DK0464178T3 - Fremgangsmåde til fremstilling af ergolinderivater - Google Patents

Fremgangsmåde til fremstilling af ergolinderivater

Info

Publication number: DK0464178T3
Authority: DK; Denmark
Prior art keywords: pct; represents hydrogen; alkyl; image; compounds
Prior art date: 1990-01-25

Application number

DK91902706.0T

Other languages

English (en)

Inventor

Sergio Mantegani

Gabriella Traquandi

Tiziano Bandiera

Enzo Brambilla

Original Assignee

Pharmacia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-25

Filing date

1991-01-21

Publication date

1996-01-02

1990-01-25 Priority claimed from GB909001774A external-priority patent/GB9001774D0/en

1990-11-28 Priority claimed from GB909025849A external-priority patent/GB9025849D0/en

1991-01-21 Application filed by Pharmacia Spa filed Critical Pharmacia Spa

1996-01-02 Application granted granted Critical

1996-01-02 Publication of DK0464178T3 publication Critical patent/DK0464178T3/da

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
239000001257 hydrogen Substances 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
230000000561 anti-psychotic effect Effects 0.000 abstract 1
239000000939 antiparkinson agent Substances 0.000 abstract 1
229940125688 antiparkinson agent Drugs 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000000460 chlorine Chemical group 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK91902706.0T 1990-01-25 1991-01-21 Fremgangsmåde til fremstilling af ergolinderivater DK0464178T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909001774A GB9001774D0 (en)	1990-01-25	1990-01-25	Process for preparing ergoline derivatives
GB909025849A GB9025849D0 (en)	1990-11-28	1990-11-28	Process for preparing ergoline derivatives

Publications (1)

Publication Number	Publication Date
DK0464178T3 true DK0464178T3 (da)	1996-01-02

Family

ID=26296553

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91902706.0T DK0464178T3 (da)	1990-01-25	1991-01-21	Fremgangsmåde til fremstilling af ergolinderivater

Country Status (21)

Country	Link
US (1)	US5210194A (da)
EP (1)	EP0464178B1 (da)
JP (1)	JPH04504582A (da)
KR (1)	KR920701205A (da)
AT (1)	ATE131167T1 (da)
AU (1)	AU644625B2 (da)
CA (1)	CA2049053A1 (da)
DE (1)	DE69115138T2 (da)
DK (1)	DK0464178T3 (da)
ES (1)	ES2083564T3 (da)
FI (1)	FI96113C (da)
GR (1)	GR3019125T3 (da)
HU (1)	HU208971B (da)
IE (1)	IE72142B1 (da)
IL (1)	IL96996A (da)
MY (1)	MY106383A (da)
NO (1)	NO178373C (da)
NZ (1)	NZ236852A (da)
PT (1)	PT96557B (da)
RU (1)	RU2074857C1 (da)
WO (1)	WO1991011447A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4033496A1 (de) *	1990-10-20	1992-04-23	Sandoz Ag	Neue ergolinderivate, ihre herstellung und verwendung
PT628042E (pt) *	1992-12-24	2002-01-30	Pharmacia & Upjohn Spa	Derivados de ergolina serotoninergicos
GB9407637D0 (en)	1994-04-18	1994-06-08	Erba Carlo Spa	Serotoninergic abeo-ergoline derivatives
GB9603226D0 (en) *	1996-02-15	1996-04-17	Pharmacia Spa	Heterocyclyl-ergoline derivatives
US6060483A (en) *	1996-06-27	2000-05-09	Pharmacia & Upjohn S.P.A.	Antineurodegenerative ergoline derivatives
AU2002305845B2 (en)	2001-06-08	2006-03-30	Ipsen Pharma S.A.S.	Somatostatin-dopamine chimeric analogs
TWI523863B (zh)	2012-11-01	2016-03-01	艾普森藥品公司	體抑素－多巴胺嵌合體類似物
JP2016503402A (ja)	2012-11-01	2016-02-04	イプセンファルマソシエテパールアクシオンサンプリフィエＩｐｓｅｎＰｈａｒｍａＳ．Ａ．Ｓ．	ソマトスタチン類似体及びそのダイマー

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3763161A (en) *	1970-07-13	1973-10-02	Du Pont	Tetrasubstituted dicyanopyrazines and related compounds
JPS58172012A (ja) *	1982-04-01	1983-10-08	Clarion Co Ltd	同一放送識別受信機
PH21123A (en) *	1983-04-28	1987-07-27	Erba Farmitalia	Ergoline derivatives
US4806538A (en) *	1984-11-02	1989-02-21	Fujisawa Pharmaceutical Co., Ltd.	Piperazine compound as PAF-antagonist
GB8501078D0 (en) *	1985-01-16	1985-02-20	Erba Farmitalia	Piperazin-1-yl-ergo-line derivatives
DE3517247A1 (de) *	1985-05-13	1986-11-13	Gerhard Prof. Dr.-Ing. 8012 Ottobrunn Flachenecker	Antennendiversity-empfangsanlage zur elimination von empfangsstoerungen
US4871736A (en) *	1986-11-25	1989-10-03	The Ohio State University	Stereoisomeric tricyclic bis(dioxopiperazines) and pharmaceutical compositions
US4733402A (en) *	1987-04-23	1988-03-22	Signatron, Inc.	Adaptive filter equalizer systems
DE3814899A1 (de) *	1988-05-03	1989-11-16	Hirschmann Richard Gmbh Co	Empfangsverfahren und empfangs-antennensystem fuer mobilen empfang
NO175659C (no) *	1988-07-06	1994-11-09	Sumitomo Electric Industries	Kommunikasjonssystem med multippelmottagning og mottagerapparat for diversitetssignaler
DE3926336C2 (de) *	1989-08-09	2001-03-29	Heinz Lindenmeier	Antennendiversity-Empfangsanlage zur Elimination von Empfangsstörungen beim mobilen Empfang von Fernsehsignalen

