DK0484223T3 - 3-cyclopropanamider, deres tautomere former og deres salte samt en fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og præparater med indhold deraf - Google Patents

3-cyclopropanamider, deres tautomere former og deres salte samt en fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og præparater med indhold deraf

Info

Publication number: DK0484223T3
Authority: DK; Denmark
Prior art keywords: carbon atoms; tautomeric forms; salts; cyclopropanamides; drugs
Prior art date: 1990-10-30

Application number

DK91402890.7T

Other languages

English (en)

Inventor

Philip Thomas Hambleton

Charles John Robert Hedgecock

David Paul Kay

Elizabeth Anne Kuo

Wilfred Roger Tully

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-30

Filing date

1991-10-29

Publication date

1995-06-19

1990-10-30 Priority claimed from GB909023535A external-priority patent/GB9023535D0/en

1991-10-29 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1995-06-19 Application granted granted Critical

1995-06-19 Publication of DK0484223T3 publication Critical patent/DK0484223T3/da

Links

238000002360 preparation method Methods 0.000 title 2
AIMMVWOEOZMVMS-UHFFFAOYSA-N cyclopropanecarboxamide Chemical class NC(=O)C1CC1 AIMMVWOEOZMVMS-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
101100450129 Caenorhabditis elegans hal-3 gene Proteins 0.000 abstract 1
150000001447 alkali salts Chemical class 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
- C07C255/27—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and doubly-bound oxygen atoms bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK91402890.7T 1990-10-30 1991-10-29 3-cyclopropanamider, deres tautomere former og deres salte samt en fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og præparater med indhold deraf DK0484223T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909023535A GB9023535D0 (en)	1990-10-30	1990-10-30	Chemical compounds
GB919105516A GB9105516D0 (en)	1990-10-30	1991-03-15	Chemical compounds

Publications (1)

Publication Number	Publication Date
DK0484223T3 true DK0484223T3 (da)	1995-06-19

Family

ID=26297867

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91402890.7T DK0484223T3 (da)	1990-10-30	1991-10-29	3-cyclopropanamider, deres tautomere former og deres salte samt en fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og præparater med indhold deraf

Country Status (25)

