PT100148A - Processo para a preparacao de novos derivados dipeptidicos, contendo um anel piridinas - Google Patents

Processo para a preparacao de novos derivados dipeptidicos, contendo um anel piridinas

Info

Publication number: PT100148A
Authority: PT; Portugal
Prior art keywords: lower alkyl; aryl; pyretin; preparation; ring
Prior art date: 1991-02-27

Application number

PT100148A

Other languages

English (en)

Other versions

PT100148B (pt

Inventor

Lydia Cabeza Llorente

Francisco Pubill Coy

Carlos Malet Falco

Jose Repolles Moliner

Original Assignee

Lacer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-27

Filing date

1992-02-21

Publication date

1993-05-31

1992-02-21 Application filed by Lacer Sa filed Critical Lacer Sa

1993-05-31 Publication of PT100148A publication Critical patent/PT100148A/pt

1999-06-30 Publication of PT100148B publication Critical patent/PT100148B/pt

Links

108010016626 Dipeptides Proteins 0.000 title abstract 2
DJGAAPFSPWAYTJ-UHFFFAOYSA-M metamizole sodium Chemical group [Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 DJGAAPFSPWAYTJ-UHFFFAOYSA-M 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Crystallography & Structural Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)

PT100148A 1991-02-27 1992-02-21 Processo para a preparacao de novos derivados dipeptidicos, contendo um anel piridinas PT100148B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP91102950A EP0500989B1 (en)	1991-02-27	1991-02-27	N-(alpha-substituted-pyridinyl) carbonyl dipeptide antihypertensive agents

Publications (2)

Publication Number	Publication Date
PT100148A true PT100148A (pt)	1993-05-31
PT100148B PT100148B (pt)	1999-06-30

Family

ID=8206465

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT100148A PT100148B (pt)	1991-02-27	1992-02-21	Processo para a preparacao de novos derivados dipeptidicos, contendo um anel piridinas

Country Status (18)

Country	Link
US (1)	US5432159A (pt)
EP (1)	EP0500989B1 (pt)
JP (1)	JPH05507295A (pt)
AT (1)	ATE174343T1 (pt)
AU (1)	AU650954B2 (pt)
BR (1)	BR9204779A (pt)
CA (1)	CA2081471A1 (pt)
CZ (1)	CZ280952B6 (pt)
DE (1)	DE69130605T2 (pt)
ES (1)	ES2037613B1 (pt)
FI (1)	FI924850A7 (pt)
HU (1)	HUT62313A (pt)
NO (1)	NO924076L (pt)
PL (1)	PL167915B1 (pt)
PT (1)	PT100148B (pt)
RO (1)	RO111369B1 (pt)
RU (1)	RU2098424C1 (pt)
WO (1)	WO1992015608A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995014033A1 (en) *	1993-11-19	1995-05-26	Aktiebolaget Astra	Novel dipeptide derivatives
AU738037B2 (en) *	1997-04-04	2001-09-06	Pfizer Products Inc.	Nicotinamide derivatives
EP1035131B1 (en) *	1998-09-22	2006-11-22	Kaneka Corporation	Process for the preparation of n2 -(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-proline
ES2248231T3 (es)	2001-01-31	2006-03-16	Pfizer Products Inc.	Derivados de eteres utiles como inhibidores de las isozimas pde4.
US7250518B2 (en)	2001-01-31	2007-07-31	Pfizer Inc.	Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
EE200300360A (et)	2001-01-31	2003-12-15	Pfizer Products Inc.	PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid
CN1489588A (zh)	2001-01-31	2004-04-14	�Ʒ�	用作pde4同功酶抑制剂的噻唑基,噁唑基,吡咯基,和咪唑基羧酸酰胺衍生物
WO2003033471A1 (en) *	2001-10-17	2003-04-24	Tobishi Pharmaceutical Co.,Ltd	Novel pyridone derivative and remedial agent for circulatory disease containing the same
HRP20040784A2 (en) *	2002-01-29	2005-04-30	Wyeth	Compositions and methods for modulating connexin hemichannels
SI21507A (sl) *	2003-05-16	2004-12-31	LEK farmacevtska dru�ba d.d.	Postopek za pripravo spojin z ace inhibitornim delovanjem
CA2603835A1 (en) *	2005-04-14	2006-10-26	Merck & Co., Inc.	Vla-4 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU537592B2 (en) *	1979-04-02	1984-07-05	E.R. Squibb & Sons, Inc.	Mercaptoacyldipeptides
NZ202232A (en) *	1981-11-06	1985-08-16	Smithkline Beckman Corp	N-carboxyalkylproline-containing tripeptides and pharmaceutical compositions
DE3332633A1 (de) *	1983-09-09	1985-04-04	Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München	Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel

1991
- 1991-02-27 AT AT91102950T patent/ATE174343T1/de not_active IP Right Cessation
- 1991-02-27 DE DE69130605T patent/DE69130605T2/de not_active Expired - Fee Related
- 1991-02-27 EP EP91102950A patent/EP0500989B1/en not_active Expired - Lifetime
- 1991-12-16 ES ES9102792A patent/ES2037613B1/es not_active Expired - Fee Related
1992
- 1992-02-21 PT PT100148A patent/PT100148B/pt not_active IP Right Cessation
- 1992-02-26 HU HU9203324A patent/HUT62313A/hu unknown
- 1992-02-26 FI FI924850A patent/FI924850A7/fi unknown
- 1992-02-26 CZ CS923220A patent/CZ280952B6/cs unknown
- 1992-02-26 JP JP92504931A patent/JPH05507295A/ja active Pending
- 1992-02-26 CA CA002081471A patent/CA2081471A1/en not_active Abandoned
- 1992-02-26 RO RO92-01349A patent/RO111369B1/ro unknown
- 1992-02-26 RU RU9292016314A patent/RU2098424C1/ru active
- 1992-02-26 PL PL92296625A patent/PL167915B1/pl unknown
- 1992-02-26 AU AU12783/92A patent/AU650954B2/en not_active Ceased
- 1992-02-26 BR BR9204779A patent/BR9204779A/pt not_active Application Discontinuation
- 1992-02-26 WO PCT/EP1992/000400 patent/WO1992015608A1/en not_active Ceased
- 1992-02-26 US US07/938,248 patent/US5432159A/en not_active Expired - Lifetime
- 1992-10-21 NO NO92924076A patent/NO924076L/no unknown

