DK0474012T3 - 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-oner og -oler, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler - Google Patents

6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-oner og -oler, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Info

Publication number: DK0474012T3
Authority: DK; Denmark
Prior art keywords: chem; formula; loweralkyl; hydrogen; arylloweralkyl
Prior art date: 1990-08-23

Application number

DK91113867.5T

Other languages

English (en)

Inventor

David Gordon Wettlaufer

Peter Allen Nemoto

Gregory Michael Shutske

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-23

Filing date

1991-08-19

Publication date

1997-05-12

1991-08-19 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1997-05-12 Application granted granted Critical

1997-05-12 Publication of DK0474012T3 publication Critical patent/DK0474012T3/da

Links

BULWOEVOVZGNII-UHFFFAOYSA-N 3-phenyl-6,7-dihydro-5h-1,2-benzoxazol-4-one Chemical class C1=2C(=O)CCCC=2ON=C1C1=CC=CC=C1 BULWOEVOVZGNII-UHFFFAOYSA-N 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
-1 1-piperazinyl Chemical group 0.000 abstract 10
239000001257 hydrogen Substances 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 7
150000002431 hydrogen Chemical group 0.000 abstract 5
125000003118 aryl group Chemical group 0.000 abstract 2
125000004430 oxygen atom Chemical group O* 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002757 morpholinyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

DK91113867.5T 1990-08-23 1991-08-19 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-oner og -oler, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler DK0474012T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57148290A	1990-08-23	1990-08-23
US07/692,341 US5114936A (en)	1990-08-23	1991-04-26	6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use

Publications (1)

Publication Number	Publication Date
DK0474012T3 true DK0474012T3 (da)	1997-05-12

Family

ID=27075593

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91113867.5T DK0474012T3 (da)	1990-08-23	1991-08-19	6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-oner og -oler, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Country Status (20)

