DK0465358T3 - 2-thienylglycidsyre-derivat, fremgangsmåde til fremstilling heraf samt anvendelse af derivater som s yntesemellemprodukt - Google Patents

2-thienylglycidsyre-derivat, fremgangsmåde til fremstilling heraf samt anvendelse af derivater som s yntesemellemprodukt

Info

Publication number: DK0465358T3
Authority: DK; Denmark
Prior art keywords: preparation; derivatives; acid derivative; synthetic intermediate; thienylglycolic acid
Prior art date: 1990-07-04

Application number

DK91401833.8T

Other languages

English (en)

Inventor

Alain Heymes

Andre Bousquet

Serge Calet

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-04

Filing date

1991-07-03

Publication date

1996-05-28

1991-07-03 Application filed by Sanofi Sa filed Critical Sanofi Sa

1996-05-28 Application granted granted Critical

1996-05-28 Publication of DK0465358T3 publication Critical patent/DK0465358T3/da

Links

238000002360 preparation method Methods 0.000 title abstract 2
WPWZFAUHXAPBFF-UHFFFAOYSA-N 2-hydroxy-2-thiophen-2-ylacetic acid Chemical class OC(=O)C(O)C1=CC=CS1 WPWZFAUHXAPBFF-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
CNUDBTRUORMMPA-UHFFFAOYSA-N formylthiophene Chemical compound O=CC1=CC=CS1 CNUDBTRUORMMPA-UHFFFAOYSA-N 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
238000002483 medication Methods 0.000 abstract 1
UGIINEGDKDTHJX-UHFFFAOYSA-N n-(2-thiophen-2-ylethylidene)hydroxylamine Chemical compound ON=CCC1=CC=CS1 UGIINEGDKDTHJX-UHFFFAOYSA-N 0.000 abstract 1
GOJTYOKFWLBOGK-UHFFFAOYSA-N propan-2-yl 2-thiophen-2-yloxirane-2-carboxylate Chemical compound C=1C=CSC=1C1(C(=O)OC(C)C)CO1 GOJTYOKFWLBOGK-UHFFFAOYSA-N 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
MKYRMMMSZSVIGD-UHFFFAOYSA-N thieno[3,2-c]pyridine Chemical compound N1=CC=C2SC=CC2=C1 MKYRMMMSZSVIGD-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Epoxy Compounds (AREA)
Saccharide Compounds (AREA)

DK91401833.8T 1990-07-04 1991-07-03 2-thienylglycidsyre-derivat, fremgangsmåde til fremstilling heraf samt anvendelse af derivater som s yntesemellemprodukt DK0465358T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9008482A FR2664276B1 (fr)	1990-07-04	1990-07-04	Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese.

Publications (1)

Publication Number	Publication Date
DK0465358T3 true DK0465358T3 (da)	1996-05-28

Family

ID=9398353

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91401833.8T DK0465358T3 (da)	1990-07-04	1991-07-03	2-thienylglycidsyre-derivat, fremgangsmåde til fremstilling heraf samt anvendelse af derivater som s yntesemellemprodukt

Country Status (13)

Country	Link
US (1)	US5132435A (da)
EP (1)	EP0465358B1 (da)
JP (1)	JP3055819B2 (da)
AT (1)	ATE133950T1 (da)
CA (1)	CA2046126C (da)
DE (1)	DE69116943T2 (da)
DK (1)	DK0465358T3 (da)
ES (1)	ES2083542T3 (da)
FR (1)	FR2664276B1 (da)
GR (1)	GR3018947T3 (da)
HU (1)	HU213397B (da)
IE (1)	IE73223B1 (da)
PT (1)	PT98181B (da)

