DK0482771T3 - Heterocykliske syrer - Google Patents

Heterocykliske syrer

Info

Publication number: DK0482771T3
Authority: DK; Denmark
Prior art keywords: thromboxane; formula; group; alkyl; compounds
Prior art date: 1990-10-04

Application number

DK91308805.0T

Other languages

Danish (da)

English (en)

Inventor

Alan Wellington Faull

Keith Russell

William John Watkins

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-04

Filing date

1991-09-26

Publication date

1998-01-26

1991-09-26 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1998-01-26 Application granted granted Critical

1998-01-26 Publication of DK0482771T3 publication Critical patent/DK0482771T3/da

Links

125000000623 heterocyclic group Chemical group 0.000 title abstract 2
DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
VDFVNEFVBPFDSB-UHFFFAOYSA-N 1,3-dioxane Chemical compound C1COCOC1 VDFVNEFVBPFDSB-UHFFFAOYSA-N 0.000 abstract 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
239000005977 Ethylene Chemical group 0.000 abstract 1
208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003158 alcohol group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000000336 imidazol-5-yl group Chemical group [H]N1C([H])=NC([H])=C1[*] 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
-1 methyleneoxy, vinylene Chemical group 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
208000031225 myocardial ischemia Diseases 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000004496 thiazol-5-yl group Chemical group S1C=NC=C1* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Hydrogenated Pyridines (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

DK91308805.0T 1990-10-04 1991-09-26 Heterocykliske syrer DK0482771T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909021571A GB9021571D0 (en)	1990-10-04	1990-10-04	Heterocyclic acids

Publications (1)

Publication Number	Publication Date
DK0482771T3 true DK0482771T3 (da)	1998-01-26

Family

ID=10683219

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91308805.0T DK0482771T3 (da)	1990-10-04	1991-09-26	Heterocykliske syrer

Country Status (19)

Country	Link
US (2)	US5219874A (de)
EP (1)	EP0482771B1 (de)
JP (1)	JPH04273871A (de)
KR (1)	KR100191763B1 (de)
AT (1)	ATE154603T1 (de)
AU (1)	AU646493B2 (de)
CA (1)	CA2052294A1 (de)
DE (1)	DE69126593T2 (de)
DK (1)	DK0482771T3 (de)
ES (1)	ES2103301T3 (de)
FI (1)	FI914621A7 (de)
GB (2)	GB9021571D0 (de)
GR (1)	GR3023804T3 (de)
IE (1)	IE913111A1 (de)
IL (1)	IL99441A (de)
NO (1)	NO303781B1 (de)
NZ (1)	NZ239698A (de)
PT (1)	PT99153B (de)
ZA (1)	ZA917066B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5248780A (en) *	1988-02-16	1993-09-28	Imperial Chemical Industries, Plc	Pyridyl substituted alkenoic acid derivatives
CA2179168A1 (en) *	1993-12-17	1995-06-22	Douglas A. Kniss	Antisense oligonucleotides to suppress eicosanoid formation

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58150575A (ja) *	1982-03-04	1983-09-07	Chugai Pharmaceut Co Ltd	新規なプロスタグランジン誘導体
GB8310407D0 (en) *	1982-05-12	1983-05-25	Ici Plc	1 3 - dioxan -5- ylalkenoic acids
GB8330099D0 (en) *	1983-11-11	1983-12-21	Ici Plc	Cycloalkane derivatives
GB8330097D0 (en) *	1983-11-11	1983-12-21	Ici Plc	Cyclic ethers
GB8330094D0 (en) *	1983-11-11	1983-12-21	Ici Plc	Diphenyl compounds
GB8330120D0 (en) *	1983-11-11	1983-12-21	Ici Plc	Chemical process
GB8511895D0 (en) *	1985-05-10	1985-06-19	Ici Plc	Heterocyclic compounds
HU198706B (en) *	1985-05-10	1989-11-28	Ici Plc	Process for producing 1,3-dioxan-ethers and pharmaceutical compositions containing them
GB8511890D0 (en) *	1985-05-10	1985-06-19	Ici Plc	Benzene derivatives
GB8511892D0 (en) *	1985-05-10	1985-06-19	Ici Plc	Fluoralkane derivatives
GB8511891D0 (en) *	1985-05-10	1985-06-19	Ici Plc	Alkenoic acids
GB8511894D0 (en) *	1985-05-10	1985-06-19	Ici Plc	Phenol derivatives
DE3685775T2 (de) *	1985-05-10	1993-01-21	Ici Plc	Alkenderivate.
WO1987002983A1 (en) *	1985-11-12	1987-05-21	Imperial Chemical Industries Plc	Amide derivatives
GB8611174D0 (en) *	1986-05-08	1986-06-18	Ici Plc	Amide derivatives
GB8531892D0 (en) *	1985-12-30	1986-02-05	Ici Plc	Carboxylic acids
GB8626296D0 (en) *	1986-11-04	1986-12-03	Ici Plc	Therapeutic agents
GB8626297D0 (en) *	1986-11-04	1986-12-03	Ici Plc	Pharmaceutical compositions
GB8709794D0 (en) *	1987-04-24	1987-05-28	Ici Plc	Heterocyclic acids
GB8901201D0 (en) *	1988-02-16	1989-03-15	Ici Plc	Pyridine derivatives
EP0346511A1 (de) *	1988-06-15	1989-12-20	Fujisawa Pharmaceutical Co., Ltd.	Sauerstoff enthaltende heterozyklische Verbindung, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen
GB8814340D0 (en) *	1988-06-16	1988-07-20	Ici Plc	Process
IE81170B1 (en) *	1988-10-21	2000-05-31	Zeneca Ltd	Pyridine derivatives
IL95760A0 (en) *	1989-09-27	1992-05-25	Rhone Poulenc Sante	Imidazole derivatives,their preparation and pharmaceutical compositions containing the same
KR910006904B1 (ko) *	1989-10-16	1991-09-10	한국과학기술연구원	새로운 에스테르 화합물 및 그의 제조방법

