DK0498718T3 - Anvendelse af 4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyridinderivater som indfangere af frie radikaler - Google Patents

Anvendelse af 4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyridinderivater som indfangere af frie radikaler

Info

Publication number: DK0498718T3
Authority: DK; Denmark
Prior art keywords: free radical; radical scavengers; compounds; trifluoromethylphenyl; formula
Prior art date: 1991-02-05

Application number

DK92400289.2T

Other languages

English (en)

Inventor

Michel Heaulme

Umberto Guzzi

Original Assignee

Sanofi Elf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-05

Filing date

1992-02-05

Publication date

1994-12-05

1992-02-05 Application filed by Sanofi Elf filed Critical Sanofi Elf

1994-12-05 Application granted granted Critical

1994-12-05 Publication of DK0498718T3 publication Critical patent/DK0498718T3/da

Links

229940123457 Free radical scavenger Drugs 0.000 title abstract 2
239000002516 radical scavenger Substances 0.000 title abstract 2
IFYKRMQORZOMNY-UHFFFAOYSA-N 4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine Chemical class FC(F)(F)C1=CC=CC(C=2CCNCC=2)=C1 IFYKRMQORZOMNY-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
208000037273 Pathologic Processes Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000005779 cell damage Effects 0.000 abstract 1
208000037887 cell injury Diseases 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000009054 pathological process Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003254 radicals Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Toxicology (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Liquid Crystal Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK92400289.2T 1991-02-05 1992-02-05 Anvendelse af 4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyridinderivater som indfangere af frie radikaler DK0498718T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9101283A FR2672213B1 (fr)	1991-02-05	1991-02-05	Utilisation de derives 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridiniques comme capteurs de radicaux libres.

Publications (1)

Publication Number	Publication Date
DK0498718T3 true DK0498718T3 (da)	1994-12-05

Family

ID=9409370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92400289.2T DK0498718T3 (da)	1991-02-05	1992-02-05	Anvendelse af 4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyridinderivater som indfangere af frie radikaler

Country Status (13)

Country	Link
US (1)	US5292745A (da)
EP (1)	EP0498718B1 (da)
JP (1)	JP3471820B2 (da)
AT (1)	ATE109467T1 (da)
AU (1)	AU649099B2 (da)
CA (1)	CA2060616C (da)
DE (1)	DE69200284T2 (da)
DK (1)	DK0498718T3 (da)
ES (1)	ES2061319T3 (da)
FR (1)	FR2672213B1 (da)
HU (2)	HU212945B (da)
IE (1)	IE66593B1 (da)
MX (1)	MX9200485A (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2662442A1 (fr) *	1990-05-23	1991-11-29	Midy Spa	Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant.
FR2702656B1 (fr) *	1993-03-18	1995-06-16	Sanofi Elf	Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments cardioprotecteurs.
FR2740343B1 (fr) *	1995-10-26	1999-01-22	Sanofi Sa	Utilisation de la 1-(2-napht-2-yl-ethyl)-4- (3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de la sclerose laterale amyotrophique
JP3468526B2 (ja) *	1995-10-26	2003-11-17	サノフィーサンテラボ	筋萎縮性側索硬化症治療薬調製のための１−（２−ナフタ−２−イルエチル）−４−（３−トリフルオロメチルフェニル）−１，２，３，６−テトラヒドロピリジンの使用
FR2763847B1 (fr)	1997-05-28	2003-06-06	Sanofi Sa	Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
AU769633B2 (en) *	1998-12-01	2004-01-29	Bradley P Fuhrman	Method for reducing free-radical induced injury
PL368565A1 (en) *	2001-08-29	2005-04-04	Alcon, Inc.	Use of compounds for treating conditions resulting from injury to the corneal nerve after lasik and other ocular surgeries or trauma
US7064211B2 (en) *	2002-03-22	2006-06-20	Eisai Co., Ltd.	Hemiasterlin derivatives and uses thereof
US7687665B2 (en) *	2004-06-24	2010-03-30	Incyte Corporation	2-methylprop anamides and their use as pharmaceuticals
US8071624B2 (en)	2004-06-24	2011-12-06	Incyte Corporation	N-substituted piperidines and their use as pharmaceuticals
SG163518A1 (en) *	2004-06-24	2010-08-30	Incyte Corp	Amido compounds and their use as pharmaceuticals
US20060009491A1 (en) *	2004-06-24	2006-01-12	Incyte Corporation	Amido compounds and their use as pharmaceuticals
US20060122197A1 (en) *	2004-08-10	2006-06-08	Wenqing Yao	Amido compounds and their use as pharmaceuticals

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4691019A (en) *	1981-03-11	1987-09-01	Sanofi	Anorectic agent; 4-(3-trifluoromethylphenyl)-1-(2-cyanoethyl)-1,2,3,6-tetrahydropyridine
FR2501682A1 (fr) *	1981-03-11	1982-09-17	Sanofi Sa	Trifluoromethylphenylpyridines a activite anorexigene, un procede de preparation et compositions pharmaceutiques en contenant
FR2531707A1 (fr) *	1982-08-16	1984-02-17	Midy Spa	Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques
FR2639226B1 (fr) *	1988-11-18	1993-11-05	Sanofi	Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs
GB2226269B (en) *	1988-12-22	1992-11-25	Zdzislaw Bieganski	Cable stripper
FR2650505B1 (fr) *	1989-08-07	1994-06-03	Midy Spa	Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
FR2662355B1 (fr)	1990-05-22	1994-11-10	Sanofi Sa	Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
FR2662442A1 (fr) *	1990-05-23	1991-11-29	Midy Spa	Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant.

