DK0948349T3 - In vitro-fremgangsmåder og anvendelse af farmaceutiske præparater til behandling af indre øre-hårceller - Google Patents

In vitro-fremgangsmåder og anvendelse af farmaceutiske præparater til behandling af indre øre-hårceller

Info

Publication number
DK0948349T3
DK0948349T3 DK97949346T DK97949346T DK0948349T3 DK 0948349 T3 DK0948349 T3 DK 0948349T3 DK 97949346 T DK97949346 T DK 97949346T DK 97949346 T DK97949346 T DK 97949346T DK 0948349 T3 DK0948349 T3 DK 0948349T3
Authority
DK
Denmark
Prior art keywords
treatment
pharmaceutical compositions
inner ear
hair cells
vitro methods
Prior art date
Application number
DK97949346T
Other languages
English (en)
Inventor
Wei-Qiang Gao
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK0948349T3 publication Critical patent/DK0948349T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK97949346T 1996-11-01 1997-10-28 In vitro-fremgangsmåder og anvendelse af farmaceutiske præparater til behandling af indre øre-hårceller DK0948349T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2953696P 1996-11-01 1996-11-01
US08/743,267 US6593290B1 (en) 1996-11-01 1996-11-04 Treatment of inner ear hair cells
PCT/US1997/019585 WO1998019700A1 (en) 1996-11-01 1997-10-28 Treatment of inner ear hair cells

Publications (1)

Publication Number Publication Date
DK0948349T3 true DK0948349T3 (da) 2003-04-07

Family

ID=26705049

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97949346T DK0948349T3 (da) 1996-11-01 1997-10-28 In vitro-fremgangsmåder og anvendelse af farmaceutiske præparater til behandling af indre øre-hårceller

Country Status (15)

Country Link
US (1) US6593290B1 (da)
EP (1) EP0948349B1 (da)
JP (1) JP4191252B2 (da)
CN (1) CN1313147C (da)
AR (1) AR009603A1 (da)
AT (1) ATE229815T1 (da)
AU (1) AU724988B2 (da)
BR (1) BR9712468A (da)
CA (1) CA2268331C (da)
DE (1) DE69718053T2 (da)
DK (1) DK0948349T3 (da)
ES (1) ES2189002T3 (da)
IL (2) IL129381A0 (da)
WO (1) WO1998019700A1 (da)
ZA (1) ZA979814B (da)

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EP3189134A1 (en) 2014-09-03 2017-07-12 The Brigham and Women's Hospital, Inc. Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss
TWI710635B (zh) 2014-10-09 2020-11-21 美商珍維克公司 編碼人類無調同源物-1(hath1)之腺病毒載體
JP2018504400A (ja) 2015-01-08 2018-02-15 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． Ｌｉｎｇｏ‐１拮抗薬及び脱髄障害の治療のための使用
US11021687B2 (en) 2016-01-08 2021-06-01 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
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CN106075392B (zh) * 2016-07-18 2020-07-07 滨州医学院 促红细胞生成素衍生物在听力保护上的应用
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US11617745B2 (en) 2018-08-17 2023-04-04 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating FOXO
JP2021533788A (ja) 2018-08-17 2021-12-09 フリークエンシー セラピューティクス インコーポレイテッド Ｊａｇ−１を上方制御することにより有毛細胞を生成するための組成物及び方法
CN109182250A (zh) * 2018-09-30 2019-01-11 山东省立医院 一种小鼠耳蜗毛细胞培养方法

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Also Published As

Publication number Publication date
IL129381A0 (en) 2000-02-17
US6593290B1 (en) 2003-07-15
AR009603A1 (es) 2000-04-26
CN1251531A (zh) 2000-04-26
WO1998019700A1 (en) 1998-05-14
CA2268331C (en) 2011-07-26
EP0948349B1 (en) 2002-12-18
AU724988B2 (en) 2000-10-05
JP4191252B2 (ja) 2008-12-03
EP0948349A1 (en) 1999-10-13
ATE229815T1 (de) 2003-01-15
IL129381A (en) 2006-07-05
CA2268331A1 (en) 1998-05-14
BR9712468A (pt) 1999-10-26
ZA979814B (en) 1999-04-30
CN1313147C (zh) 2007-05-02
DE69718053T2 (de) 2003-09-11
DE69718053D1 (de) 2003-01-30
ES2189002T3 (es) 2003-07-01
JP2002514191A (ja) 2002-05-14
AU7000698A (en) 1998-05-29

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