Country	Link
US (2)	US5240960B1 (da)
EP (1)	EP0484223B1 (da)
JP (1)	JP2594855B2 (da)
CN (1)	CN1030075C (da)
AT (1)	ATE119518T1 (da)
AU (1)	AU641290B2 (da)
BG (1)	BG61924B2 (da)
BR (1)	BR9104711A (da)
CA (1)	CA2054473C (da)
CZ (1)	CZ282036B6 (da)
DE (1)	DE69107959T2 (da)
DK (1)	DK0484223T3 (da)
ES (1)	ES2069854T3 (da)
FI (2)	FI110511B (da)
GE (1)	GEP19981035B (da)
GR (1)	GR3015335T3 (da)
HR (1)	HRP920979B1 (da)
HU (2)	HU215051B (da)
IE (1)	IE69330B1 (da)
IL (1)	IL99811A (da)
NO (1)	NO175898C (da)
NZ (1)	NZ240403A (da)
PT (1)	PT99381B (da)
SI (1)	SI9111731B (da)
SK (1)	SK281720B6 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL99811A (en) *	1990-10-30	1996-03-31	Roussel Uclaf	3-cycloalkyl-propanamides their tautomer forms and their salts preparation process and compositions containing them
IL102790A (en) *	1991-09-17	1996-01-31	Roussel Uclaf	3-Cycloalkyl-prop-2- enamide derivatives
DE59203828D1 (de) *	1991-10-23	1995-11-02	Hoechst Ag	N-phenyl-2-cyano-3-hydroxycrotonsäureamidderivate und deren Verwendung als Arzneimittel mit immunmodulatorischer Eigenschaft.
GB9200275D0 (en) *	1992-01-08	1992-02-26	Roussel Lab Ltd	Chemical compounds
GB9300083D0 (en) *	1993-01-05	1993-03-03	Roussel Lab Ltd	Chemical compounds
TW314467B (da) *	1993-03-31	1997-09-01	Hoechst Ag
GB9313365D0 (en) *	1993-06-29	1993-08-11	Roussel Lab Ltd	Chemical compounds
US5519042A (en) *	1994-01-13	1996-05-21	Hoechst Aktiengesellschaft	Method of treating hyperproliferative vascular disease
FR2727628B1 (fr) *	1994-12-02	1997-01-10	Roussel Uclaf	Application des derives de 3-cycloalkyl-propanamide a titre de medicaments analgesiques
GB9520092D0 (en) *	1995-10-02	1995-12-06	Hoechst Roussel Ltd	Chemical compounds
DE19539638A1 (de) *	1995-10-25	1997-04-30	Hoechst Ag	Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen
DE19547648A1 (de) *	1995-12-20	1997-06-26	Hoechst Ag	Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
US6011051A (en) *	1996-07-31	2000-01-04	Hoechst Aktiengesellschaft	Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
US5856330A (en) *	1996-07-31	1999-01-05	Hoechst Aktiengesellschaft	Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
US5981536A (en) *	1996-07-31	1999-11-09	Hoechst Aktiengesellschaft	Use of xanthine derivatives for the modulation of apoptosis
US6355678B1 (en) *	1998-06-29	2002-03-12	Parker Hughes Institute	Inhibitors of the EGF-receptor tyrosine kinase and methods for their use
AU731777B2 (en)	1998-11-30	2001-04-05	Nihon Nohyaku Co., Ltd.	Aniline derivative and process for producing the same
US6566395B1 (en) *	1999-05-25	2003-05-20	Biomedicines, Inc.	Methods of treating proliferative disorders
KR20160079123A (ko)	2013-11-22	2016-07-05	젠자임 코포레이션	신경변성 질병을 치료하기 위한 신규한 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR831461A (fr) *	1937-01-09	1938-09-05	Ste Ind Chim Bale	Nouveaux produits de condensation
US3116312A (en) *	1960-03-31	1963-12-31	American Cyanamid Co	Substituted-2-cyanoacetanilides
NL6911567A (da) *	1968-08-08	1970-02-10
DE2307156A1 (de) *	1973-02-14	1974-08-22	Henkel & Cie Gmbh	N,n-disubstituierte alpha-cyanacrylsaeureamide und deren herstellung
DE2555789A1 (de) *	1975-12-11	1977-07-07	Hoechst Ag	Neue cyanessigsaeureanilid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4393217A (en) *	1981-01-12	1983-07-12	American Cyanamid Company	Substituted phenyl-5-aminopyrazoles
US4946867A (en) *	1987-09-07	1990-08-07	Sumitomo Chemical Company, Limited	Cyanoacetamide derivative, and plant disease protectant comprising the same as an active ingredient
US4888357A (en) *	1988-01-26	1989-12-19	Bristol-Myers Company	Antiarthritic β-cycloalkyl-β-oxopropionitriles
US5034410A (en) *	1989-10-11	1991-07-23	Syntex (U.S.A.) Inc.	Anthelmintically active benzenepropanamide derivatives
IL99811A (en) *	1990-10-30	1996-03-31	Roussel Uclaf	3-cycloalkyl-propanamides their tautomer forms and their salts preparation process and compositions containing them

