DK0454044T3 - Farmakologisk præparat indeholdende polyelektrolytkomplekser på mikropartikelform og mindst et virksomt stof - Google Patents

Farmakologisk præparat indeholdende polyelektrolytkomplekser på mikropartikelform og mindst et virksomt stof

Info

Publication number
DK0454044T3
DK0454044T3 DK91106495.4T DK91106495T DK0454044T3 DK 0454044 T3 DK0454044 T3 DK 0454044T3 DK 91106495 T DK91106495 T DK 91106495T DK 0454044 T3 DK0454044 T3 DK 0454044T3
Authority
DK
Denmark
Prior art keywords
active substance
preparation containing
polyelectrolyte complexes
pharmacological preparation
microparticle form
Prior art date
Application number
DK91106495.4T
Other languages
English (en)
Inventor
Michael Dr Magerstaedt
Dieter Dr Hoffmann
Volker Dr Krone
Axel Dr Walch
Albrecht Dr Groener
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19904013110 external-priority patent/DE4013110A1/de
Priority claimed from DE19904035187 external-priority patent/DE4035187A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0454044T3 publication Critical patent/DK0454044T3/da

Links

Classifications

    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G09B23/286—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine for scanning or photography techniques, e.g. X-rays, ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Algebra (AREA)
  • Business, Economics & Management (AREA)
  • Organic Chemistry (AREA)
  • Computational Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Medical Informatics (AREA)
  • Educational Administration (AREA)
  • Educational Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acoustics & Sound (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK91106495.4T 1990-04-25 1991-04-23 Farmakologisk præparat indeholdende polyelektrolytkomplekser på mikropartikelform og mindst et virksomt stof DK0454044T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19904013110 DE4013110A1 (de) 1990-04-25 1990-04-25 Pharmakologische zubereitung, enthaltend polyelektrolytkomplexe in mikropartikulaerer form und mindestens einen wirkstoff
DE19904035187 DE4035187A1 (de) 1990-11-06 1990-11-06 Pharmakologische zubereitung, enthaltend polyelektrolytkomplexe in mikropartikulaerer form und mindestens einen wirkstoff

Publications (1)

Publication Number Publication Date
DK0454044T3 true DK0454044T3 (da) 1996-04-22

Family

ID=25892501

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91106495.4T DK0454044T3 (da) 1990-04-25 1991-04-23 Farmakologisk præparat indeholdende polyelektrolytkomplekser på mikropartikelform og mindst et virksomt stof

Country Status (9)

