DK0457514T3 - Fremgangsmåde til forebyggelse, stabilisering eller fremkaldelse af tilbagegang af atherosklerose ved anvendelse af en kombination af et cholesterolsænkende medikament og en ACE-hæmmer - Google Patents

Fremgangsmåde til forebyggelse, stabilisering eller fremkaldelse af tilbagegang af atherosklerose ved anvendelse af en kombination af et cholesterolsænkende medikament og en ACE-hæmmer

Info

Publication number: DK0457514T3
Authority: DK; Denmark
Prior art keywords: atherosclerosis; combination; cholesterol; ace inhibitor; recurrence
Prior art date: 1990-05-15

Application number

DK91304232.1T

Other languages

Danish (da)

English (en)

Inventor

Werner Tschollar

James L Bergey

James C Kawano

Cary S Yonce

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-15

Filing date

1991-05-10

Publication date

1996-09-16

1991-05-10 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1996-09-16 Application granted granted Critical

1996-09-16 Publication of DK0457514T3 publication Critical patent/DK0457514T3/da

Links

239000005541 ACE inhibitor Substances 0.000 title abstract 2
201000001320 Atherosclerosis Diseases 0.000 title abstract 2
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title abstract 2
239000003529 anticholesteremic agent Substances 0.000 title abstract 2
230000001939 inductive effect Effects 0.000 title 1
230000003405 preventing effect Effects 0.000 title 1
230000000087 stabilizing effect Effects 0.000 title 1
206010020772 Hypertension Diseases 0.000 abstract 1
TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 abstract 1
230000003143 atherosclerotic effect Effects 0.000 abstract 1
229960000830 captopril Drugs 0.000 abstract 1
FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 abstract 1
230000001631 hypertensive effect Effects 0.000 abstract 1
230000003902 lesion Effects 0.000 abstract 1
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 abstract 1
229960002965 pravastatin Drugs 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
229960002769 zofenopril Drugs 0.000 abstract 1
IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK91304232.1T 1990-05-15 1991-05-10 Fremgangsmåde til forebyggelse, stabilisering eller fremkaldelse af tilbagegang af atherosklerose ved anvendelse af en kombination af et cholesterolsænkende medikament og en ACE-hæmmer DK0457514T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US52426690A	1990-05-15	1990-05-15

Publications (1)

Publication Number	Publication Date
DK0457514T3 true DK0457514T3 (da)	1996-09-16

Family

ID=24088484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91304232.1T DK0457514T3 (da)	1990-05-15	1991-05-10	Fremgangsmåde til forebyggelse, stabilisering eller fremkaldelse af tilbagegang af atherosklerose ved anvendelse af en kombination af et cholesterolsænkende medikament og en ACE-hæmmer

Country Status (15)

