DK0483881T3 - 3-Amidoindolylderivater - Google Patents
3-AmidoindolylderivaterInfo
- Publication number
- DK0483881T3 DK0483881T3 DK91118738.3T DK91118738T DK0483881T3 DK 0483881 T3 DK0483881 T3 DK 0483881T3 DK 91118738 T DK91118738 T DK 91118738T DK 0483881 T3 DK0483881 T3 DK 0483881T3
- Authority
- DK
- Denmark
- Prior art keywords
- amidoindolyl
- derivatives
- sulfamido
- indolyl
- amido
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Paints Or Removers (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60845790A | 1990-11-02 | 1990-11-02 | |
| US76753191A | 1991-10-02 | 1991-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0483881T3 true DK0483881T3 (da) | 1998-03-16 |
Family
ID=27085774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91118738.3T DK0483881T3 (da) | 1990-11-02 | 1991-11-04 | 3-Amidoindolylderivater |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0483881B1 (da) |
| JP (1) | JP3168565B2 (da) |
| KR (1) | KR100220882B1 (da) |
| AT (1) | ATE162519T1 (da) |
| AU (1) | AU641052B2 (da) |
| CA (1) | CA2054339C (da) |
| DE (1) | DE69128764T2 (da) |
| DK (1) | DK0483881T3 (da) |
| ES (1) | ES2113359T3 (da) |
| FI (1) | FI102676B1 (da) |
| GR (1) | GR3026349T3 (da) |
| HU (1) | HU214597B (da) |
| IE (1) | IE913834A1 (da) |
| IL (1) | IL99908A (da) |
| NO (1) | NO177139C (da) |
| NZ (1) | NZ240380A (da) |
| PT (1) | PT99400B (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4242675A1 (de) * | 1992-12-17 | 1994-06-23 | Basf Ag | Neue Hydroxyiminoalkylindolcarbonsäure-Derivate, ihre Herstellung und Verwendung |
| GB9311948D0 (en) * | 1993-06-10 | 1993-07-28 | Zeneca Ltd | Substituted nitrogen heterocycles |
| TW280819B (da) * | 1993-11-17 | 1996-07-11 | Sumitomo Pharma | |
| US5801168A (en) * | 1994-06-09 | 1998-09-01 | Zeneca Limited | Substituted nitrogen heterocycles |
| WO2002049632A1 (en) | 2000-12-18 | 2002-06-27 | Institute Of Medicinal Molecular Design. Inc. | Inhibitors against the production and release of inflammatory cytokines |
| MXPA04007253A (es) * | 2002-01-29 | 2004-10-29 | Applied Research Systems | Derivados de metilenamidas sustituidos como moduladores de proteina tirosina fosfatasas (ptp). |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| US7626042B2 (en) | 2002-06-06 | 2009-12-01 | Institute Of Medicinal Molecular Design, Inc. | O-substituted hydroxyaryl derivatives |
| AU2003242103A1 (en) | 2002-06-06 | 2003-12-22 | Institute Of Medicinal Molecular Design, Inc | Antiallergic agents |
| US20060035944A1 (en) * | 2002-06-11 | 2006-02-16 | Susumu Muto | Remedies for neurodegenerative diseases |
| MY147767A (en) | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| BRPI0512252A (pt) | 2004-06-18 | 2008-02-19 | Biolipox Ab | composto ou um sal farmaceuticamente aceitável do mesmo, formulação farmacêutica, uso de um composto, método de tratamento de uma doença, produto combinado, e, processo para a preparação de um composto |
| JP4912312B2 (ja) * | 2004-08-24 | 2012-04-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗痙攣薬として有用な新規なベンゾ−縮合ヘテロアリールスルファミド誘導体 |
