DK0444186T4 - Farmaceutisk præparat, som gør celler, der udtrykker MHC klasse II-antigener, til mål for cytotoksiske T-celler - Google Patents
Farmaceutisk præparat, som gør celler, der udtrykker MHC klasse II-antigener, til mål for cytotoksiske T-cellerInfo
- Publication number
- DK0444186T4 DK0444186T4 DK90914564T DK90914564T DK0444186T4 DK 0444186 T4 DK0444186 T4 DK 0444186T4 DK 90914564 T DK90914564 T DK 90914564T DK 90914564 T DK90914564 T DK 90914564T DK 0444186 T4 DK0444186 T4 DK 0444186T4
- Authority
- DK
- Denmark
- Prior art keywords
- cells
- cytotoxic
- antigens
- mhc class
- expressing mhc
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title abstract 3
- 102000043131 MHC class II family Human genes 0.000 title abstract 2
- 108091054438 MHC class II family Proteins 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 3
- 231100000655 enterotoxin Toxicity 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 241000202956 Mycoplasma arthritidis Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 206010044248 Toxic shock syndrome Diseases 0.000 abstract 1
- 231100000650 Toxic shock syndrome Toxicity 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000000147 enterotoxin Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8903100A SE8903100D0 (sv) | 1989-09-20 | 1989-09-20 | New pharmaceutical agent |
| PCT/SE1990/000592 WO1991004053A1 (en) | 1989-09-20 | 1990-09-14 | Pharmaceutical composition that makes cells expressing mhc class ii antigens targets for cytotoxic t-cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK0444186T3 DK0444186T3 (da) | 1996-01-02 |
| DK0444186T4 true DK0444186T4 (da) | 2003-11-24 |
Family
ID=20376934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90914564T DK0444186T4 (da) | 1989-09-20 | 1990-09-14 | Farmaceutisk præparat, som gør celler, der udtrykker MHC klasse II-antigener, til mål for cytotoksiske T-celler |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0444186B2 (da) |
| JP (1) | JP3147237B2 (da) |
| AT (1) | ATE130199T1 (da) |
| DE (1) | DE69023635T3 (da) |
| DK (1) | DK0444186T4 (da) |
| ES (1) | ES2079489T5 (da) |
| SE (1) | SE8903100D0 (da) |
| WO (1) | WO1991004053A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728388A (en) | 1989-10-03 | 1998-03-17 | Terman; David S. | Method of cancer treatment |
| US6126945A (en) | 1989-10-03 | 2000-10-03 | Pharmacia Ab | Tumor killing effects of enterotoxins, superantigens, and related compounds |
| WO1991006319A1 (en) * | 1989-10-27 | 1991-05-16 | Arch Development Corporation | Methods and compositions for promoting immunopotentiation |
| US6406696B1 (en) | 1989-10-27 | 2002-06-18 | Tolerance Therapeutics, Inc. | Methods of stimulating the immune system with anti-CD3 antibodies |
| EP1129717B2 (en) * | 1990-01-17 | 2013-03-06 | TERMAN, David S. | Use of homologues of staphylococcal enterotoxins for cancer treatment |
| US5858363A (en) * | 1990-07-20 | 1999-01-12 | Pharmacia & Upjohn Ab | Target specific antibody-superantigen conjugates and their preparation |
| SE9002484L (sv) | 1990-07-20 | 1992-01-21 | Kabi Pharmacia Ab | Nya substituerade polyetrar |
| US6491916B1 (en) | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| SE9402430L (sv) | 1994-07-11 | 1996-01-12 | Pharmacia Ab | Konjugat mellan modifierat superantigen och en målsökande förening samt användning av konjugaten |
| WO1996014744A1 (en) * | 1994-11-14 | 1996-05-23 | National Jewish Center For Immunology And Respiratory Medicine | Protective effects of mutated superantigens |
| US5935568A (en) * | 1995-05-18 | 1999-08-10 | National Jewish Medical & Research Center | Gene therapy for effector cell regulation |
| SE9601245D0 (sv) | 1996-03-29 | 1996-03-29 | Pharmacia Ab | Chimeric superantigens and their use |
| TW517061B (en) | 1996-03-29 | 2003-01-11 | Pharmacia & Amp Upjohn Ab | Modified/chimeric superantigens and their use |
| WO2007009064A2 (en) | 2005-07-11 | 2007-01-18 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| SG177907A1 (en) | 2006-06-14 | 2012-02-28 | Macrogenics Inc | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| JP2024520444A (ja) | 2021-05-24 | 2024-05-24 | プロヴェンション・バイオ・インコーポレイテッド | 1型糖尿病を治療するための方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4689222A (en) * | 1985-01-18 | 1987-08-25 | Mcmichael John | Methods and materials for alleviation of pain symptoms of malignant neoplasia |
| DK528285D0 (da) * | 1985-11-15 | 1985-11-15 | Novo Industri As | Peptider samt praeparater indeholdende disse |
| SE8801426D0 (sv) * | 1988-04-15 | 1988-04-15 | Ulf Rothman | Forfarande och medel for blodbehandling |
| EP1129717B2 (en) † | 1990-01-17 | 2013-03-06 | TERMAN, David S. | Use of homologues of staphylococcal enterotoxins for cancer treatment |
