DK0531448T3 - Mammal ekspression af BMP-2 familien - Google Patents

Mammal ekspression af BMP-2 familien

Info

Publication number: DK0531448T3
Authority: DK; Denmark
Prior art keywords: bmp; family; mammalian expression; construct; dna
Prior art date: 1990-05-24

Application number

DK91911938.8T

Other languages

English (en)

Inventor

Glenn R Hammonds

Anthony J Mason

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-24

Filing date

1991-05-20

Publication date

1995-05-01

1991-05-20 Application filed by Genentech Inc filed Critical Genentech Inc

1995-05-01 Application granted granted Critical

1995-05-01 Publication of DK0531448T3 publication Critical patent/DK0531448T3/da

Links

108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 title abstract 3
102100024506 Bone morphogenetic protein 2 Human genes 0.000 title abstract 3
239000013604 expression vector Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
238000011144 upstream manufacturing Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Orthopedic Medicine & Surgery (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK91911938.8T 1990-05-24 1991-05-20 Mammal ekspression af BMP-2 familien DK0531448T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/528,300 US5168050A (en)	1990-05-24	1990-05-24	Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion

Publications (1)

Publication Number	Publication Date
DK0531448T3 true DK0531448T3 (da)	1995-05-01

Family

ID=24105094

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91911938.8T DK0531448T3 (da)	1990-05-24	1991-05-20	Mammal ekspression af BMP-2 familien

Country Status (10)

