DK0500917T3 - Vacciner og fremgangsmåder baseret på rekombinante herpes simplex virusser. - Google Patents
Vacciner og fremgangsmåder baseret på rekombinante herpes simplex virusser.Info
- Publication number
- DK0500917T3 DK0500917T3 DK91918320T DK91918320T DK0500917T3 DK 0500917 T3 DK0500917 T3 DK 0500917T3 DK 91918320 T DK91918320 T DK 91918320T DK 91918320 T DK91918320 T DK 91918320T DK 0500917 T3 DK0500917 T3 DK 0500917T3
- Authority
- DK
- Denmark
- Prior art keywords
- herpes simplex
- vaccines
- methods based
- simplex viruses
- recombinant herpes
- Prior art date
Links
- 241000700584 Simplexvirus Species 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108020004705 Codon Proteins 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 238000011081 inoculation Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/579,834 US5328688A (en) | 1990-09-10 | 1990-09-10 | Recombinant herpes simplex viruses vaccines and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0500917T3 true DK0500917T3 (da) | 1997-10-27 |
Family
ID=24318537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91918320T DK0500917T3 (da) | 1990-09-10 | 1991-09-10 | Vacciner og fremgangsmåder baseret på rekombinante herpes simplex virusser. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5328688A (da) |
| EP (1) | EP0500917B1 (da) |
| JP (1) | JP3334876B2 (da) |
| AT (1) | ATE152355T1 (da) |
| AU (1) | AU658838B2 (da) |
| CA (1) | CA2072627C (da) |
| DE (1) | DE69125925T2 (da) |
| DK (1) | DK0500917T3 (da) |
| ES (1) | ES2102409T3 (da) |
| GR (1) | GR3024144T3 (da) |
| WO (1) | WO1992004050A1 (da) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040169A (en) | 1991-01-31 | 2000-03-21 | Medical Research Council | Herpes simplex virus-1 deletion variants and vaccines thereof |
| ES2183811T3 (es) * | 1992-03-31 | 2003-04-01 | Arch Dev Corp | Tratamiento de enfermedades tumorigenas con un hsv modificado. |
| US7223411B1 (en) | 1992-07-31 | 2007-05-29 | Dana-Farber Cancer Institute | Herpesvirus replication defective mutants |
| WO1994014971A1 (en) * | 1992-12-23 | 1994-07-07 | Arch Development Corporation | Synthetic herpes simplex virus promoters |
| US5763217A (en) * | 1993-11-10 | 1998-06-09 | University Of British Columbia | Method of using, process of preparing and composition comprising recombinant herpesvirus vectors |
| US5585096A (en) * | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
| GB9415320D0 (en) * | 1994-07-29 | 1994-09-21 | Medical Res Council | Cancer treatment |
| ZA966287B (en) * | 1995-07-27 | 1998-03-09 | American Cyanamid Co | Avirulent herpetic viruses useful as tumoricidal agents and vaccines. |
| US5834216A (en) * | 1995-09-06 | 1998-11-10 | Arch Development Corporation | Screening methods for the identification of inducers and inhibitors of programmed cell death (apoptosis) |
| US5922328A (en) * | 1995-09-11 | 1999-07-13 | Aviron | Methods and compositions for treatment of HSV-2 infections and conditions |
| DE69722608T2 (de) * | 1996-01-25 | 2004-04-29 | The University Court Of The University Of Glasgow, Glasgow | Hsv-mutant-1716 zur behandlung von mesotheliomen |
| US5824318A (en) * | 1996-07-24 | 1998-10-20 | American Cyanamid Company | Avirulent herpetic viruses useful as tumoricidal agents and vaccines |
| GB9615794D0 (en) * | 1996-07-26 | 1996-09-04 | Medical Res Council | Mutant herpes simplex virus strains and uses thereof |
| US6509020B1 (en) | 1997-03-27 | 2003-01-21 | The University Of Cincinnati | Replication-competent herpes simplex virus |
| CA2238659C (en) * | 1997-05-26 | 2010-12-14 | Akzo Nobel N.V. | Recombinant birnavirus vaccine |
