ATE202106T1 - Neue als immunsuppressiva nützliche karbozyklische adenosinanaloge - Google Patents

Neue als immunsuppressiva nützliche karbozyklische adenosinanaloge

Info

Publication number: ATE202106T1
Authority: AT; Austria
Prior art keywords: immunosupressants; adenosine analogues; analogues useful; carbocyclic adenosine; new carbocyclic
Prior art date: 1990-09-14

Application number

AT91115485T

Other languages

English (en)

Inventor

David R Borcherding

Iii Carl K Edwards

Ronald E Esser

Douglas L Cole

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-14

Filing date

1991-09-12

Publication date

2001-06-15

1991-09-12 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2001-06-15 Application granted granted Critical

2001-06-15 Publication of ATE202106T1 publication Critical patent/ATE202106T1/de

Links

OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical class C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 1
XUGWUUDOWNZAGW-UHFFFAOYSA-N neplanocin A Natural products C1=NC=2C(N)=NC=NC=2N1C1C=C(CO)C(O)C1O XUGWUUDOWNZAGW-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Transplantation (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT91115485T 1990-09-14 1991-09-12 Neue als immunsuppressiva nützliche karbozyklische adenosinanaloge ATE202106T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US58228090A	1990-09-14	1990-09-14
US74817291A	1991-08-23	1991-08-23

Publications (1)

Publication Number	Publication Date
ATE202106T1 true ATE202106T1 (de)	2001-06-15

Family

ID=27078528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91115485T ATE202106T1 (de)	1990-09-14	1991-09-12	Neue als immunsuppressiva nützliche karbozyklische adenosinanaloge

Country Status (19)

Country	Link
EP (1)	EP0475411B1 (de)
JP (1)	JP3099280B2 (de)
KR (1)	KR100249111B1 (de)
CN (1)	CN1031132C (de)
AR (1)	AR247566A1 (de)
AT (1)	ATE202106T1 (de)
AU (1)	AU647822B2 (de)
CA (1)	CA2051012C (de)
DE (1)	DE69132632T2 (de)
DK (1)	DK0475411T3 (de)
ES (1)	ES2158840T3 (de)
FI (1)	FI102755B1 (de)
GR (1)	GR3036577T3 (de)
HU (1)	HU209304B (de)
IE (1)	IE913247A1 (de)
IL (1)	IL99466A (de)
NO (1)	NO179908C (de)
NZ (1)	NZ239750A (de)
PT (1)	PT98943B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU642526B2 (en) *	1990-09-14	1993-10-21	Marion Merrell Dow Inc.	Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
US5470857A (en) *	1990-09-14	1995-11-28	Marion Merrell Dow Inc.	Carbocyclic nucleoside analogs useful as immunosuppressants
US5817661A (en)	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817672A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
CA2084222C (en) *	1991-12-06	2004-04-06	David R. Borcherding	Novel trans cyclopentanyl purine analogs useful as immunosuppressants
US5723466A (en) *	1991-12-06	1998-03-03	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817660A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5292513A (en) *	1992-05-18	1994-03-08	Anthony G. Gristina	Method for nonspecific cellular immune stimulation
US6765008B1 (en) *	1992-12-17	2004-07-20	Pfizer Inc	Pyrrolopyrimidines as CRF antagonists
DE69402548T2 (de) *	1993-06-21	1997-07-17	Merrell Pharma Inc	Carbocyclische nucleoside mittel nützlich als selektive inhibitoren von proinflammatorischen cytokinen
HUT74989A (en) *	1993-11-12	1997-03-28	Merrell Pharma Inc	6-oxo-nucleosides useful as immunosuppressants
TW282470B (de) *	1993-11-18	1996-08-01	Ajinomoto Kk
EP0682027B1 (de) *	1994-05-03	1997-10-15	Novartis AG	Pyrrolopyrimidinderivate mit antiproliferativer Wirkung
TW574214B (en) *	1994-06-08	2004-02-01	Pfizer	Corticotropin releasing factor antagonists
US6956047B1 (en)	1995-06-06	2005-10-18	Pfizer Inc.	Corticotropin releasing factor antagonists
US7125880B1 (en)	1995-06-06	2006-10-24	Pfizer Inc.	Corticotropin releasing factor antagonists
US6403599B1 (en)	1995-11-08	2002-06-11	Pfizer Inc	Corticotropin releasing factor antagonists
KR20020063934A (ko)	2000-01-18	2002-08-07	화이자 프로덕츠 인코포레이티드	코르티코트로핀 방출 인자 길항제
EP1661897B1 (de) *	2003-08-26	2013-12-04	Teijin Pharma Limited	Pyrrolopyrimidinonderivat
US8945505B2 (en)	2007-02-02	2015-02-03	Panaphix, Inc.	Use of arsenic compounds for treatment of pain and inflammation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3551428A (en) *	1956-02-10	1970-12-29	Ciba Geigy Corp	New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
US3917837A (en) *	1974-10-21	1975-11-04	American Cyanamid Co	Method of using trans-2-(6-amino-9H-purin-9-yl)-cyclopentanol
US4076711A (en) *	1976-04-05	1978-02-28	Schering Corporation	Triazolo [4,5-d]-pyrimidines
US4221794A (en) *	1979-06-21	1980-09-09	Newport Pharmaceuticals International, Inc.	Method of imparting immunomodulating and antiviral activity
US4386093A (en) *	1981-09-16	1983-05-31	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	(±)3-Deazaaristeromycin and uses
IN164556B (de) *	1986-03-06	1989-04-08	Takeda Chemical Industries Ltd
US4859677A (en) *	1987-04-17	1989-08-22	University Of Kansas	Nucleoside analogues having antiviral activity
US4782062A (en) *	1987-05-11	1988-11-01	Merck & Co., Inc.	9-(2-hydroxymethyl)cycloalkylmethyl) guanines
IL86381A0 (en) *	1987-05-19	1988-11-15	Nippon Kayaku Kk	Oxetanocins and pharmaceutical compositions containing the same
GB8826205D0 (en) *	1988-11-09	1988-12-14	Wellcome Found	Heterocyclic compounds

