DK0435749T3 - 2-Aminopyrimidin-4-carboxamid-derivater, deres fremstilling og deres terapeutiske anvendelse - Google Patents

2-Aminopyrimidin-4-carboxamid-derivater, deres fremstilling og deres terapeutiske anvendelse

Info

Publication number: DK0435749T3
Authority: DK; Denmark
Prior art keywords: aminopyrimidine; preparation; therapeutic use; carboxamide derivatives; hydrogen
Prior art date: 1989-12-28

Application number

DK90403689.4T

Other languages

Danish (da)

English (en)

Inventor

Pascal George

Jacques Froissant

Philippe Manoury

Jean-Pierre Merly

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-28

Filing date

1990-12-20

Publication date

1996-05-20

1990-12-20 Application filed by Synthelabo filed Critical Synthelabo

1996-05-20 Application granted granted Critical

1996-05-20 Publication of DK0435749T3 publication Critical patent/DK0435749T3/da

Links

ASFQWXQESJPZFG-UHFFFAOYSA-N 2-aminopyrimidine-4-carboxamide Chemical class NC(=O)C1=CC=NC(N)=N1 ASFQWXQESJPZFG-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
-1 methoxy, isopropyl Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)

DK90403689.4T 1989-12-28 1990-12-20 2-Aminopyrimidin-4-carboxamid-derivater, deres fremstilling og deres terapeutiske anvendelse DK0435749T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8917304A FR2656609B1 (fr)	1989-12-28	1989-12-28	Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number	Publication Date
DK0435749T3 true DK0435749T3 (da)	1996-05-20

Family

ID=9389050

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90403689.4T DK0435749T3 (da)	1989-12-28	1990-12-20	2-Aminopyrimidin-4-carboxamid-derivater, deres fremstilling og deres terapeutiske anvendelse

Country Status (22)

Country	Link
US (1)	US5164397A (cs)
EP (1)	EP0435749B1 (cs)
JP (1)	JP2515434B2 (cs)
KR (1)	KR910011841A (cs)
AT (1)	ATE132859T1 (cs)
AU (1)	AU630777B2 (cs)
CA (1)	CA2033303A1 (cs)
CS (1)	CS405291A3 (cs)
DE (1)	DE69024778T2 (cs)
DK (1)	DK0435749T3 (cs)
ES (1)	ES2084015T3 (cs)
FI (1)	FI94953C (cs)
FR (1)	FR2656609B1 (cs)
GR (1)	GR3019508T3 (cs)
HU (1)	HU207515B (cs)
IE (1)	IE72954B1 (cs)
IL (1)	IL96815A (cs)
MX (1)	MX172953B (cs)
NO (1)	NO178968C (cs)
NZ (1)	NZ236605A (cs)
PT (1)	PT96381B (cs)
ZA (1)	ZA9010412B (cs)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2667317B1 (fr) *	1990-10-02	1992-12-04	Synthelabo	Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2678272B1 (fr) *	1991-06-27	1994-01-14	Synthelabo	Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2678271B1 (fr) *	1991-06-27	1995-01-13	Synthelabo	Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
CZ279305B6 (cs) *	1992-01-24	1995-04-12	Lonza A.G.	Kyseliny 2-halogen pyrimidin-4-karboxylové, způsob jejich přípravy a jejich použití pro přípravu derivátů substituovaných pyrimidinů-4-karboxylový ch kyselin
US5474994A (en) *	1992-05-26	1995-12-12	Recordati S.A., Chemical And Pharmaceutical Company	Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
IT1254469B (it) *	1992-02-25	1995-09-25	Recordati Chem Pharm	Derivati benzopiranici e benzotiopiranici
FR2699171B1 (fr) *	1992-12-14	1995-02-03	Synthelabo	Dérivés de 2-amino-N[[[4-aminocarbonyl) pyrimidin-2-yl]amino]alkyl]pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.
ES2073951T3 (es) *	1992-07-03	1995-08-16	Synthelabo	Derivados de 2-amino-n-(((4-(aminocarbonil)pirimidin-2-il)amino)alquil)pirimidina-4-carboxamida, su preparacion y su aplicacion en terapeutica.
FR2693195B1 (fr) *	1992-07-03	1994-09-23	Synthelabo	Dérivés de 2-amino-N-[[[(4-aminocarbonyl)pyrimidin-2-yl]amino]alkyl] pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.
FR2703355B1 (fr) *	1993-03-29	1995-05-05	Synthelabo	Dérivés de 2-aminopyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.
FR2705344B1 (fr) *	1993-05-17	1995-06-30	Synthelabo	Dérivés de 2-aminopyrazine-5-carboxamide, leur préparation et leur application en thérapeutique.
FR2724383B1 (fr) *	1994-09-13	1996-10-18	Synthelabo	Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
US5688795A (en) *	1994-11-08	1997-11-18	Syntex (U.S.A.) Inc.	3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
FR2744722B1 (fr) *	1996-02-14	1998-03-13	Synthelabo	Devires de 2-((3-(piperazin-1-yl)propyl)amino)pyrimidine-4- carboxamide et leur application en therapeutique
TW593290B (en) *	1996-05-10	2004-06-21	Janssen Pharmaceutica Nv	Alkylaminobenzothiazole and -benzoxazole derivatives
ITMI20010164A1 (it) *	2001-01-30	2002-07-30	Recordati Chem Pharm	Alfa 1 antagonisti selettivi a + d
AR078793A1 (es)	2009-10-27	2011-12-07	Orion Corp	Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros
CA2872883A1 (en) *	2012-05-09	2013-11-14	Sunovion Pharmaceuticals Inc.	Heteroaryl compounds and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE787126A (fr) *	1971-08-04	1973-02-05	Byk Gulden Lomberg Chem Fab	Pyrimidines substituees, procedes de preparation de ces composes et medicaments contenant lesdits composes
DE2143730A1 (de) *	1971-09-01	1973-03-08	Byk Gulden Lomberg Chem Fab	Substituierte pyridine, verfahren zu deren herstellung und sie enthaltende arzneimittel