Also Published As

Publication number	Publication date
ATE174343T1 (de)	1998-12-15
RU2098424C1 (ru)	1997-12-10
HUT62313A (en)	1993-04-28
HU9203324D0 (en)	1993-01-28
CA2081471A1 (en)	1992-08-28
NO924076D0 (no)	1992-10-21
FI924850A0 (fi)	1992-10-26
NO924076L (no)	1992-12-21
RO111369B1 (ro)	1996-09-30
EP0500989A1 (en)	1992-09-02
FI924850L (fi)	1992-10-26
DE69130605D1 (de)	1999-01-21
PL296625A1 (en)	1993-08-09
AU1278392A (en)	1992-10-06
PT100148B (pt)	1999-06-30
CZ322092A3 (en)	1993-02-17
CZ280952B6 (cs)	1996-05-15
WO1992015608A1 (en)	1992-09-17
BR9204779A (pt)	1993-08-17
PL167915B1 (pl)	1995-12-30
FI924850A7 (fi)	1992-10-26
DE69130605T2 (de)	1999-05-20
US5432159A (en)	1995-07-11
ES2037613A1 (es)	1993-06-16
AU650954B2 (en)	1994-07-07
EP0500989B1 (en)	1998-12-09
ES2037613B1 (es)	1994-03-16
JPH05507295A (ja)	1993-10-21

Legal Events

Date

Code

Title

Description

1993-05-31

BB1A

Laying open of patent application

Effective date: 19930122

1999-06-30

FG3A

Patent granted, date of granting

Effective date: 19990323

2001-01-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20000930

Publication	Publication Date	Title
DK0590919T3 (da)	2000-04-17	Terapeutiske midler mod Parkinsons sygdom
PT100148A (pt)	1993-05-31	Processo para a preparacao de novos derivados dipeptidicos, contendo um anel piridinas
NO308739B1 (no)	2000-10-23	Imidazolderivater samt medisinsk sammensetning og anti-HIV- sammensetning omfattende samme
DK0731085T3 (da)	2000-04-17	Stilbenderivater og farmaceutiske sammensætinger indeholdende disse
FI951414L (fi)	1995-03-24	Menetelmä epäpuhtaan klavulaanihapon puhdistamiseksi
FI965020A0 (fi)	1996-12-13	Uusia yhdisteitä, menetelmiä niiden valmistamiseksi ja kasvaintenvastaisia aineita
DK0565377T3 (da)	1998-03-16	Terapeutiske midler til behandling af Parkinsons sygdom
DK0700911T3 (da)	2001-05-07	Imidazolderivater med anti-HIV-aktivitet
PT96226A (pt)	1991-09-30	Processo para a preparacao de derivados morfolinilicos de doxorubicina e de composicoes farmaceuticas que os contem
FI902632A0 (fi)	1990-05-25	Menetelmä terapeuttisesti käyttökelpoisten 5-substitoitujen 5,11-dihydrodibentso/b,e//1,4/tiatsepiinijohdannaisten valmistamiseksi sekä menetelmässä käyttökelpoisia välituotteita
FI884088A0 (fi)	1988-09-06	Foerfarande foer framstaellning av 17-substituerade androsta-1,4-dien-3-onderivat.
PT93126A (pt)	1990-08-31	Processo para a preparacao de eteres carboxialquilicos da 2-amino-7- -hidroxitetralina
PT90635A (pt)	1989-11-30	Processo para a preparacao de derivados do acido n-(5,6,7,8-tetra-hidropirido-{2,3-d}pirimidin-6-il-alcanoil)glutamico
PT91932A (pt)	1990-04-30	Processo de preparacao de derivados substituidos da piperazina e de preparados farmaceuticos que os contem
PT96070A (pt)	1991-09-30	Processo para a preparacao de derivados heterociclicos acilo aminodiol beta-amino acido
ES2054989T3 (es)	1994-08-16	Derivados de aminodiol inhibidores de renina.
DE68904203D1 (de)	1993-02-18	Cysteinderivate.
ATE56944T1 (de)	1990-10-15	Substituierte 2-aminotetraline.
ES2189323T3 (es)	2003-07-01	Procedimiento para la preparacion de 3-amino-2-oxo-pirrolidinas, productos intermedios y su utilizacion.
DK0578052T3 (da)	1996-06-17	Anvendelse af iminoderivater af etianaldehyd til fremstilling af et lægemiddel til behandling af hypertension
PT90815A (pt)	1989-12-29	Processo de preparacao de derivados da fenotiazina
HU9701300D0 (en)	1997-09-29	New bisimide derivatives, process for producing them and pharmaceutical compositions containing them
PT92668A (pt)	1990-06-29	Processo para a preparacao de derivados de azabiciclo-heptano
ES497823A0 (es)	1982-04-01	Un procedimiento para la preparacion de derivados de tirosi-na.