1991
- 1991-09-09 CA CA002051012A patent/CA2051012C/en not_active Expired - Lifetime
- 1991-09-09 AU AU83729/91A patent/AU647822B2/en not_active Ceased
- 1991-09-10 AR AR91320625A patent/AR247566A1/es active
- 1991-09-11 PT PT98943A patent/PT98943B/pt not_active IP Right Cessation
- 1991-09-11 NZ NZ239750A patent/NZ239750A/en unknown
- 1991-09-12 DK DK91115485T patent/DK0475411T3/da active
- 1991-09-12 EP EP91115485A patent/EP0475411B1/de not_active Expired - Lifetime
- 1991-09-12 ES ES91115485T patent/ES2158840T3/es not_active Expired - Lifetime
- 1991-09-12 IL IL9946691A patent/IL99466A/en not_active IP Right Cessation
- 1991-09-12 AT AT91115485T patent/ATE202106T1/de not_active IP Right Cessation
- 1991-09-12 DE DE69132632T patent/DE69132632T2/de not_active Expired - Lifetime
- 1991-09-13 HU HU912961A patent/HU209304B/hu not_active IP Right Cessation
- 1991-09-13 JP JP03261249A patent/JP3099280B2/ja not_active Expired - Lifetime
- 1991-09-13 NO NO913625A patent/NO179908C/no not_active IP Right Cessation
- 1991-09-13 IE IE324791A patent/IE913247A1/en not_active Application Discontinuation
- 1991-09-13 FI FI914319A patent/FI102755B1/fi active
- 1991-09-13 KR KR1019910015974A patent/KR100249111B1/ko not_active Expired - Fee Related
- 1991-09-14 CN CN91108934A patent/CN1031132C/zh not_active Expired - Fee Related
2001
- 2001-09-11 GR GR20010401434T patent/GR3036577T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI914319L (fi)	1992-03-15
HU912961D0 (en)	1992-01-28
CN1059909A (zh)	1992-04-01
JP3099280B2 (ja)	2000-10-16
EP0475411A1 (de)	1992-03-18
FI914319A0 (fi)	1991-09-13
JPH04270282A (ja)	1992-09-25
ES2158840T3 (es)	2001-09-16
PT98943B (pt)	1999-02-26
IE913247A1 (en)	1992-02-25
EP0475411B1 (de)	2001-06-13
NO913625D0 (no)	1991-09-13
IL99466A0 (en)	1992-08-18
FI102755B (fi)	1999-02-15
AR247566A1 (es)	1995-01-31
NO913625L (no)	1992-03-16
PT98943A (pt)	1992-07-31
KR100249111B1 (ko)	2000-08-01
AU8372991A (en)	1992-03-19
GR3036577T3 (en)	2001-12-31
HUT59138A (en)	1992-04-28
DE69132632D1 (de)	2001-07-19
CA2051012C (en)	2002-04-02
AU647822B2 (en)	1994-03-31
NZ239750A (en)	1994-02-25
HU209304B (en)	1994-04-28
CN1031132C (zh)	1996-02-28
DK0475411T3 (da)	2001-10-01
NO179908B (no)	1996-09-30
CA2051012A1 (en)	1992-03-15
NO179908C (no)	1997-01-08
IL99466A (en)	1996-07-23
DE69132632T2 (de)	2002-04-18
FI102755B1 (fi)	1999-02-15
KR920006357A (ko)	1992-04-27

