DK0443874T3 - Vektorer og forbindelser til ekspression af glycosyleringsmutanter af humanprotein C - Google Patents

Vektorer og forbindelser til ekspression af glycosyleringsmutanter af humanprotein C

Info

Publication number
DK0443874T3
DK0443874T3 DK91301446.0T DK91301446T DK0443874T3 DK 0443874 T3 DK0443874 T3 DK 0443874T3 DK 91301446 T DK91301446 T DK 91301446T DK 0443874 T3 DK0443874 T3 DK 0443874T3
Authority
DK
Denmark
Prior art keywords
vectors
human protein
compounds
expression
glycosylation mutants
Prior art date
Application number
DK91301446.0T
Other languages
Danish (da)
English (en)
Inventor
Bruce Edward Gerlitz
Brian William Grinnell
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0443874T3 publication Critical patent/DK0443874T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Eye Examination Apparatus (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
DK91301446.0T 1990-02-23 1991-02-22 Vektorer og forbindelser til ekspression af glycosyleringsmutanter af humanprotein C DK0443874T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48408190A 1990-02-23 1990-02-23
US62806390A 1990-12-21 1990-12-21

Publications (1)

Publication Number Publication Date
DK0443874T3 true DK0443874T3 (da) 1997-11-17

Family

ID=27047851

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91301446.0T DK0443874T3 (da) 1990-02-23 1991-02-22 Vektorer og forbindelser til ekspression af glycosyleringsmutanter af humanprotein C

Country Status (19)

Country Link
US (1) US5460953A (pt)
EP (1) EP0443874B1 (pt)
JP (1) JP3004375B2 (pt)
KR (1) KR910021477A (pt)
CN (1) CN1055560A (pt)
AT (1) ATE153069T1 (pt)
AU (1) AU645776B2 (pt)
CA (1) CA2036894C (pt)
DE (1) DE69126049T2 (pt)
DK (1) DK0443874T3 (pt)
ES (1) ES2101716T3 (pt)
FI (1) FI910854L (pt)
GR (1) GR3023756T3 (pt)
IE (1) IE910611A1 (pt)
IL (1) IL97311A0 (pt)
NO (1) NO910719L (pt)
NZ (1) NZ237199A (pt)
PT (1) PT96853A (pt)
YU (1) YU31891A (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY110664A (en) * 1992-05-21 1999-01-30 Lilly Co Eli Protein c derivatives
SE9701228D0 (sv) * 1997-04-03 1997-04-03 Bjoern Dahlbaeck Rekombinanta protein-C-och protein-S-varianter
US7081519B1 (en) 1997-04-24 2006-07-25 Zymogenetics, Inc. Antibodies to serine protease polypeptides
US6153420A (en) * 1997-04-24 2000-11-28 Zymogenetics, Inc. Serine protease polypeptides and materials and methods for making them
US6998122B1 (en) 1999-04-30 2006-02-14 Eli Lilly And Company Protein C derivatives
JP2003514545A (ja) * 1999-11-19 2003-04-22 イーライ・リリー・アンド・カンパニー プロテインｃ誘導体
EP1255821B1 (en) 2000-02-02 2004-12-29 Eli Lilly And Company Protein c derivatives
CA2400187A1 (en) * 2000-02-11 2001-08-16 Eli Lilly And Company Protein c derivatives
US6933367B2 (en) * 2000-10-18 2005-08-23 Maxygen Aps Protein C or activated protein C-like molecules
AU2002210388B2 (en) * 2000-10-18 2006-11-23 Perseid Therapeutics Llc Protein C or activated protein C like molecules
WO2006044294A2 (en) * 2004-10-14 2006-04-27 Eli Lilly And Company Human protein c analogs
US7655428B2 (en) * 2005-12-22 2010-02-02 Biosite, Inc. Latent protein C assays and their uses for diagnosis and/or prognosis in systemic inflammatory response syndromes
CA2654761A1 (en) * 2006-06-09 2007-12-13 The University Of British Columbia Interferon gamma polymorphisms as indicators of subject outcome in critically ill subjects
WO2008048646A1 (en) * 2006-10-18 2008-04-24 Socratech L.L.C. Use of human protein c with altered glycosylation and sialic acid content as a medicament
CA2712057A1 (en) * 2008-01-15 2009-07-23 The University Of British Columbia Protein c rs2069915 as a response predictor to survival and administration of activated protein c or protein c-like compound
EP2539448B1 (en) * 2010-02-26 2016-12-14 The Children's Hospital of Philadelphia Protein c zymogen and methods of use thereof to prevent cancer metastases
WO2012068519A2 (en) 2010-11-19 2012-05-24 Sirius Genomics Inc. Markers associated with response to activated protein c administration, and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
EP0215548B2 (en) * 1985-06-27 1998-01-07 Zymogenetics, Inc. Expression of protein C
US4959318A (en) * 1985-06-27 1990-09-25 Zymogenetics, Inc. Expression of protein C
US4968626A (en) * 1985-08-15 1990-11-06 Board Of Reagents Of The University Of Washington DNA sequence coding for protein C
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
DE3789664T3 (de) * 1986-01-31 2004-09-16 Genetics Institute, LLC, Cambridge Neue thrombolytische proteine.
US5135854A (en) * 1987-10-29 1992-08-04 Zymogenetics, Inc. Methods of regulating protein glycosylation
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C
ZA889497B (en) * 1987-12-28 1990-08-29 Lilly Co Eli Vectors and compounds for expression of zymogen forms of human protein c
JP2728240B2 (ja) * 1988-07-26 1998-03-18 ヘキスト薬品工業株式会社 ヒトプロテインｃ変異体及びその製造方法
US5270178A (en) * 1990-02-23 1993-12-14 Eli Lilly And Company Vectors and compounds for expression of zymogen forms of human protein C

