DK0506868T4 - Immunologisk aktive proteiner fra Borrelia burgdorferi, tilhørende testkits og vaccine - Google Patents

Immunologisk aktive proteiner fra Borrelia burgdorferi, tilhørende testkits og vaccine

Info

Publication number
DK0506868T4
DK0506868T4 DK91902687T DK91902687T DK0506868T4 DK 0506868 T4 DK0506868 T4 DK 0506868T4 DK 91902687 T DK91902687 T DK 91902687T DK 91902687 T DK91902687 T DK 91902687T DK 0506868 T4 DK0506868 T4 DK 0506868T4
Authority
DK
Denmark
Prior art keywords
immunologically active
proteins
borrelia burgdorferi
active proteins
specific
Prior art date
Application number
DK91902687T
Other languages
English (en)
Other versions
DK0506868T3 (da
Inventor
Renate Fuchs
Bettina Wilske
Vera Preac-Mursic
Manfred Motz
Erwin Soutschek
Original Assignee
Mikrogen Molekularbiol Entw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25888425&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0506868(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE3942728A external-priority patent/DE3942728C1/de
Priority claimed from DE4018988A external-priority patent/DE4018988C2/de
Application filed by Mikrogen Molekularbiol Entw filed Critical Mikrogen Molekularbiol Entw
Application granted granted Critical
Publication of DK0506868T3 publication Critical patent/DK0506868T3/da
Publication of DK0506868T4 publication Critical patent/DK0506868T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1207—Gram-negative bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK91902687T 1989-12-22 1990-12-21 Immunologisk aktive proteiner fra Borrelia burgdorferi, tilhørende testkits og vaccine DK0506868T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE3942728A DE3942728C1 (en) 1989-12-22 1989-12-22 New immunologically active proteins derived from Borelia burgdorferiensity polyethylene vessel and a high density polyethylene sealing cap - useful as vaccine and for quick accurate diagnosis of Borelia infections
DE4018988A DE4018988C2 (de) 1990-06-13 1990-06-13 Immunologisch aktive Proteine von Borrelia burgdorferi, Testkits, die diese Proteine enthalten und zum Nachweis von Antikörpern in Untersuchungsflüssigkeiten geeignet sind, monoklonale Antikörper, die gegen die immunologisch aktiven Proteine gerichtet sind und die Verwendung dieser Proteine als Impfstoffe gegen durch Borrelia-Stämme hervorgerufene Infektionen
PCT/EP1990/002282 WO1991009870A1 (de) 1989-12-22 1990-12-21 Immunologisch aktive proteine von borrelia burgdorferi, zusammenhängende testkits und impfstoff

Publications (2)

Publication Number Publication Date
DK0506868T3 DK0506868T3 (da) 1996-08-12
DK0506868T4 true DK0506868T4 (da) 2004-04-26

Family

ID=25888425

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91902687T DK0506868T4 (da) 1989-12-22 1990-12-21 Immunologisk aktive proteiner fra Borrelia burgdorferi, tilhørende testkits og vaccine

Country Status (9)