Country	Link
US (1)	US5114936A (da)
EP (1)	EP0474012B1 (da)
JP (1)	JP3018619B2 (da)
KR (1)	KR0173685B1 (da)
AT (1)	ATE145644T1 (da)
AU (1)	AU634944B2 (da)
CA (1)	CA2049733C (da)
CS (1)	CS260191A3 (da)
DE (1)	DE69123315T2 (da)
DK (1)	DK0474012T3 (da)
ES (1)	ES2095277T3 (da)
FI (1)	FI913957L (da)
GR (1)	GR3022697T3 (da)
HU (1)	HU215439B (da)
IE (1)	IE76138B1 (da)
IL (1)	IL99264A (da)
NO (1)	NO913292L (da)
NZ (1)	NZ239494A (da)
PT (1)	PT98747B (da)
YU (1)	YU142991A (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5114960A (en) *	1989-07-20	1992-05-19	Hoffmann-La Roche Inc.	Substituted isoxazole derivatives
US5225412A (en) *	1991-04-29	1993-07-06	Hoechst-Roussel Pharmaceuticals Incorporated	Benzoisothiazole-and benzisoxazole-3-carboxamides
US5143923B1 (en) *	1991-04-29	1993-11-02	Hoechst-Roussel Pharmaceuticals Incorporated	Benzoisothiazole-and benzisoxazole-3-carboxamides
GB2264299B (en) *	1992-02-19	1995-07-26	British Tech Group	Iso-oxazolidine derivatives
GB9226857D0 (en) *	1992-12-23	1993-02-17	Boyd Edward A	Pharmaceutical compositions
GB2284600A (en) *	1994-01-21	1995-06-14	Shell Int Research	Herbicidal 3-(hetero)aryl-4-acylisoxazole compositions and compounds
US7091199B1 (en)	1999-09-14	2006-08-15	Aventis Pharmaceuticals Inc.	Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
PT1216244E (pt) *	1999-09-14	2003-12-31	Aventis Pharma Inc	Derivados de benzisoxazolil- piridoisoxazolil- e benztienil-fenoxi uteis como antagonistas d4
US7125903B1 (en)	1999-09-14	2006-10-24	Aventis Pharmaceuticals Inc.	Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7253165B2 (en) *	1999-09-14	2007-08-07	Aventis Pharmaceuticals Inc.	Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
EP1484325B1 (en)	2002-03-08	2014-06-18	Japan Science and Technology Agency	Isoxazole derivatives and process for producing the same
US6770659B2 (en)	2002-08-26	2004-08-03	Sk Corporation	Benzoyl piperidine compounds
EP1997370B1 (en)	2006-03-22	2012-02-29	Kabushiki Kaisha Tominaga Jyushi Kogyosho	Filter device for water tank
ATE530065T1 (de)	2006-08-25	2011-11-15	Tominaga Jyushi Kogyosho Kk	Überlaufvorrichtung für wassertank
JP6133427B2 (ja) *	2012-09-14	2017-05-24	スパーナスファーマシューティカルズインコーポレイテッド	モリンドン及びその塩の製造方法
SG11202100011VA (en) *	2018-07-23	2021-02-25	Sumitomo Dainippon Pharma Co Ltd	Condensed lactam derivative
US10745401B2 (en)	2018-07-23	2020-08-18	Sumitomo Dainippon Pharma Co., Ltd.	Condensed lactam derivative
WO2023083445A1 (en)	2021-11-10	2023-05-19	Symrise Ag	Compositions comprising trpm8 agonistic cooling agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4010176A (en) *	1972-10-27	1977-03-01	Merck & Co., Inc.	Isoxazole substituted nitroimidazoles
US4217349A (en) *	1974-07-01	1980-08-12	Sumitomo Chemical Company, Limited	Benzisoxazole derivatives
US4156005A (en) *	1978-06-21	1979-05-22	Merck & Co., Inc.	Derivatives of 1,2-benzisoxazoles
GB2024008B (en) *	1978-06-28	1983-02-16	Merck & Co Inc	Compositions for treating trypanosomiasis infections
DE3267658D1 (en) *	1981-04-27	1986-01-09	Hoechst Roussel Pharma	1-(3-(6-fluoro-1,2-benzisoxasol-3-yl)propyl)-4-hydroxy-4-phenylpiperidines, a process for their preparation and their use as medicaments
IL66866A (en) *	1982-04-09	1987-08-31	Hoechst Roussel Pharma	1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and-piperidines,a process for the preparation thereof,and pharmaceutical compositions containing them
US4458075A (en) *	1982-04-09	1984-07-03	Hoechst-Roussel Pharmaceuticals Inc.	6-Fluoro-3-[3-(1-heterocyclo)propyl]-1,2-benzisoxazoles
DE3586794T2 (de) *	1984-12-21	1993-05-27	Duphar Int Res	Arzneimittel mit psychotroper wirkung.
US4994455A (en) *	1987-10-26	1991-02-19	Pfizer Inc.	Anti-anxiety agents
US5114960A (en) *	1989-07-20	1992-05-19	Hoffmann-La Roche Inc.	Substituted isoxazole derivatives

1991
- 1991-04-26 US US07/692,341 patent/US5114936A/en not_active Expired - Fee Related
- 1991-08-19 EP EP91113867A patent/EP0474012B1/en not_active Expired - Lifetime
- 1991-08-19 ES ES91113867T patent/ES2095277T3/es not_active Expired - Lifetime
- 1991-08-19 AT AT91113867T patent/ATE145644T1/de not_active IP Right Cessation
- 1991-08-19 DE DE69123315T patent/DE69123315T2/de not_active Expired - Fee Related
- 1991-08-19 DK DK91113867.5T patent/DK0474012T3/da active
- 1991-08-21 IL IL9926491A patent/IL99264A/en active IP Right Grant
- 1991-08-21 NZ NZ239494A patent/NZ239494A/en unknown
- 1991-08-21 YU YU142991A patent/YU142991A/sh unknown
- 1991-08-21 HU HU912756A patent/HU215439B/hu not_active IP Right Cessation
- 1991-08-21 FI FI913957A patent/FI913957L/fi not_active Application Discontinuation
- 1991-08-22 CA CA002049733A patent/CA2049733C/en not_active Expired - Fee Related
- 1991-08-22 PT PT98747A patent/PT98747B/pt not_active IP Right Cessation
- 1991-08-22 JP JP3210691A patent/JP3018619B2/ja not_active Expired - Fee Related
- 1991-08-22 NO NO91913292A patent/NO913292L/no unknown
- 1991-08-22 AU AU82617/91A patent/AU634944B2/en not_active Ceased
- 1991-08-22 IE IE297691A patent/IE76138B1/en not_active IP Right Cessation
- 1991-08-22 KR KR1019910014488A patent/KR0173685B1/ko not_active Expired - Fee Related
- 1991-08-22 CS CS912601A patent/CS260191A3/cs unknown
1997
- 1997-02-27 GR GR970400378T patent/GR3022697T3/el unknown

Also Published As

Publication number	Publication date
DE69123315D1 (de)	1997-01-09
ES2095277T3 (es)	1997-02-16
IL99264A0 (en)	1992-07-15
ATE145644T1 (de)	1996-12-15
EP0474012B1 (en)	1996-11-27
AU8261791A (en)	1991-11-07
AU634944B2 (en)	1993-03-04
YU142991A (sh)	1995-01-31
NO913292D0 (no)	1991-08-22
IL99264A (en)	1996-01-19
KR920004366A (ko)	1992-03-27
IE912976A1 (en)	1992-02-26
NZ239494A (en)	1994-08-26
GR3022697T3 (en)	1997-05-31
PT98747A (pt)	1992-07-31
HUT61533A (en)	1993-01-28
HU912756D0 (en)	1992-01-28
FI913957A0 (fi)	1991-08-21
US5114936A (en)	1992-05-19
FI913957A7 (fi)	1992-02-24
EP0474012A1 (en)	1992-03-11
KR0173685B1 (ko)	1999-02-01
IE76138B1 (en)	1997-10-08
HU215439B (hu)	1999-09-28
CA2049733A1 (en)	1992-02-24
DE69123315T2 (de)	1997-05-22
FI913957L (fi)	1992-02-24
PT98747B (pt)	1999-01-29
CS260191A3 (en)	1992-04-15
JPH04230673A (ja)	1992-08-19
NO913292L (no)	1992-02-24
CA2049733C (en)	2003-10-21
JP3018619B2 (ja)	2000-03-13

Publication	Publication Date	Title
DK0474012T3 (da)	1997-05-12	6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-oner og -oler, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
DK0417584T3 (da)	1998-09-23	N-Substituerede 4-pyrimidinaminer og -pyrimidindiaminer, fremgangsmåde til deres fremstilling og deres anvendelser som læge
DE69522703D1 (de)	2001-10-18	Aminotetrazol-derivate verwendbar als stickstoff-oxid-synthase inhibitoren
ATE180780T1 (de)	1999-06-15	2-(piperidin-4-yl, pyridin-4-yl und tetrahydropyridin-4-yl)-benzofuran-7-carbamat derivate, ihre herstellung und verwendung als acetylcholinesterase inhibitoren
FI903818A0 (fi)	1990-07-31	1-(pyridinylamino)-2-pyrrolidoner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
NO179006C (no)	1996-07-17	Analogifremgangsmåte for fremstilling av terapeutisk virksomme 1,3-dioxolanderivater
ATE130002T1 (de)	1995-11-15	1-(pyridinylalkyl)-1h-indole, -indoline und analoge.
HU9600597D0 (en)	1996-05-28	4-alkylthio-pyrimidin-5-yl acetic acid derivates and fungicidal compositions containing them as an active ingredient
AU646611B2 (en)	1994-02-24	4-{4- or 6-(trifluoromethyl-2-pyridinyl)}-1-piperazinyl- alkyl substituted lactams
MY111604A (en)	2000-09-27	Piperidinyl compounds
NO913141D0 (no)	1991-08-12	Karbamoyl-1-(pyridinylalkyl)-1h-indoler, indoliner og beslektede analoger.