DK0466662T3 - 6,7-Disubstituerede-2-aminotetraliner, der er aktive som immunmodulatorer, samt farmaceutiske præparater indeholdende sådanne forbindelser - Google Patents

6,7-Disubstituerede-2-aminotetraliner, der er aktive som immunmodulatorer, samt farmaceutiske præparater indeholdende sådanne forbindelser

Info

Publication number: DK0466662T3
Authority: DK; Denmark
Prior art keywords: disubstituted; aminotetralins; immunomodulators; compounds; active
Prior art date: 1990-06-15

Application number

DK91830261.3T

Other languages

English (en)

Inventor

Maria Ornella Tinti

Mauro Marzi

Piero Foresta

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-15

Filing date

1991-06-13

Publication date

1995-11-27

1991-06-13 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1995-11-27 Application granted granted Critical

1995-11-27 Publication of DK0466662T3 publication Critical patent/DK0466662T3/da

Links

-1 6,7-Disubstituted-2-aminotetralins Chemical class 0.000 title abstract 6
239000002955 immunomodulating agent Substances 0.000 title abstract 2
229940121354 immunomodulator Drugs 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
230000002584 immunomodulator Effects 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK91830261.3T 1990-06-15 1991-06-13 6,7-Disubstituerede-2-aminotetraliner, der er aktive som immunmodulatorer, samt farmaceutiske præparater indeholdende sådanne forbindelser DK0466662T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT48066A IT1241988B (it)	1990-06-15	1990-06-15	2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono

Publications (1)

Publication Number	Publication Date
DK0466662T3 true DK0466662T3 (da)	1995-11-27

Family

ID=11264323

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91830261.3T DK0466662T3 (da)	1990-06-15	1991-06-13	6,7-Disubstituerede-2-aminotetraliner, der er aktive som immunmodulatorer, samt farmaceutiske præparater indeholdende sådanne forbindelser

Country Status (9)

Country	Link
US (2)	US5637614A (da)
EP (1)	EP0466662B1 (da)
JP (1)	JP2875061B2 (da)
AT (1)	ATE129232T1 (da)
DE (1)	DE69113893T2 (da)
DK (1)	DK0466662T3 (da)
ES (1)	ES2078497T3 (da)
GR (1)	GR3017813T3 (da)
IT (1)	IT1241988B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1278045B1 (it) *	1995-03-09	1997-11-17	Sigma Tau Ind Farmaceuti	Uso di 2-amminotetraline-6,7-sostituite per la preparazione di composizioni farmaceutiche atte al trattamento dello shock, e di
IT1290910B1 (it) *	1997-02-03	1998-12-14	Sigma Tau Ind Farmaceuti	2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive
AUPO565997A0 (en) *	1997-03-17	1997-04-10	Fujisawa Pharmaceutical Co., Ltd.	Propanolamine derivatives
IT1294932B1 (it) *	1997-09-22	1999-04-23	Sigma Tau Ind Farmaceuti	Uso di 2-amminotetraline-6,7 sostituite per la preparazione di composizioni farmaceutiche atte al trattamento di patologie
IT1294931B1 (it) *	1997-09-22	1999-04-23	Sigma Tau Ind Farmaceuti	Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella
US7125904B2 (en)	2002-10-11	2006-10-24	Portela & C.A., S.A.	Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2803582A1 (de) *	1978-01-27	1979-08-02	Sandoz Ag	Neue tetralinderivate, ihre herstellung und verwendung
JPS639500B2 (da) *	1978-07-14	1988-02-29	Amerikan Hosupitaru Sapurai Corp
US4885308A (en) *	1984-08-13	1989-12-05	Nelson Research & Development Co.	Method and compositions for treatment of parkinsonism syndrome in mammals
US4593042A (en) *	1985-10-18	1986-06-03	G. D. Searle & Co.	Bicyclo-substituted phenylacetonitrile derivatives
US4975461A (en) *	1986-06-19	1990-12-04	E. R. Squibb & Sons, Inc.	P-aminophenols, derivatives thereof and method of use
IT1199339B (it) *	1986-12-23	1988-12-30	Sigma Tau Ind Farmaceuti	N-alchil derivati della 2-ammino-6,7-dimetossi tetralina,procedimenti per la loro preparazione e composizioni farmaceutiche ad attivita'an tiipertensiva che li contengono

