PT98181A - Processo para a preparacao de derivados 2-tienilglicidicos uteis como intermediario da sintese - Google Patents

Processo para a preparacao de derivados 2-tienilglicidicos uteis como intermediario da sintese

Info

Publication number: PT98181A
Authority: PT; Portugal
Prior art keywords: preparation; tienylglycidic; usual; derivatives; synthesis intermediary
Prior art date: 1990-07-04

Application number

PT98181A

Other languages

English (en)

Other versions

PT98181B (pt

Inventor

Andre Bousquet

Serge Calet

Alain Heymes

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-04

Filing date

1991-07-02

Publication date

1993-08-31

1991-07-02 Application filed by Sanofi Sa filed Critical Sanofi Sa

1993-08-31 Publication of PT98181A publication Critical patent/PT98181A/pt

1998-12-31 Publication of PT98181B publication Critical patent/PT98181B/pt

Links

230000015572 biosynthetic process Effects 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
238000006243 chemical reaction Methods 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
CNUDBTRUORMMPA-UHFFFAOYSA-N formylthiophene Chemical compound O=CC1=CC=CS1 CNUDBTRUORMMPA-UHFFFAOYSA-N 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
238000002483 medication Methods 0.000 abstract 1
UGIINEGDKDTHJX-UHFFFAOYSA-N n-(2-thiophen-2-ylethylidene)hydroxylamine Chemical compound ON=CCC1=CC=CS1 UGIINEGDKDTHJX-UHFFFAOYSA-N 0.000 abstract 1
GOJTYOKFWLBOGK-UHFFFAOYSA-N propan-2-yl 2-thiophen-2-yloxirane-2-carboxylate Chemical compound C=1C=CSC=1C1(C(=O)OC(C)C)CO1 GOJTYOKFWLBOGK-UHFFFAOYSA-N 0.000 abstract 1
MKYRMMMSZSVIGD-UHFFFAOYSA-N thieno[3,2-c]pyridine Chemical compound N1=CC=C2SC=CC2=C1 MKYRMMMSZSVIGD-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

PT98181A 1990-07-04 1991-07-02 Processo para a preparacao de derivados 2-tienilglicidicos uteis como intermediario da sintese PT98181B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9008482A FR2664276B1 (fr)	1990-07-04	1990-07-04	Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese.

Publications (2)

Publication Number	Publication Date
PT98181A true PT98181A (pt)	1993-08-31
PT98181B PT98181B (pt)	1998-12-31

Family

ID=9398353

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98181A PT98181B (pt)	1990-07-04	1991-07-02	Processo para a preparacao de derivados 2-tienilglicidicos uteis como intermediario da sintese

Country Status (13)

