DK0442724T3 - Modificeret hIL-6. - Google Patents

Modificeret hIL-6.

Info

Publication number
DK0442724T3
DK0442724T3 DK91301166T DK91301166T DK0442724T3 DK 0442724 T3 DK0442724 T3 DK 0442724T3 DK 91301166 T DK91301166 T DK 91301166T DK 91301166 T DK91301166 T DK 91301166T DK 0442724 T3 DK0442724 T3 DK 0442724T3
Authority
DK
Denmark
Prior art keywords
well
modified hil
modified
difficiencies
unglycosylated
Prior art date
Application number
DK91301166T
Other languages
Danish (da)
English (en)
Inventor
Toshifumi Mikayama
Toshihiko Kadoya
Makoto Kakitani
Hideo Inoue
Original Assignee
Kirin Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Amgen Inc filed Critical Kirin Amgen Inc
Application granted granted Critical
Publication of DK0442724T3 publication Critical patent/DK0442724T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK91301166T 1990-02-13 1991-02-13 Modificeret hIL-6. DK0442724T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3227390 1990-02-13
JP22235390 1990-08-22
JP2250460A JPH04218000A (ja) 1990-02-13 1990-09-21 修飾ポリペプチド

Publications (1)

Publication Number Publication Date
DK0442724T3 true DK0442724T3 (da) 2000-04-10

Family

ID=27287645

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91301166T DK0442724T3 (da) 1990-02-13 1991-02-13 Modificeret hIL-6.

Country Status (9)

Country Link
US (1) US5264209A (fr)
EP (1) EP0442724B1 (fr)
JP (1) JPH04218000A (fr)
AT (1) ATE185602T1 (fr)
AU (1) AU634343B2 (fr)
CA (1) CA2036197C (fr)
DE (1) DE69131699T2 (fr)
DK (1) DK0442724T3 (fr)
ES (1) ES2136596T3 (fr)

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US5824784A (en) * 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
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US5854398A (en) * 1996-07-25 1998-12-29 The Trustees Of Columbia University In The City Of New York Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin 6 (IL-6) and uses thereof
ATE342729T1 (de) * 1997-01-15 2006-11-15 Phoenix Pharmacologics Inc Modifizierter tumor-nekrosefaktor
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IL142875A (en) 2001-04-30 2009-08-03 Avigdor Shafferman PEG-linked cholinesterases for the detoxification of circulating organophosphorus
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US7655618B2 (en) 2002-12-27 2010-02-02 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US7314859B2 (en) 2002-12-27 2008-01-01 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US20060014248A1 (en) * 2003-01-06 2006-01-19 Xencor, Inc. TNF super family members with altered immunogenicity
US20050130892A1 (en) * 2003-03-07 2005-06-16 Xencor, Inc. BAFF variants and methods thereof
US7553930B2 (en) * 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
US20050221443A1 (en) * 2003-01-06 2005-10-06 Xencor, Inc. Tumor necrosis factor super family agonists
US7381410B2 (en) * 2003-03-12 2008-06-03 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
EP1606305A4 (fr) 2003-03-12 2009-06-24 Vasgene Therapeutics Inc Composes d'acide nucleique pouvant inhiber l'angiogenese et la croissance tumorale
EP1491554A1 (fr) * 2003-06-23 2004-12-29 CONARIS research institute AG Solubles gp130-dimeres modifiée avec du PEG pour utilisation comme medicament
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WO2005085283A1 (fr) * 2004-03-03 2005-09-15 Yamanouchi Pharmaceutical Co., Ltd. Interleukine-11 modifiée et composition thérapeutique contenant celle-ci
DK1730196T3 (da) 2004-03-12 2011-03-28 Vasgene Therapeutics Inc EphB4-bindende antistoffer til inhibering af antiogenese og tumorvækst
CN101072797B (zh) 2004-03-12 2012-05-09 瓦斯基因治疗公司 结合ephb4、抑制血管发生和肿瘤生长的抗体
AU2005229001A1 (en) * 2004-03-23 2005-10-13 Amgen Inc. Chemically modified protein compositions and methods
RU2298560C2 (ru) * 2004-04-30 2007-05-10 Открытое Акционерное Общество "Верофарм" Конъюгаты белка и производного полиэтиленгликоля, фармацевтическая композиция, способ борьбы с вирусной инфекцией
US8143380B2 (en) 2004-07-08 2012-03-27 Amgen Inc. Therapeutic peptides
CA2581423A1 (fr) * 2004-09-23 2006-03-30 Vasgene Therapeutics, Inc. Composes de polypeptides pour l'inhibition de l'angiogenese et de croissance tumorale
ES2388068T3 (es) 2004-12-23 2012-10-08 Molmed Spa Producto de conjugación
JPWO2006080171A1 (ja) 2005-01-31 2008-06-19 株式会社 エフェクター細胞研究所 免疫増強剤
WO2006116948A1 (fr) * 2005-04-30 2006-11-09 Chengdu Institute Of Biological Products Conjugue de polyethylene glycol et d’interleukine-6 et son procede de preparation et son utilisation
AU2006295340B2 (en) 2005-08-05 2010-11-11 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
KR20080074136A (ko) * 2005-10-28 2008-08-12 센토코 인코포레이티드 항체의 생성에 있어서의 ｂ 세포 팽창제의 사용
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CN103118708B (zh) 2010-09-14 2015-08-26 霍夫曼-拉罗奇有限公司 用于纯化聚乙二醇化的促红细胞生成素的方法
CA2840408A1 (fr) * 2011-06-27 2013-01-03 Galderma Research & Development Nouveaux marqueurs de differenciation th7 pour la rosacee et utilisations de ces derniers
HRP20210737T1 (hr) 2014-12-01 2021-06-11 Ferring B.V. Primjena selektivnog inhibitora il-6-trans-signalizacije
DK3227325T3 (da) 2014-12-01 2024-07-08 Ferring Bv Sammensætninger med selektive hæmmere af il-6-trans-signalering
KR102470282B1 (ko) 2016-07-15 2022-11-24 에프. 호프만-라 로슈 아게 Ｐｅｇ화 에리트로포이에틴을 정제하기 위한 방법
TW202330584A (zh) * 2022-01-20 2023-08-01 丹麥商諾佛 儂迪克股份有限公司 前藥及其用途

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Also Published As

Publication number Publication date
ATE185602T1 (de) 1999-10-15
JPH04218000A (ja) 1992-08-07
EP0442724A3 (en) 1992-02-26
DE69131699T2 (de) 2000-02-24
CA2036197A1 (fr) 1991-08-14
EP0442724A2 (fr) 1991-08-21
CA2036197C (fr) 2001-09-18
DE69131699D1 (de) 1999-11-18
AU634343B2 (en) 1993-02-18
ES2136596T3 (es) 1999-12-01
AU7087891A (en) 1991-08-15
US5264209A (en) 1993-11-23
EP0442724B1 (fr) 1999-10-13

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