| WO2006077366A1 (en) | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| CA2609185A1 (en) | 2005-05-20 | 2006-11-30 | Ahmed F. Abdel-Magid | Process for preparation of sulfamide derivatives |
| AU2006249866B2 (en) | 2005-05-26 | 2011-10-13 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
| US8716231B2 (en) | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
| US8937096B2 (en) | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
| US8497298B2 (en) | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
| US8691867B2 (en) | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
| US8492431B2 (en) | 2005-12-19 | 2013-07-23 | Janssen Pharmaceutica, N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity |
| AU2007253814A1 (en) | 2006-05-19 | 2007-11-29 | Janssen Pharmaceutica N.V. | Co-therapy for the treatment of epilepsy |
| WO2010008776A2 (en) | 2008-06-23 | 2010-01-21 | Janssen Pharmaceutica Nv | Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems |
| US8815939B2 (en) | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
| CA2782015C (en) | 2009-12-11 | 2020-08-25 | Neuron Systems, Inc. | Topical ophthalmic compositions and methods for the treatment of macular degeneration |
| KR20150118106A (ko) | 2012-12-20 | 2015-10-21 | 알데이라 테라퓨틱스, 아이엔씨. | 페리-카르비놀 |
| CN111135171B (zh) | 2013-01-23 | 2023-09-08 | 奥尔德拉医疗公司 | 与毒性醛相关的疾病和治疗 |
| AU2014209585A1 (en) | 2013-01-25 | 2015-07-23 | Aldeyra Therapeutics, Inc. | Novel traps in the treatment of macular degeneration |
| CN118724806A (zh) | 2015-08-21 | 2024-10-01 | 奥尔德拉医疗公司 | 氘化化合物和其用途 |
| CN109152774A (zh) | 2016-05-09 | 2019-01-04 | 奥尔德拉医疗公司 | 眼部炎性病症和疾病的组合治疗 |
| WO2018170476A1 (en) | 2017-03-16 | 2018-09-20 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| CN111356451A (zh) | 2017-10-10 | 2020-06-30 | 奥尔德拉医疗公司 | 炎性病症的治疗 |
| CN112714762A (zh) | 2018-08-06 | 2021-04-27 | 奥尔德拉医疗公司 | 多晶型化合物及其用途 |
| CN113784954A (zh) | 2019-05-02 | 2021-12-10 | 奥尔德拉医疗公司 | 多晶型化合物和其用途 |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| WO2021231792A1 (en) | 2020-05-13 | 2021-11-18 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60123485A (ja) * | 1983-12-08 | 1985-07-02 | Yoshitomi Pharmaceut Ind Ltd | インド−ル−３−カルボキサミド誘導体 |
| US4675332A (en) * | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
| IL84796A (en) * | 1986-12-17 | 1992-03-29 | Merck Frosst Canada Inc | Substituted n-benzyl-indoles and pharmaceutical compositions containing them |
-
1991
- 1991-10-28 AU AU86760/91A patent/AU641052B2/en not_active Expired
- 1991-10-28 CA CA002054339A patent/CA2054339C/en not_active Expired - Lifetime
- 1991-10-29 NZ NZ240380A patent/NZ240380A/en not_active IP Right Cessation
- 1991-10-30 IL IL9990891A patent/IL99908A/en not_active IP Right Cessation
- 1991-10-31 JP JP32157391A patent/JP3168565B2/ja not_active Expired - Lifetime
- 1991-10-31 PT PT99400A patent/PT99400B/pt not_active IP Right Cessation
- 1991-10-31 FI FI915146A patent/FI102676B1/fi not_active IP Right Cessation
- 1991-11-01 HU HU913454A patent/HU214597B/hu unknown
- 1991-11-01 IE IE383491A patent/IE913834A1/en not_active IP Right Cessation