Country	Link
US (1)	US5132435A (pt)
EP (1)	EP0465358B1 (pt)
JP (1)	JP3055819B2 (pt)
AT (1)	ATE133950T1 (pt)
CA (1)	CA2046126C (pt)
DE (1)	DE69116943T2 (pt)
DK (1)	DK0465358T3 (pt)
ES (1)	ES2083542T3 (pt)
FR (1)	FR2664276B1 (pt)
GR (1)	GR3018947T3 (pt)
HU (1)	HU213397B (pt)
IE (1)	IE73223B1 (pt)
PT (1)	PT98181B (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6013666A (en) *	1996-07-02	2000-01-11	Sang Sup Jew	Oxirane carboxylic acid derivative and its manufacturing method
US6043368A (en) *	1996-09-04	2000-03-28	Poli Industria Chimica, S.P.A.	Method of making thieno-pyridine derivatives
FR2760456B1 (fr) *	1997-03-05	2000-05-12	Sanofi Sa	Procede de preparation de derives de 2-thienyl-ethylamine
FR2769313B1 (fr) *	1997-10-06	2000-04-21	Sanofi Sa	Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
FR2779726B1 (fr) *	1998-06-15	2001-05-18	Sanofi Sa	Forme polymorphe de l'hydrogenosulfate de clopidogrel
ES2278010T3 (es) *	2001-01-24	2007-08-01	Cadila Healthcare Limited	Procedimiento de preparacion de clopidrogel.
US6495691B1 (en)	2001-07-06	2002-12-17	Brantford Chemicals Inc.	Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
JP2005514387A (ja) *	2001-12-18	2005-05-19	テバファーマシューティカルインダストリーズリミティド	クロピドグレル硫酸水素塩の多型体
US6767913B2 (en)	2001-12-18	2004-07-27	Teva Pharmaceutical Industries Ltd.	Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en)	2002-01-11	2006-07-11	Teva Pharmaceutical Industries, Ltd.	Polymorphs of clopidogrel hydrogensulfate
IL166593A0 (en)	2002-08-02	2006-01-15		Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) *	2002-08-02	2004-10-05	Teva Pharmaceutical Industries Ltd.	Racemization and enantiomer separation of clopidogrel
US20060100231A1 (en) *	2003-03-10	2006-05-11	Hetero Drugs Limited	Amorphous clopidogrel hydrogen sulfate
WO2004098593A1 (en) *	2003-05-05	2004-11-18	Hetero Drugs Limited	Amorphous clopidogrel hydrogen sulfate composition
ATE455778T1 (de)	2003-11-03	2010-02-15	Cadila Healthcare Ltd	Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat
EP1772455A3 (en) *	2004-03-05	2007-06-27	IPCA Laboratories Limited	Industrial process for preparation a polmorph of clopidogrel hydrogen sulphate
EP1704152A2 (en) *	2004-09-21	2006-09-27	Teva Pharmaceutical Industries Ltd	Crystalline clopidogrel hydrobromide and processes for preparation thereof
US20060223845A1 (en) *	2005-02-24	2006-10-05	Eran Turgeman	Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
US8063217B2 (en) *	2005-07-12	2011-11-22	Rpg Life Sciences Limited	Process for preparation of methyl-(+)-(S)-alpha-(2-chlorophenyl)-6, 7-dihydrothieno[3,2-C]pyridine-5(4H) -acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
US20080311636A1 (en) *	2005-09-02	2008-12-18	Daiichi Fine Chemical Co., Ltd.	Method for Producing Optically Active Alpha-Hydroxycarboxylic Acid
WO2007125544A2 (en) *	2006-04-27	2007-11-08	Ind-Swift Laboratories Limited	Process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate
EP2064217B1 (en)	2006-09-04	2011-01-19	Ranbaxy Laboratories Limited	An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts
KR100978498B1 (ko) *	2006-10-17	2010-08-30	최중헌	클로피도그렐 황산수소염의 제조방법
KR101365689B1 (ko) *	2006-10-27	2014-02-24	(주)유케이케미팜	(ｒ)-2-히드록시-2-(클로로페닐)초산 메틸 에스테르황산염의 제조방법
EP1980563A1 (en)	2007-04-09	2008-10-15	BATTULA, Srinivasa Reddy	Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
BRPI0803101A2 (pt) *	2007-04-18	2014-04-22	Teva Pharma	Processos melhores para preparação de clopidogrel
CN102186858A (zh) *	2008-10-24	2011-09-14	桑多斯股份公司	制备s-氯吡格雷的方法
CN101585842B (zh) *	2009-07-13	2011-07-20	北京赛科药业有限责任公司	氯吡格雷中杂质b的研究及控制方法
CN101987854A (zh) *	2009-08-04	2011-03-23	北京万全阳光医学技术有限公司	一种氯吡格雷及其盐的制备方法
WO2012123958A1 (en)	2011-02-14	2012-09-20	Cadila Healthcare Limited	Highly pure salts of clopidogrel free of genotoxic impurities
CN102250114B (zh) *	2011-04-27	2014-02-26	青岛黄海制药有限责任公司	一种氯吡格雷及其硫酸盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6047274B2 (ja) *	1976-07-07	1985-10-21	株式会社三和化学研究所	新規のチエノ〔３，２−ｆ〕モルファン誘導体及びその塩並びにこれ等の製法
FR2508456A1 (fr) *	1981-06-30	1982-12-31	Sanofi Sa	Procede de preparation de (thienyl-2)-2 ethylamines et (thienyl-3)-2 ethylamines
JPS62103087A (ja) *	1985-10-28	1987-05-13	Toyo Pharma- Kk	５−（２−クロロベンジル）−４，５，６，７−テトラヒドロチエノ〔３，２−ｃ〕ピリジン又はその塩の製造方法

1990
- 1990-07-04 FR FR9008482A patent/FR2664276B1/fr not_active Expired - Fee Related
1991
- 1991-07-02 PT PT98181A patent/PT98181B/pt not_active IP Right Cessation
- 1991-07-02 US US07/724,988 patent/US5132435A/en not_active Expired - Lifetime
- 1991-07-03 CA CA002046126A patent/CA2046126C/en not_active Expired - Lifetime
- 1991-07-03 HU HU912250A patent/HU213397B/hu unknown
- 1991-07-03 JP JP3162859A patent/JP3055819B2/ja not_active Expired - Lifetime
- 1991-07-03 DK DK91401833.8T patent/DK0465358T3/da active
- 1991-07-03 ES ES91401833T patent/ES2083542T3/es not_active Expired - Lifetime
- 1991-07-03 AT AT91401833T patent/ATE133950T1/de not_active IP Right Cessation
- 1991-07-03 IE IE232891A patent/IE73223B1/en not_active IP Right Cessation
- 1991-07-03 EP EP91401833A patent/EP0465358B1/fr not_active Expired - Lifetime
- 1991-07-03 DE DE69116943T patent/DE69116943T2/de not_active Expired - Lifetime
1996
- 1996-02-14 GR GR960400346T patent/GR3018947T3/el unknown

