ATE131172T1 - Heterocyclische nmda antagonisten. - Google Patents

Heterocyclische nmda antagonisten.

Info

Publication number: ATE131172T1
Authority: AT; Austria
Prior art keywords: nmda antagonists; heterocyclic; heterocyclic nmda; antagonists; phosphono
Prior art date: 1990-05-17

Application number

AT91107955T

Other languages

English (en)

Inventor

Jeffrey P Whitten

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-17

Filing date

1991-05-16

Publication date

1995-12-15

1991-05-16 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1995-12-15 Application granted granted Critical

1995-12-15 Publication of ATE131172T1 publication Critical patent/ATE131172T1/de

Links

HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
MNQZHTRAKIMKJF-UHFFFAOYSA-N piperidin-3-ylphosphonic acid Chemical class OP(O)(=O)C1CCCNC1 MNQZHTRAKIMKJF-UHFFFAOYSA-N 0.000 abstract 1
150000003235 pyrrolidines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

AT91107955T 1990-05-17 1991-05-16 Heterocyclische nmda antagonisten. ATE131172T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US52529090A	1990-05-17	1990-05-17
US07/675,156 US5194430A (en)	1990-05-17	1991-03-28	Heterocyclic-nmda antagonists

Publications (1)

Publication Number	Publication Date
ATE131172T1 true ATE131172T1 (de)	1995-12-15

Family

ID=27061745

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91107955T ATE131172T1 (de)	1990-05-17	1991-05-16	Heterocyclische nmda antagonisten.

Country Status (20)

Country	Link
US (2)	US5194430A (de)
EP (1)	EP0457324B1 (de)
JP (1)	JP2977950B2 (de)
KR (1)	KR100196239B1 (de)
CN (1)	CN1027695C (de)
AT (1)	ATE131172T1 (de)
AU (1)	AU641657B2 (de)
CA (1)	CA2042473C (de)
DE (1)	DE69115116T2 (de)
DK (1)	DK0457324T3 (de)
ES (1)	ES2083478T3 (de)
FI (1)	FI97388C (de)
GR (1)	GR3019047T3 (de)
HU (1)	HU208831B (de)
IE (1)	IE70437B1 (de)
IL (1)	IL98148A (de)
NO (1)	NO300502B1 (de)
NZ (1)	NZ238124A (de)
PT (1)	PT97692B (de)
TW (1)	TW308596B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5260286A (en) *	1992-10-16	1993-11-09	Japan Tobacco, Inc.	2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists
EP1436258A4 (de) *	2001-03-08	2005-03-23	Univ Emory	Ph-wert-abhängige nmda-rezeptorantagonisten
KR20100045983A (ko)	2007-06-29	2010-05-04	에모리 유니버시티	신경보호를 위한 ｎｍｄａ 수용체 길항물질
CN102952130B (zh) *	2011-08-24	2016-03-23	重庆华邦胜凯制药有限公司	手性合成(s,s)-2,8-二氮杂双环壬烷的方法
CN102952065A (zh) *	2011-08-24	2013-03-06	重庆华邦胜凯制药有限公司	一种拆分顺式2,3-吡啶二甲酸酯的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2706194A (en) *	1951-05-14	1955-04-12	Shell Dev	Esters of phosphonic acids
NL299936A (de) *	1963-10-30	1965-08-25
JPS5251028A (en) *	1975-10-22	1977-04-23	Nippon Tokushu Noyaku Seizo Kk	Herbicide
US4094974A (en) *	1977-02-24	1978-06-13	Stauffer Chemical Company	Isoxazole phosphates and phosphonates
US4139708A (en) *	1977-05-24	1979-02-13	Sk&F Lab Co.	Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts
CA1248531A (en) *	1984-04-17	1989-01-10	Jeffrey C. Watkins	4-substituted piperazine-2-carboxylic acids
US4906621A (en) *	1985-05-24	1990-03-06	Ciba-Geigy Corporation	Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
PH23848A (en) *	1985-05-24	1989-11-23	Ciba Geigy Ag	Certain phosphonic acids and derivatives
US4746653A (en) *	1986-02-28	1988-05-24	Ciba-Geigy Corporation	Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
US4657899A (en) *	1986-04-09	1987-04-14	Nova Pharmaceutical Corporation	Antagonists of specific excitatory amino acid neurotransmitter receptors
ATE60776T1 (de) *	1986-11-21	1991-02-15	Ciba Geigy Ag	Ungesaettigte phosphonsaeure und derivate.
SE9003652D0 (sv) *	1990-11-15	1990-11-15	Astra Ab	New heterocyclic compounds