-
1989
- 1989-09-20 SE SE8903100A patent/SE8903100D0/xx unknown
-
1990
- 1990-09-14 JP JP51367890A patent/JP3147237B2/ja not_active Expired - Fee Related
- 1990-09-14 EP EP90914564A patent/EP0444186B2/en not_active Expired - Lifetime
- 1990-09-14 DE DE69023635T patent/DE69023635T3/de not_active Expired - Fee Related
- 1990-09-14 WO PCT/SE1990/000592 patent/WO1991004053A1/en not_active Ceased
- 1990-09-14 DK DK90914564T patent/DK0444186T4/da active
- 1990-09-14 ES ES90914564T patent/ES2079489T5/es not_active Expired - Lifetime
- 1990-09-14 AT AT90914564T patent/ATE130199T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69023635T3 (de) | 2004-06-03 |
| DE69023635T2 (de) | 1996-06-20 |
| WO1991004053A1 (en) | 1991-04-04 |
| EP0444186A1 (en) | 1991-09-04 |
| EP0444186B2 (en) | 2003-10-29 |
| EP0444186B1 (en) | 1995-11-15 |
| DK0444186T3 (da) | 1996-01-02 |
| JP3147237B2 (ja) | 2001-03-19 |
| DE69023635D1 (de) | 1995-12-21 |
| JPH04505767A (ja) | 1992-10-08 |
| ES2079489T5 (es) | 2004-05-16 |
| SE8903100D0 (sv) | 1989-09-20 |
| ES2079489T3 (es) | 1996-01-16 |
| ATE130199T1 (de) | 1995-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0444186T3 (da) | Farmaceutisk præparat, som gør celler, der udtrykker MHC klasse II-antigener, til mål for cytotoksiske T-celler | |
| Ohishi | Activation of botulinum C2 toxin by trypsin | |
| ES2088873T3 (es) | Celulas dotadas con especialidad de anticuerpos. | |
| NO914206L (no) | Terapeutisk middel | |
| WO1995016038A3 (en) | Humanized antibodies and uses thereof | |
| IL77293A (en) | Stable,covalently-coupled,polysaccharide-protein conjugates comprising neutral polysaccharides and immunogenic proteins coupled through bigeneric spacers,methods for preparing them and pharmaceutical compositions containing them | |
| ES2112838T3 (es) | Peptidos receptores de celulas t como agentes terapeuticos para enfermedades autoinmunitarias y malignas. | |
| DK0957935T3 (da) | Chlamydia-vacciner og immunogene præparater indeholdende et ydre membran-antigen samt fremgangsmåde til fremstilling deraf | |
| BR9809445A (pt) | Polipeptìdeo compreendendo uma porção imunogênica de um antìgeno de m. tubercolosis, molécula de dna, vetor de expressão, célula hospedeira, composição farmacêutica, vacina, proteìna de fusão, processos para indução de imunidade protetora em um paciente, processo de detecção de tuberculose em um paciente,e , kit de diagnóstico. | |
| AU1618499A (en) | Oxygen-transporting albumin-based blood replacement composition and blood volumeexpander | |
| DE69122240D1 (de) | Antigen-wirkende proteine von borrelia burgdorferi | |
| ATE220688T1 (de) | Tumor-zerstörende effekte von enterotoxinen und verwandten verbindungen | |
| BRPI0411510A (pt) | proteìna, composição farmacêutica, uso da proteìna, polipeptìdeo, uso do mesmo, vetor, ácido nucleico, célula hospedeira, soro policlonal, anticorpo monoclonal, uso de um soro policlonal ou de um anticorpo monoclonal, método para alvejar in vitro uma molécula de interesse com as células que expressam cd11b, células que expressam cd11b, produto de terapia celular para imunizar um ser humano ou um animal contra um antìgeno uso de células que expressam cd11b, e, método para imunizar um paciente contra antìgeno | |
| BR9509172A (pt) | Proteina de via de complemento nativa sequéncia de dna construção de dna conjugado uso de uma proteína processo para reduzir proteina de via de complemento em um mamifero e formulação farmacéutica | |
| SE8008096L (sv) | Sett att binda ett protein till en berare innehallande hydroxylgrupper | |
| AR029624A1 (es) | Anticuerpos o fragmentos de anticuerpos anti-idiotipicos recombinantes y composicion farmaceutica que los contiene | |
| EP0992584A3 (en) | Purified mammalian FLT3 ligands and agonists and antagonists thereof | |
| GR3007031T3 (da) | ||
| Ohta et al. | Characterization of a cell-surface protein antigen of hydrophilic Streptococcus mutans strain GS-5 | |
| AU7556487A (en) | Immunotoxins, process for their preparation and pharmaceutical compositions in which they are present | |
| DE69524971D1 (de) | Neue familie von proteaseinhibitoren und andere biologisch aktive substanzen | |
| Dubreuil et al. | Purification, and biochemical and structural characterization of a fimbrial haemagglutinin of Renibacterium salmoninarum | |
| Spero et al. | Mitogenicity of formalinized toxoids of staphylococcal enterotoxin B | |
| Schmidt et al. | Interaction of streptococcal cell wall components with fibrinogen. I. Adsorption of fibrinogen by immobilized T-proteins of Streptococcus pyogenes | |
| SE9300139L (sv) | Framställning av ett nytt läkemedel |