DK0479210T3 - GIP-analoger og deres anvendelse - Google Patents

GIP-analoger og deres anvendelse

Info

Publication number: DK0479210T3
Authority: DK; Denmark
Prior art keywords: lys; asn; gip; analogues; homoserine
Prior art date: 1990-10-05

Application number

DK91116704.7T

Other languages

Danish (da)

English (en)

Inventor

Masayasu Kurono

Takahiko Mitani

Haruo Takahashi

Ryoichi Unno

Tomoo Suzuki

Yuji Hayashi

Yohei Kobayashi

Yoko Ishii

Kiichi Sawai

Original Assignee

Sanwa Kagaku Kenkyusho Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-05

Filing date

1991-09-30

Publication date

1995-07-31

1991-09-30 Application filed by Sanwa Kagaku Kenkyusho Co filed Critical Sanwa Kagaku Kenkyusho Co

1995-07-31 Application granted granted Critical

1995-07-31 Publication of DK0479210T3 publication Critical patent/DK0479210T3/da

Links

UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 abstract 3
WEAYSODFUHQOTI-VKHMYHEASA-N (2s)-2-amino-4-hydroxybutanamide Chemical compound NC(=O)[C@@H](N)CCO WEAYSODFUHQOTI-VKHMYHEASA-N 0.000 abstract 1
UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 abstract 1
QJPWUUJVYOJNMH-VKHMYHEASA-N L-homoserine lactone Chemical compound N[C@H]1CCOC1=O QJPWUUJVYOJNMH-VKHMYHEASA-N 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Holo Graphy (AREA)
Investigating Or Analysing Biological Materials (AREA)
Lubrication Of Internal Combustion Engines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polyesters Or Polycarbonates (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK91116704.7T 1990-10-05 1991-09-30 GIP-analoger og deres anvendelse DK0479210T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2266438A JPH04145099A (ja)	1990-10-05	1990-10-05	Ｇｉｐ様活性を有するポリペプチド誘導体及びその用途

Publications (1)

Publication Number	Publication Date
DK0479210T3 true DK0479210T3 (da)	1995-07-31

Family

ID=17430941

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91116704.7T DK0479210T3 (da)	1990-10-05	1991-09-30	GIP-analoger og deres anvendelse

Country Status (6)

