DK0487774T3 - Hjælpestof til direkte tablettering - Google Patents

Hjælpestof til direkte tablettering

Info

Publication number: DK0487774T3
Authority: DK; Denmark
Prior art keywords: direct tabletting; weight; intimate mixture; tabletting auxiliary; calcium
Prior art date: 1990-11-29

Application number

DK90122804.9T

Other languages

Danish (da)

English (en)

Inventor

Siegfried Dr Lang

Ta-Shuong Yeh

Original Assignee

Wei Ming Pharmaceutical Mfg Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-29

Filing date

1990-11-29

Publication date

1994-11-21

1990-11-29 Application filed by Wei Ming Pharmaceutical Mfg Co filed Critical Wei Ming Pharmaceutical Mfg Co

1994-11-21 Application granted granted Critical

1994-11-21 Publication of DK0487774T3 publication Critical patent/DK0487774T3/da

Links

239000000546 pharmaceutical excipient Substances 0.000 title 1
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
229920000858 Cyclodextrin Polymers 0.000 abstract 2
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 abstract 2
239000011872 intimate mixture Substances 0.000 abstract 2
229920001450 Alpha-Cyclodextrin Polymers 0.000 abstract 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 1
229920002261 Corn starch Polymers 0.000 abstract 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
108010010803 Gelatin Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 abstract 1
239000004354 Hydroxyethyl cellulose Substances 0.000 abstract 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
229920002774 Maltodextrin Polymers 0.000 abstract 1
239000005913 Maltodextrin Substances 0.000 abstract 1
229930195725 Mannitol Natural products 0.000 abstract 1
229920000168 Microcrystalline cellulose Polymers 0.000 abstract 1
229920000881 Modified starch Polymers 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 abstract 1
229940043377 alpha-cyclodextrin Drugs 0.000 abstract 1
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
229960004853 betadex Drugs 0.000 abstract 1
239000011230 binding agent Substances 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
235000010948 carboxy methyl cellulose Nutrition 0.000 abstract 1
239000008112 carboxymethyl-cellulose Substances 0.000 abstract 1
239000008120 corn starch Substances 0.000 abstract 1
229940099112 cornstarch Drugs 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 abstract 1
229940080345 gamma-cyclodextrin Drugs 0.000 abstract 1
229920000159 gelatin Polymers 0.000 abstract 1
239000008273 gelatin Substances 0.000 abstract 1
229940014259 gelatin Drugs 0.000 abstract 1
235000019322 gelatine Nutrition 0.000 abstract 1
235000011852 gelatine desserts Nutrition 0.000 abstract 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 abstract 1
239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
239000008101 lactose Substances 0.000 abstract 1
229960001375 lactose Drugs 0.000 abstract 1
229940035034 maltodextrin Drugs 0.000 abstract 1
239000000594 mannitol Substances 0.000 abstract 1
235000010355 mannitol Nutrition 0.000 abstract 1
229960001855 mannitol Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229920000609 methyl cellulose Polymers 0.000 abstract 1
239000001923 methylcellulose Substances 0.000 abstract 1
235000010981 methylcellulose Nutrition 0.000 abstract 1
239000008108 microcrystalline cellulose Substances 0.000 abstract 1
229940016286 microcrystalline cellulose Drugs 0.000 abstract 1
235000019813 microcrystalline cellulose Nutrition 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
229920003109 sodium starch glycolate Polymers 0.000 abstract 1
229940079832 sodium starch glycolate Drugs 0.000 abstract 1
239000008109 sodium starch glycolate Substances 0.000 abstract 1
239000000600 sorbitol Substances 0.000 abstract 1
229960002920 sorbitol Drugs 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
Press Drives And Press Lines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK90122804.9T 1990-11-29 1990-11-29 Hjælpestof til direkte tablettering DK0487774T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP90122804A EP0487774B1 (en)	1990-11-29	1990-11-29	A direct tabletting auxiliary

Publications (1)

Publication Number	Publication Date
DK0487774T3 true DK0487774T3 (da)	1994-11-21

Family

ID=8204768

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90122804.9T DK0487774T3 (da)	1990-11-29	1990-11-29	Hjælpestof til direkte tablettering

Country Status (6)