- 1991-11-01 KR KR1019910019414A patent/KR100220882B1/ko not_active Expired - Lifetime
- 1991-11-01 NO NO914300A patent/NO177139C/no not_active IP Right Cessation
- 1991-11-04 ES ES91118738T patent/ES2113359T3/es not_active Expired - Lifetime
- 1991-11-04 DE DE69128764T patent/DE69128764T2/de not_active Expired - Lifetime
- 1991-11-04 AT AT91118738T patent/ATE162519T1/de not_active IP Right Cessation
- 1991-11-04 DK DK91118738.3T patent/DK0483881T3/da active
- 1991-11-04 EP EP91118738A patent/EP0483881B1/en not_active Expired - Lifetime
-
1998
- 1998-03-13 GR GR980400534T patent/GR3026349T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO177139C (no) | 1995-07-26 |
| NO914300L (no) | 1992-05-04 |
| DE69128764D1 (de) | 1998-02-26 |
| GR3026349T3 (en) | 1998-06-30 |
| DE69128764T2 (de) | 1998-06-04 |
| HU214597B (hu) | 1998-04-28 |
| HUT59668A (en) | 1992-06-29 |
| CA2054339C (en) | 2002-12-24 |
| JP3168565B2 (ja) | 2001-05-21 |
| FI915146L (fi) | 1992-05-03 |
| KR100220882B1 (ko) | 1999-09-15 |
| CA2054339A1 (en) | 1992-05-03 |
| IL99908A0 (en) | 1992-08-18 |
| FI915146A0 (fi) | 1991-10-31 |
| FI102676B (fi) | 1999-01-29 |
| EP0483881A1 (en) | 1992-05-06 |
| JPH0733737A (ja) | 1995-02-03 |
| AU8676091A (en) | 1992-05-07 |
| KR920009796A (ko) | 1992-06-25 |
| NO177139B (no) | 1995-04-18 |
| IE913834A1 (en) | 1992-05-22 |
| AU641052B2 (en) | 1993-09-09 |
| NO914300D0 (no) | 1991-11-01 |
| PT99400A (pt) | 1992-09-30 |
| FI102676B1 (fi) | 1999-01-29 |
| EP0483881B1 (en) | 1998-01-21 |
| NZ240380A (en) | 1994-05-26 |
| PT99400B (pt) | 1999-04-30 |
| IL99908A (en) | 1995-10-31 |
| HU913454D0 (en) | 1992-01-28 |
| ES2113359T3 (es) | 1998-05-01 |
| ATE162519T1 (de) | 1998-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE162519T1 (de) | 3-amidoindolylderivate | |
| DE59108381D1 (de) | Wegwerfkleidungsstück | |
| KR890016959U (ko) | 일회용 흡수성 착용 물품 | |
| DE69032509D1 (de) | Wegwerfkleider | |
| DE69030092D1 (de) | Wegwerfbare Windel | |
| FI914487A7 (fi) | 1,3-bentsoksatsiinijohdannaiset, niiden valmistus ja käyttö | |
| BR9207147A (pt) | Roupa descartável | |
| FI923458A7 (fi) | 4,5-sykloalkano-3-bentsatsepin-7-olijohdannaiset ja niiden käyttö | |
| ATE137225T1 (de) | Dihydrochinolin nmda antagonisten | |
| NO924694L (no) | 1-piperidinylalkanoylarylsulfonamidderivater | |
| ATE131172T1 (de) | Heterocyclische nmda antagonisten. | |
| IT1239064B (it) | Uso terapeutico del dipiridamolo | |
| FI890864A7 (fi) | 1,4-dihydropyridiinijohdannaisten käyttö | |
| FI893366A7 (fi) | 4-piperidyylimetyyli-2,3-dihydro-1H-isoindoli- ja 2,3,4,5-tetrahydro-1H-bentsatsepiinijohdannaiset, niiden valmistus ja terapeuttinen käyttö | |
| DE68926334D1 (de) | Textilbehandlungsmittel | |
| KR910018315U (ko) | 1회용 샴프겸용 비누 | |
| IT216368Z2 (it) | Capo d'abbigliamento intimo sanitario. | |
| ATA129290A (de) | Zusammenlegbares kinderbett | |
| SE8904189D0 (sv) | Anordning foer straeckbehandling av en maenniskas rygg | |
| IT8929572V0 (it) | Bambola atta a simulare l'azione del mangiare | |
| ES1010852Y (es) | Mobiliario infantil | |
| ITMI910966U1 (it) | Regolo per l'indicazione dell'intensita' del dolore |