DK0485219T3 - Lægemidler til forebyggelse og behandling af kredsløbsorgansygdomme indeholdende spiro-3-heteroazolidinforbindelser - Google Patents

Lægemidler til forebyggelse og behandling af kredsløbsorgansygdomme indeholdende spiro-3-heteroazolidinforbindelser

Info

Publication number: DK0485219T3
Authority: DK; Denmark
Prior art keywords: group; atom; oxygen; heteroazolidine; medicines
Prior art date: 1990-11-07

Application number

DK91310322.2T

Other languages

English (en)

Inventor

Masayasu Kurono

Kenji Sanwa Miura

Yasuaki Kondo

Toshinao Usui

Motohide Hayashi

Tunemasa Suzuki

Noboru Tomiya

Shigeyoshi Nakamura

Yukiya Tanaka

Kiichi Sawai

Original Assignee

Sanwa Kagaku Kenkyusho Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-07

Filing date

1991-11-07

Publication date

1996-07-22

1991-11-07 Application filed by Sanwa Kagaku Kenkyusho Co filed Critical Sanwa Kagaku Kenkyusho Co

1996-07-22 Application granted granted Critical

1996-07-22 Publication of DK0485219T3 publication Critical patent/DK0485219T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000003814 drug Substances 0.000 title abstract 2
210000000056 organ Anatomy 0.000 title abstract 2
229940079593 drug Drugs 0.000 title 1
230000002265 prevention Effects 0.000 title 1
229910052757 nitrogen Inorganic materials 0.000 abstract 3
229910052717 sulfur Inorganic materials 0.000 abstract 3
125000004434 sulfur atom Chemical group 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK91310322.2T 1990-11-07 1991-11-07 Lægemidler til forebyggelse og behandling af kredsløbsorgansygdomme indeholdende spiro-3-heteroazolidinforbindelser DK0485219T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2301518A JP2997894B2 (ja)	1990-11-07	1990-11-07	循環器系疾患の予防及び治療剤

Publications (1)

Publication Number	Publication Date
DK0485219T3 true DK0485219T3 (da)	1996-07-22

Family

ID=17897897

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91310322.2T DK0485219T3 (da)	1990-11-07	1991-11-07	Lægemidler til forebyggelse og behandling af kredsløbsorgansygdomme indeholdende spiro-3-heteroazolidinforbindelser

Country Status (6)

Country	Link
EP (1)	EP0485219B1 (da)
JP (1)	JP2997894B2 (da)
AT (1)	ATE135212T1 (da)
DE (1)	DE69117879T2 (da)
DK (1)	DK0485219T3 (da)
ES (1)	ES2084120T3 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0719556B1 (en) *	1994-12-28	2000-10-25	Sanwa Kagaku Kenkyusho Co., Ltd.	Use of (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazoline]-2-carboxamide for treating diabetic keratopathy
PE20050249A1 (es) *	2003-07-25	2005-06-01	Aventis Pharma Gmbh	Nuevas cianopirrolididas y procedimiento para su preparacion como medicamentos
US7094800B2 (en)	2003-07-25	2006-08-22	Sanofi-Aventis Deutschland Gmbh	Cyanopyrrolidides, process for their preparation and their use as medicaments
WO2007069727A1 (ja)	2005-12-16	2007-06-21	Sanwa Kagaku Kenkyusho Co., Ltd.	急性腎不全の予防または治療剤
EP1987829A4 (en) *	2006-02-20	2009-07-29	Sanwa Kagaku Kenkyusho Co	PROPHYLACTIC OR THERAPEUTIC AGENT FOR LESIONS DUE TO BRAIN ISCHEMIA OR LESIONS DUE TO BRAIN ISCHEMIA WITH REPERFUSION IN BRAIN VASCULAR ACCIDENTS
EP2110141B1 (en)	2007-01-31	2013-04-03	Sanwa Kagaku Kenkyusho Co., Ltd	Protective agent for retinal nerve or optic nerve
ES2468827T3 (es)	2010-01-14	2014-06-17	Sanwa Kagaku Kenkyusho Co., Ltd	Producto farmacéutico para prevenir o tratar trastornos acompañados de angiog�nesis ocular y/o permeabilidad vascular ocular elevada
EP2565196A4 (en) *	2010-04-28	2014-03-26	Sanwa Kagaku Kenkyusho Co	Prophylactic or therapeutic medication for inner ear disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61200991A (ja) *	1985-03-04	1986-09-05	Sanwa Kagaku Kenkyusho:Kk	スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
US5164391A (en) *	1989-09-20	1992-11-17	Sanwa Kagaku Kenkyusho Co., Ltd.	Hydantoin derivatives for treating complications of diabetes and circulatory diseases