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US6013666A (en) *	1996-07-02	2000-01-11	Sang Sup Jew	Oxirane carboxylic acid derivative and its manufacturing method
US6043368A (en) *	1996-09-04	2000-03-28	Poli Industria Chimica, S.P.A.	Method of making thieno-pyridine derivatives
FR2760456B1 (fr) *	1997-03-05	2000-05-12	Sanofi Sa	Procede de preparation de derives de 2-thienyl-ethylamine
FR2769313B1 (fr) *	1997-10-06	2000-04-21	Sanofi Sa	Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
FR2779726B1 (fr) *	1998-06-15	2001-05-18	Sanofi Sa	Forme polymorphe de l'hydrogenosulfate de clopidogrel
WO2002059128A2 (en) *	2001-01-24	2002-08-01	Cadila Healthcare Ltd.	Process for preparing clopidogrel
US6495691B1 (en)	2001-07-06	2002-12-17	Brantford Chemicals Inc.	Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
HRP20040647A2 (en) *	2001-12-18	2005-04-30	Teva Pharmaceutical Industries Ltd.	Polymorphs of clopidogrel hydrogensulfate
US6767913B2 (en)	2001-12-18	2004-07-27	Teva Pharmaceutical Industries Ltd.	Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en)	2002-01-11	2006-07-11	Teva Pharmaceutical Industries, Ltd.	Polymorphs of clopidogrel hydrogensulfate
IL166593A0 (en)	2002-08-02	2006-01-15		Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) *	2002-08-02	2004-10-05	Teva Pharmaceutical Industries Ltd.	Racemization and enantiomer separation of clopidogrel
AU2003216707A1 (en) *	2003-03-10	2004-09-30	Hetero Drugs Limited	Amorphous clopidogrel hydrogen sulfate
AU2003241149A1 (en) *	2003-05-05	2004-11-26	Hetero Drugs Limited	Amorphous clopidogrel hydrogen sulfate composition
ES2339944T3 (es)	2003-11-03	2010-05-27	Cadila Healthcare Limited	Procedimientos para preparar la forma i de bisulfato de (s)-(+)-clopidogrel.
EP1723141A4 (en) *	2004-03-05	2007-10-10	Ipca Lab Ltd	MOST TECHNICAL PROCESS FOR THE PREPARATION OF CLOPIDOGRAPHYDROGENSULFATE
EP1704152A2 (en) *	2004-09-21	2006-09-27	Teva Pharmaceutical Industries Ltd	Crystalline clopidogrel hydrobromide and processes for preparation thereof
US20060223845A1 (en) *	2005-02-24	2006-10-05	Eran Turgeman	Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
WO2007032023A2 (en) *	2005-07-12	2007-03-22	Rpg Life Sciences Limited	A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
WO2007026860A1 (ja) *	2005-09-02	2007-03-08	Daiichi Fine Chemical Co., Ltd.	光学活性α－ヒドロキシカルボン酸の製造方法
EP2012781A2 (en) *	2006-04-27	2009-01-14	Ind-Swift Laboratories Limited	Process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate
EP2064217B1 (en)	2006-09-04	2011-01-19	Ranbaxy Laboratories Limited	An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts
KR100978498B1 (ko) *	2006-10-17	2010-08-30	최중헌	클로피도그렐 황산수소염의 제조방법
KR101365689B1 (ko) *	2006-10-27	2014-02-24	(주)유케이케미팜	(ｒ)-2-히드록시-2-(클로로페닐)초산 메틸 에스테르황산염의 제조방법
EP1980563A1 (en)	2007-04-09	2008-10-15	BATTULA, Srinivasa Reddy	Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
MX2008016012A (es) *	2007-04-18	2009-03-06	Teva Pharma	Proceso mejorado para preparar clopidogrel.
US20110190502A1 (en) *	2008-10-24	2011-08-04	Sandoz Ag	Process for the preparation of s-clopidogrel
CN101585842B (zh) *	2009-07-13	2011-07-20	北京赛科药业有限责任公司	氯吡格雷中杂质b的研究及控制方法
CN101987854A (zh) *	2009-08-04	2011-03-23	北京万全阳光医学技术有限公司	一种氯吡格雷及其盐的制备方法
WO2012123958A1 (en)	2011-02-14	2012-09-20	Cadila Healthcare Limited	Highly pure salts of clopidogrel free of genotoxic impurities
CN102250114B (zh) *	2011-04-27	2014-02-26	青岛黄海制药有限责任公司	一种氯吡格雷及其硫酸盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6047274B2 (ja) *	1976-07-07	1985-10-21	株式会社三和化学研究所	新規のチエノ〔３，２−ｆ〕モルファン誘導体及びその塩並びにこれ等の製法
FR2508456A1 (fr) *	1981-06-30	1982-12-31	Sanofi Sa	Procede de preparation de (thienyl-2)-2 ethylamines et (thienyl-3)-2 ethylamines
JPS62103087A (ja) *	1985-10-28	1987-05-13	Toyo Pharma- Kk	５−（２−クロロベンジル）−４，５，６，７−テトラヒドロチエノ〔３，２−ｃ〕ピリジン又はその塩の製造方法

1990
- 1990-07-04 FR FR9008482A patent/FR2664276B1/fr not_active Expired - Fee Related
1991
- 1991-07-02 US US07/724,988 patent/US5132435A/en not_active Expired - Lifetime
- 1991-07-02 PT PT98181A patent/PT98181B/pt not_active IP Right Cessation
- 1991-07-03 EP EP91401833A patent/EP0465358B1/fr not_active Expired - Lifetime
- 1991-07-03 HU HU912250A patent/HU213397B/hu unknown
- 1991-07-03 DE DE69116943T patent/DE69116943T2/de not_active Expired - Lifetime
- 1991-07-03 AT AT91401833T patent/ATE133950T1/de not_active IP Right Cessation
- 1991-07-03 CA CA002046126A patent/CA2046126C/en not_active Expired - Lifetime
- 1991-07-03 IE IE232891A patent/IE73223B1/en not_active IP Right Cessation
- 1991-07-03 DK DK91401833.8T patent/DK0465358T3/da active
- 1991-07-03 JP JP3162859A patent/JP3055819B2/ja not_active Expired - Lifetime
- 1991-07-03 ES ES91401833T patent/ES2083542T3/es not_active Expired - Lifetime
1996
- 1996-02-14 GR GR960400346T patent/GR3018947T3/el unknown