Country	Link
US (1)	US5168050A (da)
EP (1)	EP0531448B1 (da)
JP (1)	JPH05507411A (da)
AT (1)	ATE114163T1 (da)
CA (1)	CA2082052A1 (da)
DE (1)	DE69105205T2 (da)
DK (1)	DK0531448T3 (da)
ES (1)	ES2067238T3 (da)
GR (1)	GR3014924T3 (da)
WO (1)	WO1991018047A2 (da)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5013649A (en) *	1986-07-01	1991-05-07	Genetics Institute, Inc.	DNA sequences encoding osteoinductive products
US6150328A (en) *	1986-07-01	2000-11-21	Genetics Institute, Inc.	BMP products
US5543394A (en) *	1986-07-01	1996-08-06	Genetics Institute, Inc.	Bone morphogenetic protein 5(BMP-5) compositions
US5459047A (en) *	1986-07-01	1995-10-17	Genetics Institute, Inc.	BMP-6 proteins
US5939388A (en) *	1986-07-01	1999-08-17	Rosen; Vicki A.	Methods of administering BMP-5 compositions
US5284756A (en) *	1988-10-11	1994-02-08	Lynn Grinna	Heterodimeric osteogenic factor
US7378392B1 (en)	1990-05-16	2008-05-27	Genetics Institute, Llc	Bone and cartilage inductive proteins
US5688678A (en) *	1990-05-16	1997-11-18	Genetics Institute, Inc.	DNA encoding and methods for producing BMP-8 proteins
US6395883B1 (en) *	1991-03-11	2002-05-28	Curis, Inc.	Soluble morphogenic protein complex compositions of matter
US5290763A (en) *	1991-04-22	1994-03-01	Intermedics Orthopedics/Denver, Inc.	Osteoinductive protein mixtures and purification processes
US5693615A (en) *	1991-06-05	1997-12-02	The Procter & Gamble Company	Therapeutic compositions for osteoinduction
US6287816B1 (en) *	1991-06-25	2001-09-11	Genetics Institute, Inc.	BMP-9 compositions
EP0592562B1 (en) *	1991-06-25	1999-01-07	Genetics Institute, Inc.	Bmp-9 compositions
WO1993009229A1 (en)	1991-11-04	1993-05-13	Genetics Institute, Inc.	Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
DE69333745T2 (de) *	1992-07-31	2005-12-29	Stryker Corp., Kalamazoo	Löslicher komplex morphogener proteine und zusammensetzungen davon
WO1994026892A1 (en) *	1993-05-12	1994-11-24	Genetics Institute, Inc.	Bmp-11 compositions
US5637480A (en) *	1993-05-12	1997-06-10	Genetics Institute, Inc.	DNA molecules encoding bone morphogenetic protein-10
US6291206B1 (en) *	1993-09-17	2001-09-18	Genetics Institute, Inc.	BMP receptor proteins
AU689184B2 (en)	1993-12-07	1998-03-26	Genetics Institute, Llc	BMP-12, BMP-13 and tendon-inducing compositions thereof
US6027919A (en)	1993-12-07	2000-02-22	Genetics Institute, Inc.	BMP-12 and BMP-13 proteins and DNA encoding them
US5962427A (en) *	1994-02-18	1999-10-05	The Regent Of The University Of Michigan	In vivo gene transfer methods for wound healing
US6074840A (en)	1994-02-18	2000-06-13	The Regents Of The University Of Michigan	Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US5763416A (en) *	1994-02-18	1998-06-09	The Regent Of The University Of Michigan	Gene transfer into bone cells and tissues
US5942496A (en)	1994-02-18	1999-08-24	The Regent Of The University Of Michigan	Methods and compositions for multiple gene transfer into bone cells
WO1995024474A1 (en) *	1994-03-10	1995-09-14	Human Genome Sciences, Inc.	Bone morphogenic protein-10
US6551618B2 (en)	1994-03-15	2003-04-22	University Of Birmingham	Compositions and methods for delivery of agents for neuronal regeneration and survival
CA2151547C (en)	1994-06-10	2010-10-12	Elliott A. Gruskin	Recombinant chimeric proteins and methods of use thereof
US6210899B1 (en)	1994-11-04	2001-04-03	The Procter & Gamble Company	Use of a BMP protein receptor complex for screening bone metabolism actives and cells co-transfected with a type II BMP receptor and type I BMP receptor
US5846770A (en) *	1994-11-22	1998-12-08	Genetics Institute, Inc.	DNA molecules encoding human chordin
US5645084A (en) *	1995-06-07	1997-07-08	Danek Medical, Inc.	Method for spinal fusion without decortication
US5719058A (en) *	1995-04-10	1998-02-17	Merck & Co., Inc.	Method for producing a highly enriched population of osteoclast cells
US5635372A (en) *	1995-05-18	1997-06-03	Genetics Institute, Inc.	BMP-15 compositions
US6492508B1 (en) *	1996-06-03	2002-12-10	United States Surgical Corp. A Division Of Tyco Healthcare Group	Nucleic acids encoding extracellular matrix proteins