Country Link
US (5) US6248538B1 (da)
EP (1) EP0506868B2 (da)
AT (1) ATE140461T1 (da)
AU (1) AU7058691A (da)
CA (1) CA2072008C (da)
DE (1) DE59010422D1 (da)
DK (1) DK0506868T4 (da)
ES (1) ES2092560T5 (da)
WO (1) WO1991009870A1 (da)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5777095A (en) * 1988-10-24 1998-07-07 Symbicom Aktiebolag Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90
US6143872A (en) * 1988-10-24 2000-11-07 Symbicom Aktiebolag Borrelia burdorferi Osp A and B proteins and immunogenic peptides
DE4015911A1 (de) * 1989-09-19 1991-03-28 Max Planck Gesellschaft Impfstoff gegen die lyme-krankheit
DK0506868T4 (da) * 1989-12-22 2004-04-26 Mikrogen Molekularbiol Entw Immunologisk aktive proteiner fra Borrelia burgdorferi, tilhørende testkits og vaccine
EP0536335A4 (en) * 1990-06-15 1993-07-14 Yale University Compositions and methods for the prevention and diagnosis of lyme disease
HU216204B (hu) * 1990-06-15 1999-05-28 MTA Műszaki Fizikai és Anyagtudományi Kutatóintézet Eljárás és berendezés kis mágneses terek és térváltozások mérésére, valamint magnetométer szonda
DE4120345C5 (de) * 1991-06-19 2004-08-12 Arnold Prof. Dr.med. Vogt Proteinfragmente aus dem mittleren Bereich des Flagellins von Borrelia burgdorferi, geeignet als Antigene zum spezifischen Antikörpernachweis sowie Verfahren zu ihrer Herstellung
US6221363B1 (en) * 1991-07-11 2001-04-24 Baxter Aktiengesellschaft Vaccine for the prevention of lyme disease
US6872550B1 (en) 1991-07-11 2005-03-29 Baxter Vaccine Ag Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens
US6676942B1 (en) * 1991-08-15 2004-01-13 Smithkline Beecham Biologicals (S.A.) Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines
WO1993008299A1 (en) * 1991-10-18 1993-04-29 Connaught Laboratories Inc. Preparation of recombinant borrelia proteins
JPH07501797A (ja) * 1991-11-12 1995-02-23 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ ライム病に対する組換えワクチン
US5618533A (en) * 1992-02-11 1997-04-08 Yale University Flagellin-based polypeptides for the diagnosis of lyme disease
WO1993024145A1 (en) * 1992-05-26 1993-12-09 Smithkline Beecham Corporation Compositions useful in diagnosis and prophylaxis of lyme disease
NZ258824A (en) * 1992-12-16 1997-11-24 Univ Melbourne Nucleic acid encoding type ii serine proteinase inhibitor precursor and its use
US5656451A (en) * 1993-07-30 1997-08-12 Yale University OspE, OspF, and S1 polypeptides in borrelia burgdorferi
US6716591B1 (en) 1993-07-30 2004-04-06 Yale University B. burgdorferi polypeptides
US7008625B2 (en) 1993-11-01 2006-03-07 Research Foundation Of The State University Of New York Recombinant constructs of Borrelia burgdorferi
US6248562B1 (en) 1993-11-01 2001-06-19 Research Foundation State University Of New York Chimeric proteins comprising borrelia polypeptides and uses therefor
US5620862A (en) * 1993-11-24 1997-04-15 University Of Connecticut Methods for diagnosing early Lyme disease
US6251405B1 (en) 1995-06-07 2001-06-26 Connaught Laboratories, Inc. Immunological combination compositions and methods
ZA964896B (en) 1995-06-07 1997-01-08 Connaught Lab Expression of lipoproteins
US6716574B2 (en) 1996-05-02 2004-04-06 Dako A/S Osp-C derived peptide fragments
ES2270523T3 (es) 1997-06-30 2007-04-01 The Administrators Of The Tulane Educational Fund Antigenos de superficie y proteinas utiles en composiciones para la diagnosis y prevencion de la enfermedad de lyme.
US6224882B1 (en) 1997-11-07 2001-05-01 Protein Science Corp. Insect cells or fractions as adjuvant for antigens
US6475492B1 (en) 1999-04-28 2002-11-05 The Administrators Of The Tulane Educational Fund Peptides and assays for the diagnosis of lyme disease
AU2001285049A1 (en) 2000-08-18 2002-03-04 Brookhaven Sciences Associates, Llc Altered ospa of borrelia burgdorferi
AU2002247905A1 (en) * 2002-03-28 2003-10-13 Markus Fritzsche Antibody against an epitope of the b. burgdorferi flagellar basal rod protein (fbrp)
US20040033623A1 (en) * 2002-08-16 2004-02-19 Igenex, Inc. Assay for detection of antigen in bodily fluid
WO2008031133A2 (en) 2006-09-15 2008-03-20 Intercell Ag Borrelia antigens
EP2155782A2 (en) 2007-03-26 2010-02-24 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
EP2167537A2 (en) 2007-07-03 2010-03-31 Dako Denmark A/S Compiled methods for analysing and sorting samples
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
CN102170903B (zh) 2008-05-02 2016-04-06 亮点医疗有限公司 用于刺激免疫反应的产品和方法
WO2010009735A2 (en) 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
ES2421885T3 (es) 2008-12-12 2013-09-06 Euroimmun Medizinische Labordiagnostika Ag Polipéptidos y procedimiento para la detección específica de anticuerpos en pacientes con una infección por Borrelia
EP2545071A2 (en) 2010-03-09 2013-01-16 Maksyutov, Amir Polyepitope constructs and methods for their preparation and use
US8142050B2 (en) 2010-06-24 2012-03-27 Mitutoyo Corporation Phosphor wheel configuration for high intensity point source
WO2012023033A2 (en) 2010-08-18 2012-02-23 Purdue Pharma L.P. Improved peptide immunogens
WO2013067448A2 (en) 2011-11-03 2013-05-10 Vca Antech Inc. Compositions and methods to detect various infectious organisms
WO2020127222A2 (en) 2018-12-17 2020-06-25 Immudex Aps Panel comprising borrelia mhc multimers
WO2023240124A1 (en) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Pseudotyped viral particles for targeting tcr-expressing cells
AU2023285085A1 (en) 2022-06-07 2024-12-19 Regeneron Pharmaceuticals, Inc. Multispecific molecules for modulating t-cell activity, and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888276A (en) 1986-06-26 1989-12-19 Minnesota Mining And Manufacturing Company Method and composition for the diagnosis of Lyme disease
DK0506868T4 (da) * 1989-12-22 2004-04-26 Mikrogen Molekularbiol Entw Immunologisk aktive proteiner fra Borrelia burgdorferi, tilhørende testkits og vaccine
US5620862A (en) 1993-11-24 1997-04-15 University Of Connecticut Methods for diagnosing early Lyme disease

