PT95854A - Processo para a preparacao de composicoes contendo derivados de pirimidona e analogos, uteis no tratamento da asma e de certas perturbacoes da pele - Google Patents

Processo para a preparacao de composicoes contendo derivados de pirimidona e analogos, uteis no tratamento da asma e de certas perturbacoes da pele

Info

Publication number: PT95854A
Authority: PT; Portugal
Prior art keywords: asthma; useful; treatment; perturbactions; analogs
Prior art date: 1989-11-13

Application number

PT95854A

Other languages

English (en)

Other versions

PT95854B (pt

Inventor

John B Cheng

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-13

Filing date

1990-11-12

Publication date

1991-09-13

1990-11-12 Application filed by Pfizer filed Critical Pfizer

1991-09-13 Publication of PT95854A publication Critical patent/PT95854A/pt

1997-11-28 Publication of PT95854B publication Critical patent/PT95854B/pt

Links

208000006673 asthma Diseases 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
150000008318 pyrimidones Chemical class 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000006592 (C2-C3) alkenyl group Chemical group 0.000 abstract 1
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000005592 polycycloalkyl group Polymers 0.000 abstract 1
208000023504 respiratory system disease Diseases 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT95854A 1989-11-13 1990-11-12 Processo para a preparacao de composicoes contendo derivados de pirimidona e analogos, uteis no tratamento da asma e de certas perturbacoes da pele PT95854B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1989/005221 WO1991007177A1 (en)	1989-11-13	1989-11-13	Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders

Publications (2)

Publication Number	Publication Date
PT95854A true PT95854A (pt)	1991-09-13
PT95854B PT95854B (pt)	1997-11-28

Family

ID=22215372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95854A PT95854B (pt)	1989-11-13	1990-11-12	Processo para a preparacao de composicoes contendo derivados de pirimidona e analogos, uteis no tratamento da asma e de certas perturbacoes da pele

Country Status (17)

Country	Link
US (1)	US5342842A (pt)
EP (1)	EP0428313B1 (pt)
JP (2)	JPH0662412B2 (pt)
KR (1)	KR930001832B1 (pt)
AT (1)	ATE101040T1 (pt)
AU (1)	AU627631B2 (pt)
CA (1)	CA2029704C (pt)
DE (1)	DE69006452T2 (pt)
DK (1)	DK0428313T3 (pt)
HU (1)	HU212311B (pt)
IE (1)	IE63472B1 (pt)
IL (1)	IL96260A (pt)
MY (1)	MY111474A (pt)
NZ (1)	NZ236038A (pt)
PT (1)	PT95854B (pt)
WO (2)	WO1991007177A1 (pt)
ZA (1)	ZA909043B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH31245A (en) *	1991-10-30	1998-06-18	Janssen Pharmaceutica Nv	1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5814651A (en) *	1992-12-02	1998-09-29	Pfizer Inc.	Catechol diethers as selective PDEIV inhibitors
BR9307570A (pt) *	1992-12-02	1999-05-25	Pfizer	Diéteres de catecol como inibidores seletivos de pdeiv
US5482944A (en) *	1993-07-13	1996-01-09	Pfizer Inc.	Pyrimidones and imidazolinones for treatment of shock
EP0730587B1 (en) *	1993-11-26	1999-12-08	Pfizer Inc.	3-phenyl-2-isoxazolines as antiinflammatory agents
US5502072A (en) *	1993-11-26	1996-03-26	Pfizer Inc.	Substituted oxindoles
CA2185019C (en) *	1994-03-09	2000-08-08	Pfizer Limited	Isoxazoline compounds as inhibitors of tnf release
WO1995024192A1 (en) *	1994-03-09	1995-09-14	Pfizer Inc.	Isoxazoline compounds as 5-lipoxygenase inhibitors
US5563143A (en) *	1994-09-21	1996-10-08	Pfizer Inc.	Catechol diether compounds as inhibitors of TNF release
JP4373497B2 (ja)	1996-06-19	2009-11-25	ローン−プーラン・ロレ・リミテツド	置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用
US6265402B1 (en)	1996-08-27	2001-07-24	Nikken Chemicals Co., Ltd.	Use of 2-phenylmorpholin-5-one derivatives
WO2001068600A2 (en) *	2000-03-16	2001-09-20	Inflazyme Pharmaceuticals Limited	Benzylated pde4 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2401446A1 (de) *	1973-01-16	1974-07-25	Voorhees	Pharmazeutische zubereitungen zur linderung von hautproliferationserkrankungen
SU888821A3 (ru) *	1976-12-03	1981-12-07	Шеринг Аг (Инофирма)	Способ получени 5-(замещенный фенил)-оксазолидинонов или их серусодержащих аналогов
DE3315797A1 (de) *	1983-04-30	1984-10-31	Beiersdorf Ag, 2000 Hamburg	Substituierte phenyl-2-(1h)-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
GB8416140D0 (en) *	1984-06-25	1984-08-01	Fujisawa Pharmaceutical Co	Pyrimidinone derivatives
HU215433B (hu) *	1986-04-29	2000-05-28	Pfizer Inc.	Eljárás új 2-oxo-5-fenil-pirimidin-származékok előállítására