1990
- 1990-11-07 JP JP2301518A patent/JP2997894B2/ja not_active Expired - Lifetime
1991
- 1991-11-07 ES ES91310322T patent/ES2084120T3/es not_active Expired - Lifetime
- 1991-11-07 AT AT91310322T patent/ATE135212T1/de not_active IP Right Cessation
- 1991-11-07 DE DE69117879T patent/DE69117879T2/de not_active Expired - Fee Related
- 1991-11-07 EP EP91310322A patent/EP0485219B1/en not_active Expired - Lifetime
- 1991-11-07 DK DK91310322.2T patent/DK0485219T3/da active

Also Published As

Publication number	Publication date
EP0485219A3 (en)	1992-10-14
JPH04173791A (ja)	1992-06-22
EP0485219B1 (en)	1996-03-13
EP0485219A2 (en)	1992-05-13
ES2084120T3 (es)	1996-05-01
ATE135212T1 (de)	1996-03-15
DE69117879T2 (de)	1996-08-08
DE69117879D1 (de)	1996-04-18
JP2997894B2 (ja)	2000-01-11

Publication	Publication Date	Title
AU556150B2 (en)	1986-10-23	Dihydropyridine derivatives
NO901300L (no)	1990-09-24	Behandling og forbindelser.
MX9306831A (es)	1995-01-31	Nuevos compuestos heterociclicos.
IE802612L (en)	1981-06-14	Bicyclo £2.2.1\| heptane derivatives
FI884879A0 (fi)	1988-10-21	Terapeutiskt anvaendbara heterocykliska foereningar.
DE69935718D1 (de)	2007-05-16	Antidiabetische medikamente
NO975666D0 (no)	1997-12-05	Pyrroldovater og medisinsk sammensetning
DK0652002T3 (da)	2001-04-17	Anvendelse af 2-phenyl-3-aroylebenzothiophener til fremstilling af et medikament til hæmning af brusknedbrydning
AR002761A1 (es)	1998-04-29	Un compuesto derivado del triazol, su uso, una composicion farmaceutica que lo contiene, un metodo de tratamiento o prevencion de una infeccion fungica enun paciente humano mediante dicho compuesto o composicion, y procedimiento y compuestos intermedios para prepararlo.
FI941863A0 (fi)	1994-04-21	Oksatsolidonijohdannainen
DE69117879D1 (de)	1996-04-18	Arzneimittel für die Verhütung und Behandlung von Krankheiten der Kreislauforgane enthaltend Spiro-3-heteroazolidin-Verbindungen
MX9206930A (es)	1993-06-01	Nuevos compuestos
DE60009517D1 (de)	2004-05-06	A-500359-derivate
DE69428206D1 (de)	2001-10-11	Chinolincarbonsäurederivate und ihre salze
DE69001004D1 (de)	1993-04-08	Zusammensetzung gegen leberkrankheiten.
DK360388D0 (da)	1988-06-30	Laegemiddel til behandling af hjerteinsufficiens
EP0982029A4 (en)	2002-07-03	PREVENTIVE / MEDICINE FOR ARTERIOSCLEROSIS
ATE132748T1 (de)	1996-01-15	Verwendung eines dihydropyridins zur verbesserung der blutzirkulation des inneren ohres