1991
- 1991-03-28 US US07/675,156 patent/US5194430A/en not_active Expired - Fee Related
- 1991-05-13 CA CA002042473A patent/CA2042473C/en not_active Expired - Fee Related
- 1991-05-13 NZ NZ238124A patent/NZ238124A/xx unknown
- 1991-05-14 AU AU76498/91A patent/AU641657B2/en not_active Ceased
- 1991-05-14 TW TW080103761A patent/TW308596B/zh active
- 1991-05-15 IL IL9814891A patent/IL98148A/en active IP Right Grant
- 1991-05-16 ES ES91107955T patent/ES2083478T3/es not_active Expired - Lifetime
- 1991-05-16 DK DK91107955.6T patent/DK0457324T3/da active
- 1991-05-16 DE DE69115116T patent/DE69115116T2/de not_active Expired - Fee Related
- 1991-05-16 NO NO911916A patent/NO300502B1/no not_active IP Right Cessation
- 1991-05-16 AT AT91107955T patent/ATE131172T1/de not_active IP Right Cessation
- 1991-05-16 FI FI912382A patent/FI97388C/fi not_active IP Right Cessation
- 1991-05-16 PT PT97692A patent/PT97692B/pt not_active IP Right Cessation
- 1991-05-16 EP EP91107955A patent/EP0457324B1/de not_active Expired - Lifetime
- 1991-05-16 HU HU911649A patent/HU208831B/hu not_active IP Right Cessation
- 1991-05-16 CN CN91103185A patent/CN1027695C/zh not_active Expired - Fee Related
- 1991-05-16 IE IE167691A patent/IE70437B1/en unknown
- 1991-05-17 JP JP3140636A patent/JP2977950B2/ja not_active Expired - Fee Related
- 1991-05-17 KR KR1019910008036A patent/KR100196239B1/ko not_active Expired - Fee Related
1993
- 1993-11-30 US US08/159,913 patent/US5470844A/en not_active Expired - Lifetime
1996
- 1996-02-21 GR GR960400451T patent/GR3019047T3/el unknown

Also Published As

Publication number	Publication date
EP0457324A1 (de)	1991-11-21
FI912382A7 (fi)	1991-11-18
IE911676A1 (en)	1991-11-20
FI912382A0 (fi)	1991-05-16
US5194430A (en)	1993-03-16
US5470844A (en)	1995-11-28
FI97388B (fi)	1996-08-30
AU7649891A (en)	1991-11-21
CA2042473C (en)	2002-01-01
NO911916L (no)	1991-11-18
NO300502B1 (no)	1997-06-09
PT97692B (pt)	1998-09-30
AU641657B2 (en)	1993-09-30
CA2042473A1 (en)	1991-11-18
PT97692A (pt)	1992-02-28
FI97388C (fi)	1996-12-10
CN1027695C (zh)	1995-02-22
IL98148A (en)	1996-10-16
IE70437B1 (en)	1996-11-27
JPH0812691A (ja)	1996-01-16
HUT59150A (en)	1992-04-28
DE69115116T2 (de)	1996-06-13
NZ238124A (en)	1993-09-27
CN1056499A (zh)	1991-11-27
HU208831B (en)	1994-01-28
EP0457324B1 (de)	1995-12-06
KR910020023A (ko)	1991-12-19
GR3019047T3 (en)	1996-05-31
DK0457324T3 (da)	1996-01-02
TW308596B (de)	1997-06-21
NO911916D0 (no)	1991-05-16
HU911649D0 (en)	1991-11-28
KR100196239B1 (ko)	1999-06-15
JP2977950B2 (ja)	1999-11-15
DE69115116D1 (de)	1996-01-18
ES2083478T3 (es)	1996-04-16

Legal Events

Date	Code	Title	Description
1996-06-15	UEP	Publication of translation of european patent specification
2005-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69128764D1 (de)	1998-02-26	3-Amidoindolylderivate
CO4230019A1 (es)	1995-10-19	Antagonistas de neuroquinina diazabiciclica
MX9102407A (es)	1994-05-31	4 arilpiperazinas y 4-arilpiperidinas novedosas.
PT641343E (pt)	2003-10-31	Derivados de 4-mercaptoacetilamino-¬2\|benzazapinona (3) e a sua utilizacao como inibidores de encefalinase
YU101791A (sh)	1997-08-22	Supstituisani ftalidi i heterociklični ftalidi
FI904591A7 (fi)	1991-03-30	Heterosyklisiä johdannaisia
FI901009A7 (fi)	1990-08-29	Heterosyklisiä sykloalkaaneja
NO924126L (no)	1992-10-23	3-indolylthioacetatderivater
FI931204A7 (fi)	1993-03-18	Uusia aminobentsosultaamijohdannaisia lipo-oksigenaasin estäjinä
DE69230224D1 (de)	1999-12-02	Potenzierung von nmda-antagonisten
DK0457324T3 (da)	1996-01-02	Heterocycliske NMDA antagonister
ATE137225T1 (de)	1996-05-15	Dihydrochinolin nmda antagonisten
DK0532629T3 (da)	1996-11-25	1-Piperidinyl-alkanoylarylsulfonamid-derivater
FI931666A7 (fi)	1993-04-14	Pyrrolidiinidionijohdannaisia
FI930379A7 (fi)	1993-03-26	Golfomysiinijohdannaiset: uudet fuusiorengassyklodekadiyynijohdannaise t
FI960929A0 (fi)	1996-02-28	Välituotteena käyttökelpoiset indolonijohdannaiset
DE69028985D1 (de)	1996-11-28	Halophenyl-substituierte heterozyklische derivate