| DE69838483T2 (de) | 1997-10-14 | 2008-07-03 | Darwin Molecular Corp. | Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten |
| US6051385A (en) * | 1997-10-22 | 2000-04-18 | The Regents Of The University Of Michigan | Compositions and methods for identifying and testing therapeutics against HSV infection |
| US6399354B1 (en) | 1998-07-31 | 2002-06-04 | President And Fellows Of Harvard College | Replication-competent virus expressing a detectable fusion protein |
| EP1141338A4 (en) * | 1998-12-31 | 2002-09-25 | Arch Dev Corp | RECOMBINANT HERPES SIMPLEX VIRUS FOR TREATING NEOPLASTIC DISEASES |
| DE60039730D1 (de) | 1999-02-05 | 2008-09-11 | Arch Dev Corp | Genetisch manipulierte Herpesviren zur Behandlung von Tumoren |
| US6774119B1 (en) | 1999-04-26 | 2004-08-10 | Cedars-Sinai Medical Center | Herpes simplex virus type 1 (hsv-1)-derived vector for selectively inhibiting malignant cells and methods for its use to treat cancers and to express desired traits in malignant and non-malignant mammalian cells |
| CA2378519C (en) | 1999-07-07 | 2011-01-25 | Zymogenetics, Inc. | Human cytokine receptor |
| US6897057B1 (en) * | 1999-08-31 | 2005-05-24 | The General Hospital Corporation | Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression |
| DE60115600T2 (de) * | 2000-01-21 | 2006-07-20 | Biovex Ltd. | Virusstämme für die onkolytische behandlung von krebs |
| AU3988401A (en) * | 2000-02-25 | 2001-09-03 | Ludwig Inst Cancer Res | Materials and methods involving hybrid vascular endothelial growth factor dnas and proteins |
| US6516246B2 (en) * | 2000-09-11 | 2003-02-04 | Mimicking Man Manually, Inc. | Method and system for determining native neurological dominant hemisphere |
| EP1356071B1 (en) * | 2000-11-28 | 2007-11-21 | The University of Chicago | Genetically engineered herpes virus for the treatment of cardiovascular disease |
| BRPI0209933B8 (pt) | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| AU2003216502B2 (en) * | 2002-03-01 | 2008-04-10 | Sloan-Kettering Institute For Cancer Research | Prevention of recurrence and metastasis of cancer |
| US7446190B2 (en) * | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| US20040197347A1 (en) * | 2002-09-23 | 2004-10-07 | Board Of Regents, The University Of Texas System | Methods for vaccine identification and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of the herpesvirus family |
| US20050272030A1 (en) * | 2002-09-27 | 2005-12-08 | Powder Ject Research Limited | Nucleic acid constructs for gene expression |
| US20070243170A1 (en) * | 2002-10-07 | 2007-10-18 | The University Of Chicago | Targeting of Herpes Simplex Virus to Specific Receptors |
| AU2003282691A1 (en) * | 2002-10-07 | 2004-05-04 | University Of Chicago | Targeting of herpes simplex virus to specific receptors |
| US7592169B2 (en) * | 2003-04-25 | 2009-09-22 | Medimmune, Llc | Methods and compositions for treatment and prevention of HSV-2 infections and conditions |
| GB0317511D0 (en) * | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
| WO2005025517A2 (en) * | 2003-09-12 | 2005-03-24 | Vertex Pharmaceuticals Incorporated | Animal model for protease activity and liver damage |
| US7897146B2 (en) * | 2003-11-17 | 2011-03-01 | Crusade Laboratories Limited | Treatment using herpes simplex virus |
| WO2005087808A2 (en) | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Growth factor binding constructs materials and methods |
| US7319015B2 (en) * | 2004-03-16 | 2008-01-15 | The Regents Of The University Of Michigan | Methods and compositions for using alveolar macrophage phospholipase A2 |
