DK0458901T3 - Hæmning af transformation af celler med forhøjet purin-metabolisk enzymaktivitet - Google Patents

Hæmning af transformation af celler med forhøjet purin-metabolisk enzymaktivitet

Info

Publication number
DK0458901T3
DK0458901T3 DK90904105T DK90904105T DK0458901T3 DK 0458901 T3 DK0458901 T3 DK 0458901T3 DK 90904105 T DK90904105 T DK 90904105T DK 90904105 T DK90904105 T DK 90904105T DK 0458901 T3 DK0458901 T3 DK 0458901T3
Authority
DK
Denmark
Prior art keywords
cells
transformation
inhibition
enzyme activity
metabolic enzyme
Prior art date
Application number
DK90904105T
Other languages
Danish (da)
English (en)
Inventor
Paul R Schimmel
Scott D Putney
Rima Kaddurah-Daouk
Ghaleb Daouk
Robert Kingston
James W Lillie
Michael Green
Original Assignee
Massachusetts Inst Technology
Gen Hospital Corp
Univ Harvard
Amira Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Gen Hospital Corp, Univ Harvard, Amira Inc filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of DK0458901T3 publication Critical patent/DK0458901T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1223—Phosphotransferases with a nitrogenous group as acceptor (2.7.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/50—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving creatine phosphokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/0102—Adenosine kinase (2.7.1.20)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/03—Phosphotransferases with a nitrogenous group as acceptor (2.7.3)
    • C12Y207/03002—Creatine kinase (2.7.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C12Y207/04003—Adenylate kinase (2.7.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01001—Aodenylate cyclase (4.6.1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
DK90904105T 1989-02-14 1990-02-14 Hæmning af transformation af celler med forhøjet purin-metabolisk enzymaktivitet DK0458901T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31077389A 1989-02-14 1989-02-14
US34496389A 1989-04-28 1989-04-28
US46714790A 1990-01-18 1990-01-18
PCT/US1990/000848 WO1990009192A1 (fr) 1989-02-14 1990-02-14 Inhibition de la transformation de cellules ayant une activite d'enzyme metabolique de purine elevee

Publications (1)

Publication Number Publication Date
DK0458901T3 true DK0458901T3 (da) 1998-08-31

Family

ID=27405474

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90904105T DK0458901T3 (da) 1989-02-14 1990-02-14 Hæmning af transformation af celler med forhøjet purin-metabolisk enzymaktivitet

Country Status (9)

Country Link
EP (2) EP0458901B1 (fr)
JP (1) JP2953535B2 (fr)
AT (1) ATE161188T1 (fr)
AU (4) AU646799B2 (fr)
CA (1) CA2046607C (fr)
DE (1) DE69031830T2 (fr)
DK (1) DK0458901T3 (fr)
ES (1) ES2114531T3 (fr)
WO (1) WO1990009192A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324731A (en) * 1989-02-14 1994-06-28 Amira, Inc. Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated
US5321030A (en) * 1989-02-14 1994-06-14 Amira, Inc. Creatine analogs having antiviral activity
ATE332127T1 (de) 1994-11-08 2006-07-15 Avicena Group Inc Verwendung von kreatin oder kreatinanologen zur behandlung von huntington chorea, morbus parkinson und amyotrophen lateralsklerose
EP0854712B1 (fr) * 1995-10-11 2003-05-07 Avicena Group, Inc. Utilisation d'analogues de creatine pour le traitement de troubles du metabolisme du glucose
US5998457A (en) * 1995-10-26 1999-12-07 Avicena Group, Inc. Creatine analogues for treatment of obesity
US6777177B1 (en) 1997-10-10 2004-08-17 Vanderbilt University Mammalian genes involved in viral infection and tumor suppression
AU742243B2 (en) 1996-04-15 2001-12-20 Vanderbilt University Mammalian genes involved in viral infection and tumor suppression
WO1999000122A1 (fr) * 1997-06-25 1999-01-07 Ipr-Institute For Pharmaceutical Research Ag Procede pour reduire le poids du corps
AU9604198A (en) * 1997-10-10 1999-05-03 Vanderbilt University Mammalian genes involved in viral infection and tumor suppression
KR100619319B1 (ko) * 1998-06-03 2006-09-06 와이어쓰 홀딩스 코포레이션 리보핵산 바이러스의 신규 구제방법
US6242491B1 (en) 1999-06-25 2001-06-05 Rima Kaddurah-Daouk Use of creatine or creatine compounds for skin preservation
US6444695B1 (en) 2000-09-21 2002-09-03 The Regents Of The University Of California Inhibition of thrombin-induced platelet aggregation by creatine kinase inhibitors
US7683043B2 (en) 2006-06-06 2010-03-23 Xenoport, Inc. Creatine phosphate analog prodrugs, compositions and uses thereof
US9233099B2 (en) 2012-01-11 2016-01-12 University Of Cincinnati Methods of treating cognitive dysfunction by modulating brain energy metabolism
WO2015168465A1 (fr) 2014-04-30 2015-11-05 Rgenix, Inc. Inhibiteurs de transport de la créatine et leurs utilisations
EP4072561A4 (fr) 2019-12-11 2023-11-29 Inspirna, Inc. Méthodes de traitement du cancer

