DK0475443T3 - Fremgangsmåde til kemisk syntese af oligonucleotider - Google Patents
Fremgangsmåde til kemisk syntese af oligonucleotiderInfo
- Publication number
- DK0475443T3 DK0475443T3 DK91115583.6T DK91115583T DK0475443T3 DK 0475443 T3 DK0475443 T3 DK 0475443T3 DK 91115583 T DK91115583 T DK 91115583T DK 0475443 T3 DK0475443 T3 DK 0475443T3
- Authority
- DK
- Denmark
- Prior art keywords
- chemical synthesis
- oligonucleotides
- ease
- protective group
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
- C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
- C07C309/35—Naphthalene sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4029244A DE4029244A1 (de) | 1990-09-14 | 1990-09-14 | Verfahren zur chemischen synthese von oligonukleotiden |
| DE4111363 | 1991-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0475443T3 true DK0475443T3 (da) | 1995-04-03 |
Family
ID=25896883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91115583.6T DK0475443T3 (da) | 1990-09-14 | 1991-09-13 | Fremgangsmåde til kemisk syntese af oligonucleotider |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5631362A (fr) |
| EP (1) | EP0475443B1 (fr) |
| JP (2) | JP3539978B2 (fr) |
| KR (1) | KR100228606B1 (fr) |
| AT (1) | ATE113031T1 (fr) |
| AU (1) | AU641882B2 (fr) |
| CA (1) | CA2051217C (fr) |
| DE (1) | DE59103277D1 (fr) |
| DK (1) | DK0475443T3 (fr) |
| ES (1) | ES2065595T3 (fr) |
| FI (1) | FI102072B (fr) |
| HU (1) | HUT63432A (fr) |
| IE (1) | IE65094B1 (fr) |
| IL (1) | IL99465A (fr) |
| NO (1) | NO178333C (fr) |
| NZ (1) | NZ239766A (fr) |
| PT (1) | PT98963B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048975A (en) * | 1991-09-12 | 2000-04-11 | Hoechst Aktiengesellschaft | Process for the chemical synthesis of oligonucleotides |
| DE19842164B4 (de) * | 1998-09-15 | 2004-06-03 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Verfahren zur Qualitätskontrolle beim Aufbau von Oligomerrastern |
| CN102887841A (zh) * | 2012-11-02 | 2013-01-23 | 天津希恩思生化科技有限公司 | 化合物丹磺酰氯的制备方法 |
| CN113993876B (zh) | 2019-06-11 | 2024-06-14 | 豪夫迈·罗氏有限公司 | 使用改进的氧化方案制备寡核苷酸的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE757863A (fr) * | 1969-10-24 | 1971-04-22 | Hoechst Ag | Colorants anthraquinoniques solubles dans l'eau et leur preparation |
| EP0267996A1 (fr) * | 1986-11-20 | 1988-05-25 | Tamir Biotechnology Ltd. | Dérivés de nucléotides |
| US4960700A (en) * | 1986-12-24 | 1990-10-02 | Genentech, Inc. | Compositions and methods for the synthesis and assay of a mammalian enkephalinase |
| US4997928A (en) * | 1988-09-15 | 1991-03-05 | E. I. Du Pont De Nemours And Company | Fluorescent reagents for the preparation of 5'-tagged oligonucleotides |
| AU6603690A (en) * | 1989-10-05 | 1991-04-28 | University Patents Inc. | Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes |
-
1991
- 1991-09-12 FI FI914293A patent/FI102072B/fi active IP Right Grant
- 1991-09-12 CA CA002051217A patent/CA2051217C/fr not_active Expired - Fee Related
- 1991-09-12 IL IL9946591A patent/IL99465A/en not_active IP Right Cessation
- 1991-09-12 HU HU912936A patent/HUT63432A/hu unknown
- 1991-09-12 NZ NZ239766A patent/NZ239766A/en not_active IP Right Cessation
- 1991-09-13 AT AT91115583T patent/ATE113031T1/de not_active IP Right Cessation
- 1991-09-13 EP EP91115583A patent/EP0475443B1/fr not_active Expired - Lifetime
- 1991-09-13 PT PT98963A patent/PT98963B/pt not_active IP Right Cessation
- 1991-09-13 DK DK91115583.6T patent/DK0475443T3/da active
- 1991-09-13 AU AU83865/91A patent/AU641882B2/en not_active Ceased
- 1991-09-13 NO NO913626A patent/NO178333C/no unknown
- 1991-09-13 KR KR1019910015958A patent/KR100228606B1/ko not_active Expired - Fee Related
- 1991-09-13 IE IE325091A patent/IE65094B1/en not_active IP Right Cessation
- 1991-09-13 ES ES91115583T patent/ES2065595T3/es not_active Expired - Lifetime
