DK0533131T3 - Fremgangsmåde til selektiv mono-ortho-hydroxy-alkylering af 4-substituerede pyridin-derivater - Google Patents
Fremgangsmåde til selektiv mono-ortho-hydroxy-alkylering af 4-substituerede pyridin-derivaterInfo
- Publication number
- DK0533131T3 DK0533131T3 DK92115832.5T DK92115832T DK0533131T3 DK 0533131 T3 DK0533131 T3 DK 0533131T3 DK 92115832 T DK92115832 T DK 92115832T DK 0533131 T3 DK0533131 T3 DK 0533131T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxyalkylation
- ortho
- pyridine derivatives
- substituted pyridine
- selective mono
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 4-Substituted Pyridine Chemical class 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 abstract 2
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 125000005385 peroxodisulfate group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4131217 | 1991-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0533131T3 true DK0533131T3 (da) | 1995-12-04 |
Family
ID=6441003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92115832.5T DK0533131T3 (da) | 1991-09-19 | 1992-09-16 | Fremgangsmåde til selektiv mono-ortho-hydroxy-alkylering af 4-substituerede pyridin-derivater |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5693819A (da) |
| EP (1) | EP0533131B1 (da) |
| JP (1) | JP3151786B2 (da) |
| AT (1) | ATE126214T1 (da) |
| CA (1) | CA2078585A1 (da) |
| DE (1) | DE59203209D1 (da) |
| DK (1) | DK0533131T3 (da) |
| ES (1) | ES2076642T3 (da) |
| GR (1) | GR3017398T3 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2204580A1 (en) * | 1997-05-06 | 1998-11-06 | Michel Zoghbi | Synthesis of pharmaceutically useful pyridine derivatives |
| WO1999033807A2 (en) * | 1997-12-24 | 1999-07-08 | Pdi-Research Laboratories, Inc. | Synthesis of pharmaceutically useful pyridine derivatives (intermediates) employing free radical substitution reactions to functionalize the 2-position of the pyridine |
| US6437139B1 (en) | 1997-05-06 | 2002-08-20 | Pdi-Research Laboratories, Inc. | Synthesis of pharmaceutically useful pyridine derivatives |
-
1992
- 1992-09-16 DK DK92115832.5T patent/DK0533131T3/da active
- 1992-09-16 AT AT92115832T patent/ATE126214T1/de not_active IP Right Cessation
- 1992-09-16 ES ES92115832T patent/ES2076642T3/es not_active Expired - Lifetime
- 1992-09-16 DE DE59203209T patent/DE59203209D1/de not_active Expired - Fee Related
- 1992-09-16 EP EP92115832A patent/EP0533131B1/de not_active Expired - Lifetime
- 1992-09-18 CA CA002078585A patent/CA2078585A1/en not_active Abandoned
- 1992-09-18 JP JP24912992A patent/JP3151786B2/ja not_active Expired - Fee Related
-
1993
- 1993-12-27 US US08/173,479 patent/US5693819A/en not_active Expired - Fee Related
-
1995
- 1995-09-13 GR GR950402528T patent/GR3017398T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05194399A (ja) | 1993-08-03 |
| DE59203209D1 (de) | 1995-09-14 |
| JP3151786B2 (ja) | 2001-04-03 |
| EP0533131A1 (de) | 1993-03-24 |
| ATE126214T1 (de) | 1995-08-15 |
| EP0533131B1 (de) | 1995-08-09 |
| US5693819A (en) | 1997-12-02 |
| CA2078585A1 (en) | 1993-03-19 |
| GR3017398T3 (en) | 1995-12-31 |
| ES2076642T3 (es) | 1995-11-01 |
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