DK0492369T3 - Hidtil ukendte tricycliske amino- og nitro-forbindelser med ACE-hæmmende virkning - Google Patents

Hidtil ukendte tricycliske amino- og nitro-forbindelser med ACE-hæmmende virkning

Info

Publication number: DK0492369T3
Authority: DK; Denmark
Prior art keywords: inhibitory effect; hydrogen; amino; nitro compounds; ace inhibitory
Prior art date: 1990-12-21

Application number

DK91121638.0T

Other languages

English (en)

Inventor

Gary A Flynn

Douglas W Beight

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-21

Filing date

1991-12-17

Publication date

1997-10-13

1991-12-17 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1997-10-13 Application granted granted Critical

1997-10-13 Publication of DK0492369T3 publication Critical patent/DK0492369T3/da

Links

125000002924 primary amino group Chemical group [H]N([H])* 0.000 title abstract 4
230000002401 inhibitory effect Effects 0.000 title 1
150000002828 nitro derivatives Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
150000002431 hydrogen Chemical group 0.000 abstract 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
101150047265 COR2 gene Proteins 0.000 abstract 1
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
101100467189 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) QCR2 gene Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK91121638.0T 1990-12-21 1991-12-17 Hidtil ukendte tricycliske amino- og nitro-forbindelser med ACE-hæmmende virkning DK0492369T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63357290A	1990-12-21	1990-12-21
US77762591A	1991-10-23	1991-10-23

Publications (1)

Publication Number	Publication Date
DK0492369T3 true DK0492369T3 (da)	1997-10-13

Family

ID=27091923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91121638.0T DK0492369T3 (da)	1990-12-21	1991-12-17	Hidtil ukendte tricycliske amino- og nitro-forbindelser med ACE-hæmmende virkning

Country Status (18)

Country	Link
EP (1)	EP0492369B1 (da)
JP (1)	JP3112327B2 (da)
KR (2)	KR100220880B1 (da)
CN (1)	CN1040985C (da)
AT (1)	ATE158303T1 (da)
AU (1)	AU642321B2 (da)
CA (1)	CA2057786C (da)
DE (1)	DE69127681T2 (da)
DK (1)	DK0492369T3 (da)
ES (1)	ES2108027T3 (da)
FI (1)	FI95800C (da)
GR (1)	GR3025622T3 (da)
HU (1)	HU210167B (da)
IE (1)	IE914507A1 (da)
IL (1)	IL100416A (da)
NO (1)	NO180196C (da)
NZ (1)	NZ241023A (da)
PT (1)	PT99849B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5308841A (en) *	1990-12-21	1994-05-03	Merrell Dow Pharmaceuticals Inc.	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
EP0534363B1 (en) *	1991-09-27	1997-07-09	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
AU657793B2 (en) *	1991-09-27	1995-03-23	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078759C (en) *	1991-09-27	2003-09-16	Alan M. Warshawsky	Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
WO1993023403A1 (en) *	1992-05-15	1993-11-25	Merrell Dow Pharmaceuticals Inc.	NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
AU673857B2 (en) *	1992-10-30	1996-11-28	Aventisub Ii Inc.	Mercaptoacetylamide bicyclic lactam derivatives
US5362727A (en) *	1993-07-26	1994-11-08	Bristol-Myers Squibb	Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) *	1993-11-18	1996-06-11	Bristol-Myers Squibb Co.	Compounds containing a fused multiple ring lactam
JPH09508906A (ja) *	1994-02-14	1997-09-09	メレルファーマスーティカルズインコーポレーテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類
CA2183320C (en) *	1994-02-14	1999-10-26	Gary A. Flynn	Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
EP0746566A1 (en) *	1994-02-14	1996-12-11	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
HUT74584A (en) *	1994-02-14	1997-01-28	Merrell Pharma Inc	Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
WO1995025532A1 (en) *	1994-03-24	1995-09-28	Merrell Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
AU688012B2 (en) *	1994-03-24	1998-03-05	Merrell Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
ATE266040T1 (de) *	1994-12-21	2004-05-15	Aventis Pharma Inc	Verfahren zur herstellung von zwischenprodukten von inhibitoren von enkephalinase und angiotensin konvertierendem enzym und zwischenprodukte davon
US5641880A (en) *	1994-12-21	1997-06-24	Hoechst Marion Roussel, Inc.	Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US7078225B2 (en)	2000-06-02	2006-07-18	Nippon Shokubai Co., Ltd.	Method for enzymatically producing an optically active cyanohydrin
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4584294A (en) *	1984-11-07	1986-04-22	Merck & Co., Inc.	Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
CA1337654C (en) *	1986-06-13	1995-11-28	Gary A. Flynn	Fused tricyclic lactams as antihypertensive agents
AU636101B2 (en) *	1987-04-10	1993-04-22	Monash University	1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino-(1,2-a)azepino derivatives and 10-aza, 10-oxa and 10-thia analogues
US4824832A (en) *	1987-12-30	1989-04-25	Merrell Dow Pharmaceuticals Inc.	Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) *	1990-10-18	2002-04-02	Timothy P. Burkholder	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