- 1991-09-13 JP JP26329091A patent/JP3539978B2/ja not_active Expired - Lifetime
- 1991-09-13 DE DE59103277T patent/DE59103277D1/de not_active Expired - Lifetime
-
1995
- 1995-05-09 US US08/437,566 patent/US5631362A/en not_active Expired - Lifetime
- 1995-06-07 US US08/487,229 patent/US5945524A/en not_active Expired - Lifetime
-
2003
- 2003-02-27 JP JP2003051774A patent/JP3983691B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU641882B2 (en) | 1993-09-30 |
| IL99465A (en) | 2001-04-30 |
| FI914293A0 (fi) | 1991-09-12 |
| NZ239766A (en) | 1994-05-26 |
| FI102072B1 (fi) | 1998-10-15 |
| IE65094B1 (en) | 1995-10-04 |
| NO913626L (no) | 1992-03-16 |
| US5945524A (en) | 1999-08-31 |
| NO913626D0 (no) | 1991-09-13 |
| EP0475443A3 (en) | 1992-07-08 |
| ATE113031T1 (de) | 1994-11-15 |
| FI914293L (fi) | 1992-03-15 |
| HUT63432A (en) | 1993-08-30 |
| ES2065595T3 (es) | 1995-02-16 |
| NO178333C (no) | 1996-03-06 |
| JP2003292499A (ja) | 2003-10-15 |
| US5631362A (en) | 1997-05-20 |
| FI102072B (fi) | 1998-10-15 |
| DE59103277D1 (de) | 1994-11-24 |
| PT98963B (pt) | 1999-02-26 |
| HU912936D0 (en) | 1992-01-28 |
| KR920006305A (ko) | 1992-04-27 |
| JPH05320122A (ja) | 1993-12-03 |
| CA2051217A1 (fr) | 1992-03-15 |
| EP0475443B1 (fr) | 1994-10-19 |
| JP3539978B2 (ja) | 2004-07-07 |
| IL99465A0 (en) | 1992-08-18 |
| CA2051217C (fr) | 2003-12-09 |
| JP3983691B2 (ja) | 2007-09-26 |
| EP0475443A2 (fr) | 1992-03-18 |
| NO178333B (no) | 1995-11-27 |
| IE913250A1 (en) | 1992-02-25 |
| KR100228606B1 (ko) | 1999-11-01 |
| PT98963A (pt) | 1992-08-31 |
| AU8386591A (en) | 1992-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL102154A0 (en) | Nucleic acid hybridization assays-using detector probes as primers for nucleic acid copy synthesis | |
| DE69133329D1 (de) | Markierte Oligonukleotide | |
| DE59108143D1 (de) | 3'- Amino- oder thiolmodifizierte, Fluoreszenzfarbstoff-gekoppelte Nukleoside, Nukleotide und Oligonukleotide sowie ein Verfahren zur Herstellung und ihre Verwendung | |
| WO1993016094A3 (fr) | Utilisation de n-nucleosides fluorescents et de leurs analogues structurels fluorescents | |
| EP1034302A4 (fr) | Matrice de sequen age de novo ou "universelle" | |
| AU6180190A (en) | Fast process for detecting and/or identifying a single base on a nucleic acid sequence and its applications | |
| ATE521718T1 (de) | Prozess zur synthetisierung von nukleinsäure | |
| NZ332753A (en) | Artificial mismatch hybridization | |
| DK0475443T3 (da) | Fremgangsmåde til kemisk syntese af oligonucleotider | |
| FR2680520B1 (fr) | Procede de detection de nouvelles regions hypervariables dans une sequence d'adn, sequences de nucleotides constituant des sondes d'hybridation et leur application biologique. | |
| DE3567875D1 (en) | Process for the dissolution of deoxyribonucleic acids in non-aqueous solvents and mixed non-aqueous/aqueous solvent systems, solutions thereby obtained and their use | |
| DE3884669D1 (de) | Verfahren zur Herstellung von doppelsträngiger DNA. | |
| WO1994012518A3 (fr) | Reactif pour le couplage de diverses substances a des acides nucleiques et procede pour sa preparation | |
| AU7429591A (en) | Nucleic acid probes for the detection of giardia lamblia | |
| WO1998049341A3 (fr) | Sequençage d'un polynucleotide au moyen d'amorces semidegenerees | |
| Kerby | A cytological and biochemical characterization of the potential B genome donors to common wheat, Triticum aestivum | |
| JPS57128700A (en) | P1-guanosine-5', p4-adenosine-5'-tetraphosphate | |
| JPS6491058A (en) | Labeling method for non-radioactive nucleic acid and detection method using the same | |
| JPS5538322A (en) | S6,5'-cyclopyrimidine nucleoside derivative and its preparation | |
| JPS5538321A (en) | S6,2'-cyclopyrimidine nucleoside derivative and its preparation |