DK0511234T3 - Stabil injicerbar opløsning af faktor VIII - Google Patents

Stabil injicerbar opløsning af faktor VIII

Info

Publication number: DK0511234T3
Authority: DK; Denmark
Prior art keywords: factor viii; injectable solution; stable injectable; stable; concentrations
Prior art date: 1990-01-19

Application number

DK91901746.7T

Other languages

English (en)

Inventor

Horst Schwinn

Original Assignee

Octapharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-19

Filing date

1990-12-19

Publication date

1995-08-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6398370&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0511234(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-12-19 Application filed by Octapharma Ag filed Critical Octapharma Ag

1995-08-21 Application granted granted Critical

1995-08-21 Publication of DK0511234T3 publication Critical patent/DK0511234T3/da

Links

102000001690 Factor VIII Human genes 0.000 title abstract 3
108010054218 Factor VIII Proteins 0.000 title abstract 3
229960000301 factor viii Drugs 0.000 title abstract 3
229940102223 injectable solution Drugs 0.000 title abstract 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 2
229930006000 Sucrose Natural products 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
235000013681 dietary sucrose Nutrition 0.000 abstract 2
150000002016 disaccharides Chemical class 0.000 abstract 2
229960004793 sucrose Drugs 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 1
230000000087 stabilizing effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
General Engineering & Computer Science (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

DK91901746.7T 1990-01-19 1990-12-19 Stabil injicerbar opløsning af faktor VIII DK0511234T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4001451A DE4001451A1 (de)	1990-01-19	1990-01-19	Stabile injizierbare loesungen von faktor viii und faktor ix

Publications (1)

Publication Number	Publication Date
DK0511234T3 true DK0511234T3 (da)	1995-08-21

Family

ID=6398370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91901746.7T DK0511234T3 (da)	1990-01-19	1990-12-19	Stabil injicerbar opløsning af faktor VIII

Country Status (8)

Country	Link
US (1)	US5328694A (da)
EP (1)	EP0511234B1 (da)
JP (1)	JPH05504342A (da)
AT (1)	ATE120960T1 (da)
DE (2)	DE4001451A1 (da)
DK (1)	DK0511234T3 (da)
ES (1)	ES2071292T3 (da)
WO (1)	WO1991010439A1 (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4111393A1 (de) *	1991-04-09	1992-10-15	Behringwerke Ag	Stabilisierte faktor viii-praeparationen
GB9122609D0 (en) *	1991-10-24	1991-12-04	Brownlee George G	Improvements relating to the treatment of haemophilia
CA2124690C (en) *	1992-10-02	2007-09-11	Thomas Osterberg	Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
SE9301581D0 (sv) *	1993-05-07	1993-05-07	Kabi Pharmacia Ab	Protein formulation
US6288030B1 (en)	1993-12-22	2001-09-11	Amgen Inc.	Stem cell factor formulations and methods
US6242417B1 (en)	1994-03-08	2001-06-05	Somatogen, Inc.	Stabilized compositions containing hemoglobin
IL113010A (en) *	1994-03-31	1999-10-28	Pharmacia & Upjohn Ab	Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration
US6372716B1 (en) *	1994-04-26	2002-04-16	Genetics Institute, Inc.	Formulations for factor IX
SE9501189D0 (sv) *	1995-03-31	1995-03-31	Pharmacia Ab	Protein formulation
US5770700A (en) *	1996-01-25	1998-06-23	Genetics Institute, Inc.	Liquid factor IX formulations
US5763401A (en) *	1996-07-12	1998-06-09	Bayer Corporation	Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
DK1820516T3 (da)	1999-02-22	2013-10-28	Univ Connecticut	Nye albuminfrie faktor VIII-præparater
AU2002213441B2 (en) *	2000-10-12	2006-10-26	Genentech, Inc.	Reduced-viscosity concentrated protein formulations
US8703126B2 (en)	2000-10-12	2014-04-22	Genentech, Inc.	Reduced-viscosity concentrated protein formulations
EP1458408B1 (en)	2001-12-21	2009-04-15	Novo Nordisk Health Care AG	Liquid composition of factor vii polypeptides
CN1671410B (zh)	2002-06-21	2010-05-12	诺和诺德医疗保健公司	因子ⅶ多肽的稳定化固体组合物
US7897734B2 (en)	2003-03-26	2011-03-01	Novo Nordisk Healthcare Ag	Method for the production of proteins
MXPA05010555A (es)	2003-04-04	2006-03-09	Genentech Inc	Formulaciones de proteina y anticuerpo de alta concentracion.
RU2364609C2 (ru)	2003-05-23	2009-08-20	Ново Нордиск Хелт Кэр Аг	Стабилизация белка в растворе
EP1641487B1 (en)	2003-06-25	2012-02-29	Novo Nordisk Health Care AG	Liquid composition of factor vii polypeptides
JP5653572B2 (ja)	2003-08-14	2015-01-14	ノボノルディスクヘルスケアアクチェンゲゼルシャフト	第ｖｉｉ因子ポリペプチドの液状水性医薬組成物
CA2538794C (en)	2003-09-12	2016-04-19	Antigenics, Inc.	Vaccine for treatment and prevention of herpes simplex virus infection
CN1917861B (zh)	2003-12-19	2012-03-21	诺和诺德医疗保健公司	因子vii多肽的稳定化固体组合物
KR100624013B1 (ko)	2004-06-25	2006-09-19	주식회사 녹십자홀딩스	동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제
FI121025B (fi) *	2004-12-07	2010-06-15	Sandvik Mining & Constr Oy	Menetelmä putkiporaukseen, porausyksikkö sekä adapterilaite
CN101163506B (zh)	2004-12-27	2012-09-26	巴克斯特国际公司	聚合物-von Willebrand因子偶联物
AU2007245190B2 (en) *	2006-03-31	2011-07-21	Takeda Pharmaceutical Company Limited	Pegylated factor VIII
US7645860B2 (en)	2006-03-31	2010-01-12	Baxter Healthcare S.A.	Factor VIII polymer conjugates
MX2011001624A (es)	2008-08-21	2011-03-28	Octapharma Ag	Factor viii y ix humano producido en forma recombinante.
WO2010026186A1 (en) *	2008-09-03	2010-03-11	Octapharma Ag	New protecting compositions for recombinantly produced factor viii
MX339060B (es)	2008-11-07	2016-05-09	Baxter Int	Formulaciones del factor viii.
AU2010221156A1 (en)	2009-03-06	2011-09-22	Genentech, Inc.	Antibody formulation
CN106687126B (zh)	2014-08-04	2020-07-28	杰特有限公司	因子viii制剂
EA201792501A1 (ru)	2015-05-13	2018-10-31	Эйдженус Инк.	Вакцины для лечения и профилактики рака
MA52363A (fr)	2018-04-26	2021-03-03	Agenus Inc	Compositions peptidiques de liaison à une protéine de choc thermique (hsp) et leurs méthodes d'utilisation
WO2021001522A1 (en)	2019-07-04	2021-01-07	CSL Behring Lengnau AG	A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii
JP2025512143A (ja)	2020-11-09	2025-04-17	武田薬品工業株式会社	酸化ケイ素吸着を使用する血漿からのｆｖｉｉｉの精製