1990
- 1990-06-15 IT IT48066A patent/IT1241988B/it active IP Right Grant
1991
- 1991-06-13 AT AT91830261T patent/ATE129232T1/de not_active IP Right Cessation
- 1991-06-13 ES ES91830261T patent/ES2078497T3/es not_active Expired - Lifetime
- 1991-06-13 DE DE69113893T patent/DE69113893T2/de not_active Expired - Fee Related
- 1991-06-13 DK DK91830261.3T patent/DK0466662T3/da active
- 1991-06-13 EP EP91830261A patent/EP0466662B1/en not_active Expired - Lifetime
- 1991-06-14 JP JP3143211A patent/JP2875061B2/ja not_active Expired - Fee Related
1995
- 1995-10-19 GR GR950401870T patent/GR3017813T3/el unknown
1996
- 1996-04-29 US US08/639,431 patent/US5637614A/en not_active Expired - Fee Related
1997
- 1997-06-09 US US08/871,050 patent/US5962525A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0466662A2 (en)	1992-01-15
JP2875061B2 (ja)	1999-03-24
JPH04230247A (ja)	1992-08-19
US5962525A (en)	1999-10-05
HK1005862A1 (en)	1999-01-29
DE69113893D1 (de)	1995-11-23
ES2078497T3 (es)	1995-12-16
IT1241988B (it)	1994-02-02
US5637614A (en)	1997-06-10
GR3017813T3 (en)	1996-01-31
EP0466662B1 (en)	1995-10-18
IT9048066A1 (it)	1991-12-15
EP0466662A3 (en)	1992-12-09
ATE129232T1 (de)	1995-11-15
DE69113893T2 (de)	1996-04-04
IT9048066A0 (it)	1990-06-15

Publication	Publication Date	Title
TR199501253A2 (tr)	1996-06-21	Amino(tio) eter türevleri.
DK0622361T3 (da)	2001-12-03	Heterocykliske forbindelser som bradykininantagonister
ES2176204T3 (es)	2002-12-01	Antidepresivos que contienen un derivado de xantina.
ATE156116T1 (de)	1997-08-15	Auf aromatischen sulfonamiden basierende hydroxamsäurederivate
DE69122418D1 (de)	1996-11-07	Arzneimittellösung enhaltend Derivate von FK506
ATE194335T1 (de)	2000-07-15	4,5-diaryloxazol-derivate
MX9300222A (es)	1993-07-01	Nuevos derivados de arilcicloalquilo, su preparacion y su utilizacion.
DE69511424D1 (de)	1999-09-16	Antifungale sordaridinderivate
NO923721L (no)	1992-11-23	4-desoksy-4-epipodophyllotoxin-derivat eller farmasoeytiskakseptabelt salt derav
ATE156486T1 (de)	1997-08-15	Fungizide 3,4-diaryl-(5h)-furan-2-onederivate
EP0466662A3 (en)	1992-12-09	6,7-disubstituted-2-aminotetralines active as immunomodulators and pharmaceutical compositions containing same
SE8005784L (sv)	1981-02-18	Heterocykliska foreningar
ES2140524T3 (es)	2000-03-01	Derivados de metotrexato.
AU597923B2 (en)	1990-06-14	5-aminoalkyl-beta-carboline derivatives, their production and their use as drugs
ATE140460T1 (de)	1996-08-15	Echinocandin-b-derivat
NO910309L (no)	1991-07-29	Fremgangsmaate for fremstilling samt anvedelse av et nytt antibiotisk deoksymulundocandin.
FI904449A0 (fi)	1990-09-10	N-azasicyklo/3.3.0/oktanamider av aromatiska syror.
ATE127806T1 (de)	1995-09-15	Antibiotikverbindungen und ihre herstellung.
FI921475A0 (fi)	1992-04-03	1,4-dihydro-4-oxo-3-kinolinderivat som selektivt toxiska antibakteriella aemenn hos daeggdjur.
ATE97408T1 (de)	1993-12-15	Fungizide heterozyklische stickstoffverbindungen.
TH17540A (th)	1996-01-23	อนุพันธ์ของเบนซีนซัลโฟแนมีด และกรรมวิธีเตรียมสาร?เหล่านั้น
ATE113047T1 (de)	1994-11-15	2-fluorneplanocin a und seine herstellung.