ES2108027T3 - Nuevos compuestos triciclicos que contienen amino y nitro, utiles como inhibidores de ace. - Google Patents

Nuevos compuestos triciclicos que contienen amino y nitro, utiles como inhibidores de ace.

Info

Publication number
ES2108027T3
ES2108027T3 ES91121638T ES91121638T ES2108027T3 ES 2108027 T3 ES2108027 T3 ES 2108027T3 ES 91121638 T ES91121638 T ES 91121638T ES 91121638 T ES91121638 T ES 91121638T ES 2108027 T3 ES2108027 T3 ES 2108027T3
Authority
ES
Spain
Prior art keywords
sub
nitro
hydrogen
useful
compounds containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91121638T
Other languages
English (en)
Inventor
Gary A Flynn
Douglas W Beight
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2108027T3 publication Critical patent/ES2108027T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA DONDE A ES METILENO, OXIGENO, AZUFRE O N-B DONDE B ES R SUB 1 O COR SUB 2 DONDE R SUB 1 ES HIDROGENO, UN ALQUILO C SUB 1-C SUB 4 O UN GRUPO AR-Z DONDE AR ES ARILO Y Z ES UN ALQUILO C SUB 0-C SUB 4 Y R SUB 2 ES UN -CF SUB 3, UN ALQUILO C SUB 1-C SUB 10 O UN GRUPO AR-Z; R ES UN HIDROGENO O UN ALQUILO C SUB 1-C SUB 4; Y X E Y SON CADA UNO DE ELLOS, INDEPENDIENTEMENTE, HIDROGENO, NITRO O AMINO, A CONDICION QUE CUANDO X ES NITRO O AMINO, Y DEBE SER HIDROGENO, CUANDO Y ES NITRO O AMINO, X DEBE SER HIDROGENO; Y SALES DEL MISMO FARMACEUTICAMENTE ACEPTABLES, QUE SON INHIBIDORES DEL ENZIMA CONVERTIDOR DE ANGIOTENSIN.
ES91121638T 1990-12-21 1991-12-17 Nuevos compuestos triciclicos que contienen amino y nitro, utiles como inhibidores de ace. Expired - Lifetime ES2108027T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63357290A 1990-12-21 1990-12-21
US77762591A 1991-10-23 1991-10-23

Publications (1)

Publication Number Publication Date
ES2108027T3 true ES2108027T3 (es) 1997-12-16

Family

ID=27091923

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91121638T Expired - Lifetime ES2108027T3 (es) 1990-12-21 1991-12-17 Nuevos compuestos triciclicos que contienen amino y nitro, utiles como inhibidores de ace.

Country Status (18)

Country Link
EP (1) EP0492369B1 (es)
JP (1) JP3112327B2 (es)
KR (2) KR100220880B1 (es)
CN (1) CN1040985C (es)
AT (1) ATE158303T1 (es)
AU (1) AU642321B2 (es)
CA (1) CA2057786C (es)
DE (1) DE69127681T2 (es)
DK (1) DK0492369T3 (es)
ES (1) ES2108027T3 (es)
FI (1) FI95800C (es)
GR (1) GR3025622T3 (es)
HU (1) HU210167B (es)
IE (1) IE914507A1 (es)
IL (1) IL100416A (es)
NO (1) NO180196C (es)
NZ (1) NZ241023A (es)
PT (1) PT99849B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
EP0534363B1 (en) * 1991-09-27 1997-07-09 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
WO1993023403A1 (en) * 1992-05-15 1993-11-25 Merrell Dow Pharmaceuticals Inc. NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
AU673857B2 (en) * 1992-10-30 1996-11-28 Aventisub Ii Inc. Mercaptoacetylamide bicyclic lactam derivatives
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
JPH09508906A (ja) * 1994-02-14 1997-09-09 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類
CA2183320C (en) * 1994-02-14 1999-10-26 Gary A. Flynn Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
EP0746566A1 (en) * 1994-02-14 1996-12-11 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
WO1995025532A1 (en) * 1994-03-24 1995-09-28 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
AU688012B2 (en) * 1994-03-24 1998-03-05 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
ATE266040T1 (de) * 1994-12-21 2004-05-15 Aventis Pharma Inc Verfahren zur herstellung von zwischenprodukten von inhibitoren von enkephalinase und angiotensin konvertierendem enzym und zwischenprodukte davon
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US7078225B2 (en) 2000-06-02 2006-07-18 Nippon Shokubai Co., Ltd. Method for enzymatically producing an optically active cyanohydrin
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
CA1337654C (en) * 1986-06-13 1995-11-28 Gary A. Flynn Fused tricyclic lactams as antihypertensive agents
AU636101B2 (en) * 1987-04-10 1993-04-22 Monash University 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino-(1,2-a)azepino derivatives and 10-aza, 10-oxa and 10-thia analogues
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

Also Published As

Publication number Publication date
CA2057786C (en) 2002-06-18
EP0492369A1 (en) 1992-07-01
FI95800C (fi) 1996-03-25
NO180196C (no) 1997-03-05
NO180196B (no) 1996-11-25
FI916017L (fi) 1992-06-22
JPH04342588A (ja) 1992-11-30
DE69127681T2 (de) 1998-01-15
IE914507A1 (en) 1992-07-01
JP3112327B2 (ja) 2000-11-27
PT99849A (pt) 1992-11-30
IL100416A0 (en) 1992-09-06
NO915068D0 (no) 1991-12-20
CN1062729A (zh) 1992-07-15
KR100220880B1 (ko) 1999-09-15
DE69127681D1 (de) 1997-10-23
DK0492369T3 (da) 1997-10-13
NO915068L (no) 1992-06-22
PT99849B (pt) 1999-06-30
GR3025622T3 (en) 1998-03-31
IL100416A (en) 1995-11-27
FI916017A0 (fi) 1991-12-19
HU914092D0 (en) 1992-03-30
CN1040985C (zh) 1998-12-02
AU8981991A (en) 1992-06-25
FI95800B (fi) 1995-12-15
KR100220879B1 (ko) 2000-03-15
AU642321B2 (en) 1993-10-14
EP0492369B1 (en) 1997-09-17
HUT60271A (en) 1992-08-28
ATE158303T1 (de) 1997-10-15
NZ241023A (en) 1994-10-26
KR920012082A (ko) 1992-07-25
HU210167B (en) 1995-02-28
CA2057786A1 (en) 1992-06-22

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