1989
- 1989-12-28 FR FR8917304A patent/FR2656609B1/fr not_active Expired - Fee Related
1990
- 1990-12-19 KR KR1019900021093A patent/KR910011841A/ko not_active Abandoned
- 1990-12-20 EP EP90403689A patent/EP0435749B1/fr not_active Expired - Lifetime
- 1990-12-20 AT AT90403689T patent/ATE132859T1/de not_active IP Right Cessation
- 1990-12-20 DE DE69024778T patent/DE69024778T2/de not_active Expired - Fee Related
- 1990-12-20 DK DK90403689.4T patent/DK0435749T3/da active
- 1990-12-20 ES ES90403689T patent/ES2084015T3/es not_active Expired - Lifetime
- 1990-12-21 NZ NZ236605A patent/NZ236605A/xx unknown
- 1990-12-26 MX MX023931A patent/MX172953B/es unknown
- 1990-12-27 NO NO905591A patent/NO178968C/no unknown
- 1990-12-27 US US07/634,469 patent/US5164397A/en not_active Expired - Fee Related
- 1990-12-27 PT PT96381A patent/PT96381B/pt not_active IP Right Cessation
- 1990-12-27 JP JP2417563A patent/JP2515434B2/ja not_active Expired - Fee Related
- 1990-12-27 IL IL9681590A patent/IL96815A/en not_active IP Right Cessation
- 1990-12-27 CA CA002033303A patent/CA2033303A1/en not_active Abandoned
- 1990-12-27 AU AU68451/90A patent/AU630777B2/en not_active Ceased
- 1990-12-27 FI FI906408A patent/FI94953C/fi not_active IP Right Cessation
- 1990-12-27 ZA ZA9010412A patent/ZA9010412B/xx unknown
- 1990-12-27 HU HU908480A patent/HU207515B/hu not_active IP Right Cessation
- 1990-12-28 IE IE471990A patent/IE72954B1/en not_active IP Right Cessation
1991
- 1991-12-23 CS CS914052A patent/CS405291A3/cs unknown
1996
- 1996-04-02 GR GR960400896T patent/GR3019508T3/el unknown

