DK0537007T3 - Anvendelse af farnesyl-protein-transferase-inhibitorer til fremstilling af et lægemiddel til blokering af neoplastisk transformation af celler fremkaldt af ras-oncogener - Google Patents

Anvendelse af farnesyl-protein-transferase-inhibitorer til fremstilling af et lægemiddel til blokering af neoplastisk transformation af celler fremkaldt af ras-oncogener

Info

Publication number: DK0537007T3
Authority: DK; Denmark
Prior art keywords: drug; prepare; cells induced; protein transferase; transferase inhibitors
Prior art date: 1991-10-11

Application number

DK92309184.7T

Other languages

English (en)

Inventor

Scott A Biller

Mariano Barbacid

David R Magnin

Eric M Gordon

Chester A Meyers

Veerasway Manne

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-11

Filing date

1992-10-08

Publication date

1995-09-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25102836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0537007(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-10-08 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1995-09-25 Application granted granted Critical

1995-09-25 Publication of DK0537007T3 publication Critical patent/DK0537007T3/da

Links

108700042226 ras Genes Proteins 0.000 title abstract 2
231100000504 carcinogenesis Toxicity 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
230000010309 neoplastic transformation Effects 0.000 title 1
239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 1
102000043276 Oncogene Human genes 0.000 abstract 1
229940121659 Prenyltransferase inhibitor Drugs 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
230000013823 prenylation Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK92309184.7T 1991-10-11 1992-10-08 Anvendelse af farnesyl-protein-transferase-inhibitorer til fremstilling af et lægemiddel til blokering af neoplastisk transformation af celler fremkaldt af ras-oncogener DK0537007T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US77495791A	1991-10-11	1991-10-11

Publications (1)

Publication Number	Publication Date
DK0537007T3 true DK0537007T3 (da)	1995-09-25

Family

ID=25102836

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92309184.7T DK0537007T3 (da)	1991-10-11	1992-10-08	Anvendelse af farnesyl-protein-transferase-inhibitorer til fremstilling af et lægemiddel til blokering af neoplastisk transformation af celler fremkaldt af ras-oncogener

Country Status (9)

Country	Link
US (1)	US6087349A (da)
EP (1)	EP0537007B1 (da)
JP (1)	JPH05221866A (da)
AT (1)	ATE126059T1 (da)
CA (1)	CA2080172A1 (da)
DE (1)	DE69204007T2 (da)
DK (1)	DK0537007T3 (da)
ES (1)	ES2075630T3 (da)
GR (1)	GR3017904T3 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5312814A (en) *	1992-12-09	1994-05-17	Bristol-Myers Squibb Co.	α-phosphonocarboxylate squalene synthetase inhibitors
HUT77406A (hu) *	1994-03-15	1998-04-28	Eisai Co., Ltd.,	1-(4-Amino-5-tio-pent-2-en)-il oldalláncot tartalmazó peptidomimetikumok és az ezeket tartalmazó gyógyszerkészítmények
US5436263A (en) *	1994-03-22	1995-07-25	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5420334A (en) *	1994-04-04	1995-05-30	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5510371A (en) *	1994-06-06	1996-04-23	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
GB9515975D0 (en)	1995-08-04	1995-10-04	Zeneca Ltd	Chemical compounds
US20020034725A1 (en) *	1996-04-15	2002-03-21	W. Gillies Mckenna	Sensitization of cells to radiation and and chemotherapy
US6946468B1 (en)	1996-08-17	2005-09-20	Zeneca Limited	3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
FR2780974B1 (fr) *	1998-07-08	2001-09-28	Sod Conseils Rech Applic	Utilisation de derives d'imidazopyrazines pour preparer un medicament destine a traiter les pathologies qui resultent de la formation de la proteine g heterotrimetrique
GB9930318D0 (en)	1999-12-22	2000-02-09	Zeneca Ltd	Novel compounds
GB9930317D0 (en)	1999-12-22	2000-02-09	Zeneca Ltd	Novel compounds
CA2372450A1 (en) *	2001-05-10	2001-09-19	Pharmaceutical Partners Of Canada Inc.	Liquid injectable formulation of disodium pamidronate
WO2005000858A2 (en)	2003-06-27	2005-01-06	Akira Odani	Bisphosphonate complexes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4871721A (en) *	1988-01-11	1989-10-03	E. R. Squibb & Sons, Inc.	Phosphorus-containing squalene synthetase inhibitors
EP0356866A3 (en) *	1988-08-29	1991-03-27	E.R. SQUIBB & SONS, INC.	Phosphorus-containing squalene synthetase inhibitors and method
US5196409A (en) *	1989-08-20	1993-03-23	Yissum, Research Development Company Of The Hebrew University Of Jerusalem	Bisphosphonates, pharmaceutical compositions, and process for the treatment of irregularities in calcium metabolism
US5025003A (en) *	1989-09-18	1991-06-18	E. R. Squibb & Sons, Inc.	Isoprenoid phosphinylformic acid squalene synthetase inhibitors
US5185248A (en) *	1990-05-08	1993-02-09	E. R. Squibb & Sons, Inc.	Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation

1992
- 1992-10-08 EP EP92309184A patent/EP0537007B1/en not_active Revoked
- 1992-10-08 DK DK92309184.7T patent/DK0537007T3/da active
- 1992-10-08 CA CA002080172A patent/CA2080172A1/en not_active Abandoned
- 1992-10-08 ES ES92309184T patent/ES2075630T3/es not_active Expired - Lifetime
- 1992-10-08 AT AT92309184T patent/ATE126059T1/de not_active IP Right Cessation
- 1992-10-08 DE DE69204007T patent/DE69204007T2/de not_active Revoked
- 1992-10-12 JP JP92272813A patent/JPH05221866A/ja active Pending
1995
- 1995-10-27 GR GR950403003T patent/GR3017904T3/el unknown
1998
- 1998-05-06 US US09/081,972 patent/US6087349A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69204007T2 (de)	1996-03-21
CA2080172A1 (en)	1993-04-12
DE69204007D1 (de)	1995-09-14
EP0537007B1 (en)	1995-08-09
GR3017904T3 (en)	1996-01-31
ATE126059T1 (de)	1995-08-15
ES2075630T3 (es)	1995-10-01
JPH05221866A (ja)	1993-08-31
EP0537007A1 (en)	1993-04-14
US6087349A (en)	2000-07-11

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