Country	Link
EP (1)	EP0479210B1 (de)
JP (1)	JPH04145099A (de)
AT (1)	ATE123296T1 (de)
DE (1)	DE69110101T2 (de)
DK (1)	DK0479210T3 (de)
ES (1)	ES2076437T3 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ258824A (en) *	1992-12-16	1997-11-24	Univ Melbourne	Nucleic acid encoding type ii serine proteinase inhibitor precursor and its use
AU6294899A (en) *	1998-10-07	2000-04-26	Medical College Of Georgia Research Institute, Inc.	Glucose-dependent insulinotropic peptide for use as an osteotropic hormone
US20050272652A1 (en)	1999-03-29	2005-12-08	Gault Victor A	Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
WO2001081919A2 (en) *	2000-04-27	2001-11-01	Bionebraska, Inc.	Gastric inhibitory polypeptide diagnostic test for detecting susceptibility to type-2 diabetes, impaired glucose tolerance, or impaired fasting glucose
EP1515746A2 (de) *	2002-06-11	2005-03-23	Eisai Co. Ltd	Verwendung von verbindungen mit gip-aktivität zur behandlung von erkrankungen in zusammenhang mit abnormalem verlust von zellen und/oder zur behandlung von adipositas
AU2005298689A1 (en)	2004-10-25	2006-05-04	Cytos Biotechnology Ag	Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof
US8263545B2 (en)	2005-02-11	2012-09-11	Amylin Pharmaceuticals, Inc.	GIP analog and hybrid polypeptides with selectable properties
BRPI0606992A2 (pt)	2005-02-11	2009-07-28	Amylin Pharmaceuticals Inc	análogo e polipeptìdeos hìbridos de gip com propriedades selecionáveis
CA2628241C (en)	2005-11-07	2016-02-02	Indiana University Research And Technology Corporation	Glucagon analogs exhibiting physiological solubility and stability
CN101578102B (zh)	2007-01-05	2013-07-17	印第安纳大学研究及科技有限公司	在生理性pH缓冲液中显示增强的溶解性的胰高血糖素类似物
MX2009008241A (es)	2007-02-15	2009-10-08	Univ Indiana Res & Tech Corp	Co-agonistas de receptor de glucagon/glp-1.
CA2707861A1 (en)	2007-10-30	2009-05-07	Indiana University Research And Technology Corporation	Glucagon antagonists
JP5771005B2 (ja)	2007-10-30	2015-08-26	インディアナユニバーシティーリサーチアンドテクノロジーコーポレーションＩｎｄｉａｎａＵｎｉｖｅｒｓｉｔｙＲｅｓｅａｒｃｈＡｎｄＴｅｃｈｎｏｌｏｇｙＣｏｒｐｏｒａｔｉｏｎ	グルカゴンアンタゴニスト及びｇｌｐ−１アゴニスト活性を示す化合物
TWI541023B (zh)	2008-06-17	2016-07-11	印第安納大學科技研究公司	在生理ｐｈ緩衝液中呈現增強之溶解度及穩定性之升糖激素類似物
TWI474835B (zh)	2008-06-17	2015-03-01	Univ Indiana Res & Tech Corp	用於治療代謝病症及肥胖症之基於ｇｉｐ之混合激動劑
EP2300037B1 (de)	2008-06-17	2016-03-30	Indiana University Research and Technology Corporation	Coagonisten des glucagon/glp-1 rezeptors
KR20110043688A (ko) *	2008-08-07	2011-04-27	입센 파마 에스.에이.에스	포도당 의존적인 인슐린 분비 자극성 폴리펩타이드 유사체
MX2011001031A (es)	2008-08-07	2011-04-26	Ipsen Pharma Sas	Analogos de polipeptidos insulinotropicos dependientes de glucosa.
RU2550696C2 (ru)	2008-12-19	2015-05-10	Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн	Основанные на амидах пролекарства пептидов глюкагонового надсемейства
WO2010148089A1 (en)	2009-06-16	2010-12-23	Indiana University Research And Technology Corporation	Gip receptor-active glucagon compounds
US8703701B2 (en)	2009-12-18	2014-04-22	Indiana University Research And Technology Corporation	Glucagon/GLP-1 receptor co-agonists
EP2528618A4 (de)	2010-01-27	2015-05-27	Univ Indiana Res & Tech Corp	Glucagon-antagonisten- und gip-agonisten-konjugate sowie zusammensetzungen zur behandlung von stoffwechselerkrankungen und adipositas
WO2011143208A1 (en)	2010-05-13	2011-11-17	Indiana University Research And Technology Corporation	Glucagon superfamily peptides exhibiting g protein-coupled receptor activity
CA2797095A1 (en)	2010-05-13	2011-11-17	Indiana University Research And Technology Corporation	Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
MX2012014576A (es)	2010-06-24	2013-02-21	Univ Indiana Res & Tech Corp	Profarmacos de peptido de la superfamilia de glucagon basado en amida.
WO2012088116A2 (en)	2010-12-22	2012-06-28	Indiana University Research And Technology Corporation	Glucagon analogs exhibiting gip receptor activity
US9453062B2 (en)	2011-06-10	2016-09-27	Beijing Hanmi Pharmaceutical Co., Ltd.	Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof
CN103857408B (zh)	2011-06-22	2017-04-12	印第安那大学科技研究公司	胰高血糖素/glp‑1受体协同激动剂
MX2013015168A (es)	2011-06-22	2014-03-31	Univ Indiana Res & Tech Corp	Co-agonista del receptor de glucagon/glp-1.
HK1198810A1 (en)	2011-11-17	2015-06-12	Indiana University Research And Technology Corporation	Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
US9340600B2 (en)	2012-06-21	2016-05-17	Indiana University Research And Technology Corporation	Glucagon analogs exhibiting GIP receptor activity
FR2994848B1 (fr)	2012-08-30	2014-08-22	Univ Paris Curie	Traitement de l'arthrose par les hormones incretines ou leurs analogues
JOP20190211A1 (ar)	2017-03-31	2019-09-15	Takeda Pharmaceuticals Co	ببتيد منشط لمستقبل gip
WO2024209050A1 (en)	2023-04-05	2024-10-10	Antag Therapeutics Aps	Gip activity modulators and orthostatic intolerance