Legal Events

Date	Code	Title	Description
2001-10-15	UEP	Publication of translation of european patent specification
2004-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE202106T1 (de)	2001-06-15	Neue als immunsuppressiva nützliche karbozyklische adenosinanaloge
FI935373A0 (fi)	1993-12-01	Kopplingsstycke eller koppling foer ledning
DE69310214D1 (de)	1997-05-28	Dialogsystem
DE69325333D1 (de)	1999-07-22	Antivirale Zusammensetzung
FI924299L (fi)	1992-09-25	Dambinda eller inkontinensskydd
FI931172L (fi)	1993-10-03	Vatten- och/eller oljeogenomslaepplig taetningsmatta
FI930841A7 (fi)	1993-02-25	Kombinerad kontroll- och reglerventil foer vaetskor eller gaser
FI933713L (fi)	1994-03-12	Taeppande eller taetande akrylkomposition
FI933421L (fi)	1994-02-01	Flerskiktsinloppslaoda foer en pappersmaskin eller dylik
FI925957A0 (fi)	1992-12-30	Styranordning foer en eller flera arbetspunkter
FI925930L (fi)	1993-07-09	En kosmetisk eller dermatologisk blandning innehaollande en diolester
FI932970A0 (fi)	1993-06-28	Betongtransportblandare eller liknande
FI935253L (fi)	1994-05-27	Granatkastare foersedd med en eller flera eldroer
DE69331227D1 (de)	2002-01-10	Radiergummi
FI922855L (fi)	1992-12-21	Laett foerslutningsbar paose eller saeck
KR950703757A (ko)	1995-09-20	양성-작용 포토레지스트 조성물(posivive-working pothoresist composition)
FI961105A7 (fi)	1996-03-08	Difluoristatoniviruksen vastaisia analogeja
FI960051L (fi)	1996-03-07	Difluoristatonianalogeja
KR910008699U (ko)	1991-06-27	보조 정수기
KR940014625U (ko)	1994-07-16	전침기
FR2646165B3 (fr)	1991-07-19	Peinture
FI931379A0 (fi)	1993-03-26	Foerbaettringar i eller i samband med mobilradiokommunikationssystem
FI980U1 (fi)	1993-11-02	Ledstaong eller handtag
FI450U1 (fi)	1993-01-12	Saekringssockel eller radsaekring
FI496U1 (fi)	1993-02-03	Skyddskaopa foer broedlaoda eller liknande