1991
- 1991-02-05 FR FR9101283A patent/FR2672213B1/fr not_active Expired - Fee Related
1992
- 1992-02-03 AU AU10655/92A patent/AU649099B2/en not_active Ceased
- 1992-02-04 CA CA002060616A patent/CA2060616C/en not_active Expired - Fee Related
- 1992-02-04 US US07/830,857 patent/US5292745A/en not_active Expired - Lifetime
- 1992-02-04 JP JP01895192A patent/JP3471820B2/ja not_active Expired - Fee Related
- 1992-02-04 MX MX9200485A patent/MX9200485A/es not_active IP Right Cessation
- 1992-02-04 IE IE920354A patent/IE66593B1/en not_active IP Right Cessation
- 1992-02-04 HU HU9200335A patent/HU212945B/hu not_active IP Right Cessation
- 1992-02-05 EP EP92400289A patent/EP0498718B1/fr not_active Expired - Lifetime
- 1992-02-05 ES ES92400289T patent/ES2061319T3/es not_active Expired - Lifetime
- 1992-02-05 DE DE69200284T patent/DE69200284T2/de not_active Expired - Fee Related
- 1992-02-05 AT AT92400289T patent/ATE109467T1/de not_active IP Right Cessation
- 1992-02-05 DK DK92400289.2T patent/DK0498718T3/da active
1995
- 1995-06-28 HU HU95P/P00485P patent/HU211457A9/hu unknown

Also Published As

Publication number	Publication date
HUT62563A (en)	1993-05-28
AU1065592A (en)	1992-08-13
AU649099B2 (en)	1994-05-12
DE69200284T2 (de)	1995-03-02
EP0498718B1 (fr)	1994-08-03
FR2672213B1 (fr)	1995-03-10
ES2061319T3 (es)	1994-12-01
ATE109467T1 (de)	1994-08-15
DE69200284D1 (de)	1994-09-08
HU212945B (en)	1996-12-30
US5292745A (en)	1994-03-08
HU211457A9 (en)	1995-11-28
JP3471820B2 (ja)	2003-12-02
FR2672213A1 (fr)	1992-08-07
JPH04312528A (ja)	1992-11-04
EP0498718A1 (fr)	1992-08-12
IE66593B1 (en)	1996-01-24
HU9200335D0 (en)	1992-04-28
CA2060616A1 (en)	1992-08-06
IE920354A1 (en)	1992-08-12
MX9200485A (es)	1992-11-01
CA2060616C (en)	2004-04-06

Publication	Publication Date	Title
DK0498718T3 (da)	1994-12-05	Anvendelse af 4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyridinderivater som indfangere af frie radikaler
CA2394327A1 (en)	2001-06-28	Substituted piperazine and piperidine calcium channel blockers
MXPA05007496A (es)	2005-09-21	Tienopirimidindionas y su uso en la modulacion de enfermedades autoinmunes.
NO20072115L (no)	2007-07-24	Farmasoytiske forbindelser
NO20054264L (no)	2005-10-14	Ikke-Nukleoside Revers Transkriptase-Inhibitorer I for behandling av HIV-medierte sydommer
NO954681L (no)	1995-11-20	Kjemiske forbindelser
NO20015172L (no)	2002-01-23	1-metyl-erytromycin-derivater
ATE154937T1 (de)	1997-07-15	Steroide zur behandlung von prostatisch- hypertrophe, ihre herstellung und verwendung
NO983493L (no)	1999-02-01	Nye benzimidazol-, benzoksazol- og benzotiazolforbindelser, fremgangsmÕte ved fremstilling derav og farmas°ytiske sammensetninger inneholdende slike
KR920701178A (ko)	1992-08-11	3-아릴옥사졸리디논 유도체, 그의 제조방법 및 그의 치료 용도
NO20003773L (no)	2001-01-23	Syklobutenderivater, deres fremstilling og deres terapeutiske anvendelser
NO161174C (no)	1989-07-12	Analogifremgangsm te ved fremstilling av terapeutisk aktive 1-4 dihydropyridin-derivater.
NO972887L (no)	1997-08-20	Piperidineddiksyrederivater anvendelige som fibrinogen-antagonistmiddel
ATE152453T1 (de)	1997-05-15	Guanidinalkyl-1,1-bisphosphonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung
NO812355L (no)	1982-01-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,1-benzoksazin-2-on-derivater
NO960441L (no)	1996-02-02	Benzopyraner og farmasöytiske forbindelser inneholdende dem
ATE62908T1 (de)	1991-05-15	Neue derivate von 4,5-dihydro-oxazolen, verfahren zu ihrer herstellung und ihre verwendung.
ATE42295T1 (de)	1989-05-15	Penem-derivate, verfahren zu deren herstellung, ihre verwendung und pharmazeutische zusammensetzungen.
ATE96434T1 (de)	1993-11-15	2-(heteroalkyl)-1,4-dihydropyridine, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE27455T1 (de)	1987-06-15	Heterocyclische guanidino-phenylamidine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
NO20030781L (no)	2003-02-19	Prodrugs til NMDA-reseptor-ligander
NO20010801L (no)	2001-08-20	Nye 6-amino- eller 6-hydroazino-sulfonyl-3- kinolynylfosfonsyreforbindelse, fremgangsmåte ved deresfremstilling og farmasöytiske sammensetninger inneholdende dem
RU2003105827A (ru)	2004-08-10	Средства против слабоумия, содержащие производные 2-арил-8-оксодигидропурина, в качестве активного ингредиента
ATE4541T1 (de)	1983-09-15	Alkyl- und cycloalkylsubstituierte 2-(2-(2hydroxy-3-tert.-butylamino-propoxy)-5-acylamino phenyl)-1,3,4-oxadiazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen.
NO20022891L (no)	2002-12-19	Nye cykliske <alfa>-amino-<gamma>-hydroksyamidforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetningerinneholdende dem