Also Published As

Publication number	Publication date
EP0465358B1 (fr)	1996-02-07
US5132435A (en)	1992-07-21
ES2083542T3 (es)	1996-04-16
IE73223B1 (en)	1997-05-07
HU213397B (en)	1997-06-30
DK0465358T3 (da)	1996-05-28
ATE133950T1 (de)	1996-02-15
CA2046126A1 (en)	1992-01-05
CA2046126C (en)	2001-11-20
PT98181B (pt)	1998-12-31
HU912250D0 (en)	1991-12-30
JPH04261174A (ja)	1992-09-17
EP0465358A1 (fr)	1992-01-08
DE69116943T2 (de)	1996-09-19
DE69116943D1 (de)	1996-03-21
GR3018947T3 (en)	1996-05-31
IE912328A1 (en)	1992-01-15
FR2664276B1 (fr)	1992-10-23
JP3055819B2 (ja)	2000-06-26
FR2664276A1 (fr)	1992-01-10
HUT61754A (en)	1993-03-01

Legal Events

Date	Code	Title	Description
1993-08-31	BB1A	Laying open of patent application	Effective date: 19930331
1998-12-31	FG3A	Patent granted, date of granting	Effective date: 19980917
2001-12-28	PC3A	Transfer or assignment	Free format text: 20011002 SANOFI-SYNTHELABO FR
2005-03-31	PD3A	Change of proprietorship	Free format text: SANOFI-AVENTIS FR Effective date: 20050117
2013-09-24	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20130917

Publication	Publication Date	Title
PT98181A (pt)	1993-08-31	Processo para a preparacao de derivados 2-tienilglicidicos uteis como intermediario da sintese
HUT61556A (en)	1993-01-28	New process for producing n-phenylacetic acid derivative of tetrahydrothieno/3,2-c/pyridine
ES2133430T3 (es)	1999-09-16	Derivados de n-heteroaril-n-fenilurea, su preparacion y utilizacion.
PT94486A (pt)	1991-05-22	Processo de preparacao de derivados fenilaceticos de tienopiridinas e de acidos alfa-bromo-fenilaceticos intermediarios
HUT54119A (en)	1991-01-28	Process for producing antiinflammatory aminophenol derivatives
CA2015473A1 (en)	1990-10-28	Triphenylmethane derivatives
PT97796A (pt)	1992-02-28	Processo para a preparacao de piperidinas substituidas
PT92307A (pt)	1990-05-31	Processo para a preparacao de derivados de 3,5-dimetil-4-metoxipiridina e de produtos intermediarios
ATE18054T1 (de)	1986-03-15	Derivate und reduktionsprodukte der dglucopyranosyl-alpha(1-5)-d-arabonsaeure, deren herstellung und verwendung.
AU7249481A (en)	1982-01-07	Imidazole derivatives
FI883314A0 (fi)	1988-07-12	Menetelmä tiofeenijohdannaisten valmistamiseksi, jotka ovat substituoituja -asemassa bromiatomilla
GR3018761T3 (en)	1996-04-30	Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom.
IT1201963B (it)	1989-02-02	Derivati delle rifamicine e procedimento per la loro preparazione
PT98268A (pt)	1992-05-29	Processo para a preparacao de indano-pirrolidino-carbamatos
SE8504093D0 (sv)	1985-09-03	Substituted 7-oxomitosanes
PT81282A (fr)	1985-11-01	Procede de preparation de derives de thieno et furo-<2,3-c> pyrroles
ES540260A0 (es)	1985-12-01	Procedimiento para preparar derivados de 2-alcoxiaminosulfo-nilbencenosulfonilurea
GB1552166A (en)	1979-09-12	Polycyclic scents
EP0490224A3 (de)	1992-07-15	Salicylaldehyd- und Salicylsäurederivate sowie deren Schwefelanaloge, Verfahren und Zwischenprodukte zu ihrer Herstellung
PL312966A1 (en)	1996-05-27	Derivatives of thiocarbamoil
OA09221A (fr)	1992-06-30	"Synthèse asymétrique des dérivés de la furo (3, 4-c) pyridine".
FR2396766A1 (fr)	1979-02-02	Nouveaux derives de tunicamine et leur procede de preparation
PT92175A (pt)	1990-05-31	Processo para a preparacao de 3-amino-sidnoniminas substituidas e de produtos intermediarios farmacologicamente activos
DE69004320D1 (de)	1993-12-09	Hydroxyphenethylamin-Derivat und dessen Salze, Verfahren zur Herstellung, medizinische Verwendung und Verwendung als spezifisches pharmakologisches Werkzeug.
TW363986B (en)	1999-07-11	A process for producing polyparahydroxy styrene derivatives