| US7582442B2 (en) | 2004-03-16 | 2009-09-01 | The Regents Of The University Of Michigan | Methods and compositions for using aleveolar macrophage phospholipase A2 |
| US7731952B2 (en) * | 2004-06-24 | 2010-06-08 | New York University | Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response |
| US20090233986A1 (en) * | 2004-07-27 | 2009-09-17 | Mount Sinai School Of Medicine | Methods and compositions for using sax2 |
| FI20050753A7 (fi) | 2004-09-03 | 2006-03-04 | Licentia Oy | Uudet peptidit |
| WO2006101629A2 (en) * | 2005-02-17 | 2006-09-28 | Vertex Pharmaceuticals Incorporated | SODIUM CHANNEL PROTEIN TYPE III α-SUBUNIT SPLICE VARIANT |
| WO2007016239A2 (en) * | 2005-07-29 | 2007-02-08 | President And Fellows Of Harvard College | Herpes simplex virus mutant and uses therefore |
| EP1919944B1 (en) | 2005-08-15 | 2011-03-23 | Vegenics Pty Ltd | Modified vegf and pdgf with improved angiogenic properties |
| US7972813B2 (en) * | 2005-09-30 | 2011-07-05 | Vertex Pharmaceuticals Incorporated | Tetrodotoxin-resistant sodium channel alpha subunit |
| US20080200408A1 (en) * | 2005-09-30 | 2008-08-21 | Mccormack Kenneth | Deletion mutants of tetrodotoxin-resistant sodium channel alpha subunit |
| DE602005023550D1 (de) | 2005-12-14 | 2010-10-21 | Licentia Ltd | Verwendungen eines neurotrophischen Faktors |
| WO2007089780A2 (en) * | 2006-01-30 | 2007-08-09 | Licentia, Ltd. | Bmx/etk tyrosine kinase gene therapy materials and methods |
| AU2007254243B2 (en) | 2006-05-17 | 2013-06-13 | Ludwig Institute For Cancer Research | Targeting VEGF-B regulation of fatty acid transporters to modulate human diseases |
| US8586028B2 (en) * | 2007-05-09 | 2013-11-19 | Board Of Supervisors Of Lousiana State University And Agricultural And Mechanical College | Synthetic herpes simplex viruses type-1 for treatment of cancers |
| FI20070808A0 (fi) | 2007-10-25 | 2007-10-25 | Mart Saarma | GDNF:n silmukointivariantit ja niiden käytöt |
| US20090196854A1 (en) * | 2008-02-04 | 2009-08-06 | Kytos Biosystems S.A. | Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery |
| FI20080326A0 (fi) | 2008-04-30 | 2008-04-30 | Licentia Oy | Neurotroofinen tekijä MANF ja sen käytöt |
| EP2318036B1 (en) * | 2008-06-30 | 2015-06-03 | The Regents of the University of Michigan | Lysosomal phospholipase a2 (lpla2) activity as a diagnostic and therapeutic target for identifying and treating systemic lupus erythematosis |
| CA2840175C (en) | 2011-05-19 | 2021-11-16 | The Regents Of The University Of Michigan | Integrin alpha-2 binding agents and use thereof to inhibit cancer cell proliferation |
| DK2751279T3 (da) | 2011-08-31 | 2017-11-20 | St Jude Children's Res Hospital | Fremgangsmåder og sammensætninger til påvisning af niveauet af lysosomal exocytose-aktivitet og fremgangsmåder til anvendelse |
| US9365496B2 (en) | 2011-11-30 | 2016-06-14 | Ludwig Institute For Cancer Research | iNKT cell modulators and methods of using the same |
| GB201120860D0 (en) | 2011-12-05 | 2012-01-18 | Cambridge Entpr Ltd | Cancer immunotherapy |
| AU2013252909B2 (en) | 2012-04-24 | 2017-09-28 | University Of Miami | Perforin 2 defense against invasive and multidrug resistant pathogens |
| WO2013184209A1 (en) | 2012-06-04 | 2013-12-12 | Ludwig Institute For Cancer Research Ltd. | Mif for use in methods of treating subjects with a neurodegenerative disorder |
| CA2884245C (en) | 2012-09-06 | 2023-03-14 | The University Of Chicago | Antisense polynucleotides to induce exon skipping and methods of treating dystrophies |