Country Link
US (1) US5700459A (da)
EP (1) EP0454044B1 (da)
JP (1) JP3168215B2 (da)
AT (1) ATE131042T1 (da)
CA (1) CA2041093C (da)
DE (1) DE59107006D1 (da)
DK (1) DK0454044T3 (da)
ES (1) ES2081384T3 (da)
IE (1) IE70747B1 (da)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
RU2114637C1 (ru) * 1991-09-17 1998-07-10 Сонус Фармасьютикалз, Инк. Биосовместимая контрастная среда и способ получения ультразвукового изображения
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
DE69207589T2 (de) 1992-06-01 1996-05-23 Basf Ag Anwendung von Dispersionen von magneto-ionischen Partikeln in MRI-Kontrast-Mitteln
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
NZ262237A (en) * 1993-01-25 1997-06-24 Sonus Pharma Inc Ultrasound contrast agents comprising phase shift colloids having a boiling point below the body temperature of the animal it is used in
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
AUPM572294A0 (en) * 1994-05-18 1994-06-09 Vaccine Technologies Pty. Ltd. Delivery vehicle for bioactive molecule
EP0773975A4 (en) * 1994-08-04 1998-06-10 Gordon George Wallace CONDUCTIVE ELECTROACTIVE BIOMATERIALS
US6165988A (en) * 1995-02-10 2000-12-26 Christian Noe Medicament in particulate form
GB9522351D0 (en) * 1995-11-01 1996-01-03 Medeva Holdings Bv Vaccine compositions
DE19611769A1 (de) * 1996-03-14 1997-09-18 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie deren Verwendung in der Ultraschall Diagnostik
CN1135265C (zh) * 1996-04-12 2004-01-21 诺沃奇梅兹有限公司 含酶颗粒及其生产方法
US6048550A (en) * 1996-10-03 2000-04-11 Chan; Daniel C. F. Hydrophilic microparticles and methods to prepare same
AU4941297A (en) * 1996-11-15 1998-06-10 Dumex-Alpharma A/S A method for promoting tissue repair
DE19712718C2 (de) * 1997-03-26 1999-09-23 Asta Medica Ag Immobilisierte und aktivitätsstabilisierte Komplexe von LHRH-Antagonisten und Verfahren zu deren Herstellung
US20030170313A1 (en) * 1997-10-09 2003-09-11 Ales Prokop Micro-particulate and nano-particulate polymeric delivery system
EP1021168A4 (en) * 1997-10-09 2006-08-30 Univ Vanderbilt MICRO AND NANOAPARTICULAR, POLYMERIC ADMINISTRATION SYSTEM
US6726934B1 (en) * 1997-10-09 2004-04-27 Vanderbilt University Micro-particulate and nano-particulate polymeric delivery system
DE19810965A1 (de) * 1998-03-13 1999-09-16 Aventis Res & Tech Gmbh & Co Nanopartikel, Verfahren zu ihrer Herstellung und ihre Verwendung
BR0007974A (pt) * 1999-02-03 2001-10-30 Powderject Res Ltd Usos de um agente farmacologicamente ativo, deum constructo de gene e de um antìgeno, métodospara produzir uma composição farmacêutica em póe para administrar uma droga a um indivìduo emnecessidade dela, composição farmacêutica, formade dosagem unitária, e, artigo de manufatura parasuprimento transdérmico ou transmucoso de umagente farmacologicamente ativo a um indivìduo
AU1186401A (en) 1999-06-23 2001-01-22 Sedum Laboratories, Inc. Ionically formulated biomolecule microcarriers
DE19940795A1 (de) * 1999-08-27 2001-03-01 Lohmann Therapie Syst Lts Schnellzerfallende Pellets auf der Basis von Chitosan
WO2002019989A2 (en) * 2000-09-08 2002-03-14 Powderject Research Limited Alginate particle formulation
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
DE10132669B4 (de) * 2001-07-05 2008-08-07 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pharmakologische Zubereitung aus einem nanopartikulären mesomorphen Polyelektrolyt-Lipid-Komplex und mindestens einem Wirkstoff
US20050191361A1 (en) * 2001-08-03 2005-09-01 Powederject Research Ltd. Hydrogel particle formation
US7169752B2 (en) 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
WO2003057716A2 (en) * 2002-01-08 2003-07-17 New River Pharmaceuticals, Inc. Dendritic encapsulation of active agents
US8088388B2 (en) * 2002-02-14 2012-01-03 United Biomedical, Inc. Stabilized synthetic immunogen delivery system
FR2843302B1 (fr) * 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
FR2843301B1 (fr) * 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
KR20050090430A (ko) * 2002-12-31 2005-09-13 알투스 파마슈티컬스 인코포레이티드 인간 성장 호르몬 결정 및 이것의 제조 방법
NZ554885A (en) * 2002-12-31 2009-07-31 Altus Pharmaceuticals Inc Complexes of hgh crystals and protamine polymers
US8133881B2 (en) 2003-01-13 2012-03-13 Shire Llc Carbohydrate conjugates to prevent abuse of controlled substances
EP1610752B1 (en) * 2003-01-31 2013-01-02 Boston Scientific Limited Localized drug delivery using drug-loaded nanocapsules and implantable device coated with the same
US7364585B2 (en) * 2003-08-11 2008-04-29 Boston Scientific Scimed, Inc. Medical devices comprising drug-loaded capsules for localized drug delivery
DE10350248A1 (de) * 2003-10-28 2005-06-16 Magnamedics Gmbh Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US20090036553A1 (en) * 2004-07-08 2009-02-05 Shire Llc Dendritic encapsulation of active agents
BRPI0518582A2 (pt) * 2004-11-24 2008-11-25 Therakine Corp implante para liberaÇço de medicamento intra-ocular
BRPI0606943A2 (pt) * 2005-02-09 2009-07-28 Da Volterra fornecimento no cólon de agentes ativos
WO2006112477A1 (ja) * 2005-04-20 2006-10-26 Taiho Pharmaceutical Co., Ltd. アジュバントとしてのポリアミノ酸
ES2277743B2 (es) * 2005-06-02 2008-12-16 Universidade De Santiago De Compostela Nanoparticulas que comprenden quitosano y ciclodextrina.
EP1760467A1 (en) * 2005-09-02 2007-03-07 Schering AG Optically fluorescent nanoparticles
CA2634053A1 (en) * 2005-12-23 2007-07-05 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
US8273376B2 (en) 2006-11-17 2012-09-25 Da Volterra Colonic delivery of metallo-dependent enzymes
US20080124279A1 (en) * 2006-11-17 2008-05-29 Antoine Andremont Colonic delivery using Zn/pectin beads with a Eudragit coating
EP2135601A1 (en) * 2008-06-20 2009-12-23 Capsulution Nanoscience AG Stabilization of amorphous drugs using sponge-like carrier matrices
WO2010087781A1 (en) * 2009-01-28 2010-08-05 Agency For Science, Technology And Research Polyelectrolyte complexes with bound peptides
EP2412758B1 (en) * 2009-03-27 2017-05-10 Kagoshima University Polyion complex comprising hydrophobized polyamino acid and use of the same
EP2540311A4 (en) * 2010-02-26 2016-07-06 Univ Nagasaki COMPOSITE BODY FOR THE ADMINISTRATION OF ANTIGENES OR MEDICINES
GB201014121D0 (en) * 2010-08-24 2010-10-06 Univ Gent Particulate biologic drug delivery system
FR2967580A1 (fr) * 2010-11-18 2012-05-25 Centre Nat Rech Scient Materiau comprenant un polysaccharide acide et un biopolymere cationique
TW201249843A (en) * 2011-06-14 2012-12-16 Univ Kaohsiung Medical Processes for preparing amine salts of KMUP-3 and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5227M (da) * 1966-03-18 1967-08-14
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4495288A (en) * 1981-03-13 1985-01-22 Damon Biotech, Inc. Method of culturing anchorage dependent cells
CA1196862A (en) * 1983-06-01 1985-11-19 Connaught Laboratories Limited Microencapsulation of living tissue and cells
EP0127989A3 (en) * 1983-06-01 1986-03-26 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
EP0152898B1 (en) * 1984-02-15 1990-01-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system(
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
GB8500121D0 (en) * 1985-01-03 1985-02-13 Connaught Lab Microencapsulation of living cells
EP0245840B1 (de) * 1986-05-15 1993-12-01 Hoechst Aktiengesellschaft Biologisch abbaubare Polymere für Depotzubereitungen mit kontrollierter Wirkstoffabgabe
US4741872A (en) * 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
US5354844A (en) * 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
CA2014244A1 (en) * 1989-04-13 1990-10-13 Takeda Chemical Industries, Ltd. Stabilized composition of anthracyclines

