en) *	1993-02-03	1994-05-30	Gensia Inc	Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
RU2153873C2 (ru) *	1994-08-09	2000-08-10	Кортендо АБ	Применение кетоконазола и родственных веществ в лекарствах, предназначенных для лечения диабета типа ii
WO1998039342A1 (en)	1997-03-07	1998-09-11	Metabasis Therapeutics, Inc.	Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
EP1402895A1 (de) *	1997-03-07	2004-03-31	Metabasis Therapeutics, Inc.	Benzimidazolinhibitoren der Fructose 1,6-biphosphatase
WO1998039344A1 (en)	1997-03-07	1998-09-11	Metabasis Therapeutics, Inc.	Novel purine inhibitors of fructose-1,6-bisphosphatase
ZA981936B (en)	1997-03-07	1999-09-06	Metabasis Therapeutics Inc	Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
US6312662B1 (en)	1998-03-06	2001-11-06	Metabasis Therapeutics, Inc.	Prodrugs phosphorus-containing compounds
CN1900087A (zh) *	1998-09-09	2007-01-24	症变治疗公司	新的果糖1,6－二磷酸酶的杂芳族抑制剂
AU2003242500B2 (en) *	1998-09-09	2006-11-02	Metabasis Therapeutics, Inc.	Novel Heteroaromatic Inhibitors of Fructose 1,6-bisphosphatase
WO2000014095A1 (en)	1998-09-09	2000-03-16	Metabasis Therapeutics, Inc.	Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
US6756360B1 (en)	1998-12-24	2004-06-29	Metabasis Therapeutics, Inc.	Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
RU2227749C2 (ru) *	1998-12-24	2004-04-27	Метабэйсис Терапьютикс, Инк.	Комбинация ингибиторов fbpазы и сенсибилизаторов инсулина для лечения диабета
KR20020079988A (ko)	2000-03-08	2002-10-21	메타베이시스 테라퓨틱스, 인크.	신규한 아릴 프럭토스-1,6-비스포스파타제 억제제
US7563774B2 (en)	2000-06-29	2009-07-21	Metabasis Therapeutics, Inc.	Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
HUP0301830A3 (en) *	2000-07-06	2007-10-29	Metabasis Therapeutics Inc	Pharmaceutical composition containing a combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes
ES2192495B1 (es)	2002-03-21	2005-02-16	Universidad De Barcelona	Nuevo uso terapeutico del ribosido de 5-aminoimidazol-4-carboxamida (acadesina).
EP1752450A1 (de)	2005-08-01	2007-02-14	Merck Sante	Imidazolderivate als Fruktose-1,6-biphosphataseinhibitoren und pharmazeutische Zusammensetzungen diese enthaltend
WO2008086341A1 (en) *	2007-01-09	2008-07-17	Pericor Therapeutics, Inc.	Methods. compositions, and formulations for preventing or reducing adverse effects in a patient
EP2058308A1 (de)	2007-11-12	2009-05-13	Merck Sante	Benzimidazoldihydrothiadiazinonderivate als Fructose-1,6-biphosphatase-Hemmer und diese enthaltende pharmazeutische Zusammensetzungen.
WO2010040110A1 (en) *	2008-10-03	2010-04-08	Pericor Therapeutics, Inc.	Methods and compositions for treatment of acute heart failure

Family Cites Families (4)

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Publication number	Priority date	Publication date	Assignee	Title
FR1535561A (fr) *	1966-06-18	1968-08-09	Ajinomoto Kk	Méthode de préparation de l'adénine, de ses dérivés et intermédiaires
US4575498A (en) *	1983-07-21	1986-03-11	Duke University	Method for restoring depleted purine nucleotide pools
US4912092A (en) *	1986-03-27	1990-03-27	The Regents Of The University Of California	Methods for increasing extracellular adenosine and for stabilizing mast cells
ATE135914T1 (de) *	1986-03-27	1996-04-15	Gensia Inc	Aica riboside zur prophylaktischen behandlung von krankheiten mit einer verminderten durchblutung.

