DK0443891T3 - Anvendelse af N-myristotyl-(S)-phenylalanin eller et additionssalt deraf med en farmaceutisk acceptabel base til opnåelse af et farmaceutisk middel og farmaceutisk middel til behandling af sygdomme ved indgribning i myristoyleringen - Google Patents

Anvendelse af N-myristotyl-(S)-phenylalanin eller et additionssalt deraf med en farmaceutisk acceptabel base til opnåelse af et farmaceutisk middel og farmaceutisk middel til behandling af sygdomme ved indgribning i myristoyleringen

Info

Publication number: DK0443891T3
Authority: DK; Denmark
Prior art keywords: pharmaceutical; phenylalanine; diseases; treatment; myristotyl
Prior art date: 1990-01-25

Application number

DK91400163.1T

Other languages

English (en)

Inventor

Michel Vincent

Georges Remond

Yolande Herve

Jean-Albert Boutin

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-25

Filing date

1991-01-25

Publication date

1993-12-27

1991-01-25 Application filed by Adir filed Critical Adir

1993-12-27 Application granted granted Critical

1993-12-27 Publication of DK0443891T3 publication Critical patent/DK0443891T3/da

Links

201000010099 disease Diseases 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 title 2
230000007498 myristoylation Effects 0.000 title 1
239000008177 pharmaceutical agent Substances 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
GFNNQTYRJPFJGX-NRFANRHFSA-N (2s)-3-phenyl-2-(tetradecanoylamino)propanoic acid Chemical compound CCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 GFNNQTYRJPFJGX-NRFANRHFSA-N 0.000 abstract 1
208000030507 AIDS Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK91400163.1T 1990-01-25 1991-01-25 Anvendelse af N-myristotyl-(S)-phenylalanin eller et additionssalt deraf med en farmaceutisk acceptabel base til opnåelse af et farmaceutisk middel og farmaceutisk middel til behandling af sygdomme ved indgribning i myristoyleringen DK0443891T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9000834A FR2657259A1 (fr)	1990-01-25	1990-01-25	Utilisation de la n-myristoyl-(s)-phenylalanine pour l'obtention de medicaments destines au traitement des maladies faisant intervenir la myristoylation.

Publications (1)

Publication Number	Publication Date
DK0443891T3 true DK0443891T3 (da)	1993-12-27

Family

ID=9393082

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91400163.1T DK0443891T3 (da)	1990-01-25	1991-01-25	Anvendelse af N-myristotyl-(S)-phenylalanin eller et additionssalt deraf med en farmaceutisk acceptabel base til opnåelse af et farmaceutisk middel og farmaceutisk middel til behandling af sygdomme ved indgribning i myristoyleringen

Country Status (14)