1991
- 1991-10-21 IL IL9981191A patent/IL99811A/en not_active IP Right Cessation
- 1991-10-29 NO NO914232A patent/NO175898C/no not_active IP Right Cessation
- 1991-10-29 AT AT91402890T patent/ATE119518T1/de not_active IP Right Cessation
- 1991-10-29 JP JP3308260A patent/JP2594855B2/ja not_active Expired - Lifetime
- 1991-10-29 EP EP91402890A patent/EP0484223B1/fr not_active Expired - Lifetime
- 1991-10-29 IE IE376891A patent/IE69330B1/en not_active IP Right Cessation
- 1991-10-29 DE DE69107959T patent/DE69107959T2/de not_active Expired - Lifetime
- 1991-10-29 DK DK91402890.7T patent/DK0484223T3/da active
- 1991-10-29 ES ES91402890T patent/ES2069854T3/es not_active Expired - Lifetime
- 1991-10-29 CZ CS913273A patent/CZ282036B6/cs not_active IP Right Cessation
- 1991-10-29 FI FI915091A patent/FI110511B/fi not_active IP Right Cessation
- 1991-10-29 HU HU913394A patent/HU215051B/hu unknown
- 1991-10-29 SK SK3273-91A patent/SK281720B6/sk not_active IP Right Cessation
- 1991-10-29 CA CA002054473A patent/CA2054473C/fr not_active Expired - Lifetime
- 1991-10-30 US US07785087 patent/US5240960B1/en not_active Expired - Lifetime
- 1991-10-30 BR BR919104711A patent/BR9104711A/pt not_active Application Discontinuation
- 1991-10-30 NZ NZ240403A patent/NZ240403A/en not_active IP Right Cessation
- 1991-10-30 SI SI9111731A patent/SI9111731B/sl unknown
- 1991-10-30 CN CN91111132A patent/CN1030075C/zh not_active Expired - Lifetime
- 1991-10-30 PT PT99381A patent/PT99381B/pt not_active IP Right Cessation
- 1991-10-30 AU AU86869/91A patent/AU641290B2/en not_active Expired
1992
- 1992-10-02 HR HR920979A patent/HRP920979B1/xx not_active IP Right Cessation
1993
- 1993-04-22 US US08/051,178 patent/US5384423A/en not_active Expired - Lifetime
- 1993-07-31 GE GEAP19931341A patent/GEP19981035B/en unknown
1994
- 1994-02-23 BG BG098526A patent/BG61924B2/bg unknown
1995
- 1995-03-09 GR GR940402650T patent/GR3015335T3/el unknown
- 1995-06-30 HU HU95P/P00667P patent/HU211614A9/hu unknown
2002
- 2002-09-20 FI FI20021681A patent/FI119986B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL99811A0 (en)	1992-08-18
PT99381B (pt)	1999-04-30
SI9111731A (en)	1997-12-31
GR3015335T3 (en)	1995-06-30
NO914232L (no)	1992-05-04
BG61924B2 (bg)	1998-09-30
EP0484223A3 (en)	1993-04-07
CZ282036B6 (cs)	1997-04-16
GEP19981035B (en)	1998-03-26
HRP920979A2 (en)	1997-12-31
CS327391A3 (en)	1992-05-13
NO175898C (no)	1994-12-28
CA2054473A1 (fr)	1992-05-01
EP0484223B1 (fr)	1995-03-08
US5240960A (en)	1993-08-31
PT99381A (pt)	1992-09-30
FI119986B (fi)	2009-05-29
HRP920979B1 (en)	2000-06-30
ES2069854T3 (es)	1995-05-16
DE69107959D1 (de)	1995-04-13
FI915091A0 (fi)	1991-10-29
CA2054473C (fr)	2003-07-29
CN1030075C (zh)	1995-10-18
AU8686991A (en)	1992-05-07
NO175898B (no)	1994-09-19
CN1064482A (zh)	1992-09-16
SI9111731B (en)	2001-02-28
ATE119518T1 (de)	1995-03-15
AU641290B2 (en)	1993-09-16
US5384423A (en)	1995-01-24
FI110511B (fi)	2003-02-14
SK281720B6 (sk)	2001-07-10
HUT59661A (en)	1992-06-29
HU211614A9 (en)	1995-12-28
JP2594855B2 (ja)	1997-03-26
HU215051B (hu)	1998-12-28
EP0484223A2 (fr)	1992-05-06
DE69107959T2 (de)	1995-11-16
BR9104711A (pt)	1992-06-16
FI20021681A7 (fi)	2002-09-20
IE69330B1 (en)	1996-09-04
HU913394D0 (en)	1992-01-28
US5240960B1 (en)	1995-05-02
NO914232D0 (no)	1991-10-29
NZ240403A (en)	1994-10-26
FI915091A7 (fi)	1992-05-01
IL99811A (en)	1996-03-31
IE913768A1 (en)	1992-05-22
JPH04288048A (ja)	1992-10-13

Publication	Publication Date	Title
US5240960B1 (en)	1995-05-02	3-cycloalkyl-propanamides.
DK0590919T3 (da)	2000-04-17	Terapeutiske midler mod Parkinsons sygdom
DZ1694A1 (fr)	2002-02-17	"n-(2-Aminoethyl)-benzothialozones".
ES8401961A1 (es)	1984-01-01	Procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil-bencimidazolonas sustituidas.
SE8505715D0 (sv)	1985-12-03	Indolderivat
DK283487D0 (da)	1987-06-03	Thiazolyl-2-yl-imidazo(1,2-a)pyrimidiner, deres fremstilling og brug
ATE185143T1 (de)	1999-10-15	Glatten-muskelzellen-proliferation-inhibitoren
ES455741A1 (es)	1978-04-16	Un procedimiento para la preparacion de nuevos derivados de 1,3-bencenodimetanol.
DK96086D0 (da)	1986-03-03	8-thiotetrahydroquinolinderivater, deres fremstilling og anvendelsesom laegemidler
DK470888D0 (da)	1988-08-23	Imidazobenzodiazepinderivater, deres fresmtilling samt laegemidler med indholdd deraf
ES8401456A1 (es)	1983-12-01	Procedimiento para la preparacion de 2-aminometilfenoles.
ATE18211T1 (de)	1986-03-15	Chinolinessigsaeuren und diese enthaltende pharmazeutische zubereitungen.
PT92494A (pt)	1990-06-29	Processo para a preparacao de novos derivados do indol
DK0395527T3 (da)	1995-02-20	Imidazobenzodiazepiner og deres salte, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og præparater med indhold deraf
ES500108A0 (es)	1982-06-01	Procedimiento para preparar nuevas benzotiopirano (2,3-c)pi-ridinas
NO167201C (no)	1991-10-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive semikarbazid-derivater.