DK0452680T3 - Substituerede puriner, fremgangsmåde til deres fremstilling samt anvendelse som antivirale midler - Google Patents

Substituerede puriner, fremgangsmåde til deres fremstilling samt anvendelse som antivirale midler

Info

Publication number: DK0452680T3
Authority: DK; Denmark
Prior art keywords: ch2ph; alkyl; dialkylamino; diacylamino; acylamino
Prior art date: 1990-03-20

Application number

DK91104126.7T

Other languages

Danish (da)

English (en)

Inventor

Matthias Dr Helsberg

Irvin Dr Winkler

Gerhard Dr Jaehne

Manfred Dr. Roesner

Thomas Dr Scholl

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-20

Filing date

1991-03-18

Publication date

1997-04-07

1991-03-18 Application filed by Hoechst Ag filed Critical Hoechst Ag

1997-04-07 Application granted granted Critical

1997-04-07 Publication of DK0452680T3 publication Critical patent/DK0452680T3/da

Links

239000003443 antiviral agent Substances 0.000 title 1
229940121357 antivirals Drugs 0.000 title 1
150000003212 purines Chemical class 0.000 title 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 6
125000004442 acylamino group Chemical group 0.000 abstract 3
125000003282 alkyl amino group Chemical group 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 3
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
-1 -N(CH2Ph)2 Chemical group 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000005035 acylthio group Chemical group 0.000 abstract 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK91104126.7T 1990-03-20 1991-03-18 Substituerede puriner, fremgangsmåde til deres fremstilling samt anvendelse som antivirale midler DK0452680T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4008858A DE4008858A1 (de)	1990-03-20	1990-03-20	Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel

Publications (1)

Publication Number	Publication Date
DK0452680T3 true DK0452680T3 (da)	1997-04-07

Family

ID=6402601

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91104126.7T DK0452680T3 (da)	1990-03-20	1991-03-18	Substituerede puriner, fremgangsmåde til deres fremstilling samt anvendelse som antivirale midler

Country Status (19)

Country	Link
EP (1)	EP0452680B1 (cs)
JP (1)	JP3146423B2 (cs)
KR (1)	KR910016751A (cs)
CN (1)	CN1054982A (cs)
AT (1)	ATE144984T1 (cs)
AU (1)	AU644414B2 (cs)
CA (1)	CA2038589A1 (cs)
CS (1)	CS70891A2 (cs)
DE (2)	DE4008858A1 (cs)
DK (1)	DK0452680T3 (cs)
ES (1)	ES2093651T3 (cs)
FI (1)	FI911310A7 (cs)
GR (1)	GR3021591T3 (cs)
HU (1)	HUT57764A (cs)
IE (1)	IE910908A1 (cs)
IL (1)	IL97586A0 (cs)
NO (1)	NO911081L (cs)
PT (1)	PT97080A (cs)
ZA (1)	ZA912015B (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4210221A1 (de) *	1992-03-28	1993-09-30	Hoechst Ag	Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
DE59310344D1 (de) *	1992-09-24	2003-07-24	Hoechst Ag	N1-Substituierte 1H-1,2,3-Triazolo[4,5-d]pyrimidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
DE4311801A1 (de) *	1993-04-09	1994-10-13	Hoechst Ag	Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
DE19536164A1 (de) *	1995-09-28	1997-04-03	Boehringer Ingelheim Kg	Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
US5891881A (en) *	1997-11-21	1999-04-06	Clarion Pharmaceuticals Inc.	Aminoheterocycle-substituted glycerols
FR2793794B1 (fr) *	1999-05-21	2001-07-27	Hoechst Marion Roussel Inc	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
PE20030008A1 (es)	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1523865A (en) *	1974-09-02	1978-09-06	Wellcome Found	Purine compunds and salts thereof
US4816447A (en) *	1981-08-26	1989-03-28	Merck & Co., Inc.	Anti-viral guanine compounds
DE3627024A1 (de) *	1985-09-24	1987-04-02	Hoechst Ag	In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
AP55A (en) *	1987-08-15	1989-09-26	The Wellcome Foundation Ltd	Therapeutic Acyclic Nucleosides