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4186192A (en) *	1978-12-18	1980-01-29	Cutter Laboratories, Inc.	Stabilized immune serum globulin
DE2916711A1 (de) *	1979-04-25	1980-11-06	Behringwerke Ag	Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
EP0035204B2 (en) *	1980-03-05	1991-05-22	Miles Inc.	Pasteurized therapeutically active protein compositions
DE3045153A1 (de) *	1980-11-29	1982-07-08	Behringwerke Ag, 3550 Marburg	Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x
US4495278A (en) *	1981-04-27	1985-01-22	Baxter Travenol Laboratories, Inc.	Process for making novel blood clotting enzyme compositions
JPS5874617A (ja) *	1981-10-28	1983-05-06	Green Cross Corp:The	人由来血液凝固第７因子含有水溶液の加熱処理方法
JPS58191881A (ja) *	1982-05-01	1983-11-09	服部　盛義	自動車用ドア−の両開き装置
DE3237512A1 (de) *	1982-10-09	1984-04-12	Behringwerke Ag, 3550 Marburg	Verfahren zur pasteurisierung von antihaemophilem kryopraezipitat (ahk) und danach hergestelltes antihaemophiles kryopraezipitat
JPS59112630A (ja) *	1982-12-17	1984-06-29	Matsushita Electric Ind Co Ltd	ワイヤボンデイング装置
JPS59134730A (ja) *	1983-01-20	1984-08-02	Green Cross Corp:The	血液凝固第８因子の加熱処理法
DE3336631A1 (de) *	1983-10-08	1985-04-18	Behringwerke Ag, 3550 Marburg	Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x
DE3432083A1 (de) *	1984-08-31	1986-03-06	Behringwerke Ag, 3550 Marburg	Pasteurisierte, isoagglutininfreie faktor viii-praeparation und verfahren zu ihrer herstellung
US4847362A (en) *	1985-02-01	1989-07-11	New York University	Method for purifying antihemophilic factor
DE3625090A1 (de) *	1986-07-24	1988-01-28	Behringwerke Ag	Mittel zur therapie faktor viii-resistenter haemophilie a und verfahren zu seiner herstellung
CA1329760C (en) *	1987-10-29	1994-05-24	Ted C. K. Lee	Plasma and recombinant protein formulations in high ionic strength media
US5110907A (en) *	1989-08-01	1992-05-05	Alpha Therapeutic Corporation	Factor viii complex purification using heparin affinity chromatography