1991
- 1991-12-17 DE DE69127681T patent/DE69127681T2/de not_active Expired - Fee Related
- 1991-12-17 ES ES91121638T patent/ES2108027T3/es not_active Expired - Lifetime
- 1991-12-17 DK DK91121638.0T patent/DK0492369T3/da active
- 1991-12-17 AU AU89819/91A patent/AU642321B2/en not_active Ceased
- 1991-12-17 CA CA002057786A patent/CA2057786C/en not_active Expired - Fee Related
- 1991-12-17 EP EP91121638A patent/EP0492369B1/en not_active Expired - Lifetime
- 1991-12-17 AT AT91121638T patent/ATE158303T1/de not_active IP Right Cessation
- 1991-12-17 NZ NZ241023A patent/NZ241023A/en unknown
- 1991-12-18 IL IL10041691A patent/IL100416A/en not_active IP Right Cessation
- 1991-12-18 PT PT99849A patent/PT99849B/pt not_active IP Right Cessation
- 1991-12-19 FI FI916017A patent/FI95800C/fi active IP Right Grant
- 1991-12-20 KR KR1019910023702A patent/KR100220880B1/ko not_active Expired - Fee Related
- 1991-12-20 JP JP03354999A patent/JP3112327B2/ja not_active Expired - Fee Related
- 1991-12-20 HU HU914092A patent/HU210167B/hu not_active IP Right Cessation
- 1991-12-20 NO NO915068A patent/NO180196C/no unknown
- 1991-12-20 CN CN91111735A patent/CN1040985C/zh not_active Expired - Fee Related
- 1991-12-20 IE IE450791A patent/IE914507A1/en not_active IP Right Cessation
1997
- 1997-12-10 GR GR970403274T patent/GR3025622T3/el unknown
1999
- 1999-03-27 KR KR1019990010649A patent/KR100220879B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2057786C (en)	2002-06-18
EP0492369A1 (en)	1992-07-01
FI95800C (fi)	1996-03-25
NO180196C (no)	1997-03-05
NO180196B (no)	1996-11-25
FI916017L (fi)	1992-06-22
JPH04342588A (ja)	1992-11-30
DE69127681T2 (de)	1998-01-15
IE914507A1 (en)	1992-07-01
JP3112327B2 (ja)	2000-11-27
PT99849A (pt)	1992-11-30
IL100416A0 (en)	1992-09-06
NO915068D0 (no)	1991-12-20
CN1062729A (zh)	1992-07-15
KR100220880B1 (ko)	1999-09-15
DE69127681D1 (de)	1997-10-23
NO915068L (no)	1992-06-22
PT99849B (pt)	1999-06-30
GR3025622T3 (en)	1998-03-31
IL100416A (en)	1995-11-27
FI916017A0 (fi)	1991-12-19
HU914092D0 (en)	1992-03-30
CN1040985C (zh)	1998-12-02
AU8981991A (en)	1992-06-25
FI95800B (fi)	1995-12-15
KR100220879B1 (ko)	2000-03-15
AU642321B2 (en)	1993-10-14
EP0492369B1 (en)	1997-09-17
HUT60271A (en)	1992-08-28
ATE158303T1 (de)	1997-10-15
ES2108027T3 (es)	1997-12-16
NZ241023A (en)	1994-10-26
KR920012082A (ko)	1992-07-25
HU210167B (en)	1995-02-28
CA2057786A1 (en)	1992-06-22

Publication	Publication Date	Title
DK0492369T3 (da)	1997-10-13	Hidtil ukendte tricycliske amino- og nitro-forbindelser med ACE-hæmmende virkning
EA199900591A1 (ru)	2000-08-28	АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха
DK1265606T3 (da)	2007-02-12	Celleadhæsionsinhibitorer
EA200200446A1 (ru)	2002-12-26	НОВЫЕ α-АМИНОКИСЛОТНЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ИХ СОДЕРЖАЩИЕ
HUP0100064A2 (hu)	2001-05-28	Amidszármazékot és klórtalonilt tartalmazó, szinergetikus fungicid kombináció és alkalmazása
DE69835430D1 (de)	2006-09-14	Sulfonamidderivate, ihre herstellung und verwendung
CA2079143A1 (en)	1993-03-28	Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
BRPI0014526C1 (pt)	2021-05-25	compostos cíclicos de seis elementos contendo nitrogênio aromático, composição farmacêutica e uso do mesmo
DK0624584T3 (da)	1999-05-25	Piperazinderivater, der er nyttige som calmodulininhibitorer
DK0759899T3 (da)	1999-12-20	Nitroforbindelser og sammensætninger deraf med antiinflammatoriske, analgetiske og antitrombotiske aktiviteter
AU2910600A (en)	2000-08-29	Phenyl urea and phenyl thiourea derivatives
DK0790987T3 (da)	2001-11-12	Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer
CO4920250A1 (es)	2000-05-29	Compuestos heterociclicos utiles en la inhibicion de la spla2
NO20052976L (no)	2005-08-18	Fosfodiesterase-4-inhibitorer.
DE60107435D1 (de)	2004-12-30	2-adamantylethylamine und deren verwendung bei der behandlung von abnormalitäten in der glutamat transmission
DE3853577D1 (de)	1995-05-18	Benzyliden-Malononitril-Derivate zur Hemmung von proliferativen Prozessen in Säugetierzellen.
BG105417A (en)	2001-12-29	Derivatives of isosorbid mononitrate, utilization as vasodilator agents with reduced tolerance
BR0004535A (pt)	2001-02-28	Compostos, e, uso dos mesmos.
WO2001010834A3 (en)	2001-06-28	Antibacterial agents
DE69924887D1 (de)	2005-05-25	Antibakterielle mittel
UA26459C2 (uk)	1999-08-30	Іhгібітор впливу амілоїдhих білків
GB8823405D0 (en)	1988-11-09	Aryloxy-arythio-heteraryloxy-heteroarylthio-alkenylene derivatives of amines
NO20003075D0 (no)	2000-06-15	Nervebeskyttende midler
ATE65986T1 (de)	1991-08-15	Propanolabkoemmlinge.
NO954764D0 (no)	1995-11-24	Psoralen-derivater, deres fremstilling og anvendelse