DK0428313T3 - Pyrimidonderivater samt analoge til behandling af astma og visse hudlidelser - Google Patents

Pyrimidonderivater samt analoge til behandling af astma og visse hudlidelser

Info

Publication number: DK0428313T3
Authority: DK; Denmark
Prior art keywords: asthma; treatment; analogues; well; skin disorders
Prior art date: 1989-11-13

Application number

DK90312117.6T

Other languages

English (en)

Inventor

John B Cheng

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-13

Filing date

1990-11-06

Publication date

1994-03-07

1990-11-06 Application filed by Pfizer filed Critical Pfizer

1994-03-07 Application granted granted Critical

1994-03-07 Publication of DK0428313T3 publication Critical patent/DK0428313T3/da

Links

208000006673 asthma Diseases 0.000 title abstract 2
208000017520 skin disease Diseases 0.000 title abstract 2
150000008318 pyrimidones Chemical class 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000006592 (C2-C3) alkenyl group Chemical group 0.000 abstract 1
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000005592 polycycloalkyl group Polymers 0.000 abstract 1
208000023504 respiratory system disease Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK90312117.6T 1989-11-13 1990-11-06 Pyrimidonderivater samt analoge til behandling af astma og visse hudlidelser DK0428313T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1989/005221 WO1991007177A1 (en)	1989-11-13	1989-11-13	Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders

Publications (1)

Publication Number	Publication Date
DK0428313T3 true DK0428313T3 (da)	1994-03-07

Family

ID=22215372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90312117.6T DK0428313T3 (da)	1989-11-13	1990-11-06	Pyrimidonderivater samt analoge til behandling af astma og visse hudlidelser

Country Status (17)

Country	Link
US (1)	US5342842A (da)
EP (1)	EP0428313B1 (da)
JP (2)	JPH0662412B2 (da)
KR (1)	KR930001832B1 (da)
AT (1)	ATE101040T1 (da)
AU (1)	AU627631B2 (da)
CA (1)	CA2029704C (da)
DE (1)	DE69006452T2 (da)
DK (1)	DK0428313T3 (da)
HU (1)	HU212311B (da)
IE (1)	IE63472B1 (da)
IL (1)	IL96260A (da)
MY (1)	MY111474A (da)
NZ (1)	NZ236038A (da)
PT (1)	PT95854B (da)
WO (2)	WO1991007177A1 (da)
ZA (1)	ZA909043B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH31245A (en) *	1991-10-30	1998-06-18	Janssen Pharmaceutica Nv	1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
DK0672031T3 (da) *	1992-12-02	2003-06-10	Pfizer	Catecholdiethere som selektive PDE IV-inhibitorer
US5814651A (en) *	1992-12-02	1998-09-29	Pfizer Inc.	Catechol diethers as selective PDEIV inhibitors
US5482944A (en) *	1993-07-13	1996-01-09	Pfizer Inc.	Pyrimidones and imidazolinones for treatment of shock
JP2818820B2 (ja) *	1993-11-26	1998-10-30	ファイザー・インク．	抗炎症剤としての３−アリール−２−イソオキサゾリン類
US5502072A (en) *	1993-11-26	1996-03-26	Pfizer Inc.	Substituted oxindoles
AU684887B2 (en) *	1994-03-09	1998-01-08	Pfizer Inc.	Isoxazoline compounds as inhibitors of TNF release
MX9603943A (es) *	1994-03-09	1997-04-30	Pfizer	Compuestos de isoxazolina como inhibidores de 5-lipooxigenasa.
US5563143A (en) *	1994-09-21	1996-10-08	Pfizer Inc.	Catechol diether compounds as inhibitors of TNF release
CA2258728C (en)	1996-06-19	2011-09-27	Rhone Poulenc Rorer Limited	Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
WO1998008828A1 (en) *	1996-08-27	1998-03-05	Nikken Chemicals Co., Ltd.	2-phenylmorpholin-5-one derivatives and pharmaceutical composition comprising the same
CA2402384A1 (en) *	2000-03-16	2001-09-20	Inflazyme Pharmaceuticals Ltd.	Benzylated pde4 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2401446A1 (de) *	1973-01-16	1974-07-25	Voorhees	Pharmazeutische zubereitungen zur linderung von hautproliferationserkrankungen
SU888821A3 (ru) *	1976-12-03	1981-12-07	Шеринг Аг (Инофирма)	Способ получени 5-(замещенный фенил)-оксазолидинонов или их серусодержащих аналогов
DE3315797A1 (de) *	1983-04-30	1984-10-31	Beiersdorf Ag, 2000 Hamburg	Substituierte phenyl-2-(1h)-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
GB8416140D0 (en) *	1984-06-25	1984-08-01	Fujisawa Pharmaceutical Co	Pyrimidinone derivatives
HU215433B (hu) *	1986-04-29	2000-05-28	Pfizer Inc.	Eljárás új 2-oxo-5-fenil-pirimidin-származékok előállítására