Also Published As

Publication number Publication date
IE911369A1 (en) 1991-11-06
ATE131042T1 (de) 1995-12-15
CA2041093C (en) 2004-08-03
DE59107006D1 (de) 1996-01-18
US5700459A (en) 1997-12-23
EP0454044B1 (de) 1995-12-06
JP3168215B2 (ja) 2001-05-21
CA2041093A1 (en) 1991-10-26
ES2081384T3 (es) 1996-03-01
JPH04225915A (ja) 1992-08-14
EP0454044A3 (en) 1993-01-13
EP0454044A2 (de) 1991-10-30
IE70747B1 (en) 1996-12-30

Similar Documents

Publication Publication Date Title
DK0454044T3 (da) Farmakologisk præparat indeholdende polyelektrolytkomplekser på mikropartikelform og mindst et virksomt stof
UA26855C2 (uk) Фармацевтичhа композиція, яка регулює гематопоез
NZ512792A (en) Stable liquid interferon beta formulations
ATE167396T1 (de) Mittel zur oralen gabe von wirkstoffen
NO974618L (no) Farmasöytiske preparater for intranasal administrasjon
SE8504945L (sv) Farmaceutiska kompositioner innehallande antracyklinglykosider
AU6819294A (en) Oral drug delivery compositions and methods
NO960651D0 (no) Farmasöytiske preparater av nervevekstfaktor
FI955439A0 (fi) Suurannosvalmisteet
GEP20022734B (en) Pharmaceutical Preparation Comprising Lyophilized Liposomes Encapsulating an Active Principle Which Is Highly Insoluble in Water, and the Process for Preparing the Said Preparation
EP0233013A3 (en) Modified enzyme
DE69125715D1 (de) Heterozyklische verbindungen
SE8800080L (sv) Laekemedelskomposition
NZ219829A (en) Tissue-type plasminogen activator modified in the region of amino acids 67-69 and pharmaceutical compositions thereof
UA27055C2 (uk) Лікарський препарат імуhозаміhhої дії hа осhові клітиhhої суспеhзії та спосіб лікуваhhя сиhдрому hабутого імуhодефіциту (віл-іhфекції) з використаhhям цього препарату
GB2065135B (en) Pharmacologically active peptides their preparation and pharmaceutical compositions containing them
GB2065132B (en) Pharmacologically active peptides their preparation and pharmaceutical compositions containing them
GB2065133B (en) Pharmacologically active peptides their preparation and pharmaceutical compositions containing them
FI891712A7 (fi) Terapeuttisesti vaikuttavia syklometyleeni-1,2-bikarboksyylihappojen amiineja, menetelmiä niiden valmistamiseksi sekä niitä sisältäviä farmaseuttisia koostumuksia
GB2065134B (en) Pharmacologically active peptides their preparation and pharmaceutical compositions containing them
BE837312A (fr) Nouveaux amides peptidiques d'acides ergoline-8-carboxyliques, leur preparation et leur application comme medicaments
FR2275212A1 (fr) Nouveaux amides peptidiques d'acides 6-alkyl-ergoline-8-carboxyliques, leur preparation et leur application comme medicaments
GB1327560A (en) Effervescent pharmaceutical preparations
ZA791844B (en) Process for the preparation of sulphur-containing n-benzyl amino acids, such compounds in optically active form, and pharmaceutical compositions thereof
IT1053845B (it) Procedimento per l arricchimento di prodotti agricoli in proteine e vitamine