DK0461012T3 - Derivater af ((1-arylpyrrolidin-2-yl)methyl)piperazin, fremstillingen heraf og deres terapeutiske anvendelse - Google Patents

Derivater af ((1-arylpyrrolidin-2-yl)methyl)piperazin, fremstillingen heraf og deres terapeutiske anvendelse

Info

Publication number: DK0461012T3
Authority: DK; Denmark
Prior art keywords: group; denotes; formula; arylpyrrolidin; methyl
Prior art date: 1990-06-07

Application number

DK91401431.1T

Other languages

English (en)

Inventor

Pascal George

Daniel Obitz

Dennis Bigg

Jacques Menin

Jean-Pierre Merly

Michel Peynot

Corinne Veronique

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-07

Filing date

1991-06-03

Publication date

1994-09-12

1991-06-03 Application filed by Synthelabo filed Critical Synthelabo

1994-09-12 Application granted granted Critical

1994-09-12 Publication of DK0461012T3 publication Critical patent/DK0461012T3/da

Links

125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title abstract 3
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
230000001225 therapeutic effect Effects 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
101150047265 COR2 gene Proteins 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
101100467189 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) QCR2 gene Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK91401431.1T 1990-06-07 1991-06-03 Derivater af ((1-arylpyrrolidin-2-yl)methyl)piperazin, fremstillingen heraf og deres terapeutiske anvendelse DK0461012T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9007067A FR2663026B1 (fr)	1990-06-07	1990-06-07	Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number	Publication Date
DK0461012T3 true DK0461012T3 (da)	1994-09-12

Family

ID=9397358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91401431.1T DK0461012T3 (da)	1990-06-07	1991-06-03	Derivater af ((1-arylpyrrolidin-2-yl)methyl)piperazin, fremstillingen heraf og deres terapeutiske anvendelse

Country Status (21)

Country	Link
US (1)	US5192763A (da)
EP (1)	EP0461012B1 (da)
JP (1)	JPH04235958A (da)
KR (1)	KR100188902B1 (da)
AT (1)	ATE104662T1 (da)
AU (1)	AU634391B2 (da)
CA (1)	CA2043981A1 (da)
CS (1)	CS173691A3 (da)
DE (1)	DE69101740T2 (da)
DK (1)	DK0461012T3 (da)
ES (1)	ES2054460T3 (da)
FI (1)	FI97055C (da)
FR (1)	FR2663026B1 (da)
HU (1)	HU209620B (da)
IE (1)	IE64688B1 (da)
IL (1)	IL98372A (da)
NO (1)	NO177931C (da)
NZ (1)	NZ238431A (da)
PL (1)	PL165187B1 (da)
PT (1)	PT97885B (da)
ZA (1)	ZA914339B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1245712B (it) *	1991-04-09	1994-10-14	Boehringer Mannheim Italia	Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
FR2684374B1 (fr) *	1991-12-02	1995-05-19	Synthelabo	Derives substitues de 1-[(1-arylpyrrolidin-2-yl)methyl]piperazine, leur preparation et leur application en therapeutique.
IT1255704B (it) *	1992-09-30	1995-11-10	Boehringer Mannheim Italia	Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3250771A (en) *	1962-12-17	1966-05-10	Geigy Chem Corp	5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof
GB1428493A (en) *	1973-05-02	1976-03-17	Science Union & Cie	Heterocyclic amides processes for their preparation and pharma ceutical compositions containing them
US5063242A (en) *	1989-04-21	1991-11-05	Warner-Lambert Company	7-((substituted)amino)-8-((substituted)carbonyl)-methylamino-1-oxaspiro[4,5]decanes as diuretics antiinflammatory, and cerebrovascular agents