Country	Link
EP (1)	EP0457514B1 (fr)
JP (1)	JPH04226921A (fr)
KR (1)	KR100200467B1 (fr)
AT (1)	ATE141514T1 (fr)
AU (1)	AU651579B2 (fr)
CA (1)	CA2040865C (fr)
DE (1)	DE69121464T2 (fr)
DK (1)	DK0457514T3 (fr)
ES (1)	ES2090244T3 (fr)
GR (1)	GR3021703T3 (fr)
HU (1)	HU212102B (fr)
IE (1)	IE77637B1 (fr)
NZ (1)	NZ237929A (fr)
PT (1)	PT97660B (fr)
ZA (1)	ZA913509B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5157025A (en) *	1991-04-01	1992-10-20	E. R. Squibb & Sons, Inc.	Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug
AU3473193A (en) *	1992-01-17	1993-08-03	Procter & Gamble Company, The	Treatment for atherosclerosis
AU1095695A (en) *	1993-11-09	1995-05-29	Brigham And Women's Hospital	Hmg-coa reductase inhibitors in the normalization of vascular endothelial dysfunction
DE4402379C2 (de) *	1994-01-27	1997-09-25	Lohmann Therapie Syst Lts	Orale Arzneiform mit sauren Wirkstoffen und Verfahren zu ihrer Herstellung
CA2186606A1 (fr) *	1994-03-29	1995-10-05	Edward B. Nelson	Traitement de l'atherosclerose
EP0914158B2 (fr) *	1996-04-05	2006-01-25	Takeda Chemical Industries, Ltd.	Combinaison pharmaceutique comprenant un compose avec activite antagoniste de l'angiotensine ii et un compose qui augmente la sensibilite a l'insuline
EP1514543A1 (fr)	1997-08-29	2005-03-16	Pfizer Inc.	Ttherapie combinee utilisant de l'atorvastatine et un antihypertenseur
SI20305A (sl)	1999-08-06	2001-02-28	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Kristali natrijeve soli pravastatina
GB0001662D0 (en)	1999-02-06	2000-03-15	Zeneca Ltd	Pharmaceutical compositions
AU2007200367B2 (en) *	1999-02-06	2010-04-08	Astrazeneca Ab	Use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for the manufacture of a medicament for the treatment of diabetic neuropathy
US6172441B1 (en)	1999-06-28	2001-01-09	Visteon Global Technologies, Inc.	Rotor assembly
DK1216038T3 (da)	1999-08-30	2005-12-27	Sanofi Aventis Deutschland	Anvendelse af inhibitorer af reninangiotensinsystemet ved forebyggelsen af cardiovaskulære hændelser
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
HU230253B1 (hu)	2001-01-26	2015-11-30	Merck Sharp & Dohme Corp	Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére
DK1355644T3 (da)	2001-01-26	2006-10-23	Schering Corp	Anvendelse af substituerede azetidinonforbindelser til behandling af sitosterolæmi
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
US6576256B2 (en)	2001-08-28	2003-06-10	The Brigham And Women's Hospital, Inc.	Treatment of patients at elevated cardiovascular risk with a combination of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
US6669955B2 (en) *	2001-08-28	2003-12-30	Longwood Pharmaceutical Research, Inc.	Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
JP2005504091A (ja)	2001-09-21	2005-02-10	シェーリング　コーポレイション	ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置
EP1501546B1 (fr) *	2002-05-03	2012-10-10	Hexal AG	Formulation pharmaceutique stable contenant une statine combinee avec un inhibiteur de l'ace
AR040588A1 (es)	2002-07-26	2005-04-13	Schering Corp	Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
WO2004043457A1 (fr)	2002-11-06	2004-05-27	Schering Corporation	Inhibiteurs d'absorption de cholesterol pour le traitement de troubles auto-immuns
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CA2517571C (fr)	2003-03-07	2011-07-05	Schering Corporation	Azetidinones substituees , procedes pour leur preparation, formulations et utilisations de celles-ci
JP2006519869A (ja)	2003-03-07	2006-08-31	シェーリング　コーポレイション	置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
JP4589919B2 (ja)	2003-03-07	2010-12-01	シェーリングコーポレイション	高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
WO2004085448A2 (fr) *	2003-03-19	2004-10-07	Genzyme Corporation	Inhibiteurs du transport de phosphate comprenant un groupe phosphinyl-phosphonate insature
GB0322552D0 (en)	2003-09-26	2003-10-29	Astrazeneca Uk Ltd	Therapeutic treatment
JP2012510511A (ja) *	2008-12-01	2012-05-10	インヴアスクセラピューテイックスインコーポレイテッド	レニン−アンジオテンシン−アルドステロン系阻害剤及びリポ酸化合物を含有する組成物、並びに、レニン−アンジオテンシン−アルドステロン系に関連した疾患の治療のためのそれらの使用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3536687A1 (de) *	1985-10-15	1987-04-16	Hoechst Ag	Verfahren zur behandlung von atherosklerose, thrombose und der peripheren gefaesskrankheit

1991
- 1991-04-19 CA CA002040865A patent/CA2040865C/fr not_active Expired - Lifetime
- 1991-04-24 NZ NZ237929A patent/NZ237929A/en unknown
- 1991-04-26 AU AU76270/91A patent/AU651579B2/en not_active Expired
- 1991-04-29 IE IE143191A patent/IE77637B1/en not_active IP Right Cessation
- 1991-05-08 ZA ZA913509A patent/ZA913509B/xx unknown
- 1991-05-10 AT AT91304232T patent/ATE141514T1/de not_active IP Right Cessation
- 1991-05-10 DE DE69121464T patent/DE69121464T2/de not_active Expired - Lifetime
- 1991-05-10 EP EP91304232A patent/EP0457514B1/fr not_active Expired - Lifetime
- 1991-05-10 DK DK91304232.1T patent/DK0457514T3/da active
- 1991-05-10 ES ES91304232T patent/ES2090244T3/es not_active Expired - Lifetime
- 1991-05-14 HU HU911620A patent/HU212102B/hu unknown
- 1991-05-14 KR KR1019910007749A patent/KR100200467B1/ko not_active Expired - Lifetime
- 1991-05-14 PT PT97660A patent/PT97660B/pt not_active IP Right Cessation
- 1991-05-15 JP JP3110268A patent/JPH04226921A/ja not_active Withdrawn
1996
- 1996-11-19 GR GR960403096T patent/GR3021703T3/el unknown

