DK0440930T3 - Fremgangsmåde til debromering af 2-substituerede 5-brom-6-methoxynaphthalener - Google Patents
Fremgangsmåde til debromering af 2-substituerede 5-brom-6-methoxynaphthalenerInfo
- Publication number
- DK0440930T3 DK0440930T3 DK90123978.0T DK90123978T DK0440930T3 DK 0440930 T3 DK0440930 T3 DK 0440930T3 DK 90123978 T DK90123978 T DK 90123978T DK 0440930 T3 DK0440930 T3 DK 0440930T3
- Authority
- DK
- Denmark
- Prior art keywords
- methoxynaphthalenes
- debromination
- bromo
- substituted
- alkyl
- Prior art date
Links
- -1 2-substituted 5-bromo-6-methoxynaphthalenes Chemical class 0.000 title 1
- 238000007256 debromination reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 239000000370 acceptor Substances 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 150000002790 naphthalenes Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT01929990A IT1238008B (it) | 1990-02-08 | 1990-02-08 | Procedimento per la debromurazione di 2-sostituiti-5-bromo- 6-metossinaftaleni |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0440930T3 true DK0440930T3 (da) | 1995-04-10 |
Family
ID=11156536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90123978.0T DK0440930T3 (da) | 1990-02-08 | 1990-12-12 | Fremgangsmåde til debromering af 2-substituerede 5-brom-6-methoxynaphthalener |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5107013A (de) |
| EP (1) | EP0440930B2 (de) |
| AT (1) | ATE120172T1 (de) |
| DE (1) | DE69018058T3 (de) |
| DK (1) | DK0440930T3 (de) |
| ES (1) | ES2070258T5 (de) |
| GR (1) | GR3015528T3 (de) |
| IT (1) | IT1238008B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4318069C1 (de) * | 1993-06-01 | 1994-03-31 | Cassella Ag | Verfahren zur Herstellung von 5-Brom-6-methoxy-1-naphthoesäuremethylester |
| IT1285567B1 (it) | 1996-02-21 | 1998-06-18 | Alfa Chem Ital | Nuovo processo per la sintesi del nabumetone |
| CN110183323A (zh) * | 2019-07-09 | 2019-08-30 | 重庆医药高等专科学校 | D,l-体萘普生的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1168387B (it) * | 1981-04-01 | 1987-05-20 | Alfa Farmaceutici Spa | Procedimento per la preparazione dell'acido 2-(6-metossi-2-naftil)-propionico |
| IT1190362B (it) * | 1985-05-30 | 1988-02-16 | Zambon Spa | Preparazione del (6-metossi-2-naftil)-(1-bormoetil)-chetone e dei suoi derivati |
-
1990
- 1990-02-08 IT IT01929990A patent/IT1238008B/it active IP Right Grant
- 1990-12-12 AT AT90123978T patent/ATE120172T1/de not_active IP Right Cessation
- 1990-12-12 ES ES90123978T patent/ES2070258T5/es not_active Expired - Lifetime
- 1990-12-12 DE DE69018058T patent/DE69018058T3/de not_active Expired - Fee Related
- 1990-12-12 DK DK90123978.0T patent/DK0440930T3/da active
- 1990-12-12 EP EP90123978A patent/EP0440930B2/de not_active Expired - Lifetime
- 1990-12-27 US US07/634,742 patent/US5107013A/en not_active Expired - Lifetime
-
1995
- 1995-03-23 GR GR940402780T patent/GR3015528T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69018058T3 (de) | 2002-04-18 |
| EP0440930B2 (de) | 2001-09-12 |
| ES2070258T5 (es) | 2002-02-01 |
| GR3015528T3 (en) | 1995-06-30 |
| IT9019299A0 (it) | 1990-02-08 |
| US5107013A (en) | 1992-04-21 |
| IT1238008B (it) | 1993-06-21 |
| IT9019299A1 (it) | 1991-08-09 |
| ES2070258T3 (es) | 1995-06-01 |
| DE69018058D1 (de) | 1995-04-27 |
| DE69018058T2 (de) | 1995-09-28 |
| EP0440930B1 (de) | 1995-03-22 |
| ATE120172T1 (de) | 1995-04-15 |
| EP0440930A2 (de) | 1991-08-14 |
| EP0440930A3 (en) | 1992-04-08 |
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