Also Published As

Publication number Publication date
FI910854A7 (fi) 1991-08-24
NO910719D0 (no) 1991-02-22
CA2036894C (en) 2002-01-15
NZ237199A (en) 1993-04-28
FI910854A0 (fi) 1991-02-22
IE910611A1 (en) 1991-08-28
CA2036894A1 (en) 1991-08-24
FI910854L (fi) 1991-08-24
EP0443874A3 (en) 1991-10-16
EP0443874A2 (en) 1991-08-28
GR3023756T3 (en) 1997-09-30
YU31891A (sh) 1994-06-10
ATE153069T1 (de) 1997-05-15
IL97311A0 (en) 1992-05-25
ES2101716T3 (es) 1997-07-16
PT96853A (pt) 1991-10-31
DE69126049T2 (de) 1997-09-25
AU645776B2 (en) 1994-01-27
KR910021477A (ko) 1991-12-20
NO910719L (no) 1991-08-26
EP0443874B1 (en) 1997-05-14
JPH04211380A (ja) 1992-08-03
US5460953A (en) 1995-10-24
DE69126049D1 (de) 1997-06-19
JP3004375B2 (ja) 2000-01-31
CN1055560A (zh) 1991-10-23
AU7130791A (en) 1991-08-29

Similar Documents

Publication Publication Date Title
DK0443874T3 (da) Vektorer og forbindelser til ekspression af glycosyleringsmutanter af humanprotein C
NO931840L (no) Protein-C-derivater
DE3382760D1 (de) Herstellung von funktionellen menschlichen Urokinasepolypeptiden.
DK0652966T3 (da) Fremgangsmåde til forøgelse af ekspression af virale proteiner
ATE162221T1 (de) Herstellung von glukoseoxidase in rekombinanten systemen
FI90667C (fi) Menetelmä valmistaa uutta ihmisen tyypin I interferoniproteiinia
KR950701347A (ko) 신규한 향종양성 사이토킨(A novel anti-neoplastic cytokine)