DK0471706T3 - Fremgangsmåde til fremstilling af L-alfa-glycerylphosphorylcholin og L-alfa-glycerylphosphorylethanolamin - Google Patents

Fremgangsmåde til fremstilling af L-alfa-glycerylphosphorylcholin og L-alfa-glycerylphosphorylethanolamin

Info

Publication number: DK0471706T3
Authority: DK; Denmark
Prior art keywords: pct; alpha; glycerylphosphorylethanolamine; glycerylphosphorylcholine; date nov
Prior art date: 1989-05-08

Application number

DK90906950.2T

Other languages

Danish (da)

English (en)

Inventor

Giovanni Tronconi

Original Assignee

Prime Europ Therapeuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-08

Filing date

1990-05-04

Publication date

1994-11-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11166558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0471706(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-05-04 Application filed by Prime Europ Therapeuticals filed Critical Prime Europ Therapeuticals

1994-11-21 Application granted granted Critical

1994-11-21 Publication of DK0471706T3 publication Critical patent/DK0471706T3/da

Links

239000008777 Glycerylphosphorylcholine Substances 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 title 1
SUHOQUVVVLNYQR-MRVPVSSYSA-O glycerylphosphorylcholine Chemical compound C[N+](C)(C)CCO[P@](O)(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-O 0.000 abstract 3
229960004956 glycerylphosphorylcholine Drugs 0.000 abstract 3
FRMZOWIQVCBEAC-UHFFFAOYSA-N glycerylphosphorylethanolamine Chemical compound OCCN(P(O)(O)=O)CC(O)CO FRMZOWIQVCBEAC-UHFFFAOYSA-N 0.000 abstract 3
239000011347 resin Substances 0.000 abstract 3
229920005989 resin Polymers 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 2
238000005406 washing Methods 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002091 cationic group Chemical group 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK90906950.2T 1989-05-08 1990-05-04 Fremgangsmåde til fremstilling af L-alfa-glycerylphosphorylcholin og L-alfa-glycerylphosphorylethanolamin DK0471706T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8920413A IT1229238B (it)	1989-05-08	1989-05-08	Procedimento per la preparazione di l-alfa-glicerilfosforilcolina e l alfa glicerilfosforiletanolammina.

Publications (1)

Publication Number	Publication Date
DK0471706T3 true DK0471706T3 (da)	1994-11-21

Family

ID=11166558

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90906950.2T DK0471706T3 (da)	1989-05-08	1990-05-04	Fremgangsmåde til fremstilling af L-alfa-glycerylphosphorylcholin og L-alfa-glycerylphosphorylethanolamin

Country Status (11)