Country	Link
EP (1)	EP0487774B1 (es)
AT (1)	ATE113202T1 (es)
DE (1)	DE69013689T2 (es)
DK (1)	DK0487774T3 (es)
ES (1)	ES2066092T3 (es)
TW (1)	TW221279B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4318577A1 (de) *	1993-06-04	1994-12-08	Merck Patent Gmbh	Schmiermittelfreie, arzneimittelhaltige Tabletten
WO1994028936A1 (en) *	1993-06-08	1994-12-22	Ciba-Geigy Ag	Process for the preparation of an oral solid dosage form containing diclofenac
FR2710637B1 (fr) *	1993-09-28	1995-12-08	Roquette Freres	Mannitol pulvérulent de friabilité modérée et son procédé de préparation.
IL115445A (en) *	1994-10-17	1999-08-17	Akzo Nobel Nv	Solid pharmaceutical compositions comprising low dosage active ingredient oil and excipient capable of binding water and their preparation
ES2079327B1 (es) *	1994-12-13	1996-08-01	Lilly Sa	Formulaciones farmaceuticas de cefaclor.
FR2766710B1 (fr) *	1997-08-04	1999-10-29	Inst Pharma De Rech Applic Et	Composition pharmaceutique, comprime forme a partir de celle-ci et son utilisation comme antiseptique vaginal a action prolongee
GB9716432D0 (en) *	1997-08-05	1997-10-08	Cerestar Holding Bv	Tableting of erythritol
AR016827A1 (es)	1997-08-22	2001-08-01	Smithkline Beecham Corp	PROCEDIMIENTO PARA LA PREPARACIoN DE UNA TABLETA FARMACÉUTICA
AR017512A1 (es)	1997-08-22	2001-09-12	Smithkline Beecham Corp	Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas
AU5904698A (en) *	1997-12-29	1999-07-19	Procter & Gamble Company, The	Tablet composition
GB9825033D0 (en)	1998-11-13	1999-01-13	Nycomed Pharma As	Process
EP1133984B1 (en)	2000-03-17	2005-05-11	Shin-Etsu Chemical Co., Ltd.	Solid preparation containing low-substituted hydroxypropyl cellulose and production process thereof
US6242003B1 (en)	2000-04-13	2001-06-05	Novartis Ag	Organic compounds
JP2004525109A (ja)	2001-02-15	2004-08-19	キング・ファーマシューティカルズ・インコーポレイティッド	安定化された甲状腺ホルモン医薬組成物、及びその製法
US20060127474A1 (en)	2001-04-11	2006-06-15	Oskar Kalb	Pharmaceutical compositions comprising fluvastatin
US6761905B2 (en) *	2001-05-01	2004-07-13	Wei Ming Pharmaceutical Mfg. Co., Ltd.	Process for the preparation of direct tabletting formulations and aids
FR2826549A1 (fr) *	2001-06-28	2003-01-03	Roquette Freres	Procede de preparation d'un comprime edulcorant et comprime edulcorant ainsi obtenu.
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
AUPS244002A0 (en)	2002-05-20	2002-06-13	John Kohnke Products Pty Ltd	Agent delivery system
US20040109889A1 (en)	2002-12-04	2004-06-10	Bunick Frank J.	Surface treatment composition for soft substrates
PL2708225T3 (pl)	2004-04-23	2019-07-31	Cydex Pharmaceuticals, Inc.	Formulacja DPI zawierająca eter sulfoalkilowy cyklodekstryny
EA013867B1 (ru)	2005-02-03	2010-08-30	Никомед Фарма Ас	Способ получения гранулята, содержащего карбонат кальция
US20110142928A1 (en) *	2005-03-04	2011-06-16	Nycomed Pharma As	Process for the production of calcium compositions in a continuous fluid bed
AU2006272978B2 (en)	2005-07-26	2012-06-07	Bial - Portela & Ca, S.A.	Nitrocatechol derivatives as COMT inhibitors
US7629331B2 (en)	2005-10-26	2009-12-08	Cydex Pharmaceuticals, Inc.	Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
EP1845097A1 (en) *	2006-04-10	2007-10-17	Portela & Ca., S.A.	Oxadiazole derivatives as COMT inhibitors
CN101631548B (zh)	2007-01-31	2014-08-27	比艾尔-坡特拉有限公司	Comt抑制剂的单次药物剂量单元和药物组合物
DE102008014237A1 (de) *	2008-03-14	2009-09-17	J. Rettenmaier & Söhne Gmbh + Co. Kg	Direktverpressbares Tablettierhilfsmittel
AU2009226221A1 (en)	2008-03-17	2009-09-24	Bial - Portela & Ca., S.A.	Crystal forms of 5- [3- (2, 5-dichloro-4, 6-dimethyl-1-oxy-pyridine-3-yl) [1,2,3] oxadiazol-5-yl] -3-nit robenzene-1, 2-diol
KR102023255B1 (ko)	2009-04-01	2019-09-19	바이알 - 포르텔라 앤드 씨에이 에스에이	니트로카테콜 유도체를 포함하는 제약 제제 및 그의 제조 방법
US20140045900A1 (en)	2011-02-11	2014-02-13	Bial-Portela & Ca, S.A.	Administration regime for nitrocatechols
BR112014014341A2 (pt)	2011-12-13	2017-08-22	Bial Portela & Ca Sa	Intermediário metilado, seu método de preparação e seus usos, e composição farmacêutica
AR086505A1 (es)	2012-05-21	2013-12-18	Consejo Nac Invest Cient Tec	Un excipiente co-procesado, obtenido mediante secado por atomizacion, utilizable como excipiente farmaceutico o aditivo alimenticio
WO2016083863A1 (en)	2014-11-28	2016-06-02	Bial - Portela & Ca, S.A.	Medicaments for slowing parkinson's disease
CN112076166A (zh) *	2020-09-21	2020-12-15	湖州展望药业有限公司	一种直压淀粉及其生产方法
CN119524142A (zh) *	2024-11-28	2025-02-28	江苏西典药用辅料有限公司	一种药辅改性甘露醇的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3337802A1 (de)	1983-10-18	1985-04-25	Merck Patent Gmbh, 6100 Darmstadt	Pharmazeutische zubereitung
DE3505433A1 (de) *	1985-02-16	1986-08-21	Basf Ag, 6700 Ludwigshafen	Direkttablettierhilfsmittel
CA1325707C (en)	1986-10-31	1994-01-04	Chihang Raymond Chu	Granular tricalcium phosphate compositions suitable for direct compression tableting

