ATE126059T1 - Verwendung von farnesyl-protein transferaseinhibitoren zur herstellung eines arzneimittels zur blockierung von durch ras- oncogenen hervorgerufenen neoplastischen transformationen von zellen. - Google Patents
Verwendung von farnesyl-protein transferaseinhibitoren zur herstellung eines arzneimittels zur blockierung von durch ras- oncogenen hervorgerufenen neoplastischen transformationen von zellen.Info
- Publication number
- ATE126059T1 ATE126059T1 AT92309184T AT92309184T ATE126059T1 AT E126059 T1 ATE126059 T1 AT E126059T1 AT 92309184 T AT92309184 T AT 92309184T AT 92309184 T AT92309184 T AT 92309184T AT E126059 T1 ATE126059 T1 AT E126059T1
- Authority
- AT
- Austria
- Prior art keywords
- ras
- protein
- transferasin
- hibitors
- farnesyl
- Prior art date
Links
- 230000000903 blocking effect Effects 0.000 title abstract 2
- 108700042226 ras Genes Proteins 0.000 title abstract 2
- 231100000504 carcinogenesis Toxicity 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 230000010309 neoplastic transformation Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000043276 Oncogene Human genes 0.000 abstract 1
- 229940121659 Prenyltransferase inhibitor Drugs 0.000 abstract 1
- 230000013823 prenylation Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77495791A | 1991-10-11 | 1991-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE126059T1 true ATE126059T1 (de) | 1995-08-15 |
Family
ID=25102836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92309184T ATE126059T1 (de) | 1991-10-11 | 1992-10-08 | Verwendung von farnesyl-protein transferaseinhibitoren zur herstellung eines arzneimittels zur blockierung von durch ras- oncogenen hervorgerufenen neoplastischen transformationen von zellen. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6087349A (de) |
| EP (1) | EP0537007B1 (de) |
| JP (1) | JPH05221866A (de) |
| AT (1) | ATE126059T1 (de) |
| CA (1) | CA2080172A1 (de) |
| DE (1) | DE69204007T2 (de) |
| DK (1) | DK0537007T3 (de) |
| ES (1) | ES2075630T3 (de) |
| GR (1) | GR3017904T3 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5312814A (en) * | 1992-12-09 | 1994-05-17 | Bristol-Myers Squibb Co. | α-phosphonocarboxylate squalene synthetase inhibitors |
| HUT77406A (hu) * | 1994-03-15 | 1998-04-28 | Eisai Co., Ltd., | 1-(4-Amino-5-tio-pent-2-en)-il oldalláncot tartalmazó peptidomimetikumok és az ezeket tartalmazó gyógyszerkészítmények |
| US5436263A (en) * | 1994-03-22 | 1995-07-25 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5420334A (en) * | 1994-04-04 | 1995-05-30 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5510371A (en) * | 1994-06-06 | 1996-04-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| GB9515975D0 (en) | 1995-08-04 | 1995-10-04 | Zeneca Ltd | Chemical compounds |
| US20020034725A1 (en) * | 1996-04-15 | 2002-03-21 | W. Gillies Mckenna | Sensitization of cells to radiation and and chemotherapy |
| US6946468B1 (en) | 1996-08-17 | 2005-09-20 | Zeneca Limited | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors |
| FR2780974B1 (fr) * | 1998-07-08 | 2001-09-28 | Sod Conseils Rech Applic | Utilisation de derives d'imidazopyrazines pour preparer un medicament destine a traiter les pathologies qui resultent de la formation de la proteine g heterotrimetrique |
| GB9930318D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| GB9930317D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| CA2372450A1 (en) * | 2001-05-10 | 2001-09-19 | Pharmaceutical Partners Of Canada Inc. | Liquid injectable formulation of disodium pamidronate |
| WO2005000858A2 (en) | 2003-06-27 | 2005-01-06 | Akira Odani | Bisphosphonate complexes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4871721A (en) * | 1988-01-11 | 1989-10-03 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors |
| EP0356866A3 (de) * | 1988-08-29 | 1991-03-27 | E.R. SQUIBB & SONS, INC. | Phosphor enthaltende Squalen-Synthetase-Inhibitoren und Verfahren |
| US5196409A (en) * | 1989-08-20 | 1993-03-23 | Yissum, Research Development Company Of The Hebrew University Of Jerusalem | Bisphosphonates, pharmaceutical compositions, and process for the treatment of irregularities in calcium metabolism |
| US5025003A (en) * | 1989-09-18 | 1991-06-18 | E. R. Squibb & Sons, Inc. | Isoprenoid phosphinylformic acid squalene synthetase inhibitors |
| US5185248A (en) * | 1990-05-08 | 1993-02-09 | E. R. Squibb & Sons, Inc. | Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation |
-
1992
- 1992-10-08 EP EP92309184A patent/EP0537007B1/de not_active Revoked
- 1992-10-08 DK DK92309184.7T patent/DK0537007T3/da active
- 1992-10-08 CA CA002080172A patent/CA2080172A1/en not_active Abandoned
- 1992-10-08 ES ES92309184T patent/ES2075630T3/es not_active Expired - Lifetime
- 1992-10-08 AT AT92309184T patent/ATE126059T1/de not_active IP Right Cessation
- 1992-10-08 DE DE69204007T patent/DE69204007T2/de not_active Revoked
- 1992-10-12 JP JP92272813A patent/JPH05221866A/ja active Pending
-
1995
- 1995-10-27 GR GR950403003T patent/GR3017904T3/el unknown
-
1998
- 1998-05-06 US US09/081,972 patent/US6087349A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69204007T2 (de) | 1996-03-21 |
| CA2080172A1 (en) | 1993-04-12 |
| DE69204007D1 (de) | 1995-09-14 |
| EP0537007B1 (de) | 1995-08-09 |
| GR3017904T3 (en) | 1996-01-31 |
| ES2075630T3 (es) | 1995-10-01 |
| JPH05221866A (ja) | 1993-08-31 |
| EP0537007A1 (de) | 1993-04-14 |
| US6087349A (en) | 2000-07-11 |
| DK0537007T3 (da) | 1995-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| RZN | Patent revoked |