Also Published As

Publication number Publication date
CA2046607C (fr) 2002-04-16
EP0758681A3 (fr) 1997-06-04
AU1650395A (en) 1995-06-29
DE69031830T2 (de) 1998-09-24
CA2046607A1 (fr) 1990-08-15
EP0458901A1 (fr) 1991-12-04
EP0758681A2 (fr) 1997-02-19
WO1990009192A1 (fr) 1990-08-23
AU5196990A (en) 1990-09-05
AU646799B2 (en) 1994-03-10
JPH04506058A (ja) 1992-10-22
ATE161188T1 (de) 1998-01-15
JP2953535B2 (ja) 1999-09-27
EP0458901B1 (fr) 1997-12-17
ES2114531T3 (es) 1998-06-01
DE69031830D1 (de) 1998-01-29
AU6192198A (en) 1998-06-11
AU7287794A (en) 1994-11-24

Similar Documents

Publication Publication Date Title
WO1992008456A3 (fr) Procede d'inhibition de la transformation, de la croissance et de la metastase de cellules dans lesquelles l'activite enzymatique metabolique purique est elevee
DK0458901T3 (da) Hæmning af transformation af celler med forhøjet purin-metabolisk enzymaktivitet
EP0846160A4 (fr) Procede d'amelioration de la production de vaccins antiviraux dans une culture cellulaire par suppression d'interferon
ATE104699T1 (de) Hervorrufung physischer veraenderungen in pflanzen durch verwendung von negativstrangigen rnas.
BR9805900B1 (pt) processo para integrar um fragmento de dna no genoma de uma célula de uma planta manocotiledÈnea.
ATE86663T1 (de) Glucoamylasegen.
DE69530001D1 (de) Verbesserungen von oder in bezug auf endometrialfunktion
BR9905776A (pt) Processo de fermentação para a preparação de ácido d-pantotênico através da amplificação do gene pand em microorganismos
MX9606476A (es) Inhibicion citoplasmica de expresion de genes.
DK0794256T3 (da) Fremgangsmåde til dyrkning af mikroorganismer med methanolmetabolisk proces
SE8501534D0 (sv) Interferon epsilon
MY111158A (en) Identifying microorganisms by measuring enzyme activity in the presence of enzyme activity affecting agents.
EP0682121A4 (fr) Procede d'amplification et de detection d'une sequence nucleotidique au moyen d'enzymes thermostables.
FI801752A7 (fi) Menetelmä mikro-organismien aineenvaihdunta-aktiviteetin optimoimiseksi biologisen reaktiojärjestereaktiojärjestelmän substraatissa.
ATE275195T1 (de) Saccharose-stoffwechsel-mutanten
SE8303925L (sv) Interferon e
DK0755438T3 (da) Fremgangsmåde til bekæmpelse af metallophosphatpræcipitation i fermenteringer med høj celledensitet
DK340882A (da) Fremgangsmaade til fremstilling af sur protease og mutanter af slaegten rhizopus, som danner denne
ATE129287T1 (de) Bakterielles kollagenase-gen.
Lynch et al. Separate genetic regulation of cyclic nucleotide phosphodiesterase and its protein activator in cultured mouse fibroblasts
Reddy et al. In vitro inhibitory effects of ammonium salts on glutamate dehydrogenase levels in the fish Tilapia mossambica.
Siracusa et al. Low-salt and high-salt RNA polymerase activity during preimplantation development in the mouse
Tidwell et al. Methylation and synthesis of transfer ribonucleic acid in synchronized Chinese hamster fibroblasts
JPS5639792A (en) Preparation of l-valine by fermentation method
Akhmadieva et al. DNA damage and repair in Chinese hamster fibroblasts exposed to gamma and secondary radiation generated by 70 GeV protons