1989
- 1989-11-13 WO PCT/US1989/005221 patent/WO1991007177A1/en not_active Ceased
1990
- 1990-04-20 WO PCT/US1990/002162 patent/WO1991007178A1/en not_active Ceased
- 1990-04-20 US US07/855,046 patent/US5342842A/en not_active Expired - Fee Related
- 1990-04-20 HU HU9201575A patent/HU212311B/hu not_active IP Right Cessation
- 1990-11-06 DE DE90312117T patent/DE69006452T2/de not_active Expired - Fee Related
- 1990-11-06 EP EP90312117A patent/EP0428313B1/en not_active Expired - Lifetime
- 1990-11-06 AT AT90312117T patent/ATE101040T1/de not_active IP Right Cessation
- 1990-11-06 IL IL9626090A patent/IL96260A/en active IP Right Grant
- 1990-11-06 DK DK90312117.6T patent/DK0428313T3/da active
- 1990-11-09 CA CA002029704A patent/CA2029704C/en not_active Expired - Fee Related
- 1990-11-09 MY MYPI90001979A patent/MY111474A/en unknown
- 1990-11-12 AU AU66536/90A patent/AU627631B2/en not_active Ceased
- 1990-11-12 PT PT95854A patent/PT95854B/pt not_active IP Right Cessation
- 1990-11-12 KR KR1019900018241A patent/KR930001832B1/ko not_active Expired - Fee Related
- 1990-11-12 NZ NZ236038A patent/NZ236038A/en unknown
- 1990-11-12 IE IE405890A patent/IE63472B1/en not_active IP Right Cessation
- 1990-11-12 ZA ZA909043A patent/ZA909043B/xx unknown
- 1990-11-13 JP JP2306973A patent/JPH0662412B2/ja not_active Expired - Fee Related
1994
- 1994-02-03 JP JP6011680A patent/JP2514163B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR930001832B1 (ko)	1993-03-15
WO1991007178A1 (en)	1991-05-30
JPH0748255A (ja)	1995-02-21
KR910009259A (ko)	1991-06-28
EP0428313B1 (en)	1994-02-02
EP0428313A3 (en)	1991-11-06
NZ236038A (en)	1997-03-24
WO1991007177A1 (en)	1991-05-30
AU627631B2 (en)	1992-08-27
JPH03209322A (ja)	1991-09-12
IE63472B1 (en)	1995-04-19
HU212311B (en)	1996-05-28
ATE101040T1 (de)	1994-02-15
IE904058A1 (en)	1991-05-22
IL96260A (en)	1995-11-27
MY111474A (en)	2000-06-30
CA2029704A1 (en)	1991-05-14
IL96260A0 (en)	1991-08-16
JP2514163B2 (ja)	1996-07-10
DE69006452D1 (de)	1994-03-17
HUT70052A (en)	1995-09-28
EP0428313A2 (en)	1991-05-22
CA2029704C (en)	1995-02-07
PT95854B (pt)	1997-11-28
DK0428313T3 (da)	1994-03-07
US5342842A (en)	1994-08-30
JPH0662412B2 (ja)	1994-08-17
DE69006452T2 (de)	1994-05-11
HU9201575D0 (en)	1993-04-28
AU6653690A (en)	1991-08-01
ZA909043B (en)	1992-06-24

Legal Events

Date	Code	Title	Description
1991-09-13	BB1A	Laying open of patent application	Effective date: 19910404
1997-11-28	FG3A	Patent granted, date of granting	Effective date: 19970812
2002-06-28	NF3A	Restitutio in integrum	Free format text: 20020315 RESTITUTIO IN INTEGRUM
2005-04-29	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20050214

Publication	Publication Date	Title
PT88019A (pt)	1989-06-30	Processo para a preparacao de um derivado de ester do acido nitrico
HUT70052A (en)	1995-09-28	Process for producing pharmaceutical compositions containing pirimidone derivatives in the treatment of certain airway or skin diseases
AU2868689A (en)	1989-07-27	Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
PT90725A (pt)	1989-12-29	Processo para a preparacao de novos compostos cefem
ES2055235T3 (es)	1994-08-16	Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation.
EP0186023A3 (en)	1986-10-22	Biliary acid derivatives, process for their preparation and pharmaceutical compositions containing them
HU906230D0 (en)	1991-03-28	Process for the preparation of benzanilide derivatives and medical preparations containing them
PT93126A (pt)	1990-08-31	Processo para a preparacao de eteres carboxialquilicos da 2-amino-7- -hidroxitetralina
PT92540A (pt)	1990-06-29	Processo para a preparacao de derivados de anfotericina b
DE3666223D1 (en)	1989-11-16	Anticonvulsant agents
ATE52776T1 (de)	1990-06-15	1-phenyl-3-benzazepine.
PT99674A (pt)	1992-10-30	Processo para a preparacao de 5-amino-5,6,7,8-tetra-hidroquinolinas e de composicoes farmaceuticas que as contem
FI103885B1 (fi)	1999-10-15	Menetelmä terapeuttisesti aktiivisten 1-bentsyyli-4-fenyylipiperatsiinijohdannaisten valmistamiseksi ja välituotteina käyttökelpoisia yhdisteitä
BR9406996A (pt)	1996-09-10	Enanciômero processo para preparar o mesmo processo para ciclizar um composto e composto intermediário
MY101746A (en)	1992-01-17	1,5-benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof.