DK0475411T3 - Nye carbocycliske adenosinanaloge til anvendelse som immunsuppressiva - Google Patents

Nye carbocycliske adenosinanaloge til anvendelse som immunsuppressiva

Info

Publication number: DK0475411T3
Authority: DK; Denmark
Prior art keywords: immunosuppressants; adenosine analogues; carbocyclic adenosine; new carbocyclic; new
Prior art date: 1990-09-14

Application number

DK91115485T

Other languages

English (en)

Inventor

Iii Carl K Edwards

Douglas L Cole

David R Borcherding

Ronald E Esser

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-14

Filing date

1991-09-12

Publication date

2001-10-01

1991-09-12 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2001-10-01 Application granted granted Critical

2001-10-01 Publication of DK0475411T3 publication Critical patent/DK0475411T3/da

Links

150000003838 adenosines Chemical class 0.000 title 1
229960003444 immunosuppressant agent Drugs 0.000 title 1
239000003018 immunosuppressive agent Substances 0.000 title 1
XUGWUUDOWNZAGW-UHFFFAOYSA-N neplanocin A Natural products C1=NC=2C(N)=NC=NC=2N1C1C=C(CO)C(O)C1O XUGWUUDOWNZAGW-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

DK91115485T 1990-09-14 1991-09-12 Nye carbocycliske adenosinanaloge til anvendelse som immunsuppressiva DK0475411T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US58228090A	1990-09-14	1990-09-14
US74817291A	1991-08-23	1991-08-23

Publications (1)

Publication Number	Publication Date
DK0475411T3 true DK0475411T3 (da)	2001-10-01

Family

ID=27078528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91115485T DK0475411T3 (da)	1990-09-14	1991-09-12	Nye carbocycliske adenosinanaloge til anvendelse som immunsuppressiva

Country Status (19)

Country	Link
EP (1)	EP0475411B1 (da)
JP (1)	JP3099280B2 (da)
KR (1)	KR100249111B1 (da)
CN (1)	CN1031132C (da)
AR (1)	AR247566A1 (da)
AT (1)	ATE202106T1 (da)
AU (1)	AU647822B2 (da)
CA (1)	CA2051012C (da)
DE (1)	DE69132632T2 (da)
DK (1)	DK0475411T3 (da)
ES (1)	ES2158840T3 (da)
FI (1)	FI102755B1 (da)
GR (1)	GR3036577T3 (da)
HU (1)	HU209304B (da)
IE (1)	IE913247A1 (da)
IL (1)	IL99466A (da)
NO (1)	NO179908C (da)
NZ (1)	NZ239750A (da)
PT (1)	PT98943B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5470857A (en) *	1990-09-14	1995-11-28	Marion Merrell Dow Inc.	Carbocyclic nucleoside analogs useful as immunosuppressants
AU642526B2 (en) *	1990-09-14	1993-10-21	Marion Merrell Dow Inc.	Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
US5723466A (en) *	1991-12-06	1998-03-03	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817672A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817660A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
CA2084222C (en) *	1991-12-06	2004-04-06	David R. Borcherding	Novel trans cyclopentanyl purine analogs useful as immunosuppressants
US5817661A (en)	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5292513A (en) *	1992-05-18	1994-03-08	Anthony G. Gristina	Method for nonspecific cellular immune stimulation
ATE177101T1 (de)	1992-12-17	1999-03-15	Pfizer	Pyrrolopyrimidine als crf antagonisten
ES2103131T3 (es) *	1993-06-21	1997-08-16	Merrell Pharma Inc	Nuevos agentes de nucleosido carbociclico utiles como inhibidores selectivos de citoquinas proinflamatorias.
HUT74989A (en) *	1993-11-12	1997-03-28	Merrell Pharma Inc	6-oxo-nucleosides useful as immunosuppressants
TW282470B (da) *	1993-11-18	1996-08-01	Ajinomoto Kk
EP0682027B1 (de) *	1994-05-03	1997-10-15	Novartis AG	Pyrrolopyrimidinderivate mit antiproliferativer Wirkung
TW530047B (en) *	1994-06-08	2003-05-01	Pfizer	Corticotropin releasing factor antagonists
US6403599B1 (en)	1995-11-08	2002-06-11	Pfizer Inc	Corticotropin releasing factor antagonists
US6956047B1 (en)	1995-06-06	2005-10-18	Pfizer Inc.	Corticotropin releasing factor antagonists
US7125880B1 (en)	1995-06-06	2006-10-24	Pfizer Inc.	Corticotropin releasing factor antagonists
HRP20020599A2 (en)	2000-01-18	2004-08-31	Pfizer Prod Inc	Corticotropin releasing factor antagonists
CA2536887C (en) *	2003-08-26	2012-03-06	Teijin Pharma Limited	Pyrrolopyrimidinone derivatives
US8945505B2 (en)	2007-02-02	2015-02-03	Panaphix, Inc.	Use of arsenic compounds for treatment of pain and inflammation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3551428A (en) *	1956-02-10	1970-12-29	Ciba Geigy Corp	New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
US3917837A (en) *	1974-10-21	1975-11-04	American Cyanamid Co	Method of using trans-2-(6-amino-9H-purin-9-yl)-cyclopentanol
US4076711A (en) *	1976-04-05	1978-02-28	Schering Corporation	Triazolo [4,5-d]-pyrimidines
US4221794A (en) *	1979-06-21	1980-09-09	Newport Pharmaceuticals International, Inc.	Method of imparting immunomodulating and antiviral activity
US4386093A (en) *	1981-09-16	1983-05-31	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	(±)3-Deazaaristeromycin and uses
IN164556B (da) *	1986-03-06	1989-04-08	Takeda Chemical Industries Ltd
US4859677A (en) *	1987-04-17	1989-08-22	University Of Kansas	Nucleoside analogues having antiviral activity
US4782062A (en) *	1987-05-11	1988-11-01	Merck & Co., Inc.	9-(2-hydroxymethyl)cycloalkylmethyl) guanines
IL86381A0 (en) *	1987-05-19	1988-11-15	Nippon Kayaku Kk	Oxetanocins and pharmaceutical compositions containing the same
GB8826205D0 (en) *	1988-11-09	1988-12-14	Wellcome Found	Heterocyclic compounds

1991
- 1991-09-09 CA CA002051012A patent/CA2051012C/en not_active Expired - Lifetime
- 1991-09-09 AU AU83729/91A patent/AU647822B2/en not_active Ceased
- 1991-09-10 AR AR91320625A patent/AR247566A1/es active
- 1991-09-11 PT PT98943A patent/PT98943B/pt not_active IP Right Cessation
- 1991-09-11 NZ NZ239750A patent/NZ239750A/en unknown
- 1991-09-12 AT AT91115485T patent/ATE202106T1/de not_active IP Right Cessation
- 1991-09-12 EP EP91115485A patent/EP0475411B1/en not_active Expired - Lifetime
- 1991-09-12 ES ES91115485T patent/ES2158840T3/es not_active Expired - Lifetime
- 1991-09-12 DE DE69132632T patent/DE69132632T2/de not_active Expired - Lifetime
- 1991-09-12 DK DK91115485T patent/DK0475411T3/da active
- 1991-09-12 IL IL9946691A patent/IL99466A/en not_active IP Right Cessation
- 1991-09-13 FI FI914319A patent/FI102755B1/fi active
- 1991-09-13 HU HU912961A patent/HU209304B/hu not_active IP Right Cessation
- 1991-09-13 NO NO913625A patent/NO179908C/no not_active IP Right Cessation
- 1991-09-13 IE IE324791A patent/IE913247A1/en not_active Application Discontinuation
- 1991-09-13 JP JP03261249A patent/JP3099280B2/ja not_active Expired - Lifetime
- 1991-09-13 KR KR1019910015974A patent/KR100249111B1/ko not_active Expired - Fee Related
- 1991-09-14 CN CN91108934A patent/CN1031132C/zh not_active Expired - Fee Related
2001
- 2001-09-11 GR GR20010401434T patent/GR3036577T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR920006357A (ko)	1992-04-27
EP0475411A1 (en)	1992-03-18
PT98943B (pt)	1999-02-26
NO913625D0 (no)	1991-09-13
NO179908B (no)	1996-09-30
JP3099280B2 (ja)	2000-10-16
FI102755B (fi)	1999-02-15
IE913247A1 (en)	1992-02-25
PT98943A (pt)	1992-07-31
NO913625L (no)	1992-03-16
DE69132632T2 (de)	2002-04-18
KR100249111B1 (ko)	2000-08-01
CA2051012C (en)	2002-04-02
IL99466A0 (en)	1992-08-18
DE69132632D1 (de)	2001-07-19
HU209304B (en)	1994-04-28
AU647822B2 (en)	1994-03-31
FI914319L (fi)	1992-03-15
NZ239750A (en)	1994-02-25
CA2051012A1 (en)	1992-03-15
AR247566A1 (es)	1995-01-31
AU8372991A (en)	1992-03-19
FI914319A0 (fi)	1991-09-13
EP0475411B1 (en)	2001-06-13
ES2158840T3 (es)	2001-09-16
ATE202106T1 (de)	2001-06-15
FI102755B1 (fi)	1999-02-15
HUT59138A (en)	1992-04-28
CN1059909A (zh)	1992-04-01
CN1031132C (zh)	1996-02-28
HU912961D0 (en)	1992-01-28
JPH04270282A (ja)	1992-09-25
NO179908C (no)	1997-01-08
IL99466A (en)	1996-07-23
GR3036577T3 (en)	2001-12-31

Publication	Publication Date	Title
DK0475411T3 (da)	2001-10-01	Nye carbocycliske adenosinanaloge til anvendelse som immunsuppressiva
FI934226L (fi)	1993-09-27	Foerbaettringar i eller relaterande till kontrastmedel
FI934227L (fi)	1993-09-27	Foerbaettringar i eller relaterande till kontrastmedel
FI903839A0 (fi)	1990-08-01	Tuggummi innehaollande mycket effektiva soetningsmedelspartiklar som har en modifierad zeinbelaeggning.
FI930876L (fi)	1994-05-17	System som matar delar anpassat till en roerlig produktionslinje
FI913533A7 (fi)	1992-01-25	Tiettyjen nukleosidien uusia karbosyklisiä analogeja
FI890391L (fi)	1989-08-11	Torkanordning foer torkning av en materialbana som flyter pao ett tryck foerorsakat av en parallellt ledd stroemning.
FI924260A7 (fi)	1993-04-29	Stoedjande och styrning av en lodraet transportanordning som finns i avlastningsmynningen pao en av lastningsanordningar foer fartyg
NO900740L (no)	1990-08-17	Fremgangsmaate for syntetisering av tris-hydroxymethyl-alkanestere som fettimitasjoner med lavt kaloriinnhold.
DK345588A (da)	1988-12-25	1,2-diketo-derivater til anvendelse som renin-inhibitorer
FI921225L (fi)	1992-09-24	Belagd glasskiva som har hoeg aoterspegling foer vaermestraolning
FI920735A7 (fi)	1992-08-22	Vattenhaltiga polymerdispersioner som innehaoller organiska foereningar med karbonat- och karbonylgrupper, liksom daermed framstaellda maolnings-och ytbehandlingssystem
FI883643A7 (fi)	1989-02-08	Cyklopeptider som befraemjar absorption under anvaendning pao slemhinnorna.
FI871691A7 (fi)	1987-10-23	Klockrenegeringsarrangemang tillaempligt speciellt pao ett informationstransmissionssystem som anvaender den tiddelade fleraotkomstprincipen i en transmissionsriktning.
FI882118A7 (fi)	1989-11-07	Betraktningsapparat avsedd foer reproduktion eller avdragning som baserar sig pao kolorimetrisk faergbestaemning.
FI962010A0 (fi)	1996-05-10	Immuunivastetta heikentävinä aineina käytettäviä 6-okso-nukleosideja
FI875538A0 (fi)	1987-12-16	Nya foereningar baserade pao maleimider och nya ljushaerdbara sammansaettningar som innehaoller dem.
NO954399D0 (no)	1995-11-03	8-substituerte xanthiner som selektive adenosinreseptormidler
FI914890L (fi)	1993-04-17	Separations- och koncentrationsfoerfarande som grundar sig pao selektiv absorption av en blandning i aongfas
FI54679C (fi)	1979-02-12	Autoklav foer pao en roterande baerstaellning placerade foeremaol som behandlas med hetvattensterilisering
ZA917151B (en)	1992-05-27	Carbocyclic nucleoside analogs useful as immunosuppressants
FI885736A0 (fi)	1988-12-09	Foerfarande i pappersmaskin foer att effektivera avvattningen fraon en pappersbana som haoller pao att bildas.
FI890934L (fi)	1990-06-10	Foerfarande i pappersmaskin foer att effektivera avvattningen fraon en pappersbana som haoller pao att bildas.
FI1146U1 (fi)	1994-01-24	Beklaednad, som faests pao ett underlag medelst limning, laminering eller pao annat motsvarande saett
ES1015570Y (es)	1992-01-16	Cabezal de contrapunto para taladros multiples.