1990
- 1990-06-07 FR FR9007067A patent/FR2663026B1/fr not_active Expired - Fee Related
1991
- 1991-06-03 AT AT9191401431T patent/ATE104662T1/de not_active IP Right Cessation
- 1991-06-03 DE DE69101740T patent/DE69101740T2/de not_active Expired - Fee Related
- 1991-06-03 ES ES91401431T patent/ES2054460T3/es not_active Expired - Lifetime
- 1991-06-03 DK DK91401431.1T patent/DK0461012T3/da active
- 1991-06-03 EP EP91401431A patent/EP0461012B1/fr not_active Expired - Lifetime
- 1991-06-04 IL IL9837291A patent/IL98372A/en not_active IP Right Cessation
- 1991-06-06 FI FI912733A patent/FI97055C/fi active
- 1991-06-06 CS CS911736A patent/CS173691A3/cs unknown
- 1991-06-06 NO NO912168A patent/NO177931C/no not_active IP Right Cessation
- 1991-06-06 IE IE194191A patent/IE64688B1/en unknown
- 1991-06-06 PT PT97885A patent/PT97885B/pt not_active IP Right Cessation
- 1991-06-06 CA CA002043981A patent/CA2043981A1/en not_active Abandoned
- 1991-06-06 US US07/710,711 patent/US5192763A/en not_active Expired - Fee Related
- 1991-06-06 ZA ZA914339A patent/ZA914339B/xx unknown
- 1991-06-06 AU AU78196/91A patent/AU634391B2/en not_active Ceased
- 1991-06-06 NZ NZ238431A patent/NZ238431A/xx unknown
- 1991-06-06 PL PL91290572A patent/PL165187B1/pl unknown
- 1991-06-06 JP JP3134761A patent/JPH04235958A/ja active Pending
- 1991-06-06 HU HU911895A patent/HU209620B/hu not_active IP Right Cessation
- 1991-06-07 KR KR1019910009395A patent/KR100188902B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IE64688B1 (en)	1995-08-23
NO912168L (no)	1991-12-09
JPH04235958A (ja)	1992-08-25
IE911941A1 (en)	1991-12-18
IL98372A (en)	1996-01-31
PT97885A (pt)	1992-03-31
PT97885B (pt)	1998-10-30
FR2663026A1 (fr)	1991-12-13
AU7819691A (en)	1991-12-12
FR2663026B1 (fr)	1992-08-07
FI912733L (fi)	1991-12-08
EP0461012A1 (fr)	1991-12-11
DE69101740D1 (de)	1994-05-26
AU634391B2 (en)	1993-02-18
KR920000751A (ko)	1992-01-29
ATE104662T1 (de)	1994-05-15
EP0461012B1 (fr)	1994-04-20
NO177931B (no)	1995-09-11
ZA914339B (en)	1992-03-25
HU911895D0 (en)	1991-12-30
FI912733A0 (fi)	1991-06-06
NO912168D0 (no)	1991-06-06
ES2054460T3 (es)	1994-08-01
KR100188902B1 (ko)	1999-06-01
NO177931C (no)	1995-12-20
US5192763A (en)	1993-03-09
CA2043981A1 (en)	1991-12-08
HUT58070A (en)	1992-01-28
FI97055B (fi)	1996-06-28
NZ238431A (en)	1992-09-25
FI97055C (fi)	1996-10-10
IL98372A0 (en)	1992-07-15
PL165187B1 (pl)	1994-11-30
HU209620B (en)	1994-09-28
CS173691A3 (en)	1992-02-19
DE69101740T2 (de)	1994-10-20
PL290572A1 (en)	1992-02-10

Publication	Publication Date	Title
DK0565377T3 (da)	1998-03-16	Terapeutiske midler til behandling af Parkinsons sygdom
NO914960L (no)	1991-12-16	Medikamenter for canserterapi med antihistaminegenskaper
ATE100103T1 (de)	1994-01-15	1,8-benzonaphthyridinderivate, ihre herstellung und diese enthaltende zusammensetzungen.
CS183791A3 (en)	1992-01-15	Derivatives of 2-(aminoalkyl)-5-(arylalkyl)-1,3-dioxanes, process for their preparation and their therapeutical application
NO890440L (no)	1990-01-15	Fremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater.
DK0437128T3 (da)	1994-03-14	Anvendelse af et fluorquinolonderivat til fremstilling af et lægemiddel til behandling af pneumocystosis
DK0461012T3 (da)	1994-09-12	Derivater af ((1-arylpyrrolidin-2-yl)methyl)piperazin, fremstillingen heraf og deres terapeutiske anvendelse
AU536912B2 (en)	1984-05-31	Benzothiazole derivatives
EE03355B1 (et)	2001-02-15	Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamine ja kasutamine
ATE139441T1 (de)	1996-07-15	Verwendung von 2-iminothiazolidin-4-onderivaten als neuartige arzneimittelwirkstoffe
NO170274C (no)	1992-09-30	Analogifremgangsmaate for fremstilling av nye terapeutisk virksomme benzhydryloksyetylpiperidin-derivater
SE8901060D0 (sv)	1989-03-28	New compounds
DE3862660D1 (de)	1991-06-13	2,3-dihydro-2-oxo-3-benzofuranyl-essigsaeurederivate und diese enthaltende arzneimittel.
SE8302452D0 (sv)	1983-04-29	Method for treatment of senile dementia
NO893039D0 (no)	1989-07-26	Bruk av imidazopyrazol-derivater som analgesiske og antiinflammatoriske midler.
FI921298A7 (fi)	1992-03-25	Menetelmä lääkeaineena käyttökelpoisen 5-(6-imidatso/1,2-a/pyridyyli)pyridiini-johdannaisen valmistamiseksi