DK0473671T3 - Anvendelse af sigma-receptorligander til fremstilling af et anxiolytisk middel - Google Patents

Anvendelse af sigma-receptorligander til fremstilling af et anxiolytisk middel

Info

Publication number: DK0473671T3
Authority: DK; Denmark
Prior art keywords: prepare; sigma receptor; receptor ligands; anxiolytic agent; anxiolytic
Prior art date: 1989-05-02

Application number

DK90908385.9T

Other languages

English (en)

Inventor

Eckard Weber

John F W Keana

Original Assignee

Oregon State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-02

Filing date

1990-05-02

Publication date

1994-09-19

1990-05-02 Application filed by Oregon State filed Critical Oregon State

1994-09-19 Application granted granted Critical

1994-09-19 Publication of DK0473671T3 publication Critical patent/DK0473671T3/da

Links

239000002249 anxiolytic agent Substances 0.000 title abstract 2
239000003982 sigma receptor ligand Substances 0.000 title 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
-1 N,N'-disubstituted guanidine Chemical class 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
108010085082 sigma receptors Proteins 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

DK90908385.9T 1989-05-02 1990-05-02 Anvendelse af sigma-receptorligander til fremstilling af et anxiolytisk middel DK0473671T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34649489A	1989-05-02	1989-05-02

Publications (1)

Publication Number	Publication Date
DK0473671T3 true DK0473671T3 (da)	1994-09-19

Family

ID=23359655

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90908385.9T DK0473671T3 (da)	1989-05-02	1990-05-02	Anvendelse af sigma-receptorligander til fremstilling af et anxiolytisk middel

Country Status (9)

Country	Link
EP (1)	EP0473671B1 (da)
JP (1)	JPH05500798A (da)
AT (1)	ATE110265T1 (da)
AU (1)	AU642881B2 (da)
CA (1)	CA2054211A1 (da)
DE (1)	DE69011859T2 (da)
DK (1)	DK0473671T3 (da)
ES (1)	ES2057568T3 (da)
WO (1)	WO1990014067A2 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5312840A (en) *	1986-07-10	1994-05-17	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education	Substituted guanidines having high binding to the sigma receptor and the use thereof
US5385946A (en) *	1986-07-10	1995-01-31	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	Method for treating hypertension with disubstituted granidine compounds
IE910719A1 (en)	1990-03-02	1991-09-11	Oregon State	Tri- and tetra-substituted guanidines and their use as¹excitatory amino acid and antagonists
US5262568A (en) *	1990-03-02	1993-11-16	State Of Oregon	Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
JPH05508836A (ja) *	1990-05-25	1993-12-09	オレゴン州	シグマ受容体に対して高い結合性を有する置換グアニジンおよびその使用
US5741661A (en) *	1991-02-08	1998-04-21	Cambridge Neuroscience, Inc.	Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers
EP0940139B1 (en) *	1991-02-08	2005-02-02	Scion Pharmaceuticals, Inc.	Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers
US5847006A (en) *	1991-02-08	1998-12-08	Cambridge Neuroscience, Inc.	Therapeutic guanidines
NZ243065A (en) *	1991-06-13	1995-07-26	Lundbeck & Co As H	Piperidine derivatives and pharmaceutical compositions
DK78692D0 (da) *	1992-06-12	1992-06-12	Lundbeck & Co As H	Dimere piperidin- og piperazinderivater
JP3610368B2 (ja) *	1993-05-27	2005-01-12	セネスリミティド	治療用置換グアニジン
WO1995014467A1 (en) *	1993-11-22	1995-06-01	Cambridge Neuroscience, Inc.	Therapeutic guanidines
WO1995014461A1 (en) *	1993-11-23	1995-06-01	Cambridge Neuroscience, Inc.	Therapeutic substituted guanidines
AU1912595A (en)	1994-02-03	1995-08-21	Cambridge Neuroscience, Inc.	Therapeutic guanidines
US6787569B1 (en)	1994-02-03	2004-09-07	Cambridge Neuroscience, Inc.	Therapeutic guanidines
US7351743B1 (en)	1994-02-03	2008-04-01	Wyeth	Therapeutic guanidines
US6143791A (en) *	1994-02-03	2000-11-07	Cambridge Neuroscience, Inc.	Therapeutic guanidines
WO1995023132A1 (en) *	1994-02-23	1995-08-31	Cambridge Neuroscience, Inc.	Blockers of ion channels and methods of use thereof
US6756389B2 (en)	1996-08-09	2004-06-29	Cambridge Neuroscience, Inc.	Pharmaceutically active compounds and methods of use
US6875759B1 (en)	1999-07-21	2005-04-05	Kadmus Pharmaceuticals	Substituted guanidines and the use thereof
EP1749824A1 (en)	2005-08-03	2007-02-07	Neuro3D	Benzodiazepine derivatives, their preparation and the therapeutic use thereof
WO2007022964A2 (de)	2005-08-24	2007-03-01	Abbott Gmbh & Co. Kg	Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
WO2007047978A2 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
EP2314289A1 (en)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2021000A2 (en)	2006-05-09	2009-02-11	Braincells, Inc.	Neurogenesis by modulating angiotensin
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
WO2014015157A2 (en) *	2012-07-19	2014-01-23	Philadelphia Health & Education Corporation	Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same
US11117870B2 (en)	2017-11-01	2021-09-14	Drexel University	Compounds, compositions, and methods for treating diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4709094A (en) *	1986-07-10	1987-11-24	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	Sigma brain receptor ligands and their use

1990
- 1990-05-02 DE DE69011859T patent/DE69011859T2/de not_active Expired - Fee Related
- 1990-05-02 EP EP90908385A patent/EP0473671B1/en not_active Expired - Lifetime
- 1990-05-02 JP JP2508151A patent/JPH05500798A/ja active Pending
- 1990-05-02 CA CA002054211A patent/CA2054211A1/en not_active Abandoned
- 1990-05-02 ES ES90908385T patent/ES2057568T3/es not_active Expired - Lifetime
- 1990-05-02 AT AT90908385T patent/ATE110265T1/de not_active IP Right Cessation
- 1990-05-02 AU AU57287/90A patent/AU642881B2/en not_active Ceased
- 1990-05-02 DK DK90908385.9T patent/DK0473671T3/da active
- 1990-05-02 WO PCT/US1990/002398 patent/WO1990014067A2/en not_active Ceased

Also Published As

Publication number	Publication date
JPH05500798A (ja)	1993-02-18
DE69011859T2 (de)	1994-12-15
WO1990014067A2 (en)	1990-11-29
EP0473671A1 (en)	1992-03-11
AU5728790A (en)	1990-12-18
ATE110265T1 (de)	1994-09-15
CA2054211A1 (en)	1990-11-03
EP0473671B1 (en)	1994-08-24
WO1990014067A3 (en)	1991-04-04
DE69011859D1 (de)	1994-09-29
EP0473671A4 (en)	1992-04-01
ES2057568T3 (es)	1994-10-16
AU642881B2 (en)	1993-11-04

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