Country	Link
US (1)	US5164414A (da)
EP (1)	EP0443891B1 (da)
JP (1)	JPH0717503B2 (da)
AT (1)	ATE94387T1 (da)
AU (1)	AU633395B2 (da)
CA (1)	CA2034861A1 (da)
DE (1)	DE69100364T2 (da)
DK (1)	DK0443891T3 (da)
ES (1)	ES2060310T3 (da)
FR (1)	FR2657259A1 (da)
IE (1)	IE65573B1 (da)
OA (1)	OA09478A (da)
PT (1)	PT96571A (da)
ZA (1)	ZA91574B (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2672598A1 (fr) *	1991-02-11	1992-08-14	Adir	Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5599947A (en) *	1993-01-14	1997-02-04	G. D. Searle & Co.	Fatty acid analogs and prodrugs
US5859052A (en) *	1993-01-14	1999-01-12	G. D. Searle & Co.	Fatty acid analogs and prodrugs
US6127393A (en) *	1995-12-29	2000-10-03	Novactyl, Inc.	Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method
US6407125B1 (en)	1995-12-29	2002-06-18	Novactyl, Inc.	Pharmacological agent and method of treatment
US6743771B2 (en)	1995-12-29	2004-06-01	Novactyl, Inc.	Methods and compositions for controlling protein assembly or aggregation
US6579891B1 (en)	1995-12-29	2003-06-17	Novactyl, Inc.	Agent and method for prevention and treatment of cancer in animals
US6441009B1 (en)	1998-08-01	2002-08-27	Novactyl, Inc.	Agent and method of preventing and treating heavy metal exposure and toxicity
EP1220669A4 (en) *	1999-10-13	2004-12-08	Marco A Chacon	THERAPEUTIC MEASURE TO IMPROVE THE EFFECT OF A CALORY RESTRICTION
US6403618B1 (en)	2000-02-15	2002-06-11	Novactyl, Inc.	Agent and method for controlling angiogenesis
WO2003007876A2 (en) *	2001-06-25	2003-01-30	University Of Massachusetts	N-fatty acid-amino acid conjugates and therapeutic uses
DE10353806A1 (de) *	2003-11-14	2005-07-07	Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Gesundheit, dieses vertreten durch das Robert-Koch-Institut, vertreten durch seinen Präsidenten	Verwendung von Aminosäure- und Zucker-Amphiphilen zur Inaktivierung von lipidumhüllten Viren
US7544714B2 (en) *	2004-07-16	2009-06-09	University Of Massachusetts	Lipid-amino acid conjugates and methods of use
IL172896A0 (en) *	2005-12-29	2006-06-11	Yeda Res & Dev	Cxcr4 inhibition
MX368261B (es)	2011-07-22	2019-09-25	Pacylex Pharmaceuticals Inc	Letalidad sintetica y el tratamiento de cancer.
SG11201405413SA (en)	2012-03-30	2014-10-30	Givaudan Sa	N-acyl derivatives of gamma amino - butyric acid and and beta alanine as food flavouring compounds
CN104219964B (zh)	2012-03-30	2016-09-21	奇华顿股份有限公司	作为食品加香化合物的n-酰基脯氨酸衍生物
US10856563B2 (en)	2012-03-30	2020-12-08	Givaudan S.A.	N-acyl-amino acid derivatives for improvement of the flavor profile of edible compositions
JP6320367B2 (ja)	2012-03-30	2018-05-09	ジボダンエスエー	食品フレーバー付与化合物としてのｎ−アシル化メチオニン誘導体
JP6248092B2 (ja)	2012-03-30	2017-12-13	ジボダンエスエー	食品フレーバー付与化合物としてのｎ−アシル化１−アミノシクロアルキルカルボン酸
US10582715B2 (en)	2012-03-30	2020-03-10	Givaudan Sa	Powder flavour composition
BR122020006518B1 (pt)	2012-03-30	2022-02-22	Givaudan Sa	Composição de sabor
KR102496892B1 (ko) *	2012-10-30	2023-02-06	페이실렉스 파마슈티컬스 인코포레이티드	암의 합성치사 및 치료
EP3057448B1 (en)	2013-10-02	2017-12-06	Givaudan S.A.	Organic compounds having taste-modifying properties
EP3057446B1 (en)	2013-10-02	2017-12-06	Givaudan S.A.	Organic compounds having taste-modifying properties
WO2015050535A1 (en)	2013-10-02	2015-04-09	Givaudan S.A.	Organic compounds
WO2015048991A1 (en)	2013-10-02	2015-04-09	Givaudan Sa	Organic compounds having taste-modifying properties
GB201317424D0 (en)	2013-10-02	2013-11-13	Givaudan Sa	Improvements in or relating to organic compounds
EP3057447B1 (en)	2013-10-02	2017-12-06	Givaudan S.A.	Organic compounds having taste-modifying properties
CN105636934B (zh)	2013-10-02	2019-03-29	奇华顿股份有限公司	N-酰化的2-氨基异丁酸化合物和包含它们的香味组合物
WO2015048990A1 (en)	2013-10-02	2015-04-09	Givaudan Sa	Organic compounds having taste-modifying properties
EP3325662B1 (en)	2015-07-17	2023-08-30	Pacylex Pharmaceuticals Inc.	Epigenetic silencing of nmt2

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4778877A (en) *	1986-08-07	1988-10-18	Washington University	Novel inhibitor peptides II
US4778878A (en) *	1986-08-07	1988-10-18	Washington University	Novel inhibitor peptides I

1990
- 1990-01-25 FR FR9000834A patent/FR2657259A1/fr active Granted
1991
- 1991-01-24 JP JP3007188A patent/JPH0717503B2/ja not_active Expired - Lifetime
- 1991-01-24 IE IE24291A patent/IE65573B1/en not_active IP Right Cessation
- 1991-01-24 PT PT96571A patent/PT96571A/pt not_active Application Discontinuation
- 1991-01-24 US US07/645,124 patent/US5164414A/en not_active Expired - Fee Related
- 1991-01-24 CA CA002034861A patent/CA2034861A1/fr not_active Abandoned
- 1991-01-25 EP EP91400163A patent/EP0443891B1/fr not_active Expired - Lifetime
- 1991-01-25 ES ES91400163T patent/ES2060310T3/es not_active Expired - Lifetime
- 1991-01-25 AU AU69987/91A patent/AU633395B2/en not_active Ceased
- 1991-01-25 DE DE91400163T patent/DE69100364T2/de not_active Expired - Fee Related
- 1991-01-25 DK DK91400163.1T patent/DK0443891T3/da active
- 1991-01-25 OA OA59940A patent/OA09478A/xx unknown
- 1991-01-25 ZA ZA91574A patent/ZA91574B/xx unknown
- 1991-01-25 AT AT91400163T patent/ATE94387T1/de active