US6927287B1 (en) *	1996-06-03	2005-08-09	United States Surgical Corporation	Nucleic acid encoding extracellular matrix protein or fragment thereof
US5965403A (en) *	1996-09-18	1999-10-12	Genetics Institute, Inc.	Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
US6034062A (en) *	1997-03-13	2000-03-07	Genetics Institute, Inc.	Bone morphogenetic protein (BMP)-9 compositions and their uses
US7057017B2 (en) *	1997-04-16	2006-06-06	Millennium Pharmaceuticals, Inc.	Human dickkopf-related protein and nucleic acid molecules and uses therefor
US6818440B2 (en) *	1997-04-28	2004-11-16	Sugen, Inc.	Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) *	1997-05-20	2001-05-08	Sugen, Inc.	Diagnosis and treatment of PTP04 related disorders
US7923250B2 (en)	1997-07-30	2011-04-12	Warsaw Orthopedic, Inc.	Methods of expressing LIM mineralization protein in non-osseous cells
ES2320603T3 (es)	1997-07-30	2009-05-25	Emory University	Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos.
CA2308511C (en)	1997-10-29	2016-01-19	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Use of transfected or transduced mammalian cells for treating bone pathologies
US7446181B2 (en) *	1998-01-15	2008-11-04	Millennium Pharmaceuticals, Inc.	Antibodies that bind human Dickkopf-1 proteins
US20050096274A1 (en) *	1998-04-07	2005-05-05	Lough John W.	Bone morphogenetic protein and fibroblast growth factor compositions and methods for the induction of cardiogenesis
US6344541B1 (en) *	1998-09-25	2002-02-05	Amgen Inc.	DKR polypeptides
US6727224B1 (en)	1999-02-01	2004-04-27	Genetics Institute, Llc.	Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de)	1999-02-13	2000-08-17	Walter Sebald	Protein mit einem Heparin-bindenden Epitop
DK1223990T3 (da)	1999-10-15	2004-11-29	Inst Genetics Llc	Formuleringer af hyaluronsyre til tilförsel af osteogene proteiner
US7226587B2 (en)	2001-06-01	2007-06-05	Wyeth	Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en)	2001-06-08	2006-12-01	Wyeth Corp	Calcium phosphate delivery vehicles for osteoinductive proteins
KR20030085337A (ko) *	2002-04-30	2003-11-05	주식회사 서린바이오사이언스	인간 유래의 ｂｍｐ-2 단백질 발현벡터 및 이를 이용한ｂｍｐ-2 대량 생산방법
US20040023322A1 (en) *	2002-08-01	2004-02-05	Goodheart Clyde R.	Method of producing non-recombinant BMP-2 and use thereof
WO2004058181A2 (en)	2002-12-20	2004-07-15	Board Of Regents, The University Of Texas System	Vmp-like sequences of pathogenic borrelia species and strains
JP5392981B2 (ja)	2003-09-12	2014-01-22	ワイス・エルエルシー	骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト
US20080249038A1 (en) *	2003-10-07	2008-10-09	Quark Biotech, Inc.	Bone Morphogenetic Protein (Bmp) 2A and Uses Thereof
US20070066525A1 (en) *	2004-02-04	2007-03-22	Lee John C	Compositions and therapeutic methods using morphogenic proteins
WO2006015373A2 (en) *	2004-08-04	2006-02-09	Amgen Inc	Antibodies to dkk-1
WO2007070705A2 (en) *	2005-12-15	2007-06-21	The Trustees Of The University Of Pennsylvania	Cationic lipid-mediated vectors
US8450107B1 (en)	2011-11-30	2013-05-28	The Broad Institute Inc.	Nucleotide-specific recognition sequences for designer TAL effectors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1486334A1 (de) *	1964-11-16	1969-04-17	Eastman Kodak Co	Verwendung von synthetischen Polymeren zur Herstellung von Verpackungen und Verpackungsmaterialien,insbesondere fuer Nahrungsmittel
DE2316697A1 (de) *	1972-04-07	1973-10-11	Leer Koninklijke Emballage	Durch einwirken von ultravioletter bestrahlung photozersetzbare polymersubstanz
US4495311A (en) *	1972-07-06	1985-01-22	Princeton Polymer Laboratories, Inc.	Degradable hydrocarbon polymers
CA1073581A (en) *	1974-01-25	1980-03-11	Canadian Titanium Pigments Ltd.	Photodegradable polyolefin material
US4877864A (en) *	1987-03-26	1989-10-31	Genetics Institute, Inc.	Osteoinductive factors
US5013649A (en) *	1986-07-01	1991-05-07	Genetics Institute, Inc.	DNA sequences encoding osteoinductive products
IL83003A (en) *	1986-07-01	1995-07-31	Genetics Inst	Osteoinductive factors
US5221620A (en) *	1987-10-06	1993-06-22	Oncogen	Cloning and expression of transforming growth factor β2