Also Published As

Publication number Publication date
US20030157562A1 (en) 2003-08-21
US6183755B1 (en) 2001-02-06
US7083792B2 (en) 2006-08-01
US6753183B2 (en) 2004-06-22
CA2072008C (en) 2003-01-28
AU7058691A (en) 1991-07-24
ES2092560T5 (es) 2004-09-16
DE59010422D1 (de) 1996-08-22
WO1991009870A1 (de) 1991-07-11
ATE140461T1 (de) 1996-08-15
EP0506868B1 (de) 1996-07-17
US6248538B1 (en) 2001-06-19
CA2072008A1 (en) 1991-06-23
EP0506868B2 (de) 2004-02-11
ES2092560T3 (es) 1996-12-01
US20040253611A1 (en) 2004-12-16
DK0506868T3 (da) 1996-08-12
EP0506868A1 (de) 1992-10-07
US6509019B1 (en) 2003-01-21

Similar Documents

Publication Publication Date Title
DK0506868T3 (da) Immunologisk aktive proteiner fra Borrelia burgdorferi, tilhørende testkits og vaccine
Iqbal et al. Comparison of PCR with other tests for early diagnosis of canine ehrlichiosis
Núñez et al. Multiplex polymerase chain reaction amplification and differentiation of Entamoeba histolytica and Entamoeba dispar DNA from stool samples.
KR0171617B1 (ko) 단백질-핵산 프로브 및 그를 사용하는 면역분석법
DE60128908D1 (de) Verfahren zum Nachweis und zur Lokalisierung von Genen in situ durch Hybridisierung einer verzweigten DNA
ATE459716T1 (de) Zytokin zcyt018
Kim et al. A novel simple one-step single-tube RT-duplex PCR method with an internal control for detection of bovine viral diarrhoea virus in bulk milk, blood, and follicular fluid samples
Wagter et al. PCR detection of lentiviral GAG segment DNA in the white blood cells of sheep and goats
ATE127924T1 (de) Nachweisverfahren.
US20020006608A1 (en) Whole blood/mitogen assay for the early detection of a subject infected with hepatitis c virus and kit
US6322989B1 (en) Whole blood/mitogen assay for the early detection of a subject with ovarian or breast cancer and kit
WO2006136639A1 (es) Método y kit de detección de especies bacterianas mediante análisis de adn
US6280962B1 (en) Whole blood/mitogen assay for the early detection of a subject with cancer and kit
ÖZKUL et al. Comparison of four diagnostic techniques for detecting bovine virus diarrhoea virus (BVDV) in buffy coat samples after long-term storage
US6268123B1 (en) Direct and biochemically functional detection process of retrovirus in biological samples
CN119639746A (zh) 一种非洲猪瘟病毒的快速可视化检测方法
KR19990014922A (ko) 항원의 동일 반응계내 면역 검정 방법
JPH11511027A (ja) Ｇｂ型肝炎ウィルス遺伝子型の検出
Seal Molecular methods for detection and discrimination of Ralstonia solanacearum
Gupte et al. Diagnostic approach to Brucellosis
DE60131962D1 (de) Verfahren und zusammensetzungen zum nachweis von taenia solium larven mittels eines klonierten antigens
Liu et al. Rapid identification and authentication of closely related animal cell culture by polymerase chain reaction
Sauer et al. Identification of Ophiosphaerella herpotricha by cloned DNA probes.
RU2206574C2 (ru) Полипептид, содержащий антигенный участок растворимого антигена м. tuberculosis, способ (варианты) и диагностический набор (варианты) для выявления инфекции m. tuberculosis
RU2164945C1 (ru) Синтетические олигонуклеотиды-праймеры, используемые для выявления днк цитомегаловируса человека