1991
- 1991-01-21 JP JP3503074A patent/JPH04504582A/ja active Pending
- 1991-01-21 RU SU915001733A patent/RU2074857C1/ru active
- 1991-01-21 KR KR1019910701178A patent/KR920701205A/ko not_active Abandoned
- 1991-01-21 EP EP91902706A patent/EP0464178B1/en not_active Expired - Lifetime
- 1991-01-21 AT AT91902706T patent/ATE131167T1/de not_active IP Right Cessation
- 1991-01-21 AU AU70788/91A patent/AU644625B2/en not_active Ceased
- 1991-01-21 CA CA002049053A patent/CA2049053A1/en not_active Abandoned
- 1991-01-21 WO PCT/EP1991/000104 patent/WO1991011447A1/en not_active Ceased
- 1991-01-21 DE DE69115138T patent/DE69115138T2/de not_active Expired - Fee Related
- 1991-01-21 US US07/761,977 patent/US5210194A/en not_active Expired - Fee Related
- 1991-01-21 DK DK91902706.0T patent/DK0464178T3/da active
- 1991-01-21 HU HU913121A patent/HU208971B/hu not_active IP Right Cessation
- 1991-01-21 ES ES91902706T patent/ES2083564T3/es not_active Expired - Lifetime
- 1991-01-22 IL IL9699691A patent/IL96996A/en not_active IP Right Cessation
- 1991-01-22 NZ NZ236852A patent/NZ236852A/en unknown
- 1991-01-22 MY MYPI91000103A patent/MY106383A/en unknown
- 1991-01-23 PT PT96557A patent/PT96557B/pt not_active IP Right Cessation
- 1991-01-24 IE IE24491A patent/IE72142B1/en not_active IP Right Cessation
- 1991-09-16 NO NO913647A patent/NO178373C/no unknown
- 1991-09-23 FI FI914458A patent/FI96113C/fi not_active IP Right Cessation
1996
- 1996-02-28 GR GR960400549T patent/GR3019125T3/el unknown

Also Published As

Publication number	Publication date
AU7078891A (en)	1991-08-21
HUT58092A (en)	1992-01-28
EP0464178B1 (en)	1995-12-06
GR3019125T3 (en)	1996-05-31
ES2083564T3 (es)	1996-04-16
MY106383A (en)	1995-05-30
US5210194A (en)	1993-05-11
FI96113C (fi)	1996-05-10
KR920701205A (ko)	1992-08-11
DE69115138D1 (de)	1996-01-18
DE69115138T2 (de)	1996-05-09
AU644625B2 (en)	1993-12-16
FI96113B (fi)	1996-01-31
IL96996A (en)	1994-11-28
IE910244A1 (en)	1991-07-31
NO913647D0 (no)	1991-09-16
RU2074857C1 (ru)	1997-03-10
CA2049053A1 (en)	1991-07-26
PT96557A (pt)	1991-10-15
NO178373B (no)	1995-12-04
NZ236852A (en)	1992-05-26
NO913647L (no)	1991-09-16
PT96557B (pt)	1998-07-31
EP0464178A1 (en)	1992-01-08
WO1991011447A1 (en)	1991-08-08
JPH04504582A (ja)	1992-08-13
IL96996A0 (en)	1992-03-29
ATE131167T1 (de)	1995-12-15
FI914458A0 (fi)	1991-09-23
NO178373C (no)	1996-03-13
IE72142B1 (en)	1997-03-26
HU208971B (en)	1994-02-28

Publication	Publication Date	Title
ATE208779T1 (de)	2001-11-15	Substituierte spiroheterocyclische 1h-3-aryl- pyrrolidin-2,4-dion-derivate, verfahren zu deren herstellung und deren verwendung als schädlingsbekämpfungsmittel
DK149885A (da)	1985-10-07	Fremgangsmaade til fremstilling af optisk aktive alpha-arylalkansyrer og mellemprodukter til brug herved
KR950700278A (ko)	1995-01-16	벤조사이클로헵텐, 벤조옥세핀 및 벤조티에핀(benzocycloheptenes, benzoxepines and benzothiepines)
ATE296300T1 (de)	2005-06-15	Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
FI96113C (fi)	1996-05-10	Menetelmä ergoliinijohdannaisten valmistamiseksi
NO864516D0 (no)	1986-11-12	Fremgangsmaate for fremstilling av alkyl-beta-carboliner.
ES2093394T3 (es)	1996-12-16	Derivados de hidrazina antiretrovirales.
DE3575140D1 (de)	1990-02-08	Dreizyklische oxindole als antientzuendungsmittel.
DK0689534T3 (da)	2003-02-03	Amidderivater som 5-HT1A-ligander
DK16980A (da)	1980-10-27	Fremgangsmaade til fremstilling af derivater af pyrido og imidazopyridoindoler
PT85822A (pt)	1987-10-01	Process for preparing indolo-pyrazino-benzodiazepine derivatives
ATE255111T1 (de)	2003-12-15	Abeo-ergolinderivate als 5ht1a liganden
DK113180A (da)	1980-09-16	Fremgangsmaade til fremstilling af derivater af dithiepino (1,4) (2,3-c) pyrrol
DK0513285T3 (da)	1996-02-12	Imidazol-2-yl-derivater af substituerede bicycliske forbindelser og fremsgangsmåde til fremstilling deraf
TW351717B (en)	1999-02-01	Pyenyl-substituted cyclic ketoenols