1990
- 1990-01-19 DE DE4001451A patent/DE4001451A1/de not_active Ceased
- 1990-12-19 DE DE59008910T patent/DE59008910D1/de not_active Revoked
- 1990-12-19 ES ES91901746T patent/ES2071292T3/es not_active Expired - Lifetime
- 1990-12-19 JP JP91502059A patent/JPH05504342A/ja active Pending
- 1990-12-19 EP EP91901746A patent/EP0511234B1/de not_active Revoked
- 1990-12-19 AT AT91901746T patent/ATE120960T1/de not_active IP Right Cessation
- 1990-12-19 WO PCT/EP1990/002238 patent/WO1991010439A1/de not_active Ceased
- 1990-12-19 DK DK91901746.7T patent/DK0511234T3/da active
1992
- 1992-07-20 US US07/916,644 patent/US5328694A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0511234A1 (de)	1992-11-04
JPH05504342A (ja)	1993-07-08
EP0511234B1 (de)	1995-04-12
ES2071292T3 (es)	1995-06-16
US5328694A (en)	1994-07-12
ATE120960T1 (de)	1995-04-15
DE4001451A1 (de)	1991-08-01
WO1991010439A1 (de)	1991-07-25
DE59008910D1 (de)	1995-05-18

Publication	Publication Date	Title
DK0511234T3 (da)	1995-08-21	Stabil injicerbar opløsning af faktor VIII
DE3689056D1 (de)	1993-10-28	Verfahren und Zusammensetzung zur Herstellung von Liposomen.
DE3881364D1 (de)	1993-07-01	Verfahren zur herstellung und zusammensetzungen von kollagen-derivaten.
DE59209051D1 (de)	1998-01-22	Stabilisierte Faktor VIII-Präparationen
DE69220938D1 (de)	1997-08-21	Vorrichtung zur aufbewahrung von organen
ATA105892A (de)	1995-06-15	Nagellack zur behandlung von onychomykosis enthaltend terbinafine
DE69214610D1 (de)	1996-11-21	Verfahren zur Behandlung von Erdgas
DE69208418D1 (de)	1996-03-28	Verfahren und Anlage zur gemischten Herstellung von Sauerstoff hoher und niederer Reinheit
DE69131967D1 (de)	2000-03-09	Verfahren zur Herstellung von 1,1-Diarylprolinolen
DE68916988D1 (de)	1994-09-01	Verfahren zur Herstellung von gasförmigen Fluoriden.
IT1247945B (it)	1995-01-05	Agente avente attivita' batteriostatica e battericida
DE68927949D1 (de)	1997-05-15	3,9-Diphosphaspiroundecane und Verfahren zur Herstellung von 3,9-Diphosphaspiroundecanen
DE59208629D1 (de)	1997-07-24	Verfahren zur Herstellung von 1,1,1,2,3,3,3-Heptafluorpropan (R 227)
DK0410207T3 (da)	1997-07-14	Stabilisering af højrensede proteiner.
ATE140962T1 (de)	1996-08-15	Dns-klone von menschlichem thrombomodulin
DE69004648D1 (de)	1993-12-23	Verfahren zur Herstellung von Alpha-Hydroxycarbonsäure-Amiden.
DE58907083D1 (de)	1994-04-07	Verfahren zur Herstellung von Benztriazolderivaten.
DE59308628D1 (de)	1998-07-09	Verfahren zur Herstellung von Faktor VIII
FI902713A0 (fi)	1990-05-31	Menetelmä stabiilin karboplatiinivesiliuoksen valmistamiseksi
NO930830L (no)	1993-09-13	Nye beta-aminosyrederivater
DE69132472D1 (de)	2000-12-21	Verfahren zur Herstellung von optisch aktivem 1,3-Butandiol
DE58906335D1 (de)	1994-01-20	Verfahren zur Modifizierung von cellulosischen Dialysemembranen zur Verbesserung der Biocompatibilität und Vorrichtung zur Durchführung des Verfahrens.
DE68908619D1 (de)	1993-09-30	Verfahren zur Herstellung von Cyanamid aus Calciumcyanamid.
ATE174383T1 (de)	1998-12-15	Verwendung von tri-n-butylphosphat bei niedrigem ph in lösungen von biologisch aktiven proteinen für eine verbesserte viruzide wirkung
DE59105224D1 (de)	1995-05-24	Verfahren zur Herstellung von N-substituierten Pyrrolidonen.