1990
- 1990-03-20 DE DE4008858A patent/DE4008858A1/de not_active Withdrawn
1991
- 1991-03-18 FI FI911310A patent/FI911310A7/fi unknown
- 1991-03-18 DK DK91104126.7T patent/DK0452680T3/da active
- 1991-03-18 EP EP91104126A patent/EP0452680B1/de not_active Expired - Lifetime
- 1991-03-18 IL IL97586A patent/IL97586A0/xx unknown
- 1991-03-18 AT AT91104126T patent/ATE144984T1/de not_active IP Right Cessation
- 1991-03-18 ES ES91104126T patent/ES2093651T3/es not_active Expired - Lifetime
- 1991-03-18 CS CS91708A patent/CS70891A2/cs unknown
- 1991-03-18 DE DE59108319T patent/DE59108319D1/de not_active Expired - Lifetime
- 1991-03-19 CN CN91101664A patent/CN1054982A/zh active Pending
- 1991-03-19 NO NO91911081A patent/NO911081L/no unknown
- 1991-03-19 JP JP07829291A patent/JP3146423B2/ja not_active Expired - Lifetime
- 1991-03-19 ZA ZA912015A patent/ZA912015B/xx unknown
- 1991-03-19 CA CA002038589A patent/CA2038589A1/en not_active Abandoned
- 1991-03-19 PT PT97080A patent/PT97080A/pt not_active Application Discontinuation
- 1991-03-19 AU AU73514/91A patent/AU644414B2/en not_active Ceased
- 1991-03-19 KR KR1019910004302A patent/KR910016751A/ko not_active Withdrawn
- 1991-03-19 IE IE090891A patent/IE910908A1/en unknown
- 1991-03-20 HU HU91928A patent/HUT57764A/hu unknown
1996
- 1996-11-08 GR GR960402968T patent/GR3021591T3/el unknown

Also Published As

Publication number	Publication date
HUT57764A (en)	1991-12-30
IE910908A1 (en)	1991-09-25
AU644414B2 (en)	1993-12-09
IL97586A0 (en)	1992-06-21
ES2093651T3 (es)	1997-01-01
CN1054982A (zh)	1991-10-02
GR3021591T3 (en)	1997-02-28
CS70891A2 (en)	1991-11-12
FI911310L (fi)	1991-09-21
FI911310A7 (fi)	1991-09-21
AU7351491A (en)	1991-09-26
NO911081D0 (no)	1991-03-19
CA2038589A1 (en)	1991-09-21
JPH04217984A (ja)	1992-08-07
ATE144984T1 (de)	1996-11-15
FI911310A0 (fi)	1991-03-18
DE4008858A1 (de)	1991-09-26
HU910928D0 (en)	1991-10-28
JP3146423B2 (ja)	2001-03-19
EP0452680A1 (de)	1991-10-23
DE59108319D1 (de)	1996-12-12
KR910016751A (ko)	1991-11-05
ZA912015B (en)	1991-12-24
PT97080A (pt)	1991-11-29
NO911081L (no)	1991-09-23
EP0452680B1 (de)	1996-11-06

Publication	Publication Date	Title
NO177674C (no)	1995-11-01	Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte propan-fosfinsyre-forbindelser
IE872650L (en)	1988-04-07	Imidazopyridine derivatives, their production, and¹pharmaceutical compositions containing them
FR2692265B1 (fr)	1996-11-08	Composes biologiquement actifs de type phosphotriesters.
NZ513402A (en)	2003-06-30	Novel nucleosides and oligonucleotide analogues
ATE498624T1 (de)	2011-03-15	Enantiomerisch reine beta-d-dioxolan-nukleoside
PL244141A1 (en)	1985-06-18	Process for preparing derivatives of purine
NO911081D0 (no)	1991-03-19	Fremgangsmaate for fremstilling av substituerte puriner, og deres anvendelse som antivirale midler.
EP0310673A4 (en)	1990-10-10	2'-alkylidenepyrimidine nucleoside derivatives, process for their preparation, and their use
EP0371139A4 (en)	1991-08-28	6-substituted acyclicpyrimidine nucleoside derivatives and antiviral agents containing same as active ingredients
EP0231081A3 (en)	1989-11-15	Hydroxamic acids
GR3018105T3 (en)	1996-02-29	Antiviral purine derivatives and process for their preparation.
HU9503879D0 (en)	1996-02-28	Substituted benzol-sulfonyl-ureas and thioureas, process for producing them, pharmaceutical and diagnostical use of them and pharmaceutical compositions containing them
PT100148A (pt)	1993-05-31	Processo para a preparacao de novos derivados dipeptidicos, contendo um anel piridinas
PL281368A1 (en)	1990-05-28	Method of obtaining novel purine derivatives
ES2013379A6 (es)	1990-05-01	Procedimiento para preparar 6-sulfenamido-6, sulfinamido- y 6-sulfonamido-purinas, nucleosidos de purinas y nucleotidos de purinas antitumorales.
ES2031584T3 (es)	1992-12-16	Procedimiento mejorado para controlar las incrustaciones de oxalato calcico dentro de amplios limites de ph.
GR3023653T3 (en)	1997-09-30	N(1) substituted pyrazino Ä2,3-cÜ-1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals
HUP9700105A2 (hu)	1999-06-28	5-Fenil-1,3,4-tiadiazol-származékok, eljárás az előállításukra, és ilyen hatóanyagot tartalmazó gyógyászati készítmények
HUT55790A (en)	1991-06-28	Process for producing dihydro-pyrimidino-thiazine derivatives
HUP9700104A2 (hu)	1999-06-28	1,3,4-Tiadiazol-származékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények, és eljárás a hatóanyag előállítására