Also Published As

Publication number	Publication date
NO905591L (no)	1991-07-01
AU6845190A (en)	1991-07-04
FR2656609B1 (fr)	1992-03-27
EP0435749B1 (fr)	1996-01-10
PT96381B (pt)	1998-06-30
ZA9010412B (en)	1991-10-30
CA2033303A1 (en)	1991-06-29
MX172953B (es)	1994-01-25
JP2515434B2 (ja)	1996-07-10
HUT56092A (en)	1991-07-29
FI906408A0 (fi)	1990-12-27
IE904719A1 (en)	1991-07-17
NO178968B (no)	1996-04-01
ATE132859T1 (de)	1996-01-15
NZ236605A (en)	1992-08-26
KR910011841A (ko)	1991-08-07
NO905591D0 (no)	1990-12-27
DE69024778D1 (de)	1996-02-22
DE69024778T2 (de)	1996-09-19
FR2656609A1 (fr)	1991-07-05
IE72954B1 (en)	1997-05-07
CS405291A3 (en)	1992-04-15
FI94953C (fi)	1995-11-27
IL96815A (en)	1996-06-18
FI94953B (fi)	1995-08-15
AU630777B2 (en)	1992-11-05
NO178968C (no)	1996-07-10
JPH04139173A (ja)	1992-05-13
HU207515B (en)	1993-04-28
IL96815A0 (en)	1991-09-16
FI906408L (fi)	1991-06-29
US5164397A (en)	1992-11-17
PT96381A (pt)	1991-10-15
ES2084015T3 (es)	1996-05-01
GR3019508T3 (en)	1996-07-31
EP0435749A1 (fr)	1991-07-03

Publication	Publication Date	Title
GR3019508T3 (en)	1996-07-31	Derivatives of 2-aminopyrimidine-4-carboxamide, their preparation and therapeutic use
DK0534859T3 (da)	1995-05-08	3-Benzazepin-2-oner, som er substituerede med en benzocyklobutyl- eller indanylalkylaminoalkylgruppe, og som er anvendelige til behandling af cardiovaskulære sygdomme
NO1999018I1 (no)	1999-07-22	Lamivudin og zidovudin
DK0539204T3 (da)	1998-09-07	Antivirale 4-substituerede-deoxy-2,3-didehydroderivater af alfa-D-neuraminsyre
DK0522915T3 (da)	1996-07-22	Pyrimidin-4-carboxamidderivater, deres fremstilling og deres anvendelse til terapeutisk behandling
DK0497816T3 (da)	1995-10-09	Behandling af HIV-infektioner og forbindelser anvendelige derved
FI892344A0 (fi)	1989-05-16	6-fenyl-3-piperazinylalkyl-1h,3h -pyrimidin-2-4-dionderivat, deras framstaellning och deras terapeutiska anvaendning.
DK47688D0 (da)	1988-01-29	5-(3-alkyl-5-tert.butyl-4-hydroxyphenyl)-2-amino-6h-1,3,4-thiadiaziner, deres fremstilling og anvendelse som laegemiddel
DK192988A (da)	1988-10-10	Dihydropyridinamider, deres fremstilling og anvendelse
NO172846C (no)	1993-09-15	Fremgangsmaate for fremstilling av 7,8-dihalogen-3-metyl-2,3-dihydro-2m-benzoksazinderivater og propoksybenzenderivater for utoevelse av fremgangsmaaten.
DK0607129T3 (da)	1995-12-18	Methylpiperazinoazepinderivater, deres fremstilling og deres anvendelse
DK610287A (da)	1988-05-22	Peptider, deres fremstilling og anvendelse
NO890158L (no)	1989-07-17	Fremgangsmaate for fremstilling av hydroksialkyleringsmiddel, de oppnaadde midler og deres anvendelse.
NO882113D0 (no)	1988-05-13	Substituerte vinylcefalosporiner, fremgangsmaate til deres fremstilling, og deres anvendelse som legemiddel.
DK0589908T3 (da)	1998-10-26	Aminoalkylsubsituerede thiazolin-2-oner, deres fremstilling og deres anvendelse
ES555030A0 (es)	1987-07-16	Procedimiento para la obtencion de nuevos derivados de isoxazol
DK0589903T3 (da)	1999-06-07	Aminoalkylsubstituerede 5-mercaptothiazoler, deres fremstilling og anvendelse
ATE63309T1 (de)	1991-05-15	2,3-dihydro-2-oxo-3-benzofuranylessigs\|urederivate und diese enthaltende arzneimittel.
DK0520882T3 (da)	1995-12-11	Derivater af 2-aminopyrimidin-4-carboxamid, deres fremstilling og deres terapeutiske anvendelse
FI890173L (fi)	1989-01-13	Isoxazoler med nootropisk verkan.
DK48489D0 (da)	1989-02-02	Heteroanellerede phenylglycin-beta-lactam-antibiotika og farmaceutisk acceptable salte deraf, deres fremstilling og anvendelse
DK0424248T3 (da)	1996-03-04	20,21-dinoreburnamein med substitution i 15-stillingen, fremgangsmåde til deres fremstilling samt mellemprodukter til brug derved, deres anvendelse som lægemidler og præparater med indhold deraf
DK613386D0 (da)	1986-12-18	Substituerede cyclopropyl-oximethere, deres fremstilling og anvendelse