1990
- 1990-01-24 EP EP90903063A patent/EP0427799B1/de not_active Expired - Lifetime
- 1990-01-24 DK DK90903063.7T patent/DK0427799T3/da active
- 1990-01-24 DE DE69014562T patent/DE69014562T2/de not_active Expired - Fee Related
- 1990-01-24 IL IL93164A patent/IL93164A0/xx unknown
- 1990-01-24 WO PCT/US1990/000359 patent/WO1990009163A2/en not_active Ceased
- 1990-01-24 AT AT90903063T patent/ATE114474T1/de active
- 1990-01-24 IE IE27490A patent/IE75372B1/en not_active IP Right Cessation
- 1990-01-24 JP JP2503252A patent/JPH03504728A/ja active Pending
- 1990-01-24 AU AU50861/90A patent/AU5086190A/en not_active Abandoned
- 1990-01-24 CA CA002008325A patent/CA2008325A1/en not_active Abandoned
- 1990-01-24 FI FI904694A patent/FI904694A0/fi not_active Application Discontinuation
- 1990-09-24 NO NO90904149A patent/NO904149L/no unknown
- 1990-09-26 KR KR1019900702149A patent/KR910700057A/ko not_active Withdrawn
1993
- 1993-12-13 AU AU52360/93A patent/AU5236093A/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0427799B1 (de)	1994-11-30
KR910700057A (ko)	1991-03-13
DE69014562D1 (de)	1995-01-12
DE69014562T2 (de)	1995-06-22
ATE114474T1 (de)	1994-12-15
AU5086190A (en)	1990-09-05
EP0427799A4 (en)	1991-07-24
FI904694A7 (fi)	1990-09-24
NO904149D0 (no)	1990-09-24
IE75372B1 (en)	1997-09-10
AU5236093A (en)	1994-02-24
IL93164A0 (en)	1990-11-05
WO1990009163A3 (en)	1991-01-24
WO1990009163A2 (en)	1990-08-23
EP0427799A1 (de)	1991-05-22
JPH03504728A (ja)	1991-10-17
FI904694A0 (fi)	1990-09-24
IE900274L (en)	1990-07-24
NO904149L (no)	1990-11-26
CA2008325A1 (en)	1990-07-24

Publication	Publication Date	Title
KR910700057A (ko)	1991-03-13	Aica리보시드 전달 및 혈당을 저하시키기 위한 방법 및 화합물
PL346520A1 (en)	2002-02-11	Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
DE3765045D1 (de)	1990-10-25	Fluorierte nucleoside, ihre herstellung und ihre pharmazeutische verwendung gegen aids.
DK69090D0 (da)	1990-03-16	Forbindelsesstykke med y-form til anvendelse ved angioplastik
HU907065D0 (en)	1991-05-28	Process for manufacturing pharmaceutical preparative of transdermal action containing 2-amino-6-(n-propyl-amino)-4,5,6,7-tetrahydro-benzothiazole
MX9203418A (es)	1992-07-01	Nucleosidos terapeuticos.
GEP20074095B (en)	2007-04-25	Analogs of human insulin modified at position 29 of the b chain thereof
IL151248A0 (en)	2003-04-10	Novel aryl fructose-1,6-bisphosphatase inhibitors
DE69007697D1 (de)	1994-05-05	Verfahren zum Herstellen von elastischen, flüssigkeitsgefüllten Lagern mit Druckaufnahme- und Ausgleichskammern.
DE69905368D1 (en)	2003-03-20	Oxydiertes thymosin beta 4
EP0354322A3 (de)	1990-06-13	Antidiabetische alpha-substituierte Phosphonate
DE3781005D1 (de)	1992-09-17	Adsorptionsmittel fuer chromatographie, methode zur herstellung desselben und saeulensystem fuer chromatographie.
NO882853L (no)	1989-01-18	Korreksjon med dobbeltraadet rna av unormale tilstander i immunkomplekser som er i omloep, og i monocyttfunkjon.
ATE116984T1 (de)	1995-01-15	Therapeutische nukleoside.
EP0306347A3 (en)	1990-10-03	Diagnosis and treatment of double-stranded rna deficiency states
EP0334361A3 (de)	1991-04-03	Durch Acetylen, Cyan oder Allen substituierte Aristeromycin- oder Adenosin-Derivate
NL960024I2 (nl)	1997-06-02	Farmaceutisch preparaat omvattend 3'-deoxythymidine-2'-een (3'-deoxy-2',3'-didehydrothymidine) voor de behandeling van met retrovirus besmette patiënten.
NO900575D0 (no)	1990-02-07	Anordning ved flaske med medisinsk vaeske.
NO20035056D0 (no)	2003-11-13	Adenosinanaloger for behandling av insulinresistenssyndrom og diabetes
DK688787D0 (da)	1987-12-28	Indretning ved stol, udstyret med omstilbar laegstoettedel
DK0538690T3 (da)	1995-03-06	Arylquinolyl-substituerede 1,4-dihydropyridin-dicarboxylsyrederivater, fremgangsmåde til deres fremstilling af deres anvendelse i lægemidler
Senczuk et al.	1984	Toxicodynamic propertes of toluidines. Part II. Blood absorption of toluidines.
FR2711481B1 (fr)	1997-11-28	Hydroxystilbènes chlorés utilisés dans des nématicides, leur procédé de préparation et nouveaux dichlorohydroxystilbènes.
GB9818650D0 (en)	1998-10-21	Therapeutic compounds and methods of making and using the same
ES2085937T3 (es)	1996-06-16	Desacilacion enzimatica de acil-aminosorbosas y su uso en la fabricacion de 1-desoxinoyirimicina.