Also Published As

Publication number	Publication date
IE65573B1 (en)	1995-11-01
EP0443891B1 (fr)	1993-09-15
EP0443891A1 (fr)	1991-08-28
ES2060310T3 (es)	1994-11-16
ZA91574B (en)	1991-11-27
AU633395B2 (en)	1993-01-28
PT96571A (pt)	1991-10-15
DE69100364T2 (de)	1994-04-21
DE69100364D1 (de)	1993-10-21
OA09478A (fr)	1992-11-15
US5164414A (en)	1992-11-17
FR2657259A1 (fr)	1991-07-26
AU6998791A (en)	1991-08-01
FR2657259B1 (da)	1994-08-19
JPH04210916A (ja)	1992-08-03
CA2034861A1 (fr)	1991-07-26
JPH0717503B2 (ja)	1995-03-01
IE910242A1 (en)	1991-07-31
ATE94387T1 (de)	1993-10-15

Publication	Publication Date	Title
ZA91574B (en)	1991-11-27	Use of n-myristoyl-(s)-phenylalanine for obtaining medicinal products for the treatment of diseases involving myristoylation
NO894296D0 (no)	1989-10-27	Fremgangsmaate for behandling av leddgikt og betennelsessykdommer.
DE59101397D1 (de)	1994-05-19	O-glycosyliertes ifn-alpha.
IT1131776B (it)	1986-06-25	Protesi anulare regolabile per chirurgia cardiaca
DK1368060T3 (da)	2010-08-30	HMGB1-proteininhibitorer og/eller antagonister til behandlingen af vaskulære sygdomme
DK156098C (da)	1990-02-12	Thixotropt middel til brug ved fraktionering af blod
SE7905593L (sv)	1979-12-28	Acylderivat av karnitin och forfarande for framstellning derav
ES2056180T3 (es)	1994-10-01	Nuevos derivados de 2'-halometiliden, 2'-eteniliden y 2'-etinil citidina.
ES2071663T3 (es)	1995-07-01	Analogo de fluoxetina.
NO931413L (no)	1993-04-16	Fremgangsmaater og preparater for behandling av celleproliferasjonssykdommer
ES2120962T3 (es)	1998-11-16	Composicion antivirica.
DK160816C (da)	1991-10-07	Benzoyl-urinstof-derivater, fremgangsmaade til fremstilling af disse, fremgangsmaade til bekaempelse af insektangreb samt insekticidt middel indeholdende disse
IT9020968A0 (it)	1990-07-18	Metodi e composizioni farmaceutiche per il trattamento di malattie oftalmiche
NO913117D0 (no)	1991-08-09	Fremgangsmaate for behandling av benoedeleggende sykdommer.
DK632388A (da)	1989-05-14	Pharmaceutisk middel til behandling af hyperlipidaemi hol pattedyr
SE9000948D0 (sv)	1990-03-16	New use
DK0458892T3 (da)	1994-08-15	Anvendelse af chlormethiazol ved fremstillingen af et medikament til forebyggelsen og/eller behandlingen af neurodegeneration
IS3743A7 (is)	1992-02-16	Ný notkun á 5-(2 klóró-1-hýdroxíetýl)-4-metýlþíasól
NO960347D0 (no)	1996-01-26	Anvendelse av benzydamid ved behandling av patologiske tilstander forårsaket av TNF
NL7803642A (nl)	1978-10-09	Individuele endo-osseo inplant voor odonto-stomalogie (mondchirurgie) en werkwijze voor de snelle en perfek- te aanbrenging van de inplant in de patient.
IT7829846A0 (it)	1978-11-16	Composizione farmaceutica per la cura della sordita' e del ronzio auricolare.
DK670588D0 (da)	1988-12-01	Farmaceutisk praeparat til behandling af phlebektasi og fremgangsmaade til fremstilling af praeparatet
IT9009354A0 (it)	1990-03-30	Procedimento e camera di fermentazione per il trattamento di pezzi di pasta alimentare
SE9000288D0 (sv)	1990-01-26	New use
DK305289D0 (da)	1989-06-20	Apparat til behandling af reumatiske sygdomme