| PT2956476T (pt) | 2013-02-18 | 2020-02-21 | Vegenics Pty Ltd | Moléculas de ligação e usos destas |
| WO2014191630A2 (en) | 2013-05-28 | 2014-12-04 | Helsingin Yliopisto | Non-human animal model encoding a non-functional manf gene |
| EP3054946A2 (en) | 2013-10-09 | 2016-08-17 | University Of Miami | Perforin-2 activators and inhibitors as drug targets for infectious disease and gut inflammation |
| TN2017000427A1 (en) | 2015-04-08 | 2019-04-12 | Univ Northwestern | Compositions and methods for correcting limb girdle muscular dystrophy type 2c using exon skipping |
| EP3778881A1 (en) | 2016-01-08 | 2021-02-17 | Replimune Limited | Modified oncolytic virus |
| GB201700350D0 (en) | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
| AU2019284362A1 (en) | 2018-06-11 | 2021-01-07 | University Of Florida Research Foundation, Inc. | Materials and methods for treating stress-related disorders and cancer |
| WO2024228167A1 (en) | 2023-05-03 | 2024-11-07 | Iox Therapeutics Inc. | Inkt cell modulator liposomal compositions and methods of use |
| AR134514A1 (es) | 2023-12-01 | 2026-01-21 | Gilead Sciences Inc | Proteína de fusión anti-fap-ligera y uso de esta |
| US20260056209A1 (en) | 2024-06-14 | 2026-02-26 | Gilead Sciences, Inc. | Anti-ccr8 antibodies and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4769331A (en) * | 1981-09-16 | 1988-09-06 | University Patents, Inc. | Recombinant methods and materials |
| US4859587A (en) * | 1984-06-04 | 1989-08-22 | Institut Merieux | Recombinant herpes simplex viruses, vaccines and methods |
| US5068192A (en) * | 1986-01-27 | 1991-11-26 | Prutech Research And Development Partnership | Attenuated pseudorabies virus which includes foreign DNA encoding an amino acid sequence |
| US4999296A (en) * | 1986-04-29 | 1991-03-12 | Novagene, Inc. | Thymidine kinase negative insertion mutants of pseudorabies virus and methods for the production of same |
| IE63986B1 (en) * | 1989-12-30 | 1995-06-28 | Akzo Nv | Pharmaceutical preparation for oral administration in fluid form |
-
1990
- 1990-09-10 US US07/579,834 patent/US5328688A/en not_active Expired - Lifetime
-
1991
- 1991-09-10 JP JP51696891A patent/JP3334876B2/ja not_active Expired - Fee Related
- 1991-09-10 EP EP91918320A patent/EP0500917B1/en not_active Revoked
- 1991-09-10 ES ES91918320T patent/ES2102409T3/es not_active Expired - Lifetime
- 1991-09-10 DE DE69125925T patent/DE69125925T2/de not_active Expired - Lifetime
- 1991-09-10 DK DK91918320T patent/DK0500917T3/da active
- 1991-09-10 WO PCT/US1991/006532 patent/WO1992004050A1/en not_active Ceased
- 1991-09-10 AU AU87418/91A patent/AU658838B2/en not_active Ceased
- 1991-09-10 AT AT91918320T patent/ATE152355T1/de not_active IP Right Cessation
- 1991-09-10 CA CA 2072627 patent/CA2072627C/en not_active Expired - Fee Related
-
1994
- 1994-07-08 US US08/272,772 patent/US6120773A/en not_active Expired - Fee Related
-
1997
- 1997-07-16 GR GR970401794T patent/GR3024144T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0500917A1 (en) | 1992-09-02 |
| EP0500917B1 (en) | 1997-05-02 |
| JPH05503017A (ja) | 1993-05-27 |
| AU8741891A (en) | 1992-03-30 |
| GR3024144T3 (en) | 1997-10-31 |
| EP0500917A4 (en) | 1993-02-17 |
| AU658838B2 (en) | 1995-05-04 |
| US5328688A (en) | 1994-07-12 |
| DE69125925D1 (de) | 1997-06-05 |
| CA2072627A1 (en) | 1992-03-11 |
| WO1992004050A1 (en) | 1992-03-19 |
| ES2102409T3 (es) | 1997-08-01 |
| CA2072627C (en) | 2003-12-16 |
| US6120773A (en) | 2000-09-19 |
| JP3334876B2 (ja) | 2002-10-15 |
| ATE152355T1 (de) | 1997-05-15 |
| DE69125925T2 (de) | 1997-09-25 |
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