Country	Link
US (1)	US5250719A (fr)
EP (1)	EP0471706B1 (fr)
JP (1)	JP2883202B2 (fr)
AT (1)	ATE109785T1 (fr)
AU (1)	AU5550490A (fr)
CA (1)	CA2055503C (fr)
DE (1)	DE69011516T2 (fr)
DK (1)	DK0471706T3 (fr)
ES (1)	ES2057561T3 (fr)
IT (1)	IT1229238B (fr)
WO (1)	WO1990013552A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE158295T1 (de) *	1991-07-04	1997-10-15	Asta Medica Ag	Verfahren zur herstellung von alkylphosphocholinen und reinherstellung derselben
GB9201371D0 (en) *	1992-01-22	1992-03-11	Enzymatix Ltd	Crystallisation process
IT1254991B (it) *	1992-06-24	1995-10-11	Chemi Spa	Procedimento per la preparazione di glicerofosfolipidi
US5917068A (en) *	1995-12-29	1999-06-29	Eastman Chemical Company	Polyunsaturated fatty acid and fatty acid ester mixtures free of sterols and phosphorus compounds
US6063946A (en) *	1996-01-26	2000-05-16	Eastman Chemical Company	Process for the isolation of polyunsaturated fatty acids and esters thereof from complex mixtures which contain sterols and phosphorus compounds
US6200624B1 (en)	1996-01-26	2001-03-13	Abbott Laboratories	Enteral formula or nutritional supplement containing arachidonic and docosahexaenoic acids
US5883273A (en) *	1996-01-26	1999-03-16	Abbott Laboratories	Polyunsaturated fatty acids and fatty acid esters free of sterols and phosphorus compounds
EP2297291A4 (fr) *	2008-06-02	2012-08-22	Univ Saskatchewan	Récupération de plusieurs composés et d'eau recyclage des résidus de distillation
US8658401B2 (en) *	2011-03-24	2014-02-25	Jiannan University	Method for preparing high purity L-α glycerylphosphorylcholine
ITVI20120063A1 (it) *	2012-03-22	2013-09-23	Fortom Chimica S R L	Procedimento per l'estrazione e raffinazione di fosfatidilcolina e altri fosfolipidi da lecitine vegetali
CN102875592A (zh) *	2012-09-29	2013-01-16	常熟富士莱医药化工有限公司	天然的L-α-甘油磷脂酰胆碱的制备方法
CN103172659A (zh) *	2013-03-29	2013-06-26	山东罗欣药业股份有限公司	L-α-甘油磷酰胆碱晶型化合物
WO2015108355A1 (fr) *	2014-01-15	2015-07-23	지준홍	Cristal de glycérylphosphorylcholine et son procédé de préparation
KR101616945B1 (ko)	2014-02-10	2016-04-29	엔자이텍 주식회사	라세믹 또는 광학적으로 활성이 있는 α―글리세로포스포릴 콜린의 제조방법
MX370921B (es)	2014-06-10	2020-01-09	Chemi Spa	Proceso para la purificación de l-alfa-glicerofosforilcolina.
RU2685238C1 (ru) *	2016-07-01	2019-04-17	Общество с ограниченной ответственностью "ФАРМАЦЕЛЬ"	Способ получения кристаллического глицерофосфатидилхолина
RU2635665C1 (ru) *	2017-02-16	2017-11-15	Общество с ограниченной ответственностью "БИОН"	Способ получения l-a-глицерофосфорилхолина фармакопейного качества
WO2023026449A1 (fr) *	2021-08-26	2023-03-02	協和発酵バイオ株式会社	Procédé de fabrication de composé d'acide cytidine－５'－diphosphorique
CN114106036A (zh) *	2021-11-08	2022-03-01	云南开放大学(云南国防工业职业技术学院)	一种L-α-甘油磷脂酰胆碱的分离提取方法
CN119161378A (zh) *	2023-06-19	2024-12-20	广州白云山汉方现代药业有限公司	一种同时制备高纯度鞘磷脂和甘油磷酸胆碱的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1543722A1 (de) *	1966-08-25	1969-09-11	Knoll Ag	Verfahren zur Gewinnung von reinen natuerlichen Cholinphosphorsaeurediglyceridestern
FR2587574B1 (fr) *	1985-09-18	1987-10-30	Commissariat Energie Atomique	Resistor pour le traitement de materiaux
IT1201477B (it) *	1985-10-04	1989-02-02	Istituto Chemioterapico	Procedimento per la preparazione di l-alfa-glicerilfosforilcolina,l-alfa-glicerilfosforiletanolommina e l-alfa-glicerilfosforilinositolo da lecitine grezze e/o deoleate

1989
- 1989-05-08 IT IT8920413A patent/IT1229238B/it active
1990
- 1990-05-04 ES ES90906950T patent/ES2057561T3/es not_active Expired - Lifetime
- 1990-05-04 DK DK90906950.2T patent/DK0471706T3/da active
- 1990-05-04 WO PCT/EP1990/000717 patent/WO1990013552A1/fr not_active Ceased
- 1990-05-04 CA CA002055503A patent/CA2055503C/fr not_active Expired - Fee Related
- 1990-05-04 JP JP2506592A patent/JP2883202B2/ja not_active Expired - Fee Related
- 1990-05-04 EP EP90906950A patent/EP0471706B1/fr not_active Expired - Lifetime
- 1990-05-04 AT AT90906950T patent/ATE109785T1/de not_active IP Right Cessation
- 1990-05-04 AU AU55504/90A patent/AU5550490A/en not_active Abandoned
- 1990-05-04 US US07/773,923 patent/US5250719A/en not_active Expired - Lifetime
- 1990-05-04 DE DE69011516T patent/DE69011516T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2055503A1 (fr)	1990-11-09
AU5550490A (en)	1990-11-29
JP2883202B2 (ja)	1999-04-19
IT8920413A0 (it)	1989-05-08
ATE109785T1 (de)	1994-08-15
DE69011516T2 (de)	1994-12-08
EP0471706B1 (fr)	1994-08-10
JPH04505013A (ja)	1992-09-03
CA2055503C (fr)	2000-01-18
DE69011516D1 (de)	1994-09-15
US5250719A (en)	1993-10-05
IT1229238B (it)	1991-07-26
EP0471706A1 (fr)	1992-02-26
ES2057561T3 (es)	1994-10-16
WO1990013552A1 (fr)	1990-11-15

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