ES2071303T3 - Compuestos homologados de vitamina d2 y los derivados hidroxilados en 1alfa correspondientes. - Google Patents

Compuestos homologados de vitamina d2 y los derivados hidroxilados en 1alfa correspondientes.

Info

Publication number
ES2071303T3
ES2071303T3 ES91905084T ES91905084T ES2071303T3 ES 2071303 T3 ES2071303 T3 ES 2071303T3 ES 91905084 T ES91905084 T ES 91905084T ES 91905084 T ES91905084 T ES 91905084T ES 2071303 T3 ES2071303 T3 ES 2071303T3
Authority
ES
Spain
Prior art keywords
vitamin
alpha
hydroxylated derivatives
approved compounds
corresponding hydroxylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91905084T
Other languages
English (en)
Inventor
Hector Floyd Deluca
Heinrich Konstantine Schnoes
Kato Leonard Perlman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of ES2071303T3 publication Critical patent/ES2071303T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE VITAMINA D2 HOMOLOGADOS 24, 26 Y/O 27, COMO 26, 27-DIHOMO-1 ALFA-HIDROXIVITAMINA D2, 26, 27-DIHOMO-1 ALFA-HIDROXI-24-EPI-VITAMINA D2, 26, 27 -DIHOMO-1 ALFA, 25-DIHIDROXI-24-EPI-VITAMINA D2 Y CIERTOS DERIVADOS SUYOS HIDROXI-PROTEGIDOS. LOS NUEVOS COMPUESTOS EPI MUESTRAN EN ESPECIAL UN PATRON DE ACTIVIDAD DISTINTIVO QUE COMPRENDE UNA ALTA POTENCIA PARA LA ESTIMULACION DEL TRANSPORTE DE CALCIO INTESTINAL Y POCA O NINGUNA ACTIVIDAD PARA INDUCIR LA MOVILIZACION DEL CALCIO EN LOS HUESOS O DIFERENCIAR CELULAS NO DIFERENCIADAS EN CULTIVO, MOSTRANDO ASI SU UTILIDAD PARA EL TRATAMIENTO DE ENFERMEDADES CARACTERIZADAS POR LA PERDIDA DE MASA OSEA. EN CONTRASTE, LA FORMA NATURAL NO MUESTRA ACTIVIDAD NI EN LA MOVILIZACION DEL CALCIO DE LOS HUESOS O EN LA ESTIMULACION DEL TRANSPORTE DE CALCIO INTESTINAL. TAMBIEN SE DESCRIBE UN PROCESO PARA PREPARAR ESTOS COMPUESTOS.
ES91905084T 1990-02-14 1991-02-13 Compuestos homologados de vitamina d2 y los derivados hidroxilados en 1alfa correspondientes. Expired - Lifetime ES2071303T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/481,990 US5030772A (en) 1990-02-14 1990-02-14 Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives

Publications (1)

Publication Number Publication Date
ES2071303T3 true ES2071303T3 (es) 1995-06-16

Family

ID=23914203

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91905084T Expired - Lifetime ES2071303T3 (es) 1990-02-14 1991-02-13 Compuestos homologados de vitamina d2 y los derivados hidroxilados en 1alfa correspondientes.

Country Status (7)

Country Link
US (1) US5030772A (es)
EP (1) EP0468042B1 (es)
JP (1) JP2731839B2 (es)
AT (1) ATE121387T1 (es)
DE (1) DE69109006T2 (es)
ES (1) ES2071303T3 (es)
WO (1) WO1991012239A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
AU656829B2 (en) * 1991-12-26 1995-02-16 Wisconsin Alumni Research Foundation 26, 27-dimethylene-1 alpha, 25-dihydroxyvitamin D2 and 26,27-dihydroxyvitamin D2 and methods for preparing same
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
ES2204165T3 (es) 1998-05-29 2004-04-16 Bone Care International, Inc. Procedimiento para la preparacion de compuestos 25-eno-vitamina d hidroxilo.
US6479474B2 (en) 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US7745226B2 (en) 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
US7972868B2 (en) 2007-11-28 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
AU2010208323B2 (en) 2009-01-27 2016-03-10 Berg Llc Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (en) 2009-08-14 2019-05-22 Berg LLC Vitamin d3 and analogs thereof for treating alopecia
US7977117B2 (en) 2009-12-03 2011-07-12 Quest Diagnostics Investments Incorprated Vitamin D metabolite determination utilizing mass spectrometry following derivatization
JP6113504B2 (ja) 2009-12-11 2017-04-12 クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド 非誘導体化非代謝化ビタミンｄの質量分析法による決定
US9034653B2 (en) 2009-12-11 2015-05-19 Quest Diagnostics Investments Inc. Mass spectrometry of steroidal compounds in multiplexed patient samples
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3585221A (en) * 1969-03-24 1971-06-15 Wisconsin Alumni Res Found 25-hydroxyergocalciferol
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
JPS51108048A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidokishikorekarushifuerooruno seizoho
JPS51108046A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * r * *255 torihidorokishikorekarushifuerooruno seizoho
JPS51108049A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidorokishikorekarushifuerooruno seizoho
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4226787A (en) * 1978-07-26 1980-10-07 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
FR2545824B1 (fr) * 1983-05-09 1987-11-20 Wisconsin Alumni Res Found Derive 1a, 25-dihydroxyles de la vitamine d2 et produits intermediaires pour leur preparation et compositions pharmaceutiques renfermant ces derives
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
AU584071B2 (en) * 1984-03-05 1989-05-18 Wisconsin Alumni Research Foundation 1a-hydroxyvitamin d2 analogs and process for preparing same
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
JPS62500301A (ja) * 1984-10-04 1987-02-05 ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン ２４―ホモビタミンｄ誘導体
US4554106A (en) * 1984-11-01 1985-11-19 Wisconsin Alumni Research Foundation Method for preparing 1α-hydroxyvitamin D compounds
JPS62501505A (ja) * 1985-01-17 1987-06-18 ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン ビタミンｄ誘導体
DE3687377T2 (de) * 1985-01-17 1993-04-29 Wisconsin Alumni Res Found Vitamin-d-abkoemmlinge und deren herstellungsverfahren.
EP0412110B1 (en) * 1988-04-21 1993-07-07 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
US4847012A (en) * 1988-04-29 1989-07-11 Wisconsin Alumni Research Foundation Vitamin D related compounds and processes for their preparation
JPH0699454B2 (ja) * 1988-04-29 1994-12-07 ウィスコンシン・アルムナイ・リサーチ・ファウンデイション １α―ヒドロキシビタミンＤ同族体
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
EP0402982B1 (en) * 1989-06-15 1994-01-05 Duphar International Research B.V Adduct-aldehyde and its use for the preparation of a vitamin-D compound
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0468042A1 (en) 1992-01-29
US5030772A (en) 1991-07-09
EP0468042B1 (en) 1995-04-19
DE69109006D1 (de) 1995-05-24
WO1991012239A1 (en) 1991-08-22
JP2731839B2 (ja) 1998-03-25
DE69109006T2 (de) 1995-08-31
ATE121387T1 (de) 1995-05-15
JPH04505468A (ja) 1992-09-24

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