1990
- 1990-11-29 AT AT90122804T patent/ATE113202T1/de not_active IP Right Cessation
- 1990-11-29 DE DE69013689T patent/DE69013689T2/de not_active Expired - Fee Related
- 1990-11-29 EP EP90122804A patent/EP0487774B1/en not_active Expired - Lifetime
- 1990-11-29 ES ES90122804T patent/ES2066092T3/es not_active Expired - Lifetime
- 1990-11-29 DK DK90122804.9T patent/DK0487774T3/da active
1992
- 1992-05-29 TW TW081104227A patent/TW221279B/zh active

Also Published As

Publication number	Publication date
ATE113202T1 (de)	1994-11-15
DE69013689D1 (de)	1994-12-01
TW221279B (en)	1994-02-21
DE69013689T2 (de)	1995-03-02
ES2066092T3 (es)	1995-03-01
EP0487774B1 (en)	1994-10-26
EP0487774A1 (en)	1992-06-03

Publication	Publication Date	Title
ES2066092T3 (es)	1995-03-01	Coadyuvante para la formacion directa de comprimidos.
CL2004000317A1 (es)	2005-01-21	COMPOSICION FARMACEUTICA QUE COMPRENDE UN COMPUESTO DE PIPERIDINOALCANOL DEFINDO Y DIFERENTES MEZCLAS DE CROSCARMELOSA SODICA, CELULOSA MICROCRISTALINA, LACTOSA, ALMIDON PREGELATINIZADO, GELATINA, ESTEARATO MAGNESICO, CaCO3 Y GLICOLA DE ALMIDON SODIC
NO20073429L (no)	1997-06-18	Anvendelse av et antistoff mot interleukin-6-reseptor for fremstilling av et farmasoytisk preparat
EA200000317A1 (ru)	2000-10-30	Фармацевтический препарат, содержащий клодронат в качестве активного ингредиента и силикатированную микрокристаллическую целлюлозу в качестве наполнителя
PT1140945E (pt)	2003-10-31	Derivados 1 2 4 tiadiazina fundidos a sua preparacao e a sua utilizacao
DE69012008D1 (de)	1994-10-06	Vorbereitung eines Zellklumpens.
NO881732L (no)	1988-10-24	Ibuprofen-vedvarende frigjoeringsmatrise og fremgangsmaate for fremstilling derav.
FI962445A7 (fi)	1996-06-12	Paroksetiinitabletteja ja menetelmä niiden valmistamiseksi
KR890016963A (ko)	1989-12-14	약제학적 조성물
ES2245275T1 (es)	2006-01-01	Formulacion solida estable de sal de enalapril y procedimiento para su preparacion.
GB1477750A (en)	1977-06-22	Substituted chalcones
ATE92752T1 (de)	1993-08-15	Spruehgetrocknete ibuprofen-zusammensetzungen.
ES2091260T3 (es)	1996-11-01	Procedimiento para la preparacion de piridin-2,3-dicarboxilato dialquilico y derivados del mismo a partir de diclorosuccinato dialquilico.
SE8901003D0 (sv)	1989-03-21	Snabbloesliga preparat
ES2071303T3 (es)	1995-06-16	Compuestos homologados de vitamina d2 y los derivados hidroxilados en 1alfa correspondientes.
AU2571800A (en)	2000-09-04	Tablets and process for producing tablets
KR890700020A (ko)	1989-03-02	서방성과립 및 그를 함유하는 지속성 복합과립
FI906084L (fi)	1991-06-12	Menetelmä uusien terapeuttisesti käyttökelpoisten 5-(2-metyyli-4,4,4-trifluoributyylikarbamoyyli)indolijohdannaisten valmistamiseksi
PT773783E (pt)	2002-04-29	Reparacao de comprimidos de acido fusidico
MY107227A (en)	1995-10-31	Tenidap as an inhibitor of the release of elastage by neutrophils.
ES2122387T3 (es)	1998-12-16	Procedimiento para la preparacion de la forma 1 del clorhidrato de ranitidina.
ES2087100T3 (es)	1996-07-16	Proceso en un recipiente, para la preparacion de hidrocloruro de ester metilico de alfa-l-aspartil-l-fenilalanina.
KR910009287A (ko)	1991-06-28	활성 화합물의 방출이 지연되지 않는 압착물, 이의 제조방법 및 이러한 압착물 제조용 폴리하이드록시부티르산의 용도
ES294256U (es)	1987-06-16	Cilindro neumatico perfeccionado
JPS53143230A (en)	1978-12-13	Paperbase for electrophotographic light sensitive paper