ES2057568T3 - Metodos para tratar la ansiedad con ligandos de receptores sigma. - Google Patents

Metodos para tratar la ansiedad con ligandos de receptores sigma.

Info

Publication number
ES2057568T3
ES2057568T3 ES90908385T ES90908385T ES2057568T3 ES 2057568 T3 ES2057568 T3 ES 2057568T3 ES 90908385 T ES90908385 T ES 90908385T ES 90908385 T ES90908385 T ES 90908385T ES 2057568 T3 ES2057568 T3 ES 2057568T3
Authority
ES
Spain
Prior art keywords
anxiety
deal
methods
receiver links
sigma receiver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90908385T
Other languages
English (en)
Inventor
John F W Keana
Eckard Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
State Of Oregon By & Through O
Oregon Health and Science University
Original Assignee
State Of Oregon By & Through O
Oregon Health and Science University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by State Of Oregon By & Through O, Oregon Health and Science University filed Critical State Of Oregon By & Through O
Application granted granted Critical
Publication of ES2057568T3 publication Critical patent/ES2057568T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO PARA EL TRATAMIENTO O PROFILAXIS DE LA ANSIEDAD DE ANIMALES QUE CONSISTE EN ADMINISTRAR UNA CANTIDAD ANXIOLITICA DE UNA GUANIDINA N,N''-DISUSTITUIDA QUE TIENE UNA GRAN AFINIDAD CON EL RECEPTOR DE SIGMA.
ES90908385T 1989-05-02 1990-05-02 Metodos para tratar la ansiedad con ligandos de receptores sigma. Expired - Lifetime ES2057568T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34649489A 1989-05-02 1989-05-02

Publications (1)

Publication Number Publication Date
ES2057568T3 true ES2057568T3 (es) 1994-10-16

Family

ID=23359655

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90908385T Expired - Lifetime ES2057568T3 (es) 1989-05-02 1990-05-02 Metodos para tratar la ansiedad con ligandos de receptores sigma.

Country Status (9)

Country Link
EP (1) EP0473671B1 (es)
JP (1) JPH05500798A (es)
AT (1) ATE110265T1 (es)
AU (1) AU642881B2 (es)
CA (1) CA2054211A1 (es)
DE (1) DE69011859T2 (es)
DK (1) DK0473671T3 (es)
ES (1) ES2057568T3 (es)
WO (1) WO1990014067A2 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312840A (en) * 1986-07-10 1994-05-17 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education Substituted guanidines having high binding to the sigma receptor and the use thereof
US5502255A (en) * 1986-07-10 1996-03-26 State Of Oregon Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Substituted guanidines having high binding to the sigma receptor and the use thereof
US5262568A (en) * 1990-03-02 1993-11-16 State Of Oregon Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
CA2076664C (en) 1990-03-02 2004-01-13 Eckard Weber Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
WO1991018868A1 (en) * 1990-05-25 1991-12-12 STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY Substituted guanidines having high binding to the sigma receptor and the use thereof
US5847006A (en) * 1991-02-08 1998-12-08 Cambridge Neuroscience, Inc. Therapeutic guanidines
DE69230220T2 (de) * 1991-02-08 2000-06-21 Cambridge Neuroscience Research, Inc. Substituierte guanidine und derivate hiervon als modulatoren der freisetzung von neurotransmittern und neue methode zur identifizierung von inhibitoren der neurotransmitter-freisetzung
US5741661A (en) * 1991-02-08 1998-04-21 Cambridge Neuroscience, Inc. Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
KR20030097618A (ko) * 1993-05-27 2003-12-31 캠브리지 뉴로사이언스, 인코포레이티드 치료용 치환 구아니딘류
CA2177084A1 (en) * 1993-11-22 1995-06-01 Sharad Magar Therapeutic guanidines
WO1995014461A1 (en) * 1993-11-23 1995-06-01 Cambridge Neuroscience, Inc. Therapeutic substituted guanidines
US6787569B1 (en) 1994-02-03 2004-09-07 Cambridge Neuroscience, Inc. Therapeutic guanidines
JPH09509156A (ja) 1994-02-03 1997-09-16 ケンブリッジ・ニューロサイエンス・インコーポレーテッド 治療用グアニジン類
US7351743B1 (en) 1994-02-03 2008-04-01 Wyeth Therapeutic guanidines
US6143791A (en) * 1994-02-03 2000-11-07 Cambridge Neuroscience, Inc. Therapeutic guanidines
WO1995023132A1 (en) * 1994-02-23 1995-08-31 Cambridge Neuroscience, Inc. Blockers of ion channels and methods of use thereof
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6875759B1 (en) 1999-07-21 2005-04-05 Kadmus Pharmaceuticals Substituted guanidines and the use thereof
EP1749824A1 (en) 2005-08-03 2007-02-07 Neuro3D Benzodiazepine derivatives, their preparation and the therapeutic use thereof
EP1917244A2 (de) 2005-08-24 2008-05-07 Abbott GmbH & Co. KG Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CA2879454A1 (en) 2012-07-19 2014-01-23 Drexel University Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same
WO2019089902A1 (en) 2017-11-01 2019-05-09 Drexel University Compounds, compositions, and methods for treating diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4709094A (en) * 1986-07-10 1987-11-24 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Sigma brain receptor ligands and their use

Also Published As

Publication number Publication date
DK0473671T3 (da) 1994-09-19
JPH05500798A (ja) 1993-02-18
AU642881B2 (en) 1993-11-04
WO1990014067A3 (en) 1991-04-04
AU5728790A (en) 1990-12-18
DE69011859D1 (de) 1994-09-29
EP0473671A1 (en) 1992-03-11
ATE110265T1 (de) 1994-09-15
WO1990014067A2 (en) 1990-11-29
EP0473671A4 (en) 1992-04-01
EP0473671B1 (en) 1994-08-24
DE69011859T2 (de) 1994-12-15
CA2054211A1 (en) 1990-11-03

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