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01153092A (ja) *	1986-11-27	1989-06-15	Sanwa Kagaku Kenkyusho Co Ltd	ヒトガストリツクインヒビトリポリペプチド（ＧＩＰ）前駆体のｃＤＮＡクロ−ン

1990
- 1990-10-05 JP JP2266438A patent/JPH04145099A/ja active Pending
1991
- 1991-09-30 EP EP91116704A patent/EP0479210B1/de not_active Expired - Lifetime
- 1991-09-30 AT AT91116704T patent/ATE123296T1/de not_active IP Right Cessation
- 1991-09-30 DK DK91116704.7T patent/DK0479210T3/da active
- 1991-09-30 DE DE69110101T patent/DE69110101T2/de not_active Expired - Fee Related
- 1991-09-30 ES ES91116704T patent/ES2076437T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE123296T1 (de)	1995-06-15
ES2076437T3 (es)	1995-11-01
JPH04145099A (ja)	1992-05-19
DE69110101T2 (de)	1996-02-29
EP0479210A2 (de)	1992-04-08
EP0479210A3 (en)	1992-09-02
DE69110101D1 (de)	1995-07-06
EP0479210B1 (de)	1995-05-31

Publication	Publication Date	Title
EP0479210A3 (en)	1992-09-02	Gip analogues and use thereof
DK0463450T3 (da)	1994-06-27	Vasoaktive intestinale polypeptid-analoger og udnyttelsen heraf
BR1100853A (pt)	1999-12-07	Composto, composição farmacêutica, e composição veterinária
NO900824D0 (no)	1990-02-21	Halogenerte hydrokarbonloesningesmidler og anvendelse derav
DE68922405D1 (de)	1995-06-01	Deletionsanaloga von magaininpeptiden.
NO923142D0 (no)	1992-08-12	Cykliske peptider og anvendelse derav
GR3025005T3 (en)	1998-01-30	Cyclic ureas and analogues useful as retroviral protease inhibitiors.
ES2079453T3 (es)	1996-01-16	Mejoras en compuestos quimicos.
KR910700089A (ko)	1991-03-13	히드로클로로플루오로프로판의 공비 조성물 또는 공비형 조성물
ATE66675T1 (de)	1991-09-15	Stickstoffhaltige heterozyklische verbindungen.
EG18264A (en)	1992-12-30	Benzoylphenylureas,the preparation thereof and the use thereof in pest control
EP0317645A4 (de)	1989-10-04	4h-3,1-benzoxazin-4-on-verbindungen und serin protease-inhibierende arzneimittel.
FI912336A0 (fi)	1991-05-14	Omaettade polyesterhartser.
ATE104678T1 (de)	1994-05-15	Renin-hemmende aminodiol-derivate.
DK70285A (da)	1985-08-17	Organiske alfa-chlorcarbonater og fremgangsmaade til deres fremstilling og anvendelse til synteser
DK0410278T3 (da)	1994-05-24	Reninhæmmende aminooligohydroxyderivater
DK0578521T3 (da)	1996-12-09	Hidtil ukendt peptid-derivater med bradykininantagonistisk virkning, fremgangsmåde til fremstilling af derivaterne og farmaceutiske sammensætninger indeholdende disse
DK0417746T3 (da)	1994-12-12	N-Azabicyclo(3.3.0)octanamider af aromatiske syrer
DK0411313T3 (da)	1994-02-28	N,N-Disubstituerede og N,N,N-/N,N,N-trisubstituerede thiourinstoffer og fremgangsmåde til deres fremstilling (II)
DK0547502T4 (da)	1999-09-27	Hærdeligt bindemiddel og fremgangsmåde til fremstilling deraf
ES2107562T3 (es)	1997-12-01	Amidas de acidos alfa-aril-alfa-hidroxi-beta-imidazolinil-propanoicos.
ATE6401T1 (de)	1984-03-15	Schaedlingsbekaempfungsmittel.
ES8604925A1 (es)	1986-03-01	1-2 procedimiento de preparacion de derivados de 4-fluoro- benzoil-piperidina
ES2083961T3 (es)	1996-05-01	Acidos 3-anilino-2-hidroxicarbonil-4-tiofenoaceticos.
ATE144257T1 (de)	1996-11-15	Tetrahydro-4-phenylimino-3-thiophenessigsäuren