1990
- 1990-10-04 GB GB909021571A patent/GB9021571D0/en active Pending
1991
- 1991-09-02 GB GB919118729A patent/GB9118729D0/en active Pending
- 1991-09-04 IE IE311191A patent/IE913111A1/en unknown
- 1991-09-05 ZA ZA917066A patent/ZA917066B/xx unknown
- 1991-09-06 NZ NZ239698A patent/NZ239698A/en unknown
- 1991-09-08 IL IL9944191A patent/IL99441A/en not_active IP Right Cessation
- 1991-09-09 AU AU83727/91A patent/AU646493B2/en not_active Ceased
- 1991-09-20 US US07/763,304 patent/US5219874A/en not_active Expired - Fee Related
- 1991-09-26 DK DK91308805.0T patent/DK0482771T3/da active
- 1991-09-26 EP EP91308805A patent/EP0482771B1/de not_active Expired - Lifetime
- 1991-09-26 DE DE69126593T patent/DE69126593T2/de not_active Expired - Fee Related
- 1991-09-26 CA CA002052294A patent/CA2052294A1/en not_active Abandoned
- 1991-09-26 ES ES91308805T patent/ES2103301T3/es not_active Expired - Lifetime
- 1991-09-26 AT AT91308805T patent/ATE154603T1/de not_active IP Right Cessation
- 1991-10-02 FI FI914621A patent/FI914621A7/fi unknown
- 1991-10-02 KR KR1019910017387A patent/KR100191763B1/ko not_active Expired - Fee Related
- 1991-10-03 PT PT99153A patent/PT99153B/pt not_active IP Right Cessation
- 1991-10-03 NO NO913886A patent/NO303781B1/no not_active IP Right Cessation
- 1991-10-04 JP JP3257669A patent/JPH04273871A/ja active Pending
1993
- 1993-03-24 US US08/036,304 patent/US5410064A/en not_active Expired - Fee Related
1997
- 1997-06-19 GR GR970401343T patent/GR3023804T3/el unknown

Also Published As

Publication number	Publication date
KR100191763B1 (ko)	1999-06-15
NO913886D0 (no)	1991-10-03
GB9118729D0 (en)	1991-10-16
PT99153B (pt)	1999-04-30
IE913111A1 (en)	1992-04-08
GB9021571D0 (en)	1990-11-21
FI914621A7 (fi)	1992-04-05
NZ239698A (en)	1994-03-25
KR920008022A (ko)	1992-05-27
JPH04273871A (ja)	1992-09-30
PT99153A (pt)	1992-09-30
DE69126593D1 (de)	1997-07-24
FI914621A0 (fi)	1991-10-02
NO303781B1 (no)	1998-08-31
IL99441A (en)	1996-12-05
NO913886L (no)	1992-04-06
IL99441A0 (en)	1992-08-18
ES2103301T3 (es)	1997-09-16
AU646493B2 (en)	1994-02-24
EP0482771A3 (en)	1992-07-01
EP0482771B1 (de)	1997-06-18
AU8372791A (en)	1993-03-18
EP0482771A2 (de)	1992-04-29
ATE154603T1 (de)	1997-07-15
GR3023804T3 (en)	1997-09-30
ZA917066B (en)	1992-06-24
CA2052294A1 (en)	1992-04-05
DE69126593T2 (de)	1997-10-02
US5219874A (en)	1993-06-15
US5410064A (en)	1995-04-25

Publication	Publication Date	Title
ATE126216T1 (de)	1995-08-15	Pyrazolderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellung.
KR920701167A (ko)	1992-08-11	약제학적 활성 화합물
WO2002038153A1 (en)	2002-05-16	New use of 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine derivatives
WO2002051819A3 (en)	2002-12-05	Heterocyclic compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them
JP7316672B2 (ja)	2023-07-28	細菌感染を予防及び処置するためのピリミジン誘導体
BG94282A (bg)	1993-12-24	2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
MY132062A (en)	2007-09-28	Apolipoprotein-b synthesis inhibitors
ATE259376T1 (de)	2004-02-15	Heterozyklische verbindungen, ihre zwischenprodukte und elastase-inhibitoren
DE60105610D1 (en)	2004-10-21	Pyrazinonderivate
KR880013920A (ko)	1988-12-22	디하이드로피리딘 화합물 및 이의 제조방법
NZ223752A (en)	1991-09-25	Triazole and imidazole derivatives and pharmaceutical compositions
US20020198189A1 (en)	2002-12-26	New use
DK0780125T3 (da)	2001-05-07	Anvendelse af hydantoinderivater til fremstilling af et lægemiddel til behandling af sygdomme associeret med tilstedeværelse af aktivt oxygen og frie radikaler
ATE154603T1 (de)	1997-07-15	Heterozyklische säuren
ATE59387T1 (de)	1991-01-15	1,3-dioxan-4-ylalkensaeure.
KR940007008A (ko)	1994-04-26	1, 3, 4-벤조트리아제핀-5(4h)-온 유도체 및 이것의 제조 방법
NO872501L (no)	1987-12-18	Fremgangsmte for fremstilling av terapeutisk aktive triazol- og imidazol-derivater.
TH17753B (th)	2004-10-05	สารยับยั้งการสังเคราะห์แอโพลิโพโปรตีน-b
TH24376A (th)	1997-03-25	สารยับยั้งการสังเคราะห์แอโพลิโพโปรตีน-b