Also Published As

Publication number	Publication date
ATE141514T1 (de)	1996-09-15
ZA913509B (en)	1992-02-26
GR3021703T3 (en)	1997-02-28
EP0457514B1 (fr)	1996-08-21
HU212102B (en)	1996-02-28
AU651579B2 (en)	1994-07-28
KR910019614A (ko)	1991-12-19
NZ237929A (en)	1997-06-24
CA2040865A1 (fr)	1991-11-16
DE69121464T2 (de)	1997-03-27
DE69121464D1 (de)	1996-09-26
HU911620D0 (en)	1991-11-28
EP0457514A1 (fr)	1991-11-21
PT97660B (pt)	1998-09-30
HUT57993A (en)	1992-01-28
CA2040865C (fr)	2002-07-23
KR100200467B1 (ko)	1999-06-15
PT97660A (pt)	1992-02-28
IE77637B1 (en)	1997-12-31
ES2090244T3 (es)	1996-10-16
JPH04226921A (ja)	1992-08-17
AU7627091A (en)	1991-11-21
IE911431A1 (en)	1991-11-20

Publication	Publication Date	Title
DK0457514T3 (da)	1996-09-16	Fremgangsmåde til forebyggelse, stabilisering eller fremkaldelse af tilbagegang af atherosklerose ved anvendelse af en kombination af et cholesterolsænkende medikament og en ACE-hæmmer
DK0738512T3 (da)	2003-10-06	Fremgangsmåde til forebyggelse af et andet hjerteanfald ved anvendelse af en HMG coenzsym A reduktasehæmmer
MX9702175A (es)	1997-06-28	Combinacion de un inhibidor de absorcion de colesterol y un inhibidor de sintesis de colesterol.
DE69433774D1 (de)	2004-06-17	Chirurgischer extraktor
TW256839B (en)	1995-09-11	Process of preventing (methyl) acrylic acid and its ester from polymerization
DK1140184T3 (da)	2003-09-29	Kombinationer af cholesterylestertransferproteinhæmmere og nikotinsyrederivater til hjertekar indikationer
ATE199545T1 (de)	2001-03-15	Inhibitoren retroviraler proteasen
DK370486D0 (da)	1986-08-04	Hmg-coa-reduktaseinhibitor og fremgangsmaade til fremstilling deraf
DK162488D0 (da)	1988-03-24	Middel til behandling af hyperchlolesterolaemi
DE69306808D1 (de)	1997-01-30	Hilfs- oder ergänzungsorthese des knies
ATE158577T1 (de)	1997-10-15	Enzymatische auflösung von endo-bicyclo(2.2.1)- heptan-2-ol und pharmazeutische derivate
DE69306915D1 (de)	1997-02-06	Kombination zur Detektion von Weichgewebeanomalien
EP0425909A3 (en)	1992-06-17	Method for rehabilitating the vasorelaxant action of the coronary arteries impaired through atherosclerosis or hypercholesterolemia employing an ace inhibitor
DK571289D0 (da)	1989-11-15	Fremgangsmaade til behandling af spildgas
DK485888A (da)	1989-03-03	Hmg-coa reduktaseinhibitor og fremgangsmaade til fremstilling deraf
ATE133167T1 (de)	1996-02-15	Oxetanone
DK0586518T3 (da)	1997-04-01	Cholesterolnedsættende tocopherolanaloge
NO920546D0 (no)	1992-02-12	Fremgangsmaate ved fluksing og fluksholdige komponenter
DK0918521T3 (da)	2003-02-03	Formulering til behandling og/eller forebyggelse af demens
FI934550A0 (fi)	1993-10-14	Foerfarande och ugnkonstruktion foer anvaendning i processer i vilka laettflyktiga metaller produceras
DK486088A (da)	1989-03-03	Hmg-coa reduktaseinhibitor og fremgangsmaade til fremstilling deraf
KR970006087U (ko)	1997-02-21	보조서랍이 부설된 탁상금고
DK0457659T3 (da)	1994-03-07	Fremgangsmåde til spaltnng af kløvede kævler eller klov til træ til fremstilling af tøndestave og maskine beregnet hertil
NO913801D0 (no)	1991-09-27	Fremgangsmaate ved enkelthud-bygging av fartoey.
KR950015818U (ko)	1995-06-19	고조파 제거용 안정화 증폭회로