DK0460052T3 - Inhibitorer af IL-1's biologiske aktivitet - Google Patents

Inhibitorer af IL-1's biologiske aktivitet

Info

Publication number
DK0460052T3
DK0460052T3 DK90904008T DK90904008T DK0460052T3 DK 0460052 T3 DK0460052 T3 DK 0460052T3 DK 90904008 T DK90904008 T DK 90904008T DK 90904008 T DK90904008 T DK 90904008T DK 0460052 T3 DK0460052 T3 DK 0460052T3
Authority
DK
Denmark
Prior art keywords
muteins
biological activity
inhibitors
residue
humans
Prior art date
Application number
DK90904008T
Other languages
Danish (da)
English (en)
Inventor
Lee Gehrke
Philip E Auron
Lanny Rosenwasser
E Auron Philip
Original Assignee
New England Medical Center Inc
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Medical Center Inc, Massachusetts Inst Technology filed Critical New England Medical Center Inc
Application granted granted Critical
Publication of DK0460052T3 publication Critical patent/DK0460052T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK90904008T 1989-02-27 1990-02-23 Inhibitorer af IL-1's biologiske aktivitet DK0460052T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31627889A 1989-02-27 1989-02-27
PCT/US1990/000993 WO1990010068A1 (en) 1989-02-27 1990-02-23 Il-1 biological activity inhibitors

Publications (1)

Publication Number Publication Date
DK0460052T3 true DK0460052T3 (da) 1999-03-08

Family

ID=23228347

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90904008T DK0460052T3 (da) 1989-02-27 1990-02-23 Inhibitorer af IL-1's biologiske aktivitet

Country Status (10)

Country Link
US (1) US5286847A (de)
EP (1) EP0460052B1 (de)
JP (1) JPH0824595B2 (de)
AT (1) ATE165114T1 (de)
AU (1) AU5171890A (de)
CA (1) CA2046303C (de)
DE (1) DE69032251T2 (de)
DK (1) DK0460052T3 (de)
ES (1) ES2113856T3 (de)
WO (1) WO1990010068A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015226A1 (en) * 1990-04-09 1991-10-17 The American National Red Cross Rejuvenation compositions and methods for their use
EP0534978B1 (de) * 1990-05-01 1999-03-24 Chiron Corporation Interleukin-i antagonist und seine verwendung
AU1270592A (en) * 1991-02-05 1992-09-07 University Of Maryland Modified interleukin-1beta
DE4408890A1 (de) * 1994-03-16 1995-09-21 Knoll Ag Verwendung von Il-1-Antagonisten als Arzneimittel zur Behandlung von Erkrankungen mit einem erhöhten Interleukin-6 Serumspiegel
US6491922B1 (en) 1996-02-09 2002-12-10 Cornell Research Foundation, Inc. Methods and compounds for treating autoimmune and vascular disease
US6063600A (en) * 1997-05-23 2000-05-16 Uab Research Foundation DNA encoding canine interleukin-1 receptor antagonist
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
JP2003515569A (ja) * 1999-12-03 2003-05-07 セルテック アール アンド ディ リミテッド ワクチンアジュバントとして有用なインターロイキン−１ムテイン
WO2003057257A1 (en) * 2002-01-02 2003-07-17 The Johns Hopkins University Cc10 inhibits th2 cytokines and eotaxins involved in allergic diseases
ES2569917T3 (es) * 2005-06-21 2016-05-13 Xoma (Us) Llc Anticuerpos y fragmentos de los mismos que se unen a IL-1beta
US20110027220A1 (en) * 2005-09-28 2011-02-03 Cytos Biotechnology Ag Interleukin-1 Conjugates and Uses Thereof
CA2664418A1 (en) * 2006-09-28 2008-04-03 Cytos Biotechnology Ag Interleukin-1 muteins linked to virus-like particles to treat il-1 associated diseases
EP3124045A3 (de) 2006-12-20 2017-05-03 Xoma (Us) Llc Behandlung von il-1-beta-bedingten erkrankungen
DK2391650T3 (en) * 2007-12-20 2015-01-12 Xoma Us Llc Methods of treating gout
CA2727171A1 (en) * 2008-06-06 2009-12-10 Xoma Technology Ltd. Methods for the treatment of rheumatoid arthritis
CA2735939A1 (en) 2008-09-05 2010-03-11 Xoma Technology Ltd. Methods for improvement of beta cell function
WO2011140522A1 (en) 2010-05-07 2011-11-10 Xoma Technology Ltd. METHODS FOR THE TREATMENT OF IL-1β RELATED CONDITIONS
SG187231A1 (en) 2010-07-29 2013-02-28 Eleven Biotherapeutics Inc Chimeric il-1 receptor type i agonists and antagonists
CN107693781B (zh) 2013-03-13 2021-11-09 巴扎德制药公司 用于眼部递送的嵌合细胞因子制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2591615B2 (ja) * 1986-03-14 1997-03-19 大塚製薬株式会社 インターロイキン−１β誘導体及び医薬
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
US5039790A (en) * 1989-01-11 1991-08-13 Monsanto Company Bioactive fragment of interleukin-1-B that has antagonistic activity

Also Published As

Publication number Publication date
ATE165114T1 (de) 1998-05-15
ES2113856T3 (es) 1998-05-16
CA2046303C (en) 2001-05-01
EP0460052A1 (de) 1991-12-11
EP0460052B1 (de) 1998-04-15
DE69032251D1 (de) 1998-05-20
JPH04503602A (ja) 1992-07-02
JPH0824595B2 (ja) 1996-03-13
CA2046303A1 (en) 1990-08-28
WO1990010068A1 (en) 1990-09-07
DE69032251T2 (de) 1998-08-13
US5286847A (en) 1994-02-15
AU5171890A (en) 1990-09-26

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