1990
- 1990-05-24 US US07/528,300 patent/US5168050A/en not_active Expired - Lifetime
1991
- 1991-05-20 ES ES91911938T patent/ES2067238T3/es not_active Expired - Lifetime
- 1991-05-20 JP JP91511190A patent/JPH05507411A/ja active Pending
- 1991-05-20 AT AT91911938T patent/ATE114163T1/de not_active IP Right Cessation
- 1991-05-20 DK DK91911938.8T patent/DK0531448T3/da active
- 1991-05-20 WO PCT/US1991/003540 patent/WO1991018047A2/en not_active Ceased
- 1991-05-20 CA CA002082052A patent/CA2082052A1/en not_active Abandoned
- 1991-05-20 EP EP91911938A patent/EP0531448B1/en not_active Expired - Lifetime
- 1991-05-20 DE DE69105205T patent/DE69105205T2/de not_active Expired - Fee Related
1995
- 1995-02-01 GR GR950400188T patent/GR3014924T3/el unknown

Also Published As

Publication number	Publication date
ES2067238T3 (es)	1995-03-16
WO1991018047A3 (en)	1992-04-02
JPH05507411A (ja)	1993-10-28
DE69105205T2 (de)	1995-05-18
ATE114163T1 (de)	1994-12-15
WO1991018047A2 (en)	1991-11-28
GR3014924T3 (en)	1995-05-31
CA2082052A1 (en)	1991-11-25
EP0531448B1 (en)	1994-11-17
DE69105205D1 (de)	1994-12-22
US5168050A (en)	1992-12-01
EP0531448A1 (en)	1993-03-17

Publication	Publication Date	Title
DK0531448T3 (da)	1995-05-01	Mammal ekspression af BMP-2 familien
NO911502L (no)	1991-11-11	Tilkoblingslist for telekommunikasjonsteknikken.
FI892020A0 (fi)	1989-04-27	Fack foer is och iskuber formade i detta.
FI932722L (fi)	1993-12-16	Glukagonlika peptider och insulinotropinderivat
FI933580A7 (fi)	1993-10-13	Pneumokokkiproteiinin rakennegeeni
EA200000565A1 (ru)	2000-12-25	Цитокин-подобный полипептид-10 млекопитающих
KR960701528A (ko)	1996-02-24	Rf 성분을 포함하는 광학 신호를 발생하는 방법 및 장치(generation of optical signals with rf components)
DK672788D0 (da)	1988-12-02	Rekombinant-dna-vektorer til direkte udtrykkelse af aktiveret humant protein c
DE68906032D1 (de)	1993-05-27	Verstaerkung optischer signale.
DE69024074D1 (de)	1996-01-25	Herstellung von Aramidfasern
NO910720L (no)	1991-08-26	Vektorer og forbindelser for ekspresjon av zymogene former av humant protein c.
DE69033689D1 (de)	2001-02-15	Herstellung alkylierter Aromaten
DE69129795D1 (de)	1998-08-20	Wellenleiterkoppler/-verzweiger
FI901422A0 (fi)	1990-03-21	Anordning och foerfarande foer reglering av drift av klaedestorkare.
IT1198289B (it)	1988-12-21	Antigene di flavvirus
DK0646176T3 (da)	2004-11-08	Levering og ekspression af et hybridoverfladeprotein på overfladen af grampositive bakterier
DK352888D0 (da)	1988-06-27	Anordning ved indsproejtningsmekanisme
KR920702072A (ko)	1992-08-12	초박판 압전공진자의 구조
DK0939769T3 (da)	2006-03-13	Vertebrat-Smoothened-proteiner
FI943218A7 (fi)	1994-07-05	Kaseinomakropeptidin peptidit, mainittujen peptidien vasta-aineet ja k äytöt
DK638087D0 (da)	1987-12-04	Ekspressionsvektorer
DK563184A (da)	1985-05-29	Olefinsulfonatpraeparater
NO921054L (no)	1992-09-21	Fremgangsmaate ved kjemisk modifisering av proteiner
DE69105816D1 (de)	1995-01-26	Herstellung von Diisopropyläther.
FI885025A0 (fi)	1988-11-01	Koagulationshaemmande protein pp4-x, dess framstaellning och anvaendning.