Also Published As

Publication number	Publication date
CA2046126C (en)	2001-11-20
EP0465358B1 (fr)	1996-02-07
ATE133950T1 (de)	1996-02-15
EP0465358A1 (fr)	1992-01-08
HU912250D0 (en)	1991-12-30
PT98181A (pt)	1993-08-31
IE73223B1 (en)	1997-05-07
US5132435A (en)	1992-07-21
PT98181B (pt)	1998-12-31
DE69116943D1 (de)	1996-03-21
JP3055819B2 (ja)	2000-06-26
ES2083542T3 (es)	1996-04-16
JPH04261174A (ja)	1992-09-17
HU213397B (en)	1997-06-30
FR2664276A1 (fr)	1992-01-10
HUT61754A (en)	1993-03-01
GR3018947T3 (en)	1996-05-31
CA2046126A1 (en)	1992-01-05
FR2664276B1 (fr)	1992-10-23
IE912328A1 (en)	1992-01-15
DE69116943T2 (de)	1996-09-19

Publication	Publication Date	Title
DK0465358T3 (da)	1996-05-28	2-thienylglycidsyre-derivat, fremgangsmåde til fremstilling heraf samt anvendelse af derivater som s yntesemellemprodukt
ES2133430T3 (es)	1999-09-16	Derivados de n-heteroaril-n-fenilurea, su preparacion y utilizacion.
DK0466569T3 (da)	1996-08-12	Fremgangsmåde til fremstilling af et N-phenylacetylderivat af tetrahydrothieno(3,2-c)pyridin og dets syntesemellemprodukt
SE9103572D0 (sv)	1991-11-29	Organic salts of n,n'-diacetyl cystine
MA21878A1 (fr)	1990-12-31	Procede de preparation de derives pheny - lacetiques de thieno-pyridines et des acides & -bromo phenyl acetiques intermediaires .
CA2015473A1 (en)	1990-10-28	Triphenylmethane derivatives
NO940523L (no)	1994-02-15	Nye pyrazin-derivater
ES2056246T3 (es)	1994-10-01	Derivados de n-hetaril-imidazol.
PT90572A (pt)	1989-11-30	Processo para a preparacao de derivados de 6-fenil-3-piperazinilalquil-1h,3h-2,4-pirimidinadiona
KR930703312A (ko)	1993-11-29	아자비사이클로 [2.2.2]옥탄-3-이민의 제조방법 및 그의 제조용 중간체
DK0662967T3 (da)	1998-09-14	Syntese af N-acetyl-neuraminsyrederivater
CA2260469A1 (en)	1999-07-28	A process for the preparation of pyridine dicarboxylate derivatives
AU6993691A (en)	1991-08-01	Preparation of 2-(2'-thienyl)alkylamines and derivatives thereof and synthesis of 4,5,6,7-thieno(3,2-c)pyridine derivatives therefrom
DE3889022D1 (de)	1994-05-19	Verfahren zur Herstellung von Thiophenderivaten.
DK0397042T3 (da)	1995-10-02	Fremstilling af isoquinolinderivater
ZA822988B (en)	1983-03-30	5-(4-phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1h-imidazole-4-carboxylic acid derivatives
MX9401137A (es)	1994-08-31	Preparacion de sal de sodio de 1-amino-1-cianamido-2, 2-dicianoetileno.
DK0661263T3 (da)	2001-07-02	Fremgangsmåde til fremstilling af 2,4,5-tribrompyrrol-3-carbonitril
DK0647623T3 (da)	1998-04-14	Mellemprodukter til fremstilling af A-vitamin og carotenoider samt fremstilling og anvendelse af disse mellemprodukter
JPS53105583A (en)	1978-09-13	Polysaccharide sulfate derivative
JPS5439028A (en)	1979-03-24	Acetanilide derivatives and bactericides containing the same for agricultural and horticultural, uses
JPS543021A (en)	1979-01-11	Novel derivative of glutamic acid and its preparation
IT1260853B (it)	1996-04-23	Procedimento per la preparazione di un composto aromatico mediante reazione elettrofila e derivati di composto aromatico
JPS5436444A (en)	1979-03-17	Hinge for door
JPS5416458A (en)	1979-02-07	Preparation of oxime substituted phenylacetic acid derivatives