DK0434094T3 - Fremgangsmåder til anvendelse af 2-isopropyl-2-phenylaminovaleronitriler som immunosuppressorer og vasodilatatorer - Google Patents

Fremgangsmåder til anvendelse af 2-isopropyl-2-phenylaminovaleronitriler som immunosuppressorer og vasodilatatorer

Info

Publication number: DK0434094T3
Authority: DK; Denmark
Prior art keywords: immunosuppressors; isopropyl; cyclosporin; phenylaminovaleronitriles; vasodilators
Prior art date: 1989-12-21

Application number

DK90125244.5T

Other languages

English (en)

Inventor

Richard Aug Mueller

Kearn John P Mc

Terry B Strom

Kenneth J Wieder

Liang Chi-Dean

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1990-12-21

Publication date

1993-08-16

1990-12-21 Application filed by Searle & Co filed Critical Searle & Co

1993-08-16 Application granted granted Critical

1993-08-16 Publication of DK0434094T3 publication Critical patent/DK0434094T3/da

Links

229940124549 vasodilator Drugs 0.000 title 1
239000003071 vasodilator agent Substances 0.000 title 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 3
229930105110 Cyclosporin A Natural products 0.000 abstract 3
108010036949 Cyclosporine Proteins 0.000 abstract 3
229960001265 ciclosporin Drugs 0.000 abstract 3
229930182912 cyclosporin Natural products 0.000 abstract 3
206010052779 Transplant rejections Diseases 0.000 abstract 1
230000008061 calcium-channel-blocking effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
230000002195 synergetic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK90125244.5T 1989-12-21 1990-12-21 Fremgangsmåder til anvendelse af 2-isopropyl-2-phenylaminovaleronitriler som immunosuppressorer og vasodilatatorer DK0434094T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US45600789A	1989-12-21	1989-12-21

Publications (1)

Publication Number	Publication Date
DK0434094T3 true DK0434094T3 (da)	1993-08-16

Family

ID=23811068

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90125244.5T DK0434094T3 (da)	1989-12-21	1990-12-21	Fremgangsmåder til anvendelse af 2-isopropyl-2-phenylaminovaleronitriler som immunosuppressorer og vasodilatatorer

Country Status (10)

Country	Link
EP (1)	EP0434094B1 (da)
JP (1)	JPH04210632A (da)
AT (1)	ATE87614T1 (da)
CA (1)	CA2033038A1 (da)
DE (1)	DE69001240T2 (da)
DK (1)	DK0434094T3 (da)
ES (1)	ES2054207T3 (da)
GR (1)	GR3008320T3 (da)
IE (1)	IE64870B1 (da)
PT (1)	PT96283A (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI2170050T1 (sl)	2007-06-20	2014-12-31	Milestone Pharmaceuticals Inc.	Fenilalkilaminski blokatorji kalcijevih kanalov s kratkotrajnim delovanjem in njihova uporaba

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3642331A1 (de) *	1986-12-11	1988-06-23	Basf Ag	Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel

1990
- 1990-12-20 IE IE462790A patent/IE64870B1/en not_active IP Right Cessation
- 1990-12-20 PT PT96283A patent/PT96283A/pt not_active Application Discontinuation
- 1990-12-21 ES ES90125244T patent/ES2054207T3/es not_active Expired - Lifetime
- 1990-12-21 DK DK90125244.5T patent/DK0434094T3/da active
- 1990-12-21 DE DE9090125244T patent/DE69001240T2/de not_active Expired - Fee Related
- 1990-12-21 JP JP2419052A patent/JPH04210632A/ja not_active Withdrawn
- 1990-12-21 AT AT90125244T patent/ATE87614T1/de not_active IP Right Cessation
- 1990-12-21 EP EP90125244A patent/EP0434094B1/en not_active Expired - Lifetime
- 1990-12-21 CA CA002033038A patent/CA2033038A1/en not_active Abandoned
1993
- 1993-06-30 GR GR930400669T patent/GR3008320T3/el unknown

Also Published As

Publication number	Publication date
JPH04210632A (ja)	1992-07-31
PT96283A (pt)	1991-09-30
IE64870B1 (en)	1995-09-20
DE69001240T2 (de)	1993-08-05
IE904627A1 (en)	1991-07-17
GR3008320T3 (da)	1993-09-30
ATE87614T1 (de)	1993-04-15
EP0434094B1 (en)	1993-03-31
EP0434094A1 (en)	1991-06-26
ES2054207T3 (es)	1994-08-01
CA2033038A1 (en)	1991-06-22
DE69001240D1 (de)	1993-05-06

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