1989
- 1989-11-13 WO PCT/US1989/005221 patent/WO1991007177A1/en not_active Ceased
1990
- 1990-04-20 WO PCT/US1990/002162 patent/WO1991007178A1/en not_active Ceased
- 1990-04-20 US US07/855,046 patent/US5342842A/en not_active Expired - Fee Related
- 1990-04-20 HU HU9201575A patent/HU212311B/hu not_active IP Right Cessation
- 1990-11-06 DK DK90312117.6T patent/DK0428313T3/da active
- 1990-11-06 IL IL9626090A patent/IL96260A/en active IP Right Grant
- 1990-11-06 DE DE90312117T patent/DE69006452T2/de not_active Expired - Fee Related
- 1990-11-06 EP EP90312117A patent/EP0428313B1/en not_active Expired - Lifetime
- 1990-11-06 AT AT90312117T patent/ATE101040T1/de not_active IP Right Cessation
- 1990-11-09 MY MYPI90001979A patent/MY111474A/en unknown
- 1990-11-09 CA CA002029704A patent/CA2029704C/en not_active Expired - Fee Related
- 1990-11-12 KR KR1019900018241A patent/KR930001832B1/ko not_active Expired - Fee Related
- 1990-11-12 AU AU66536/90A patent/AU627631B2/en not_active Ceased
- 1990-11-12 IE IE405890A patent/IE63472B1/en not_active IP Right Cessation
- 1990-11-12 PT PT95854A patent/PT95854B/pt not_active IP Right Cessation
- 1990-11-12 NZ NZ236038A patent/NZ236038A/en unknown
- 1990-11-12 ZA ZA909043A patent/ZA909043B/xx unknown
- 1990-11-13 JP JP2306973A patent/JPH0662412B2/ja not_active Expired - Fee Related
1994
- 1994-02-03 JP JP6011680A patent/JP2514163B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1991007177A1 (en)	1991-05-30
JPH03209322A (ja)	1991-09-12
HUT70052A (en)	1995-09-28
AU6653690A (en)	1991-08-01
IL96260A0 (en)	1991-08-16
IE63472B1 (en)	1995-04-19
MY111474A (en)	2000-06-30
HU212311B (en)	1996-05-28
EP0428313A3 (en)	1991-11-06
EP0428313B1 (en)	1994-02-02
AU627631B2 (en)	1992-08-27
NZ236038A (en)	1997-03-24
IE904058A1 (en)	1991-05-22
IL96260A (en)	1995-11-27
CA2029704A1 (en)	1991-05-14
WO1991007178A1 (en)	1991-05-30
DE69006452T2 (de)	1994-05-11
HU9201575D0 (en)	1993-04-28
US5342842A (en)	1994-08-30
CA2029704C (en)	1995-02-07
EP0428313A2 (en)	1991-05-22
PT95854A (pt)	1991-09-13
DE69006452D1 (de)	1994-03-17
KR930001832B1 (ko)	1993-03-15
ZA909043B (en)	1992-06-24
JPH0748255A (ja)	1995-02-21
JP2514163B2 (ja)	1996-07-10
PT95854B (pt)	1997-11-28
JPH0662412B2 (ja)	1994-08-17
ATE101040T1 (de)	1994-02-15
KR910009259A (ko)	1991-06-28

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DK0776324T3 (da)	2002-10-07	Endothelin-antagonister
PL292101A1 (en)	1992-08-10	Method of obtaining novel derivatives of cyclopentylpurine and cyclopentylpyrimidine
DK0565549T3 (da)	1995-07-03	Anvendelse af 1,3-oxathiolannucleosidanaloger til fremstilling af et præparat til behandling af hepatitis B
NO304946B1 (no)	1999-03-08	Xantinderivat samt dets anvendelse
PT674634E (pt)	2003-09-30	Processos para preparar 1,3-oxatiolanos substituidos com propriedades antivirais
FI102069B1 (fi)	1998-10-15	Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi
NO942452D0 (no)	1994-06-29	Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser
GB9408185D0 (en)	1994-06-15	New benzamide derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
AU627631B2 (en)	1992-08-27	Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
AU2868689A (en)	1989-07-27	Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
FI94354C (fi)	1995-08-25	Menetelmä farmaseuttisesti aktiivisten peptidien valmistamiseksi
NO872382L (no)	1987-12-10	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser.
DK0617959T3 (da)	2000-01-24	Lægemiddel til behandling af hudsygdomme
IL84096A0 (en)	1988-03-31	Therapeutic agent for the treatment of peptic ulcer disease comprising a purine derivative
DK0855398T3 (da)	2003-08-04	Sesquiterpenderivater med antiviral aktivitet
DK215886D0 (da)	1986-05-09	1,3-oxathianderivater
FI103885B (fi)	1999-10-15	Menetelmä terapeuttisesti aktiivisten 1-bentsyyli-4-fenyylipiperatsiinijohdannaisten valmistamiseksi ja välituotteina käyttökelpoisia yhdisteitä
IT1213219B (it)	1989-12-14	Derivati amminoalchilnaftalenici ad attivita' farmacologica.
DK0784973T3 (da)	2002-03-18	Quinoxalinderivater til behandling af tinnitus
RO93389A (ro)	1987-12-31	Procedeu pentru prepararea unor derivati de 4-fluortiolcarbanilida
GR3002699T3 (en)	1993-01-25	Process for stabilising procaterol